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Cell Biology and Transport Physiology

The Cell Biology and Transport Physiology section considers basic experimental research relating renal cell biology, signalling and transport physiology. This section considers in vivo, in vitro and cellular model studies. This section does not consider clinical research, case reports or large epidemiological studies. 

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  1. Chronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature indicates that CKD is associated with profound lipid disorders due to the ...

    Authors: Hardik Ghelani, Valentina Razmovski-Naumovski, Dennis Chang and Srinivas Nammi

    Citation: BMC Nephrology 2019 20:431

    Content type: Research article

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  2. Peritoneal fibrosis is the most common complication of peritoneal dialysis, but there is currently no effective treatment. We previously reported that suramin pretreatment prevents the development of peritonea...

    Authors: Chongxiang Xiong, Na Liu, Xiaofei Shao, Sairah Sharif, Hequn Zou and Shougang Zhuang

    Citation: BMC Nephrology 2019 20:411

    Content type: Research article

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  3. Autosomal dominant polycystic kidney disease (ADPKD) is mainly characterised by the development and enlargement of renal cysts that lead to end-stage renal disease (ESRD) in adult patients. Other clinical mani...

    Authors: Riccardo Magistroni, Alessandra Mangolini, Sonia Guzzo, Francesca Testa, Mario R. Rapanà, Renzo Mignani, Giorgia Russo, Francesco di Virgilio and Gianluca Aguiari

    Citation: BMC Nephrology 2019 20:355

    Content type: Research article

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  4. Chronic kidney disease (CKD) has been considered as a major health problem in the world. Increasing uric acid (UA) could induce vascular endothelial injury, which is closely related to microinflammation, oxida...

    Authors: Wei Yin, Qiao-Ling Zhou, Sha-Xi OuYang, Ying Chen, Yu-Ting Gong and Yu-Mei Liang

    Citation: BMC Nephrology 2019 20:319

    Content type: Research article

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  5. Renal proximal tubular sodium and glucose reabsorption are regulated by the sodium-glucose cotransporter (SGLT2). Changes in this transporter can play a role in hyperglycaemia and reactive oxygen species (ROS)...

    Authors: Humberto Reyes-Pardo, Rocío Bautista, Hilda Vargas-Robles, Amelia Rios, Daniel Sánchez and Bruno Escalante

    Citation: BMC Nephrology 2019 20:292

    Content type: Research article

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  6. Anisodamine is used for the treatment of reperfusion injury in various organs. In this study, we investigated the effectiveness and mechanisms of action of anisodamine in promoting recovery from glycerol-induc...

    Authors: Yun-feng Li, Bing-yuan Xu, Ran An, Xin-fang Du, Kun Yu, Jia-hua Sun, Guo-hong Zhang, Wei Wang, Li-ping An and Guang-li Wu

    Citation: BMC Nephrology 2019 20:223

    Content type: Research article

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  7. Diuresis has been observed within a week following renal transplantation, suggesting that the procedure causes acute disturbance of renal water homeostasis. Aquaporin (AQP) 1 and AQP2, important proteins for r...

    Authors: Sayaka Oshikawa-Hori, Naoko Yokota-Ikeda, Hiroko Sonoda and Masahiro Ikeda

    Citation: BMC Nephrology 2019 20:216

    Content type: Research article

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  8. Glucose is a primary osmotic agent in peritoneal dialysis (PD) solutions, but its long-term use causes structural alteration of the peritoneal membrane (PM). Hyperbranched polyglycerol (HPG) is a promising alt...

    Authors: Bin Liu, Shijian Feng, Ghida Dairi, Qiunong Guan, Irina Chafeeva, Hao Wang, Richard Liggins, Gerald da Roza, Jayachandran N. Kizhakkedathu and Caigan Du

    Citation: BMC Nephrology 2019 20:181

    Content type: Research article

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  9. Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothel...

    Authors: Wei Chen, Hong Xiang, Ruifang Chen, Jie Yang, Xiaoping Yang, Jianda Zhou, Hengdao Liu, Shaoli Zhao, Jie Xiao, Pan Chen, Alex F. Chen, Shuhua Chen and Hongwei Lu

    Citation: BMC Nephrology 2019 20:135

    Content type: Research article

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  10. MicroRNAs have been related to tumor progression in diverse human cancers including clear-cell renal cell carcinoma (ccRCC). Previous study has suggested the important regulation function of miR-10b in ccRCC. ...

