Polygenic association of glomerular filtration rate decline in world trade center responders

BMC Nephrology

Table 5 Polygenic Associations of eGFR Decline

	Clinical eGFR Categories
	No eGFR Decline	eGFR Decline ( ≤ -1.00 ml/min/1.73m ² /year)
		OR (95% CI)	p ₁ p ₂
Zero-Order (not adjusted for covariates)	1.00	1.14 (1.03, 1.27)	0.011 0.034
Adjusted for age, gender, education, and the first ten genetic principal components	1.00	1.17 (1.04, 1.31)	0.008 0.031
+ adjusted for BMI, diabetes, hypertension, and cardiovascular disease	1.00	1.15 (1.03, 1.29)	0.016 0.034
+ adjusted for exposure severity	1.00	1.14 (1.01, 1.28)	0.036 0.036

Notes. Decline = ≤ -1.00 ml/min/1.73m²/year. No Decline = > -1.00 ml/min/1.73m²/year. Odds ratios (OR) are reported with 95% CI in parentheses just below point estimates. PRSs were transformed to standardized scores (M = 0, SD = 1) to facilitate the interpretation of estimated coefficients. For example, for every one-point increase in the SD of the PRS, the odds of eGFR decline, compared to no GFR decline, increases by 14%, when holding all other variables constant. P-values indicate the probability of having observed the estimated association if the null hypothesis (no association; OR = 1) were true, before (p₁) and after (p₂) adjustment for family-wise error using the Holm method, whereby the reported column of point estimates constitutes a “family”.

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