Table 2 Basal patient characteristics according to AKI occurrence
| Â | NON-AKI | AKI | P value |
|---|---|---|---|
N = 168 | N = 706 |  | |
Age, years | 55 [44; 63] | 53 [45; 60] | 0.06 |
Gender, male (%) | 114 (67.9) | 480 (68) | 0.97 |
BMI (Kg/m2) | 25.7 [22.6; 28.5] | 25.6 [22.9; 29.1] | 0.38 |
Hypertension (%) | 37 (22) | 133 (18.8) | 0.35 |
Diabetes (%) | 41 (24.4) | 25.6 [22.9; 29.1] | 0.66 |
APACHE 2 | 17 [14; 19] | 16 [14; 19] | 0.90 |
SAPS 3 | 38 [30.25; 43] | 39 [32; 44,25] |  < 0.01 |
Admission eGFR (mL/min/1.73m2) | 95.5 [76.2; 118] | 90 [63; 121] | 0.01 |
Pathogenesis of liver disease | |||
 Hepatitis C (%) | 75 (44.6) | 324 (45.9) | 0.77 |
 Hepatitis B (%) | 17 (10.1) | 53 (7.5) | 0.26 |
 Alcoholic liver cirrhosis (%) | 27 (16.1) | 148 (21) | 0.15 |
 Others (%) | 35 (20.8) | 162 (22.9) | 0.56 |
Hepatocellular carcinoma (%) | 75 (44.6) | 199 (28.2) |  < 0.01 |
Familial amyloid polyneuropathy (%) | 11 (6.5) | 28 (4) | 0.15 |
Pre-Transplant Albumin level (g/dL) | 3.1 [2.9; 3.6] | 3 [2.7; 3.3] |  < 0.01 |
CPT Score |  |  |  < 0.01 |
 A or non-cirrhotic (%) | 35 (20.8) | 89 (12.6) |  |
  B (%) | 83 (49.4) | 329 (46.6) |  |
  C (%) | 50 (29.8) | 288 (40.8) |  |
MELD score | 13 [8; 18] | 16 [11; 23] |  < 0.01 |
  Preoperative Creatinine (mg/dL) | 0.8 [0.7; 1.0] | 0.9 [0.7; 1.2] | 0.01 |
  Preoperative Total bilirubin (mg/dL) | 2.15 [1.4; 4.45] | 3 [1.8; 5.9] |  < 0.01 |
  Preoperative prothrombin time, INR | 1.5 [1.23; 1.9] | 1.7 [1.4; 2.15] |  < 0.01 |
Surgical aspects | |||
 Deceased donor (%) | 150 (89.3) | 568 (80.5) |  < 0.01 |
 Piggyback technique (%) | 161 (95.8) | 692 (98) | 0.09 |
 Operation time (h) | 6 [5.1; 7.31] | 7 [5.67; 8] |  < 0.01 |
 Total ischemia time (h) | 8.6 [6.8; 10.6] | 8.3 [6.4; 10.4] | 0.19 |
 Vasopressor (%) | 64 (38.1) | 291 (41.2) | 0.49 |
 Number of blood packs | 3 [1; 9] | 4 [2; 8] | 0.31 |
Post-transplant care | |||
 Sepsis during hospitalization (%) | 24 (14.3) | 291 (41.2) |  < 0.01 |
 Vasopressor after transplant (%) | 41 (24.4) | 293 (41.5) |  < 0.01 |
 Tacrolimus based immunosuppression (%) | 153 (91.1) | 605 (85.7) | 0.08 |
 First week Tacrolimus peak level (ng/mL) | 7.7 [5.7; 11.8] | 8.1 [4.9; 12.5] | 0.77 |
 Acute liver rejection (%) | 18 (10.7) | 174 (24.6) |  < 0.01 |
 Nephrotoxic exposure (%) | 56 (33.3) | 381 (54) |  < 0.01 |
 Urinary output (ml/Kg/H) | 0.68 [0.43; 0.97] | 0.36 [0.21; 0.56] |  < 0.01 |