    Authors: Cheng He, Zhi-Yong Chen, Yang Li, Zhong-Qing Yang, Feng Zeng, Yu Cui, Yao He, Jin-Bo Chen and He-Qun Chen

    Citation: BMC Nephrology 2019 20:127

    Content type: Research article

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  11. Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and is a significant risk factor for increased morbidity and mortality. In contrast, GLP-1 receptor (GLP-1R) activation has been ...

    Authors: Seung Jung Kim, Soon Kil Kwon, Hye-Young Kim, Sun Moon Kim, Jang-Whan Bae and Joong-Kook Choi

    Citation: BMC Nephrology 2019 20:75

    Content type: Research article

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  12. Magnesium lithospermate B (MLB) can promote renal microcirculation. The aim of the current project was to study whether MLB improves renal hemodynamics, oxygen consumption and subsequently attenuates hypoxia i...

    Authors: Pinglan Lin, Ming Wu, Junyan Qin, Jing Yang, Chaoyang Ye and Chen Wang

    Citation: BMC Nephrology 2019 20:49

    Content type: Research article

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  13. Recent researches indicate that the intestinal consequences of renal ischemia reperfusion (IR) would predispose to the translocation of gut-derived endotoxin. Here, we designed experiments to test the hypothes...

    Authors: Jiangtao Li, Krishna Rekha Moturi, Lirui Wang, Kun Zhang and Chen Yu

    Citation: BMC Nephrology 2019 20:16

    Content type: Research article

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  14. Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal...

    Authors: Di Zou, Wen Wu, Yan He, Sichao Ma and Ji Gao

    Citation: BMC Nephrology 2018 19:285

    Content type: Review

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  15. Sodium nitrite (NaNO2) causes vasodilation, presumably by enzymatic conversion to nitric oxide (NO). Several enzymes with nitrite reducing capabilities have been discovered in vitro, but their relative importance...

    Authors: Jeppe B. Rosenbaek, Erling B. Pedersen and Jesper N. Bech

    Citation: BMC Nephrology 2018 19:244

    Content type: Research article

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  16. Liver cirrhosis is characterized by avid sodium retention where the activation of the renin angiotensin aldosterone system (RAAS) is considered to be the hallmark of the sodium retaining mechanisms. The direct...

    Authors: A. D. Fialla, O. B. Schaffalitzky de Muckadell, P. Bie and H. C. Thiesson

    Citation: BMC Nephrology 2018 19:238

    Content type: Research article

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  17. Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether ...

    Authors: Vanessa Gerolde Cardoso, Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Mariana Charleaux de Ponte, Niels Olsen Saraiva Camara and Maria Oliveira-Souza

    Citation: BMC Nephrology 2018 19:179

    Content type: Research article

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  18. The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)...

    Authors: Han Xu, Na Guan, Ya-Li Ren, Qi-Jiao Wei, Ying-Hong Tao, Guo-Sheng Yang, Xiao-Ya Liu, Ding-Fang Bu, Ying Zhang and Sai-Nan Zhu

    Citation: BMC Nephrology 2018 19:140

    Content type: Research article

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  19. The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/− mice are protected from renal injury induced by systemic hypoxia and acute r...

    Authors: Tzvetanka Bondeva, Claudia Schindler, Katrin Schindler and Gunter Wolf

    Citation: BMC Nephrology 2018 19:29

    Content type: Research article

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  20. Epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R.A.) is currently widely used for the treatment of anemia associated with chronic kidney disease (CKD). Therapeutic control of anemia is a...

    Authors: Ken Aizawa, Ryohei Kawasaki, Yoshihito Tashiro, Yasushi Shimonaka and Michinori Hirata

    Citation: BMC Nephrology 2018 19:19

    Content type: Research article

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  21. Our aim was to evaluate lipid trafficking and inflammatory response of macrophages exposed to lipoproteins from subjects with moderate to severe chronic kidney disease (CKD), and to investigate the potential b...

    Authors: Ryohei Kaseda, Yohei Tsuchida, Hai-Chun Yang, Patricia G. Yancey, Jianyong Zhong, Huan Tao, Aihua Bian, Agnes B. Fogo, Mac Rae F. Linton, Sergio Fazio, Talat Alp Ikizler and Valentina Kon

    Citation: BMC Nephrology 2018 19:17

    Content type: Research article

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  22. Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular inter...

    Authors: Jing Yuan, Yan Shen, Xia Yang, Ying Xie, Xin Lin, Wen Zeng, Yingting Zhao, Maolu Tian and Yan Zha

    Citation: BMC Nephrology 2017 18:314

    Content type: Research article

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  23. The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in su...

