Table 1 Characteristics of patients

Non-diabetes

Diabetes

P Value§

continuous variables

n

regression equation

R

P value

n

regression equation

R

P value

Age (years)

313

70.8 (60.0–79.4)

uACR = -0.5779 × age + 96.32

0.126

0.026

131

68.9 (60.5–76.9)

uACR = 0.7831 × age + 6.53

0.142

0.106

0.454

uPCR = -0.00067 × age + 0.1464

0.106

0.062

uPCR = 0.00230 × age-0.04744

0.269

0.0019

BMI

313

24.1(21.9–26.7)

uACR = 3.4360 × BMI-27.51

0.227

5.0E-05

131

24.8(22.8–27.6)

uACR = -1.5507 × BMI + 100.07

0.113

0.197

0.008

uPCR = 0.003843 × BMI + 0.0062

0.183

0.0011

uPCR = -0.00364 × BMI + 0.2034

0.171

0.050

Waist circumference(WC)(cm)

 male

167

88.0(82.5–94.3)

uACR = 1.4548 × WC-69.71

0.205

0.0078

77

90.5(85.0–99.5)

uACR = -0.4629 × WC + 100.50

0.084

0.467

0.042

uPCR = 0.001589 × WC-0.0373

0.167

0.030

uPCR = -0.00086 × WC + 0.1903

0.102

0.377

 female

121

83.0(76.0–89.5)

uACR = 0.1405 × WC + 38.46

0.035

0.69

42

90.0(86.3–96.0)

uACR = -0.8046 × WC + 135.52

0.155

0.327

0.0001

uPCR = 8.96E-5 × WC + 0.0834

0.015

0.87

uPCR = -0.00213 × WC + 0.2980

0.279

0.074

Time between measurements(day)

 1–2

313

70.0 (42.0–98.0)

131

63.0 (42.0–84.0)

0.034

 2–3

313

70.0 (49.0–91.0)

131

63.0 (54.5–81.5)

0.034

Non-diabetes

Diabetes

PII

P¶

P¶

categorical variables

n

uACR(mg/gCr)

uPCR(g/gCr)

n

uACR(mg/gCr)

uPCR(g/gCr)

n

uACR

uPCR

Age

  < 70 years old

150

27.5(14–73.8)

0.07(0.03–0.14)

70

36(13–62.5)

0.06(0.03–0.12)**

0.34

0.91

0.47

  ≥ 70 years old

163

36(16–75.5)

0.08(0.04–0.14)

61

43(23–87)

0.11(0.05–0.19)

0.18

0.034

Sex

 male

184

31(13.3–76.8)

0.07(0.04–0.14)

84

33(13–72.3)

0.085(0.04–0.15)

0.051

0.84

0.53

 female

129

36(16.5–73.5)

0.08(0.035–0.14)

47

42(23–89)

0.07(0.03–0.16)

0.22

0.72

BMI

  < 25

189

25(13–69)**

0.06(0.03–0.14)*

66

40.5(14.5–94)

0.10(0.043–0.16)

0.066

0.052

0.038

  ≥ 25

124

38(18–96)

0.08(0.05–0.15)

65

36(17–64)

0.06(0.03–0.13)

0.27

0.13

Current smoking

  ( +)

41(13.1)

28(15–122)

0.09(0.04–0.16)

17(13.0)

35(13–61)

0.07(0.03–0.12)

0.905

0.52

0.40

  (-)

34(15–73.3)

0.07(0.038–0.14)

38.5(17.3–78)

0.08(0.04–0.16)

0.23

0.26

Complicated disease

n(%)

Hypertension

  ( +)

216(69.0)

38.5(17–84.5)***

0.09(0.04–0.15)**

94(71.8)

36(18–77.5)

0.08(0.04–0.158)

0.565

0.76

0.81

  (-)

20(11–41)

0.06(0.03–0.10)

37(12–87)

0.07(0.03–0.13)

0.072

0.14

Dyslipidemia

  ( +)

181(57.8)

36(15–75)

0.07(0.04–0.14)

76(58.0)

34(14.8–72.3)

0.08(0.04–0.135)

0.971

0.88

0.76

  (-)

28(14.7–75.3)

0.07(0.03–0.15)

41(20–101.5)

0.08(0.035–0.15)

0.11

0.52

Hyperuricemia

  ( +)

122(39.0)

33(11.3–85)

0.075(0.033–0.148)

35(26.7)

