Variables | Bumetanide plus placebo Mean ± SD | Bumetanide plus chlorthalidone Mean ± SD | p-value | Cohen's D |
---|---|---|---|---|
Changes of SBP | ||||
7 day | -7.5 ± 17.8 | -18.1 ± 14.1 | 0.073 | 0.66 |
30 day | -10 ± 23.3 | -26.2 ± 15.3 | 0.028 | 0.84 |
Changes of DBP | ||||
7 day | -2.25 ± 8.6 | -8.5 ± 9.3 | 0.059 | 0.69 |
30 day | -3.40 ± 11.9 | -13.5 ± 10.7 | 0.018 | 0.89 |
Changes of MAP | ||||
7 day | -3.97 ± 10.2 | -11.7 ± 8.7 | 0.029 | 0.82 |
30 day | -5.41 ± 14.3 | -18.1 ± 8.7 | 0.005 | 1.10 |
Changes of TBW | ||||
7 day | -0.59 ± 2.38 | -2.5 ± 1.9 | 0.016 | 0.89 |
30 day | -0.07 ± 1.78 | -5.3 ± 6.2 | 0.003 | 1.31 |
Changes of ECW | ||||
7 day | -0.43 ± 1.4 | -1.58 ± 0.69 | 0.007 | 1.10 |
30 day | -0.15 ± 1.2 | -3.11 ± 2.68 | < 0.000 | 1.52 |
Changes of ECW/TBW | ||||
7 day | -0.72 ± 1.7 | -1.24 ± 1.94 | 0.077 | 1.21 |
30 day | -0.24 ± 1.4 | -4.38 ± 6.49 | 0.018 | 1.05 |
Changes of FENA | ||||
7 day | -0.19 ± 3.4 | 0.78 ± 0.82 | 0.284 | 0.28 |
30 day | -0.35 ± 3.4 | 0.59 ± 2.29 | 0.371 | 0.08 |
Changes of BNP | ||||
7 day | 33.6 ± 178 | -39.3 ± 110 | 0.174 | 0.04 |
30 day | 213.5 ± 669 | -0.64 ± 146 | 0.221 | 0.52 |