Polygenic association of glomerular filtration rate decline in world trade center responders

BMC Nephrology

Table 2 Categories Based on Clinical Cut-Off for Rates of Annual Change in eGFR

	No eGFR Decline (reference) (< 1.00 ml/min/1.73m²/year)		eGFR Decline (≥ 1.00 ml/min/1.73m²/year)		p-value
n	1048		553
Age	53.68	(7.99)	54.95	(8.44)	.009^a
Male	976	(93%)	509	(92%)	.486^b
Education					.143^b
No High School Diploma	33	(3%)	9	(2%)
High School Diploma	187	(18%)	110	(20%)
< Bachelor’s Degree	475	(45%)	265	(48%)
BA/BS or Graduate Degree	307	(29%)	151	(27%)
Other or Unknown	46	(3%)	18	(3%)
BMI (kg/m²)	30.97	(5.54)	30.94	(5.06)	.468^a
Hypertension	231	(23%)	132	(25%)	.404^b
Diabetes	54	(5%)	52	(9%)	.001^c
Cardiovascular Disease	8	(1%)	10	(2%)	.078^c
Baseline eGFR (ml/min/1.73 m²)	86.89	(13.27)	84.97	(14.73)	.027^a
3rd eGFR measurement (ml/min/1.73 m²)	89.03	(11.87)	75.32	(14.26)	< .001^a
5th eGFR measurement (ml/min/1.73 m²)	89.67	(10.87)	72.24	(16.28)	< .001^a
Average rate of eGFR decline (ml/min/1.73m²/year)	0.38	(0.48)	1.47	(0.43)	< .001^a

Notes. Means are reported with SDs in parentheses for variables measured on interval and ratio scales. Frequencies are reported with percentages in parentheses for count variables measured on binary and ordinal scales. P-values for ^aKruskal-Wallis rank sum test, ^bPearson’s chi-squared test with Yate’s continuity correction, and ^cFisher’s exact test are reported.

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