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Table 3 Anticoagulant treatment in nephrotic patients

From: Safety and effectiveness of direct oral anticoagulants in patients with nephrotic syndrome: a report of 21 cases

Intervention

Nephrotic syndrome episodes

(N = 22a)

No bleeding events

(N = 17)

Bleeding events

(N = 5)

Type of DOAC – n (%)

 Apixaban

10 (45)

7 (41)

3 (60)

 Rivaroxaban

12 (55)

10 (59)

2 (40)

DOAC treatment – n (%)

 Primary prophylaxis

20 (91)

16 (94)

4 (80)

 Treatment

2 (9)

1 (6)

1 (20)

Duration of DOAC (days, median (IQR))

103 (21–403)

47 (21–378)

204 (109–897)

 Primary prophylaxis

72 (21–326)

45 (18–326)

157 (65–551)

 Secondary prophylaxis

970 (478–1462)

-

-

DOAC are stopped due to – n (%)

 Plasma-albumin > 20 g/L

11 (50)

7 (41)

4 (80)

 eGFR < 15 mL/min/1.73m2

3 (14)

3 (18)

0 (0)

 Ongoing at end of study

6 (27)

5 (29)

1 (20)

 Other

2 (9)

2 (12)

0 (0)

  1. IQR Interquartile range
  2. a One patient experienced relapse of nephrotic syndrome during the follow up period