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Table 2 Longitudinal changes in patient-reported outcomes, residual kidney function, and HD treatment time

From: Patient-reported outcomes in a pilot clinical trial of twice-weekly hemodialysis start with adjuvant pharmacotherapy and transition to thrice-weekly hemodialysis vs conventional hemodialysis

Assessment

Baseline

Week 6

Week 12

Incremental HD

Conventional HD

Incremental HD

Conventional HD

Incremental HD

Conventional HD

N

Mean (95% CI)

N

Mean (95% CI)

N

Mean (95% CI)

N

Mean (95% CI)

N

Mean (95% CI)

N

Mean (95% CI)

Model 1

 DSI

20

39.5 (26.6, 52.4)

21

41.5 (28.2, 55.7)

20

29.2 (20.1, 38.2)

21

27.5 (18.5, 36.6)

20

25.8 (18.8, 32.9)

21

24.8 (17.6, 32.0)

 GAD-7

20

3.5 (1.0, 6.0)

20

3.5 (1.0, 6.6)

20

1.6 (0, 3.4)

20

3.4 (1.5, 5.2)

20

2.0 (0.6, 3.4)

20

2.9 (1.5, 4.2)

 PHQ-9

20

5.5 (2.7, 8.3)

20

6.7 (3.8, 9.5)

20

3.0 (1.5, 4.5)

20

3.9 (2.4, 5.4)

20

3.3 (1.9, 4.6)

20

3.3 (2.0, 4.6)

 Urine volume, mL/24 h

23

914 (654–1174)

25

1424 (976–1872)

19

504 (335–673)

17

553 (384–723)

19

479 (288–670)

19

484 (292–676)

 Renal urea clearance, mL/min/1.73 m2

18

3.3 (2.0–4.5)

17

4.1 (2.9–5.3)

19

2.3 (1.6–2.9)

17

2.3 (1.6–3.0)

19

2.1 (1.4–2.8)

19

2.0 (1.4–2.7)

 HD treatment time (min)

23

232.6 (24.8)

25

209.2 (21.9)

21

234.8 (27.3)

21

214.8 (34.3)

20

230.6 (23.5)

20

211.4 (29.8)

 Dialysis spKt/Va

22

1.43 (1.32–1.53)

21

1.30 (1.20–1.40)

22

1.42 (1.32–1.51)

18

1.40 (1.30–1.50)

21

1.42 (1.34–1.50)

18

1.36 (1.29–1.45)

Model 2

 DSI

20

42.6 (29.5, 55.8)

21

41.3 (27.5, 55.0)

20

33.0 (23.4, 42.6)

21

27.5 (17.3, 37.7)

20

29.9 (21.2, 38.6)

21

25.9 (16.6, 35.2)

 GAD-7

20

3.6 (1.1, 6.2)

20

3.1 (0.5, 5.8)

20

1.7 (0, 3.6)

20

3.0 (1.0, 5.0)

20

2.1 (0.4, 3.9)

20

3.1 (1.3, 4.9)

 PHQ-9

20

5.6 (2.9, 8.4)

20

6.7 (3.8, 9.5)

20

3.1 (1.5, 4.8)

20

4.1 (2.4, 5.9)

20

3.4 (1.8, 5.0)

20

3.7 (1.9, 5.4)

  1. Model 1 represents unadjusted analyses; Model 2 includes adjustments for covariates of age, race, gender, baseline urine volume, diabetes mellitus status, and malignancy status. DSI denotes Dialysis Symptom Index, GAD-7 Generalized Anxiety Disorder 7-item, HD Hemodialysis, LS Least squares, PHQ-9 Patient Health Questionnaire 9-item, SE Standard error
  2. aspKt/V, single pool Kt/V urea per HD session as reported according to usual care and monthly lab testing at outpatient dialysis units, without adjustment for HD sessions per week