    Authors: Wararat Kittikulsuth, Peter A. Friedman, Alfred van Hoek, Yang Gao and Donald E. Kohan

    Citation: BMC Nephrology 2017 18:292

    Content type: Research article

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  24. Intermedin [IMD, adrenomedullin-2 (ADM-2)] attenuates renal fibrosis by inhibition of oxidative stress. However, the precise mechanisms remain unknown. Heme oxygenase-1 (HO-1), an antioxidant agent, is associa...

    Authors: Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yufeng Qiao, Yun Fan and Zhiqiang Peng

    Citation: BMC Nephrology 2017 18:232

    Content type: Research article

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  25. Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar...

    Authors: Miklós M. Mózes, Petra Szoleczky, László Rosivall and Gábor Kökény

    Citation: BMC Nephrology 2017 18:209

    Content type: Research article

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  26. Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures. Evidence suggests that ascorbic acid (AA...

    Authors: K. Rollins, A. Noorani, L. Janeckova, T. Jones, M. Griffiths, M. P. Baker and J. R. Boyle

    Citation: BMC Nephrology 2017 18:101

    Content type: Research article

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  27. Histone H3K4 trimethylation (H3K4 me3) is found in active euchromatic regions and plays an important role in podocyte function in which actin filaments are abundant in the foot processes. The pathogenesis of m...

    Authors: Takayuki Fujino and Naoyuki Hasebe

    Citation: BMC Nephrology 2016 17:179

    Content type: Research article

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  28. Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hypergl...

    Authors: Rosa M. Montero, Gurjeet Bhangal, Charles D. Pusey, Andrew H. Frankel and Frederick W. K. Tam

    Citation: BMC Nephrology 2016 17:139

    Content type: Research article

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  29. Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA ...

    Authors: Zongshun Huang, Li Zhang, Yuanhan Chen, Hong Zhang, Chunping Yu, Fangjian Zhou, Zhiling Zhang, Lijuan Jiang, Ruizhao Li, Jianchao Ma, Zhuo Li, Yuxiong Lai, Ting Lin, Xinchen Zhao, Qianmei Zhang, Bin Zhang…

    Citation: BMC Nephrology 2016 17:66

    Content type: Research article

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  30. Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal...

    Authors: Jiuxu Bai, Junfeng Hao, Xiaoling Zhang, Hanmin Cui, Jingming Han and Ning Cao

    Citation: BMC Nephrology 2016 17:47

    Content type: Research article

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  31. IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, affecting close to a million people. Circulating galactose-deficient IgA (gd-IgA), present in patients with IgAN, form immune complex ...

    Authors: Kerstin Ebefors, Peidi Liu, Emelie Lassén, Johannes Elvin, Emma Candemark, Kristina Levan, Börje Haraldsson and Jenny Nyström

    Citation: BMC Nephrology 2016 17:40

    Content type: Research article

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  32. Dysfunction of renal tubule epithelial cells is associated with renal tubulointerstitial fibrosis. Exploration of the proteomic profiles of senesced tubule epithelial cells is essential to elucidate the mechan...

    Authors: Yang Lu, Jingchao Wang, Chen Dapeng, Di Wu, Guangyan Cai and Xiangmei Chen

    Citation: BMC Nephrology 2016 17:39

    Content type: Research article

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  33. Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable...

    Authors: Luciana Mazzei, Mercedes García, Juan Pablo Calvo, Mariana Casarotto, Miguel Fornés, María Angélica Abud, Darío Cuello-carrión, León Ferder and Walter Manucha

    Citation: BMC Nephrology 2016 17:34

    Content type: Research article

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  34. Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).

    Authors: Chulwon Kim, Sang Hyun Baek, Jae-Young Um, Bum Sang Shim and Kwang Seok Ahn

    Citation: BMC Nephrology 2016 17:19

    Content type: Research article

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  35. Pyrrolidine dithiocarbamate (PDTC) reduces renal cyst growth in a rodent model of polycystic kidney disease (PKD) but the mechanism of action is not clear. Here, we investigated the hypothesis that PDTC reduce...

    Authors: Michelle H. T. Ta, David Liuwantara and Gopala K. Rangan

    Citation: BMC Nephrology 2015 16:212

    Content type: Research article

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  36. Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide family. Endoplasmic reticulum stress (ERS) has been implicated in the pathology of renal ischemia/reperfusion (IRI). In the ...

    Authors: Yanhong Wang, Jihua Tian, Xi Qiao, Xiaole Su, Yang Mi, Ruijing Zhang and Rongshan Li

    Citation: BMC Nephrology 2015 16:169

    Content type: Research article

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  39. Small non-coding RNA molecules (miRNAs) play a pivotal role in regulating gene expression in development. miRNAs regulate key processes at the cellular level and thereby influence organismal and tissue develop...

