The effect of calcineurin inhibitors on anthropometric measurements in kidney transplant recipients

Table 4 Comparison of effects of cyclosporine A and tacrolimus on metabolic parameters

		Pre-transplant	1^st month	3^rd month	6^th month	12^th month	24^th month	36^th month	48^th month
Variables	CsA (n)	60	60	60	60	60	60	56	55
Variables	Tac (n)	68	68	68	68	68	68	60	56
Glucose (mg/dL)	CsA	107.9 ± 48.3	108.1 ± 34.3	105.8 ± 33.6	100.2 ± 47.4	92.3 ± 23.2*	96.3 ± 32.8	97.5 ± 42.4	101.8 ± 43.2
Glucose (mg/dL)	Tac	89.6 ± 22.5	100.4 ± 23.6*	95.8 ± 22.5	92.0 ± 19.4	90.4 ± 16.9	92.6 ± 24.9	89.2 ± 25.2	90.1 ± 18.0
Total-cholesterol (mg/dL)	CsA	183.9 ± 57.6	232.5 ± 74.5**	226.9 ± 52.1**	219.9 ± 51.3**	214.9 ± 49.3**	213.1 ± 51.7*	203.9 ± 50.4*	214.7 ± 55.6*
Total-cholesterol (mg/dL)	Tac	173.0 ± 49.7	201.4 ± 55.0**	213.7 ± 46.8**	203.3 ± 56.6**	182.8 ± 38.2*	195.9 ± 44.9**	200.9 ± 54.3*	200.1 ± 50.6*
HDL-cholesterol (mg/dL)	CsA	40.1 ± 14.4	55.3 ± 18.5**	50.9 ± 18.0**	49.1 ± 13.8**	48.1 ± 12.4**	47.8 ± 13.6**	50.4 ± 12.6**	53.9 ± 14.2**
HDL-cholesterol (mg/dL)	Tac	36.8 ± 12.3	49.8 ± 17.5**	47.8 ± 16.6**	42.8 ± 14.2**	44.1 ± 12.9**	45.1 ± 12.8**	45.2 ± 12.7**	47.3 ± 13.6**
LDL-cholesterol (mg/dL)	CsA	113.5 ± 43.7	144.6 ± 63.2**	140.7 ± 47.4**	134.8 ± 43.8*	136.0 ± 44.2*	150.0 ± 120.0*	124.8 ± 42.4	129.3 ± 48.6
LDL-cholesterol (mg/dL)	Tac	102.7 ± 40.7	117.9 ± 43.8*	130.9 ± 38.8**	124.6 ± 45.1*	109.4 ± 31.1	118.9 ± 37.3**	122.8 ± 46.2*	117.6 ± 43.2*
Triglyceride (mg/dL)	CsA	150.9 ± 82.4	162.5 ± 90.5	176.2 ± 87.6	170.1 ± 82.8	159.1 ± 84.3	149.6 ± 94.9	143.1 ± 70.8	153.0 ± 80.6
Triglyceride (mg/dL)	Tac	167.1 ± 105.1	168.0 ± 70.0	175.0 ± 85.0	179.1 ± 88.2	146.2 ± 75.4	154.5 ± 75.6	165.8 ± 90.3	175.7 ± 110.1

Data were expressed as mean ± SD. CsA cyclosporine A, Tac tacrolimus, LDL low-density lipoprotein, HDL high-density lipoprotein. ^*p < 0.05 and ^**p < 0.001; compared to intragroup pre-transplant values