From: Polygenic association of glomerular filtration rate decline in world trade center responders
Empirical eGFR Categories | |||||
---|---|---|---|---|---|
Middle Quartiles | Lower Quartile | Upper Quartile | |||
RR (95% CI) | p 1 p 2 | RR (95% CI) | p 1 p 2 | ||
Zero-Order Association (not adjusted for covariates) | 1.00 | 1.18 (1.05, 1.33) | 0.007 0.014 | 1.04 (0.92, 1.17) | 0.541 1.000 |
Adjusted for age, gender, education, and the first ten genetic principal components | 1.00 | 1.22 (1.07, 1.38) | 0.003 0.009 | 1.01 (0.89, 1.15) | 0.821 1.000 |
+ adjusted for BMI, diabetes, hypertension, and cardiovascular disease | 1.00 | 1.21 (1.06, 1.38) | 0.004 0.012 | 1.04 (0.91, 1.18) | 0.565 1.000 |
+ adjusted for exposure severity | 1.00 | 1.20 (1.04, 1.38) | 0.010 0.014 | 1.07 (0.93, 1.23) | 0.343 1.000 |