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Table 2 Discrimination of uACR ≥ 30 mg/gCr and < 30 mg/gCr by uPCR according to the dipstick proteinuria in non-diabetic and diabetic patients

From: A comparison of the utility of the urine dipstick and urine protein-to-creatinine ratio for predicting microalbuminuria in patients with non-diabetic lifestyle-related diseases -a comparison with diabetes

Cause

COa of

of CKD

G stage

dipstick urine protein

number

AUC

SE

P Value

uPCR (g/gCr)

Sensitivity

Specificity

PPV

NPV

Distance

Se + Sp-1

Non-diabetes

G1-4

(-)

724

0.817

0.017

 < 0.001

0.07

0.709

0.826

0.741

0.801

0.339

0.535

(-)( ±)

843

0.839

0.014

 < 0.001

0.07

0.772

0.797

0.766

0.802

0.305

0.569

(-)( ±)( +)

918

0.857

0.013

 < 0.001

0.07

0.806

0.789

0.792

0.803

0.287

0.595

     

0.09

0.706

0.891

0.866

0.752

0.314

0.597

(-)( ±)( +)2( +)3( +)

939

0.863

0.012

 < 0.001

0.07

0.815

0.789

0.801

0.803

0.281

0.603

     

0.09

0.719

0.891

0.873

0.752

0.302

0.610

Non-diabetes

G1-3a

(-)

507

0.795

0.022

 < 0.001

0.06

0.741

0.755

0.642

0.830

0.357

0.495

     

0.07

0.677

0.843

0.719

0.815

0.359

0.520

(-)( ±)

578

0.820

0.019

 < 0.001

0.07

0.741

0.821

0.750

0.814

0.315

0.562

(-)( ±)( +)

629

0.843

0.017

 < 0.001

0.07

0.784

0.817

0.786

0.814

0.284

0.600

(-)( ±)( +)2( +)

639

0.849

0.016

 < 0.001

0.07

0.791

0.817

0.793

0.814

0.278

0.607

Non-diabetes

G3b-4

(-)

217

0.847

0.026

 < 0.001

0.07

0.764

0.776

0.778

0.761

0.326

0.539

     

0.10

0.636

0.907

0.875

0.708

0.375

0.543

(-)( ±)

265

0.864

0.022

 < 0.001

0.09

0.735

0.864

0.871

0.723

0.298

0.599

     

0.10

0.721

0.881

0.883

0.717

0.303

0.602

(-)( ±)( +)

289

0.875

0.020

 < 0.001

0.10

0.756

0.876

0.894

0.721

0.274

0.632

(-)( ±)( +)2( +)3( +)

300

0.883

0.019

 < 0.001

0.10

0.771

0.876

0.902

0.721

0.260

0.647

Diabetes

G1-4

(-)

308

0.860

0.022

 < 0.001

0.07

0.745

0.865

0.844

0.775

0.289

0.610

(-)( ±)

355

0.873

0.019

 < 0.001

0.07

0.794

0.839

0.856

0.771

0.262

0.632

(-)( ±)( +)

389

0.889

0.017

 < 0.001

0.07

0.824

0.833

0.874

0.771

0.243

0.657

( +)( ±)( +)2( +)

393

0.891

0.017

 < 0.001

0.07

0.827

0.833

0.876

0.771

0.240

0.660

Diabetes

G1-3a

(-)

245

0.835

0.028

 < 0.001

0.07

0.721

0.866

0.816

0.789

0.310

0.586

(-)( ±)

274

0.855

0.024

 < 0.001

0.07

0.772

0.848

0.833

0.791

0.274

0.620

(-)( ±)( +)

288

0.865

0.023

 < 0.001

0.07

0.792

0.842

0.843

0.791

0.261

0.634

Diabetes

G3b-4

(-)

63

0.931

0.031

 < 0.001

0.07

0.810

0.857

0.919

0.692

0.238

0.667

     

0.06

0.929

0.762

0.886

0.842

0.249

0.690

(-)( ±)

81

0.906

0.035

 < 0.001

0.07

0.845

0.783

0.907

0.667

0.267

0.627

(-)( ±)( +)

101

0.928

0.027

 < 0.001

0.07

0.885

0.783

0.932

0.667

0.246

0.667

(-)( ±)( +)2( +)

105

0.932

0.026

 < 0.001

0.07

0.890

0.783

0.936

0.667

0.244

0.673

  1. CKD Chronic kidney disease, uPCR urine protein-to-creatinine ratio, uACR urine albumin-to-creatinine ratio
  2. AUC Area under curve, SE Standard error, CO Cutoff value, Se Sensitivity, Sp Specificity, PPV Positive predictive value, NPV Negative predictive value
  3. aCO of minimum distance on the ROC curve closest to the (0,1) or Youden's Index