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Table 6 Polygenic Associations of Upper and Lower Quartiles representing Linear Changes in eGFR

From: Polygenic association of glomerular filtration rate decline in world trade center responders

 

Empirical eGFR Categories

Middle Quartiles

Lower Quartile

Upper Quartile

 

RR

(95% CI)

p 1

p 2

RR

(95% CI)

p 1

p 2

Zero-Order Association (not adjusted for covariates)

1.00

1.18

(1.05, 1.33)

0.007

0.014

1.04

(0.92, 1.17)

0.541

1.000

Adjusted for age, gender, education, and the first ten genetic principal components

1.00

1.22

(1.07, 1.38)

0.003

0.009

1.01

(0.89, 1.15)

0.821

1.000

+ adjusted for BMI, diabetes, hypertension, and cardiovascular disease

1.00

1.21

(1.06, 1.38)

0.004

0.012

1.04

(0.91, 1.18)

0.565

1.000

+ adjusted for exposure severity

1.00

1.20

(1.04, 1.38)

0.010

0.014

1.07

(0.93, 1.23)

0.343

1.000

  1. Notes. Unadjusted and adjusted relative risk ratios (RR) are reported with 95% confidence intervals (CI) in parentheses. The p-values indicate the probability of having observed the estimated association if the null hypotheses of no association (RR = 1.00) were true, unadjusted for family-wise error rate. P-values adjusted for family-wise error rate using the Holm method are reported just below unadjusted p-values.