Table 1 Baseline characteristics of the main study population across the quarters of baseline total cholesterol
Variables | Total (n = 911,360) | Q1 (n = 227,711) | Q2 (n = 222,006) | Q3 (n = 230,520) | Q4 (n = 231,123) |
|---|---|---|---|---|---|
TC, mg/dL, median [25th–75th %] | 213 [182–243] | 166 [151–174] | 197 [189–205] | 224 [217–232] | 263 [251–286] |
Age, years, mean (SD) | 54.6 (12.9) | 52.0 (14.6) | 53.7 (12.9) | 55.5 (12.0) | 57.2 (11.3) |
Female sex, n (%) | 479,498 (52.6) | 109,838 (48.2) | 113,745 (51.2) | 121,932 (52.9) | 133,983 (58.0) |
Current smoker, n (%) | 189,234 (20.8) | 47,246 (20.7) | 44,875 (20.2) | 47,006 (20.4) | 50,107 (21.7) |
IMD tenth > 5, n (%) | 381,892 (41.9) | 100,777 (44.3) | 92,536 (41.7) | 93,717 (40.7) | 94,862 (41.0) |
BMI, kg/m2, mean (SD) | 28.5 (5.8) | 28.4 (6.2) | 28.5 (5.9) | 28.7 (5.7) | 28.6 (5.3) |
BMI category, kg/m2, n (%) | |||||
< 20 | 17,862 (3.2) | 6940 (4.5) | 4484 (3.2) | 3694 (2.7) | 2744 (2.1) |
≥20, < 25 | 141,377 (25.0) | 42,219 (27.4) | 36,159 (25.8) | 33,175 (23.8) | 29,824 (22.6) |
≥25, < 30 | 214,076 (37.8) | 53,723 (34.8) | 51,854 (37.0) | 54,326 (39.0) | 54,173 (41.0) |
≥30, < 35 | 120,029 (21.2) | 30,535 (19.8) | 29,134 (20.8) | 30,366 (21.8) | 29,994 (22.7) |
≥35 | 72,311 (12.8) | 20,779 (13.5) | 18,508 (13.2) | 17,686 (12.7) | 15,338 (11.6) |
SBP, mmHg, mean (SD) | 139 (20.9) | 134 (19.9) | 138 (20.5) | 141 (20.7) | 144 (21.2) |
TG mg/dL, median [25th–75th %] | 124 [85.0–177] | 97.4 [70.9–136] | 112 [79.7–159] | 126 [88.6–181] | 159 [112–230] |
LDL-C, mg/dL, median [25th–75th %] | 128 [104–155] | 88.9 [77.3–103] | 120 [108–128] | 143 [131–151] | 174 [160–193] |
HDL-C, mg/dL, median [25th–75th %] | 53.8 [42.9–65.0] | 49.5 [40.2–58.0] | 53.4 [42.9–64.2] | 54.1 [45.6–65.7] | 55.7 [46.4–68.1] |
eGFR, mL/min/1.73 m2, mean (SD) | 79.6 (17.7) | 82.6 (19.0) | 80.7 (17.4) | 78.7 (16.8) | 76.2 (16.7) |
Prior diabetes mellitus, yes, n (%) | 93,097 (10.2) | 36,985 (16.2) | 22,607 (10.2) | 18,255 (7.9) | 15,250 (6.6) |
Prior CVD, yes, n (%) | 129,643 (14.2) | 49,824 (21.9) | 30,272 (13.6) | 25,451 (11.0) | 24,096 (10.4) |
Antihypertensive med., yes, n (%) | 317,501 (34.8) | 88,945 (39.1) | 74,634 (33.6) | 76,040 (33.0) | 77,882 (33.7) |
Insulin, yes, n (%) | 19,458 (2.1) | 9281 (4.1) | 4716 (2.1) | 3262 (1.4) | 2199 (1.0) |
Statin category, n (%) | |||||
Simvastatin | 60,696 (6.7) | 33,010 (14.5) | 13,603 (6.1) | 8143 (3.5) | 5940 (2.6) |
Atorvastatin | 34,237 (3.8) | 18,448 (8.1) | 7690 (3.5) | 4327 (1.9) | 3772 (1.6) |
Other statins | 12,345 (1.4) | 4462 (2.0) | 3249 (1.5) | 2562 (1.1) | 2072 (0.90 |