Table 2 Biopsy findings of three cases
Parameter | Case 1 | Case 2 | Case 3 | ||
|---|---|---|---|---|---|
1st | 2nd | 3rd | |||
Post-Tx, days | 64 | 64 | 48 | 68 | 88 |
Number of glomerulus, n | 9 | 23 | 11 | 31 | 6 |
LM | |||||
Glomerulus | Mesangiolysis Shrunken capillary loops Glomerular inflammatory cell infiltration | Shrunken capillary loops Segmental capillary wall double contours | Segmental glomerular capillary fibrinoid necrosis Glomerular inflammatory cell infiltration (g2) | ||
Tubulointerstitium | Interstitial hemorrhage ATIN | Tubular atrophy and interstitial fibrosis ATN | No | Tubular atrophy (ct1) | Tubular atrophy(ct2) interstitial fibrosis(ci1) |
Renal arteriole/artery | Arterial endothelial edema | Arteriolar intimal edema and thickening Arteriolar lumen occlusion | Arteriolar wall thickening | Arteriolar intimal thickening Arteriolar lumen occlusion Endoarteritis (v2) | Arteriolar wall thickening Arteriolar intimal thickening Arteriolar lumen occlusion |
Thrombi location | No | No | No | Glomerular | Glomerular, PTA |
Fragmented red blood cells location | Glomerular capillary loops | Arteriolar Glomerular capillary loops | No | Glomerular capillary loops | Glomerular capillary loops |
IF | IgA + + , IgM + | Negative | NA | NA | NA |
C4d | Negative | NA | Positive | Positive | Negative |
Pathological diagnosis | TMA, ATIN, ABMR? | TMA, ATN | ABMR | ABMR, TMA | ABMR, TMA |