    Authors: Malte P Bartram, Claudia Dafinger, Sandra Habbig, Thomas Benzing, Bernhard Schermer and Roman-Ulrich Müller

    Citation: BMC Nephrology 2015 16:55

    Content type: Research article

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  40. Hyperlipidemia is thought to be a major risk factor for the progression of renal diseases in diabetes. Recent studies have shown that lipid profiles are commonly abnormal early on type 2 diabetes mellitus (T2D...

    Authors: Liang He, Lili Hao, Xin Fu, Mingshu Huang and Rui Li

    Citation: BMC Nephrology 2015 16:51

    Content type: Research article

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  41. Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reti...

    Authors: Zeng Si Wang, Fei Xiong, Xiao Hang Xie, Dan Chen, Jian Hua Pan and Li Cheng

    Citation: BMC Nephrology 2015 16:44

    Content type: Research article

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  42. Podocyte detachment and apoptosis are two risk factors causing podocyte loss, F-actin rearrangement is involved in detachment and apoptosis. However, the nature of events that promote detachment and apoptosis ...

    Authors: Rufeng Dai, Yi Lin, Haimei Liu, Jia Rao, Yihui Zhai, Xiliang Zha, Xiaoyan Fang and Hong Xu

    Citation: BMC Nephrology 2015 16:38

    Content type: Research article

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  43. Death receptors (DRs) play an important role in renal pathology. We have shown that DR3 is inducibly expressed on renal tubular epithelial cells in the setting of inflammatory injuries. In this study we invest...

    Authors: Jun Wang, Rafia S Al-Lamki, Xinwang Zhu, Hanzhe Liu, Jordan S Pober and John R Bradley

    Citation: BMC Nephrology 2014 15:178

    Content type: Research article

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  44. MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and ...

    Authors: Youqun Huang, Yan Liu, Ling Li, Baihai Su, Lichuan Yang, Wenxin Fan, Qinghua Yin, Lijia Chen, Tianlei Cui, Jie Zhang, Yanrong Lu, Jingqiu Cheng, Ping Fu and Fang Liu

    Citation: BMC Nephrology 2014 15:142

    Content type: Research article

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  45. To evaluate the effects of contrast agents containing increasing concentrations of iodine on the renal oxygenation level determined by blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) ...

    Authors: Jia-huan Wang, Ke Ren, Wen-ge Sun, Li Zhao, Hong-shan Zhong and Ke Xu

    Citation: BMC Nephrology 2014 15:140

    Content type: Research article

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  46. Intratracheal aspiration and sepsis are leading causes of acute lung injury that frequently necessitate mechanical ventilation (MV), which may aggravate lung injury thereby potentially increasing the risk of a...

    Authors: Jan Willem Kuiper, AB Johan Groeneveld, Jack J Haitsma, Lonneke Smeding, Mark PV Begieneman, Serge Jothy, Rosanna Vaschetto and Frans B Plötz

    Citation: BMC Nephrology 2014 15:126

    Content type: Research article

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  47. CLIC4, a member of the CLIC family of proteins, was recently demonstrated to translocate to the nucleus in differentiating keratinocytes where it potentiates TGFβ-driven gene regulation. Since TGFβ signaling i...

    Authors: John C Edwards, Jonathan Bruno, Phillip Key and Yao-Wen Cheng

    Citation: BMC Nephrology 2014 15:54

    Content type: Research article

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  48. The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane a...

    Authors: Kenton P Arkill, Klaus Qvortrup, Tobias Starborg, Judith M Mantell, Carlo Knupp, C Charles Michel, Steve J Harper, Andy HJ Salmon, John M Squire, Dave O Bates and Chris R Neal

    Citation: BMC Nephrology 2014 15:24

    Content type: Research article

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  49. The purpose of this study was to determine whether AMPK influences the survival of primary cultures of mouse proximal tubular (MPT) cells subjected to metabolic stress. Previous studies, using an immortalized ...

    Authors: Wilfred Lieberthal, Meiyi Tang, Leiqing Zhang, Benoit Viollet, Vimal Patel and Jerrold S Levine

    Citation: BMC Nephrology 2013 14:251

    Content type: Research article

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  50. Chronic progressive mesangioproliferative nephropathy represents a major cause of end-stage renal disease worldwide. Until now, effective approaches to stop or even slow its progression are limited. We tested ...

    Authors: Yingrui Wang-Rosenke, Dymtro Khadzhynov, Tanja Loof, Alice Mika, Hiroshi Kawachi, Hans-H Neumayer and Harm Peters

    Citation: BMC Nephrology 2013 14:223

    Content type: Research article

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