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Cell Biology and Transport Physiology

The Cell Biology and Transport Physiology section considers basic experimental research relating renal cell biology, signalling and transport physiology. This section considers in vivo, in vitro and cellular model studies. This section does not consider clinical research, case reports or large epidemiological studies. 

  1. Content type: Research article

    Anisodamine is used for the treatment of reperfusion injury in various organs. In this study, we investigated the effectiveness and mechanisms of action of anisodamine in promoting recovery from glycerol-induc...

    Authors: Yun-feng Li, Bing-yuan Xu, Ran An, Xin-fang Du, Kun Yu, Jia-hua Sun, Guo-hong Zhang, Wei Wang, Li-ping An and Guang-li Wu

    Citation: BMC Nephrology 2019 20:223

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  2. Content type: Research article

    Diuresis has been observed within a week following renal transplantation, suggesting that the procedure causes acute disturbance of renal water homeostasis. Aquaporin (AQP) 1 and AQP2, important proteins for r...

    Authors: Sayaka Oshikawa-Hori, Naoko Yokota-Ikeda, Hiroko Sonoda and Masahiro Ikeda

    Citation: BMC Nephrology 2019 20:216

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  3. Content type: Research article

    Glucose is a primary osmotic agent in peritoneal dialysis (PD) solutions, but its long-term use causes structural alteration of the peritoneal membrane (PM). Hyperbranched polyglycerol (HPG) is a promising alt...

    Authors: Bin Liu, Shijian Feng, Ghida Dairi, Qiunong Guan, Irina Chafeeva, Hao Wang, Richard Liggins, Gerald da Roza, Jayachandran N. Kizhakkedathu and Caigan Du

    Citation: BMC Nephrology 2019 20:181

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  4. Content type: Research article

    Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothel...

    Authors: Wei Chen, Hong Xiang, Ruifang Chen, Jie Yang, Xiaoping Yang, Jianda Zhou, Hengdao Liu, Shaoli Zhao, Jie Xiao, Pan Chen, Alex F. Chen, Shuhua Chen and Hongwei Lu

    Citation: BMC Nephrology 2019 20:135

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  5. Content type: Research article

    MicroRNAs have been related to tumor progression in diverse human cancers including clear-cell renal cell carcinoma (ccRCC). Previous study has suggested the important regulation function of miR-10b in ccRCC. ...

    Authors: Cheng He, Zhi-Yong Chen, Yang Li, Zhong-Qing Yang, Feng Zeng, Yu Cui, Yao He, Jin-Bo Chen and He-Qun Chen

    Citation: BMC Nephrology 2019 20:127

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  6. Content type: Research article

    Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and is a significant risk factor for increased morbidity and mortality. In contrast, GLP-1 receptor (GLP-1R) activation has been ...

    Authors: Seung Jung Kim, Soon Kil Kwon, Hye-Young Kim, Sun Moon Kim, Jang-Whan Bae and Joong-Kook Choi

    Citation: BMC Nephrology 2019 20:75

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  7. Content type: Research article

    Magnesium lithospermate B (MLB) can promote renal microcirculation. The aim of the current project was to study whether MLB improves renal hemodynamics, oxygen consumption and subsequently attenuates hypoxia i...

    Authors: Pinglan Lin, Ming Wu, Junyan Qin, Jing Yang, Chaoyang Ye and Chen Wang

    Citation: BMC Nephrology 2019 20:49

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  8. Content type: Research article

    Recent researches indicate that the intestinal consequences of renal ischemia reperfusion (IR) would predispose to the translocation of gut-derived endotoxin. Here, we designed experiments to test the hypothes...

    Authors: Jiangtao Li, Krishna Rekha Moturi, Lirui Wang, Kun Zhang and Chen Yu

    Citation: BMC Nephrology 2019 20:16

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  9. Content type: Review

    Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term loss of kidney function. The progression of CKD has repercussions for other organs, leading to many kinds of extrarenal...

