Variable | Discovery cohort | Validation cohort | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
IgAN group (n = 18) | Healthy control (n = 6) | P value | IgAN group (n = 50) | Disease controls (n = 42) | Healthy controls (n = 20) | P value IgAN vs. HC | P value DC vs. HC | |||
Oxford classification | ||||||||||
M (M0/M1) | 6/12 | - | 15/35 | - | - | |||||
E (E0/E1) | 3/15 | - | 15/35 | - | - | |||||
S (S0/S1) | 5/13 | - | 10/40 | - | - | |||||
T (T0/T1/T2) | 6/6/6 | - | 28/13/9 | 33/5/4 | - | |||||
C (C0/C1/C2) | 2/14/2 | - | 8/40/2 | - | - | |||||
Female (%) | 9 (50%) | 3 (50%) | > 0.999 | 23(46%) | 22 (52%) | 10 (50%) | 0.827 | 0.861 | ||
Age a (years) | 34 (29,40) | 24 (21,29) | 0.172 | 34(29, 42) | 40 (31, 49) | 35 (28, 49) | 0.131 | 0.195 | ||
Scr a (µmol/L) | 179 (78, 261) | 78 (71, 83) | 0.119 | 113 (86, 196) | 87 (65, 142) | 74(68, 80) | 0.034 | 0.072 | ||
eGFR a (mL/min/1.73m2) | 37.14 (25.35, 92.32) | 109.7 (102.6, 114.0) | 0.007 | 56.9 (30.6, 93.3) | 85.6 (33.6, 106.1) | 114.3 (106.8, 123.5) | < 0.001 | < 0.001 | ||
Hemoglobin a (g/L) | 123 (114, 124) | 128 (122, 132) | 0.172 | 124 (115, 140) | 133 (107, 146) | 131 (129, 155) | 0.034 | 0.084 | ||
UTP (g/day) a | 2.49 (1.12, 3.47) | NA | < 0.001 | 1.83 (0.80, 2.94) | 3.70 (2.36, 6.96) | NA | < 0.001 | < 0.001 | ||
TG (mmol/L) a | 1.76 (1.36, 2.21) | 2.11 (1.84, 2.00) | 0.424 | 1.71 (1.07, 2.76) | 2.11 (1.48, 3.10) | 1.36 (0.97, 2.31) | 0.080 | 0.028 | ||
TCHO (mmol/L) a | 4.93 (4.01, 5.94) | 4.15 (3.93, 4.00) | 0.093 | 4.88 (3.75, 6.02) | 5.73 (4.60, 7.62) | 4.49 (4.10, 5.25) | 0.009 | 0.009 |