Table 2 (Continued)
Patient | CNI/ mTOR inhibitor | Respective trough level | ALT (U/L) | AST (U/L) | TB (umol/L) | INR | aPTT (s) | PLT (10*9/L) | Main histological findings | Abnormal Immunological indicators |
|---|---|---|---|---|---|---|---|---|---|---|
1 | CSA | C0 118.9 mg/ml C2 247.2 mg/ml | 16 | 28 | 45.8 | 1.03 | 30.7 | 85 | IgAN | C3 0.56 g/L(L), C4 0.09 g/L(L), IgA 5.44 g/L(H),IgG 22.30 g/L(H), ANA 1:80 |
2 | TAC | 3.00ng/ml | 12 | 15 | 7.9 | 0.89 | 28.0 | 132 | membranoproliferative glomerulonephritis | N |
3 | TAC/RIPA | TAC 1.40ng/ml RIPA 5.40ng/ml | 12 | 13 | 2.7 | 0.91 | 28.6 | 113 | membranoproliferative glomerulonephritis, renal arteriolar sclerosis, DKD | N |
4 | CSA | C0/C2: 79.70/606.40 mg/ml | 15 | 20 | 16.7 | 0.87 | 27.5 | 244 | glomerular sclerosis, renal arteriolar sclerosis | N |
5 | TAC | < 1.00ng/ml | 8 | 10 | 18.3 | 0.97 | 11.00 | 79 | FSGS, DKD | N |
6 | TAC/RIPA | 5.5/9.6ng/ml | 3 | 13 | 5.1 | 0.98 | 26.6 | 83 | TMA | N |
7 | RIPA | 8.2ng/ml | 18 | 19 | 8 | 0.85 | 29.6 | 174 | FSGS, renal arteriolar sclerosis | N |
8 | TAC | 3.1ng/ml | 21 | 20 | 4.2 | 0.95 | 27.6 | 177 | Membranoproliferative glomerulonephritis | C3 0.85 g/L(L), RA 25.60 IU/mL(H) |
9 | RIPA | 4.4ng/ml | 11 | 15 | 3.4 | 0.75 | 28.7 | 182 | DKD | ANA 1:80 |
10 | TAC/RIPA | TAC 6.40ng/ml RIPA NA | 24 | 37 | 14.7 | 0.94 | 29.3 | 239 | FSGS, renal arteriolar sclerosis | N |
11 | CSA | C0 9.50 mg/ml C2 355.60 mg/ml | 28 | 33 | 18.6 | 1.08 | 27.3 | 187 | FSGS, severe interstitial fibrosis and tubular atrophy | IgA 18.7 g/L(H); IgM 91.4 g/L(H) |
12 | TAC | 3.60ng/ml | 8 | 14 | 7.6 | 0.84 | 26.4 | 245 | glomerular microangiopathy, DKD, renal arteriolar sclerosis | N |
13 | TAC/RIPA | NA | 14 | 35 | 6.8 | 0.95 | 30.0 | 89 | membranoproliferative glomerulonephriti, renal arteriolar sclerosis | N |
14 | TAC | NA | 12 | 14 | 12.9 | 0.88 | 22.1 | 98 | IgAN | N |