    Authors: Di Zou, Wen Wu, Yan He, Sichao Ma and Ji Gao

    Citation: BMC Nephrology 2018 19:285

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  10. Content type: Research article

    Sodium nitrite (NaNO2) causes vasodilation, presumably by enzymatic conversion to nitric oxide (NO). Several enzymes with nitrite reducing capabilities have been discovered in vitro, but their relative importance...

    Authors: Jeppe B. Rosenbaek, Erling B. Pedersen and Jesper N. Bech

    Citation: BMC Nephrology 2018 19:244

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  11. Content type: Research article

    Liver cirrhosis is characterized by avid sodium retention where the activation of the renin angiotensin aldosterone system (RAAS) is considered to be the hallmark of the sodium retaining mechanisms. The direct...

    Authors: A. D. Fialla, O. B. Schaffalitzky de Muckadell, P. Bie and H. C. Thiesson

    Citation: BMC Nephrology 2018 19:238

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  12. Content type: Research article

    Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether ...

    Authors: Vanessa Gerolde Cardoso, Guilherme Lopes Gonçalves, Juliana Martins Costa-Pessoa, Karina Thieme, Bruna Bezerra Lins, Fernando Augusto Malavazzi Casare, Mariana Charleaux de Ponte, Niels Olsen Saraiva Camara and Maria Oliveira-Souza

    Citation: BMC Nephrology 2018 19:179

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  13. Content type: Research article

    The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)...

    Authors: Han Xu, Na Guan, Ya-Li Ren, Qi-Jiao Wei, Ying-Hong Tao, Guo-Sheng Yang, Xiao-Ya Liu, Ding-Fang Bu, Ying Zhang and Sai-Nan Zhu

    Citation: BMC Nephrology 2018 19:140

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  14. Content type: Research article

    The MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/− mice are protected from renal injury induced by systemic hypoxia and acute r...

    Authors: Tzvetanka Bondeva, Claudia Schindler, Katrin Schindler and Gunter Wolf

    Citation: BMC Nephrology 2018 19:29

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  15. Content type: Research article

    Epoetin beta pegol (continuous erythropoietin receptor activator; C.E.R.A.) is currently widely used for the treatment of anemia associated with chronic kidney disease (CKD). Therapeutic control of anemia is a...

    Authors: Ken Aizawa, Ryohei Kawasaki, Yoshihito Tashiro, Yasushi Shimonaka and Michinori Hirata

    Citation: BMC Nephrology 2018 19:19

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  16. Content type: Research article

    Our aim was to evaluate lipid trafficking and inflammatory response of macrophages exposed to lipoproteins from subjects with moderate to severe chronic kidney disease (CKD), and to investigate the potential b...

    Authors: Ryohei Kaseda, Yohei Tsuchida, Hai-Chun Yang, Patricia G. Yancey, Jianyong Zhong, Huan Tao, Aihua Bian, Agnes B. Fogo, Mac Rae F. Linton, Sergio Fazio, Talat Alp Ikizler and Valentina Kon

    Citation: BMC Nephrology 2018 19:17

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  17. Content type: Research article

    Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but the effects of Tβ4 treatment on chronic renal tubular inter...

    Authors: Jing Yuan, Yan Shen, Xia Yang, Ying Xie, Xin Lin, Wen Zeng, Yingting Zhao, Maolu Tian and Yan Zha

    Citation: BMC Nephrology 2017 18:314

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  18. Content type: Research article

    The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in su...

    Authors: Wararat Kittikulsuth, Peter A. Friedman, Alfred van Hoek, Yang Gao and Donald E. Kohan

    Citation: BMC Nephrology 2017 18:292

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  19. Content type: Research article

    Intermedin [IMD, adrenomedullin-2 (ADM-2)] attenuates renal fibrosis by inhibition of oxidative stress. However, the precise mechanisms remain unknown. Heme oxygenase-1 (HO-1), an antioxidant agent, is associa...

