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Fig. 1 | BMC Nephrology

Fig. 1

From: Cyclosporine therapy could be considered for membranoproliferative glomerulonephritis with immunoglobulin A deposits: a case report

Fig. 1

Pathological results of the first and second kidney biopsies. Light and electron microscopy Nikon ECLIPSE Ts2R and NIS Elements (Nikon Corporation, Japan) is used to capture the images. The images were obtained with eyepiece at 10X magnification and objective at 20X. The brightness and contrast were adjusted by using Phtoshop (adobe, Japan). No other downstream processing or averaging were applied to the images to enhance the resolution. a Periodic acid Schiff (PAS) staining of the first kidney biopsy showed mesangial cell proliferation and increased mesangial matrix with lobulation. Endocapillary proliferation in the glomeruli and a few neutrophil infiltrations in the capillaries of the glomeruli were observed (Magnification: × 200). b Periodic Acid-Methenamine-Silver staining of the first kidney biopsy showed some double contours of the glomerular basement membrane (Magnification: × 200). c Electron microscopy analysis showed electron-dense deposits in the subendothelial, subepithelial, and paramesangial regions (black box; Magnification: × 3000). d Enlarged views of marked regions (black box) in corresponding Fig. 1-c image. (Magnification: × 3000) Electron microscopy also showed that the subepithelial deposits were not hump-like and podocytes were partially sparse. e PAS staining of the second biopsy two years later showed mild proliferation of mesangial cells (Magnification: × 200)

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