45(21–98)

0.12(0.05–0.18)

0.014

0.093

0.22

  (-)

34(16–70)

0.07(0.04–0.14)

34.5(13–72.3)

0.07(0.03–0.135)

0.99

0.9

GFR category^c

P = 0.049^a

P = 0.18

P = 1.4E-0.9

P = 2.5E-12

 1

6(1.9)

68(45.3–98.3)

0.095(0.058–0.148)

12(9.2)

26(11.5–58.8)

0.07(0.04–0.128)

 < 0.0001

0.044

0.63

 2

89(28.4)

34(15–77)

0.07(0.04–0.14)

57(43.5)

26(11.5–60)

0.05(0.03–0.115)

0.058

0.013

 3a

118(37.7)

24.5(12.3–58)

0.06(0.03–0.128)

27(20.6)

38(23–76)^b2

0.08(0.05–0.15)^b2

0.00094

0.014

 3b

66(21.1)

47(14.3–102.5)

0.085(0.043–0.148)

24(18.3)

68(36.8–138.8)^a2b2c1

0.16(0.095–0.265)^a2b2c2

0.0081

2.5E-05

 4

34(10.9)

40(18.3–91.5)

0.11(0.06–0.158)

11(8.4)

48(24–108)^a1b1

0.08(0.05–0.19)^b1d1

0.42

0.89

1st dipstick proteinuria

P = 5.6E-12^a

P = 4.4E-19

P = 3.5E-06

P = 3.0E-06

  (-)

233(74.4)

24(13–57)

0.06(0.03–0.10)

99(75.6)

28(13–57.5)

0.06(0.03–0.12)

0.967

0.48

0.35

  ( ±)

46(14.7)

63.5(25.3–106.5)

0.145(0.093–0.20)

17(13.0)

86(41–134)

0.13(0.11–0.21)

0.39

0.89

  ( +)

30(9.6)

105(63.5–172)

0.17(0.103–0.24)

13(9.9)

108(83–197)

0.21(0.13–0.26)

0.52

0.54

 2( +)

4(1.3)

252(230.3–260.8)

0.365(0.318–0.403)

2(1.5)

223(131.3–315.8)

0.32(0.18–0.46)

1.00

1.00

 3( +)

0(0)

0(0)

1st uPCR (g/gCr)

 0–0.14

238(76.0)

P = 3.3E-33^a

P = 1.1E-61

95(72.5)

P = 3.5E-17

P = 1.1E-25

0.032

 ≦0.05

95(30.4)

15(8–25.3)

0.03(0.01–0.04)

49(37.4)

13(10–24)

0.03(0.02–0.04)

1.00

0.49

 0.06—0.10

106(33.9)

30(17–53)

0.07(0.06–0.09)

26(19.8)

32(23.8–41.5)

0.07(0.06–0.088)

0.74

0.54

 0.11—0.14

37(11.8)

67(33–80)

0.13(0.12–0.14)

20(15.3)

50(40.3–61.8)

0.12(0.11–0.13)

0.32

0.011

 0.15–0.49

75(24.0)

122(81.5–177.5)

0.20(0.16–0.26)

36(27.5)

112.5(77.5–177)

0.21(0.17–0.26)

0.90

0.46

1st uACR (mg/gCr)

P = 5.8E-52^a

P = 8.5E-25

P = 1.4E-21^b

P = 1.6E-13

  < 30

149(47.6)

14(9–19)

0.04(0.02–0.07)

55(42.0)

13(10–21.5)

0.04(0.02–0.06)

0.530

0.59

0.41

 30–299

161(51.4)

73(47–115)

0.13(0.08–0.19)

75(57.3)

68(43–110.5)

0.13(0.09–0.21)

0.65

0.37

 ≧300

3(1.0)

323(323–392.5)

0.45(0.42–0.47)

1(0.8)

P = 1.3E-39^a

P = 9.2E-24

P = 2.2E-14^b

P = 3.3E-10

normoalbuminuria

158(50.5)

15(9–23.8)

0.045(0.02–0.078)

54(41.2)

13.5(10–26.8)

0.04(0.03–0.068)

0.040

0.70

0.69

microalbuminuria

149(47.6)

71(40–117)

0.13(0.07–0.19)

77(58.8)

63(36–112)

0.13(0.07–0.21)

0.41

0.83

macroalbuminuria

6(1.9)

241.5(162.3–314)

0.36(0.25–0.44)

0(0)