Variables | KDPI ≥ 85% (N = 17,485) | Donor with AKI (N = 12,662) | Donor with Hepatitis C + ( N = 4,223) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Low (n = 5873) | Medium (n = 5917) | High (n = 5695) | p-value | Low (n = 4227) | Medium (n = 4132) | High (n = 4303) | p-value | Low (n = 1424) | Medium (n = 1394) | High (n = 1405) | p-value | |
Recipient and Transplant Factors | ||||||||||||
 Age (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  | 0.16 |
  18–35 | 4.0 | 3.0 | 3.5 | 11.8% | 11.9% | 10.2% | 2.8% | 1.8% | 1.9% | |||
  36–50 | 14.5% | 15.6 | 14.5% | 29.2% | 30.1% | 27.1% | 25.1% | 24% | 24.5% | |||
  51–65 | 48.4% | 51.5% | 48.7% | 43.2% | 41.4% | 42.5% | 60.5% | 61.5% | 63.4% | |||
   > 65 | 33% | 30% | 33.3% | 15.8% | 16.7% | 20.1% | 11.5% | 12.7% | 10.2% | |||
 Gender (%) |  |  |  | 0.67 |  |  |  | 0.19 |  |  |  | 0.11 |
  Male | 62.2% | 62.9% | 62.2% | 62.4% | 60.9% | 62.7% | 80.8% | 82.5% | 79.4% | |||
  Female | 37.8% | 37.1% | 37.8% | 37.6% | 39.1% | 37.3% | 19.2% | 17.5% | 20.6% | |||
 Race (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  White | 50.8% | 38.3% | 37.3% | 45.2% | 44.5% | 30.7% | 28.9% | 21.7% | 18.4% | |||
  Black | 28% | 44.3% | 33.5% | 31.7% | 41.5% | 28.4% | 55.8% | 68.7% | 71% | |||
  Hispanic | 12.5% | 10.7% | 16.5% | 15.5% | 8.8% | 27.7% | 11.8% | 7.1% | 7.5% | |||
  Other | 8.7% | 6.6% | 12.7% | 7.6% | 5.2% | 13.2% | 3.6% | 2.4% | 3.1% | |||
BMI (kg/m2) | 28 | 28 | 27.2 |  < .0001 | 28.2 | 28.3 | 27.7 |  < .0001 | 27.23 | 27.24 | 26.92 | 0.053 |
 Time on kidney waiting list |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  | 0.003 |
  0–1 year | 31.1% | 26.8% | 30.7% | 30.3% | 27.7% | 26.3% | 57.9% | 59% | 64% | |||
  1 to 3 years | 40.5% | 41% | 39.4% | 38.2% | 36.7% | 38.3% | 32% | 30.8% | 28.7% | |||
   > 3 years | 28.4% | 32.2% | 29.9% | 31.5% | 35.6% | 35.4% | 10.2% | 10.2% | 7.3% | |||
 HLA Mismatch Level (%) |  |  |  | 0.002 |  |  |  |  < .0001 |  |  |  | 0.1068 |
  0 | 4.3% | 3.7% | 3.2% | 6.5% | 6.1% | 3.7% | 1% | 0.7% | 0.5% | |||
  1 to 2 | 4.9% | 4.1% | 4% | 6.2% | 6.5% | 5.3% | 3.6% | 3.4% | 2.2% | |||
  3 to 6 | 90.8% | 92.2% | 92.8% | 87.2% | 87.5% | 91% | 95.4% | 95.9% | 97.3% | |||
 PRA (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  0 | 60.1% | 61.9% | 65.9% | 56.2% | 55.2% | 63.5% | 69.1% | 60.4% | 72.7% | |||
  0–20 | 21.9% | 18.2% | 17.5% | 18.7% | 16.9% | 14.1% | 15.2% | 21.2% | 12.3% | |||
  20–80 | 13.1% | 14.6% | 11.9% | 14.1% | 14.9% | 13.1% | 11.5% | 14.3% | 10.9% | |||
   > 80 | 5% | 5.3% | 4.7% | 11% | 12.9% | 9.3% | 4.2% | 4.1% | 4% | |||
 Induction (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  Basiliximab | 23.9% | 21.2% | 16% | 19.1% | 18.7% | 13.2% | 28.4% | 26.2% | 16.9% | |||
  Alemtuzumab | 8.3% | 13.3% | 14.5% | 10.8% | 13.8% | 10.6% | 5.3% | 10.8% | 2.9% | |||
