The effect of calcineurin inhibitors on anthropometric measurements in kidney transplant recipients

Sayilar, Emel Isiktas; Ersoy, Alparslan; Ersoy, Canan; Oruc, Aysegul; Ayar, Yavuz; Sigirli, Deniz

doi:10.1186/s12882-022-03004-1

BMC Nephrology

Table 3 Comparison of effects of cyclosporine A and tacrolimus on blood pressure and graft function tests

From: The effect of calcineurin inhibitors on anthropometric measurements in kidney transplant recipients

		Pre-transplant	1^st month	3^rd month	6^th month	12^th month	24^th month	36^th month	48^th month
Variables	CsA (n)	60	60	60	60	60	60	56	55
Variables	Tac (n)	68	68	68	68	68	68	60	56
Systolic BP (mmHg)	CsA	127.4 ± 23.4	127.7 ± 13.6	127.0 ± 13.0	128.5 ± 15.6	127.7 ± 15.1	124.6 ± 13.8	125.0 ± 14.0	128.8 ± 18.8
Systolic BP (mmHg)	Tac	122.2 ± 16.6	126.6 ± 14.5	123.9 ± 13.9	123.2 ± 15.2	126.4 ± 16.7	124.1 ± 18.3	125.9 ± 20.7	127.2 ± 17.4
Diastolic BP (mmHg)	CsA	79.1 ± 11.6	79.5 ± 8.3	79.8 ± 8.7	79.8 ± 8.9	78.0 ± 7.9	77.6 ± 9.4	75.1 ± 11.3*	75.8 ± 13.5
Diastolic BP (mmHg)	Tac	76.1 ± 10.0	80.1 ± 9.6*	78.5 ± 8.6	78.8 ± 9.2	77.3 ± 9.5	75.1 ± 10.9	75.3 ± 13.5	76.2 ± 12.2
Hemoglobin (g/dL)	CsA	11.59 ± 1.88	12.0 ± 1.80	12.82 ± 2.44**	12.73 ± 2.15**	12.97 ± 1.95**	12.77 ± 1.76**	12.82 ± 1.76**	12.54 ± 1.79*
Hemoglobin (g/dL)	Tac	11.16 ± 1.89	11.5 ± 1.51	12.91 ± 1.88**	12.67 ± 1.97**	12.96 ± 1.96**	13.11 ± 1.57**	13.22 ± 1.61**	13.2 ± 1.51**
Albumin (g/dL)	CsA	3.47 ± 0.63	3.44 ± 0.57	3.80 ± 0.48**	3.92 ± 0.43**	4.06 ± 0.31**	4.11 ± 0.39**	4.10 ± 0.34**	4.14 ± 0.31**
Albumin (g/dL)	Tac	3.52 ± 0.64	3.76 ± 0.44*	4.07 ± 0.58**	4.06 ± 0.55**	4.15 ± 0.34**	4.20 ± 0.39**	4.21 ± 0.35**	4.22 ± 0.38**
Creatinine (mg/dL)	CsA	8.83 ± 3.2	1.33 ± 0.5	1.27 ± 0.4	1.41 ± 0.5	1.27 ± 0.4	1.37 ± 0.7	1.44 ± 0.9	1.36 ± 0.5
Creatinine (mg/dL)	Tac	8.83 ± 2.5	1.32 ± 0.8	1.28 ± 0.5	1.42 ± 0.5	1.41 ± 0.6	1.39 ± 0.6	1.41 ± 0.6	1.52 ± 0.7
eGFR (mL/min/1.73 m²)	CsA	7.13 ± 3.7	63.8 ± 26.1	66.0 ± 24.3	58.9 ± 21.3	64.9 ± 19.7	62.5 ± 21.0	60.2 ± 23.5	60.8 ± 21.1
eGFR (mL/min/1.73 m²)	Tac	7.29 ± 3.0	69.1 ± 27.6	68.5 ± 25.2	60.6 ± 24.0^q	63.9 ± 26.2	63.6 ± 26.0	63.4 ± 26.8	59.0 ± 22.9^qq

Data were expressed as mean ± SD. CsA cyclosporine A, Tac tacrolimus, BP blood pressure, eGFR estimated glomerular filtration rate. ^*p < 0.05 and ^**p < 0.001, compared to pre-transplant values; ^qp < 0.001 and ^qqp < 0.05, compared to post-transplant 1-month values

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