Table 4 The mean (SD) and median (IQR) baseline clinical values in all randomised participants (intention to treat population)

Haemoglobin (g/L)

71

125 (12)

Platelet count (× 10^9/L)

71

236 (62), 229 (197, 281)

Ferritin (ug/L)

69

59 (45), 52 (35, 71)

Transferrin saturation (TSAT) (%)

70

22 (10), 20 (17, 25)

Urea (mmol/L)

66

11.6 (5.4), 10.0 (8.0, 14.0)

Sodium (mmol/L)

72

139.79 (2.33), 140.00 (138.00, 141.00)

Potassium (mmol/L)

72

4.57 (0.60), 5.00 (4.00, 5.00)

Creatinine (umol/l)

72

175 (71), 140 (126, 228)

Serum phosphate (mmol/L)

67

1.15 (0.20), 1.10 (1.00, 1.30)

Serum albumin (g/L)

73

42.85 (2.86), 43.00 (41.00, 45.00)

Total Protein (g/L)

54

70.8 (5.4), 71.0 (68.0, 74.0)

CRP (mg/L)

68

4.4 (4.3), 3.0 (2.0, 5.0)

eGFR (ml/min/1.73m²)

72

35 (12), 37 (24, 43)

SBP

72

134 (16), 135 (124, 144)

DBP

72

78 (10), 79 (73, 85)

Heart rate (bpm)

72

76 (13), 75 (67, 86)

Height (cm)

72

166 (11), 165 (158, 173)

Weight (kg)

72

84 (18), 80 (72, 92)

Waist circumference (cm)

71

105 (16), 105 (96, 114)

Hip circumference (cm)

71

112 (13), 109 (103, 120)

Body mass index

72

31 (7), 29 (26, 35)

6MWT Distance (metres)

70

429 (174), 480 (360, 543)

STS60 (Number of repetitions)

70

24 (8), 24 (18, 29)

VO2 peak (L/min)

45

1.36 (0.48), 1.34 (0.99, 1.62)

VE/VCO2 slope (mL/kg/min)

45

33.5 (5.5), 32.6 (29.2, 36.3)

Muscle strength

Right Leg: Highest peak torque achieved at 60 degrees angular velocity (newton meters)

70

97 (44), 90 (68, 117)

Right Leg: Highest peak torque achieved at 90 degrees angular velocity (newton meters)

70

94 (43), 88 (67, 123)

Right Leg: Highest peak torque achieved at 120 degrees angular velocity (newton meters)

70

84 (39), 77 (58, 110)

Right Leg: Isometric maximum voluntary contraction (90-degree angle): Highest peak torque (newton meters)

70

132 (66), 118 (85, 163)

Left Leg: Highest peak torque achieved at 60 degrees angular velocity (newton meters)

67

92 (44), 86 (61, 120)

Left Leg: Highest peak torque achieved at 90 degrees angular velocity (newton meters)

67

83 (39), 79 (51, 107)

Left Leg: Highest peak torque achieved at 120 degrees angular velocity (newton meters)

67

76 (33), 74 (48, 95)

Left Leg: Isometric maximum voluntary contraction (90-degree angle): Highest peak torque (newton meters)

67

124 (61), 114 (79, 150)

Right leg dominant leg

68

55 (81%)

Chalder Fatigue Score

73

17.2 (5.7), 16.0 (12.0, 22.0)

WSAS total score

72

15 (12), 12 (6, 24)

WSAS sub-scales

72

Mild functional impairment

31 (43%)

Moderately severe functional impairment

18 (25%)

Severe functional impairment

23 (32%)

KDQOL-36 SF1.3

SF-12 Physical Health Composite

71

40 (12), 38 (31, 52)

SF-12 Mental Health Composite

71

43 (11), 42 (36, 54)

Burden of kidney disease (k = 4)

72

66 (29), 75 (44, 94)

Symptoms/problems (k = 12)

72

75 (20), 78 (64, 89)

Effects of kidney disease (k = 8)

71

78 (22), 82 (70, 94)