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Table 8 Association between coagulation variables and steroid response status

From: Haemostatic profile of children with nephrotic syndrome attending University of Nigeria Teaching Hospital Ituku-Ozalla, Nigeria

Variable

No of cases

  

Steroid Sensitive

Nephrotic syndrome

Steroid Resistant

Nephrotic syndrome

Chi Square

χ2

p value

High Fib (> 3.5 g/L)

1

8

9.798

0.008*

Normal Fib ( 1.5 -3.5 g/L)

22

6

  

Low Fib (< 1.5 g/L)

1

1

  

High AT (> 144%)

11

8

0.303

0.859

Normal AT (80 -144%)

11

6

  

Low AT-III (< 80%)

2

0

  

High APTT (> 50 s)

7

3

0.037

0.982

Normal APTT ( 36 -50 s)

15

11

  

Low APTT (< 36 s)

2

1

  

High PT (> 16 s)

1

0

0.335

0.846

Normal PT (11 -16 s)

17

11

  

Low PT (< 11 s)

6

3

  

High INR (> 1.2)

5

2

6.715

0.035*

Normal INR (0.8 -1.2)

19

7

  

Low INR (< 0.8)

0

6

  

High PLT (> 400 × 103

cells/mm3

2

0

1.459

0.482

Normal PLT (150 – 400

 × 103 cells/mm3)

18

12

  

Low PLT (< 150

 × 103 cells/mm3)

4

3

  
  1. Key: Plt Platelet, APTT Activated partial thromboplastin time, PT Prothrombin time, INR International normalized ratio, AT Antithrombin, Fib Fibrinogen
  2. * Statistically significant p < 0.05