Haemostatic profile of children with nephrotic syndrome attending University of Nigeria Teaching Hospital Ituku-Ozalla, Nigeria

Table 5 Coagulation profile steroid-sensitive and steroid resistant nephrotic syndrome and controls

Sample size (N) Variable Fib(g/L)	SSNS 24	SRNS 15	CS 46	Group p value	SS vs SR	SS vs CS	SR vs CS
Median	2.4	3.7	3	*0.051*⁺	> *0.050*	> *0.050*	> *0.050*
IQR	2.0 – 3.3	2.0—5.5	2.4 – 4.0
AT (%)
Median	142.5	144	131	*0.187*	> *0.050*	> *0.050*	> *0.050*
IQR	128.0–149.0	128.0 -152.0	125—146
APTT (s)
Median	49	43	42	0.025*	> *0.050*	0.010*	> *0.050*
IQR	40.3 – 64.3	39.0—50.0	38.0—45.3
PT (s)
Median	12	11	13	0.010*	> *0.050*	> *0.050*	0.010*
IQR	11.0 – 13.0	10.0 -12.0	12.0 -14.0
INR
Median	0.9	0.8	1	0.004*	> *0.050*	> *0.050*	0.001*
IQR	0.9 -1.0	0.8—0.9	1.0—1.1
Plt Count
(x10³cells /mm³) Median	238	257	235	*0.781*	> *0.050*	> *0.050*	> *0.050*
IQR	183 -328	152 -180	197 -277

SR Steroid resistant, SS Steroid sensitive, CS Controls, vs Versus, SSNS Steroid sensitive nephrotic syndrome, SRNS Steroid resistant nephrotic syndrome, SD Standard deviation, IQR Inter-quartile range, Plt Platelet, APTT Activated partial thromboplastin time, PT Prothrombin time, INR International normalized ratio, AT Antithrombin, Fib Fibrinogen
^* Statistically significant (p < 0.05)
⁺ Group P value = trend towards statistical significance

ISSN: 1471-2369