  Thymoglobulin | 49.3% | 42.4% | 47.7% | 51.6% | 50.1% | 59.5% | 44.6% | 43.2% | 41.9% | |||
  Other | 0.5% | 0.5% | 0.4% | 0.4% | 0.6% | 0.4% | 0.8% | 0.5% | 0.4% | |||
  Missing | 18% | 22.6% | 21.3% | 18.1% | 16.9% | 16.3% | 20.9% | 19.3% | 37.9% | |||
 Year of Transplantation (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  | 0.13 |
  2000 ~ 2005 | 30.6% | 28.2% | 27.1% |  < .0001 | 23.6% | 17% | 17.7% |  < .0001 | 31% | 29.6% | 30.7% | 0.13 |
  2006 ~ 2011 | 41.2% | 42.4% | 40.9% | 35% | 43.1% | 33% | 31.5% | 34.8% | 35.5% | |||
  2012 ~ 2016 | 28.2% | 29.4% | 32% | 41.4% | 40% | 49.3% | 37.4% | 35.7% | 33.7% | |||
Donor Categories | ||||||||||||
 Age | 59.3 | 58.7 | 57.4 |  < .0001 | 35.3 | 35.5 | 36.9 |  < .0001 | 38.97 | 39.23 | 40.04 | 0.02 |
 Gender |  |  |  |  < .0001 |  |  |  | 0.03 |  |  |  | 0.14 |
  Male | 42.7% | 43.5% | 47.4% |  < .0001  < .0001 | 73.4% | 71.3% | 71% | 0.03  < .0001 | 66.3% | 65.4% | 62.8% | 0.14 0.005 |
  Female | 57.3% | 56.5% | 52.6% | 26.6% | 28.7% | 29% | 33.7% | 34.6% | 37.2% | |||
 Race | ||||||||||||
  White | 63.7% | 53.3% | 54.3% |  < .0001 0.24 | 65% | 65.7% | 55.6% |  < .0001 0.002 | 78.2% | 77% | 75.4% | 0.005 0.97 |
  Black | 24.3% | 33.1% | 27.5% | 18.5% | 22.9% | 17.5% | 9.2% | 13.3% | 12.7% | |||
  Hispanic | 8.3% | 9.5% | 11.7% | 13.2% | 8.7% | 21.7% | 11.4% | 8.5% | 10.8% | |||
  Other | 3.7% | 4% | 6.5% | 3.3% | 2.6% | 5.2% | 1.3% | 1.2% | 1.1% | |||
BMI | 28.1 | 28.3 | 28 | 28.6 | 28.9 | 29.2 | 26.15 | 26.13 | 26.32 | |||
 Hypertension |  |  |  |  < .0001 |  |  |  | 0.01 |  |  |  | 0.59 |
  No | 27% | 24.8% | 29.8% |  < .0001  < .0001 | 74.3% | 73.4% | 71.3% | 0.01  < .0001 | 78% | 78.8% | 77.2% | 0.59 0.22 |
  Yes | 73% | 75.2% | 70.2% | 25.7% | 26.6% | 28.7% | 22% | 21.2% | 22.8% | |||
 Cause of death | ||||||||||||
  Anoxia | 10.8% | 11.3% | 15.3% |  < .0001  < .0001 | 36.5% | 41.6% | 46.5% |  < .0001  < .0001 | 29.8% | 30.2% | 33% | 0.22  < .0001 |
  CVA | 77.2% | 78.7% | 72.4% | 24.8% | 23.4% | 26.3% | 33.4% | 31.7% | 32.5% | |||
  Other | 12% | 10% | 12.3% | 38.7% | 35% | 27.2% | 36.8% | 38.1% | 34.5% | |||
 Cold ischemia time (hours) | ||||||||||||
   < 12 | 30.2% | 26% | 18.4% |  < .0001  < .0001 | 25.9% | 21.3% | 14.9% |  < .0001  < .0001 | 28.9% | 22.5% | 21.5% |  < .0001  < .0001 |
  12 to 24 | 53.8% | 53.1% | 42% | 56.1% | 52.3% | 40.3% | 52.4% | 49.9% | 45.6% | |||
   > 24 | 16% | 20.9% | 39.5% | 18% | 26.4% | 44.8% | 18.7% | 27.5% | 32.9% | |||
 Total months from diagnosis to transplantation | ||||||||||||
  0 | 9.3% | 10.5% | 12.3% |  < .0001 | 10.3% | 12.2% | 10.5% |  < .0001 | 8.8% | 8.5% | 13.1% |  < .0001 |
  0–12 | 5.9% | 4.2% | 5.7% | 4.7% | 4.4% | 3.3% | 10% | 7.9% | 11.6% | |||
  12 to 24 | 14% | 12% | 13.5% | 12.3% | 11.2% | 10.5% | 20.9% | 20.7% | 21% | |||
  > 24 | 70.8% | 73.4% | 68.5% | 72.7% | 72.2% | 75.8% | 60.4% | 62.9% | 54.3% |