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Table 4 Pathological features of PLA2R positive HBV-MN patients and idiopathic MN patients

From: Favorable outcome in PLA2R positive HBV-associated membranous nephropathy

 

HBV-MN

Idiopathic MN

P value

Glomerular lesions

 Sclerotic glomeruli, n (%)

3/7 (42.9)

37/69 (53.6)

0.702

 Segmental sclerosis, n (%)

1/7 (14.3)

8/67 (11.9)

1.000

 Mesangial proliferation, n (%)

7/7 (100.0)

56/69 (81.2)

0.596

Immunofluorescence

 IgG, n (%)

7/7 (100)

69/69 (100)

 

 C3, n (%)

6/7 (85.7)

65/69 (94.2)

0.392

 IgA, n (%)

2/7 (28.6)

8/69 (11.6)

0.228

 IgM, n (%)

3/7 (42.9)

12/68 (17.6)

0.138

 C1q, n (%)

0/7 (0.0)

7/69 (10.1)

1.000

 HBsAg, n (%)

6/7 (85.8)

-

 

 HBcAg, n (%)

3/7 (42.9)

-

 

Electronic microscopy

 Subepithelial deposits, n (%)

7/7 (100.0)

46/46 (100.0)

 

 Mesangial deposits, n (%)

5/7 (71.4)

7/46 (15.2)

0.004

  1. PLA2R Phospholipase A2 receptor, HBV Hepatitis B virus, MN Membranous nephropathy, HBsAg Hepatitis B virus surface antigen, HBcAg Hepatitis B virus core antigen