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Table 4 Prediction of microalbuminuria or worse based on the sum of three uPCR values according to the G stage and the sum of three urine protein dipstick scores in non-diabetic and diabetic patients

From: A comparison of the utility of the urine dipstick and urine protein-to-creatinine ratio for predicting microalbuminuria in patients with non-diabetic lifestyle-related diseases -a comparison with diabetes

  

Sum of the three urine protein dipstick scoresa

    

CO of sum of the three uPCRs (g/gCr)d

      

P Valuee vs

P Valuef vs

G stage

n

AUC

SE

P-Value

Sensitivity

Specificity

PPV

NPV

Distance

Se + Sp-1

1st uPCR

2 nd uPCR

3rd uPCR

1st uACR

2nd uACR

3rd uACR

Non-diabetes

G1-4

0b

195

0.876

0.027

 < 0.001

0.23

0.710

0.937

0.860

0.855

0.297

0.647

 < 0.0001

0.068

0.004

0.48

0.029

0.91

0,0.5c

233

0.876

0.024

 < 0.001

0.23

0.747

0.894

0.819

0.847

0.274

0.642

 < 0.0001

0.097

0.003

0.29

0.0074

0.63

0–6.0

313

0.898

0.017

 < 0.001

0.23

0.832

0.848

0.843

0.838

0.226

0.680

 < 0.0001

0.034

0.0002

0.091

0.0094

0.41

Non-diabetes

G1-3a

0

136

0.855

0.037

 < 0.001

0.18

0.762

0.798

0.627

0.882

0.312

0.560

 < 0.0001

0.77

0.005

0.15

0.0082

0.16

     

0.23

0.667

0.936

0.824

0.863

0.339

0.603

      

0,0.5

163

0.857

0.032

 < 0.001

0.21

0.737

0.858

0.737

0.858

0.299

0.595

 < 0.0001

0.69

0.005

0.12

0.0025

0.99

     

0.23

0.719

0.887

0.774

0.855

0.303

0.606

      

0–5.0

213

0.885

0.023

 < 0.001

0.23

0.813

0.855

0.821

0.847

0.237

0.667

 < 0.0001

0.95

0.0004

0.076

0.0037

0.99

Non-diabetes

G3b-4

0

59

0.895

0.043

 < 0.001

0.23

0.778

0.938

0.913

0.833

0.231

0.715

0.072

0.006

0.42

0.79

0.87

0.27

0,0.5

70

0.905

0.036

 < 0.001

0.23

0.794

0.917

0.900

0.825

0.222

0.711

0.047

0.005

0.24

0.92

0.73

0.18

0–6.0

100

0.915

0.027

 < 0.001

0.23

0.864

0.829

0.879

0.810

0.218

0.694

0.063

0.001

0.25

0.48

0.85

0.031

Diabetes

G1-4

0

85

0.834

0.048

 < 0.001

0.20

0.806

0.796

0.744

0.848

0.282

0.601

0.021

0.011

0.48

0.97

0.062

0.16

     

0.23

0.750

0.857

0.794

0.824

0.288

0.607

      

0,0.5

102

0.863

0.038

 < 0.001

0.23

0.816

0.811

0.800

0.827

0.263

0.628

0.012

0.004

0.27

0.91

0.11

0.14

0–4.0

131

0.903

0.027

 < 0.001

0.26

0.792

0.889

0.910

0.750

0.236

0.681

0.003

0.001

0.32

0.75

0.17

0.17

     

0.28

0.779

0.907

0.923

0.742

0.239

0.687

      
  1. uPCR urinary protein-to-creatinine ratio, uACR urinary albumin-to-creatinine ratio, AUC Area under the curve, SE Standard error, CO Cut-off value
  2. PPV Positive predictive value, NPV Negative predictive value, Se Sensitivity, Sp Specificity
  3. 1.2.3 uPCR denotes the sum of the three uPCRs
  4. aurine protein dipstick score: (-) = 0,( ±) = 0.5, ( +) = 1, 2( +) = 2, 3( +) = 3
  5. bDipstick proteinuria is negative three times in a row
  6. cDipstick proteinuria is negative three times in a row: or is negative two out of three times, with once being traced
  7. dCO of the minimum distance on the ROC curve closest to the (0,1) or Youden's Index
  8. eComparison of the utility of a single uPCR and the sum of three uPCR for predicting microalbuminuria
  9. fComparison of the utility of the sum of three uPCR and a single ACR for predicting microalbuminuria
  10. Microalbuminuria: uACR(urine albumin-to-creatinine ratio) 30–299 mg/gCr at least twice for 3 measurements
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BMC Nephrology

ISSN: 1471-2369

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