Individual dynamic prediction and prognostic analysis for long-term allograft survival after kidney transplantation

Table 1 Baseline characteristics and results from the static Cox model and the dynamic Cox model (w=5)

Variables	Mean ± SD	Static Cox model			Dynamic Cox model (w = 5)
Variables	Mean ± SD	Coef	SE (coef)	P value	Time function	Coef	SE (coef)	P value
Age	4.160 ± 1.278	−0.212	0.079	0.007	1	−0.447	0.023	< 0.001
Sex	220 (male)	0.206	0.210	0.325	\	\	\	\
Weight	6.381 ± 1.142	0.126	0.090	0.162	1	0.603	0.026	< 0.001
Hematocrit	2.951 ± 0.620	0.148	0.146	0.310	1	0.256	0.083	0.143
Hematocrit	\	\	\	\	s_l / 10	−1.498	0.165	< 0.001
GFR	0.891 ± 0.549	0.133	0.128	0.298	1	−0.375	0.028	< 0.001
GFR	\	\	\	\	s_l / 10	− 0.545	0.065	0.015
Proteinuria	2.409 ± 3.583	−0.032	0.041	0.433	1	−0.182	0.039	0.053
	\	\	\	\	s_l / 10	1.948	0.171	< 0.001
	\	\	\	\	(s_l / 10)²	−1.902	0.157	< 0.001
θ(s)	\	\	\	\	s_l / 10	8.444	0.703	< 0.001
θ(s)	\	\	\	\	(s_l / 10)²	−1.957	0.454	< 0.001

Coef, coefficient; SE, standard error; age, age at transplantation (per 10 years); sex (male = 0, female = 1); weight (per 10 kg); hematocrit (per 0.1%); GFR, glomerular filtration rate (per 10 ml/min); proteinuria (per 1 g/24 hours)
Time function: β(s_l) = β₀ + β₁(s_l/10) + β₂(s_l/10)², θ(s_l) = θ₁(s_l/10) + θ₂(s_l/10)²

ISSN: 1471-2369