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BMC Nephrology

Cell Biology and Transport Physiology

Section edited by Robert Unwin

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  1. Content type: Research article

    Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular inter...

    Authors: Jing Yuan, Yan Shen, Xia Yang, Ying Xie, Xin Lin, Wen Zeng, Yingting Zhao, Maolu Tian and Yan Zha

    Citation: BMC Nephrology 2017 18:314

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  2. Content type: Research article

    The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in su...

    Authors: Wararat Kittikulsuth, Peter A. Friedman, Alfred van Hoek, Yang Gao and Donald E. Kohan

    Citation: BMC Nephrology 2017 18:292

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  3. Content type: Research article

    Intermedin [IMD, adrenomedullin-2 (ADM-2)] attenuates renal fibrosis by inhibition of oxidative stress. However, the precise mechanisms remain unknown. Heme oxygenase-1 (HO-1), an antioxidant agent, is associa...

    Authors: Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yufeng Qiao, Yun Fan and Zhiqiang Peng

    Citation: BMC Nephrology 2017 18:232

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  4. Content type: Research article

    Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar...

    Authors: Miklós M. Mózes, Petra Szoleczky, László Rosivall and Gábor Kökény

    Citation: BMC Nephrology 2017 18:209

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  5. Content type: Research article

    Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures. Evidence suggests that ascorbic acid (AA...

    Authors: K. Rollins, A. Noorani, L. Janeckova, T. Jones, M. Griffiths, M. P. Baker and J. R. Boyle

    Citation: BMC Nephrology 2017 18:101

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  6. Content type: Research article

    Histone H3K4 trimethylation (H3K4 me3) is found in active euchromatic regions and plays an important role in podocyte function in which actin filaments are abundant in the foot processes. The pathogenesis of m...

    Authors: Takayuki Fujino and Naoyuki Hasebe

    Citation: BMC Nephrology 2016 17:179

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  7. Content type: Research article

    Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hypergl...

    Authors: Rosa M. Montero, Gurjeet Bhangal, Charles D. Pusey, Andrew H. Frankel and Frederick W. K. Tam

    Citation: BMC Nephrology 2016 17:139

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  8. Content type: Research article

    Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA ...

    Authors: Zongshun Huang, Li Zhang, Yuanhan Chen, Hong Zhang, Chunping Yu, Fangjian Zhou, Zhiling Zhang, Lijuan Jiang, Ruizhao Li, Jianchao Ma, Zhuo Li, Yuxiong Lai, Ting Lin, Xinchen Zhao, Qianmei Zhang, Bin Zhang…

    Citation: BMC Nephrology 2016 17:66

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  9. Content type: Research article

    Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal...

    Authors: Jiuxu Bai, Junfeng Hao, Xiaoling Zhang, Hanmin Cui, Jingming Han and Ning Cao

    Citation: BMC Nephrology 2016 17:47

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  10. Content type: Research article

    IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, affecting close to a million people. Circulating galactose-deficient IgA (gd-IgA), present in patients with IgAN, form immune complex ...

    Authors: Kerstin Ebefors, Peidi Liu, Emelie Lassén, Johannes Elvin, Emma Candemark, Kristina Levan, Börje Haraldsson and Jenny Nyström

    Citation: BMC Nephrology 2016 17:40

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  11. Content type: Research article

    Dysfunction of renal tubule epithelial cells is associated with renal tubulointerstitial fibrosis. Exploration of the proteomic profiles of senesced tubule epithelial cells is essential to elucidate the mechan...

    Authors: Yang Lu, Jingchao Wang, Chen Dapeng, Di Wu, Guangyan Cai and Xiangmei Chen

    Citation: BMC Nephrology 2016 17:39

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  12. Content type: Research article

    Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable...

    Authors: Luciana Mazzei, Mercedes García, Juan Pablo Calvo, Mariana Casarotto, Miguel Fornés, María Angélica Abud, Darío Cuello-carrión, León Ferder and Walter Manucha

    Citation: BMC Nephrology 2016 17:34

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  13. Content type: Research article

    Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).

    Authors: Chulwon Kim, Sang Hyun Baek, Jae-Young Um, Bum Sang Shim and Kwang Seok Ahn

    Citation: BMC Nephrology 2016 17:19

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  14. Content type: Research article

    Pyrrolidine dithiocarbamate (PDTC) reduces renal cyst growth in a rodent model of polycystic kidney disease (PKD) but the mechanism of action is not clear. Here, we investigated the hypothesis that PDTC reduce...

    Authors: Michelle H. T. Ta, David Liuwantara and Gopala K. Rangan

    Citation: BMC Nephrology 2015 16:212

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  15. Content type: Research article

    Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide family. Endoplasmic reticulum stress (ERS) has been implicated in the pathology of renal ischemia/reperfusion (IRI). In the ...

    Authors: Yanhong Wang, Jihua Tian, Xi Qiao, Xiaole Su, Yang Mi, Ruijing Zhang and Rongshan Li

    Citation: BMC Nephrology 2015 16:169

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  16. Content type: Research article

    Small non-coding RNA molecules (miRNAs) play a pivotal role in regulating gene expression in development. miRNAs regulate key processes at the cellular level and thereby influence organismal and tissue develop...

    Authors: Malte P Bartram, Claudia Dafinger, Sandra Habbig, Thomas Benzing, Bernhard Schermer and Roman-Ulrich Müller

    Citation: BMC Nephrology 2015 16:55

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  17. Content type: Research article

    Hyperlipidemia is thought to be a major risk factor for the progression of renal diseases in diabetes. Recent studies have shown that lipid profiles are commonly abnormal early on type 2 diabetes mellitus (T2D...

    Authors: Liang He, Lili Hao, Xin Fu, Mingshu Huang and Rui Li

    Citation: BMC Nephrology 2015 16:51

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  18. Content type: Research article

    Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reti...

    Authors: Zeng Si Wang, Fei Xiong, Xiao Hang Xie, Dan Chen, Jian Hua Pan and Li Cheng

    Citation: BMC Nephrology 2015 16:44

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