    Authors: Xi Qiao, Lihua Wang, Yanhong Wang, Xiaole Su, Yufeng Qiao, Yun Fan and Zhiqiang Peng

    Citation: BMC Nephrology 2017 18:232

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  20. Content type: Research article

    Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar...

    Authors: Miklós M. Mózes, Petra Szoleczky, László Rosivall and Gábor Kökény

    Citation: BMC Nephrology 2017 18:209

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  21. Content type: Research article

    Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures. Evidence suggests that ascorbic acid (AA...

    Authors: K. Rollins, A. Noorani, L. Janeckova, T. Jones, M. Griffiths, M. P. Baker and J. R. Boyle

    Citation: BMC Nephrology 2017 18:101

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  22. Content type: Research article

    Histone H3K4 trimethylation (H3K4 me3) is found in active euchromatic regions and plays an important role in podocyte function in which actin filaments are abundant in the foot processes. The pathogenesis of m...

    Authors: Takayuki Fujino and Naoyuki Hasebe

    Citation: BMC Nephrology 2016 17:179

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  23. Content type: Research article

    Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hypergl...

    Authors: Rosa M. Montero, Gurjeet Bhangal, Charles D. Pusey, Andrew H. Frankel and Frederick W. K. Tam

    Citation: BMC Nephrology 2016 17:139

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  24. Content type: Research article

    Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA ...

    Authors: Zongshun Huang, Li Zhang, Yuanhan Chen, Hong Zhang, Chunping Yu, Fangjian Zhou, Zhiling Zhang, Lijuan Jiang, Ruizhao Li, Jianchao Ma, Zhuo Li, Yuxiong Lai, Ting Lin, Xinchen Zhao, Qianmei Zhang, Bin Zhang…

    Citation: BMC Nephrology 2016 17:66

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  25. Content type: Research article

    Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal...

    Authors: Jiuxu Bai, Junfeng Hao, Xiaoling Zhang, Hanmin Cui, Jingming Han and Ning Cao

    Citation: BMC Nephrology 2016 17:47

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  26. Content type: Research article

    IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, affecting close to a million people. Circulating galactose-deficient IgA (gd-IgA), present in patients with IgAN, form immune complex ...

    Authors: Kerstin Ebefors, Peidi Liu, Emelie Lassén, Johannes Elvin, Emma Candemark, Kristina Levan, Börje Haraldsson and Jenny Nyström

    Citation: BMC Nephrology 2016 17:40

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  27. Content type: Research article

    Dysfunction of renal tubule epithelial cells is associated with renal tubulointerstitial fibrosis. Exploration of the proteomic profiles of senesced tubule epithelial cells is essential to elucidate the mechan...

    Authors: Yang Lu, Jingchao Wang, Chen Dapeng, Di Wu, Guangyan Cai and Xiangmei Chen

    Citation: BMC Nephrology 2016 17:39

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  28. Content type: Research article

    Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable...

    Authors: Luciana Mazzei, Mercedes García, Juan Pablo Calvo, Mariana Casarotto, Miguel Fornés, María Angélica Abud, Darío Cuello-carrión, León Ferder and Walter Manucha

    Citation: BMC Nephrology 2016 17:34

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  29. Content type: Research article

    Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).

    Authors: Chulwon Kim, Sang Hyun Baek, Jae-Young Um, Bum Sang Shim and Kwang Seok Ahn

    Citation: BMC Nephrology 2016 17:19

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  30. Content type: Research article

    Pyrrolidine dithiocarbamate (PDTC) reduces renal cyst growth in a rodent model of polycystic kidney disease (PKD) but the mechanism of action is not clear. Here, we investigated the hypothesis that PDTC reduce...

    Authors: Michelle H. T. Ta, David Liuwantara and Gopala K. Rangan

    Citation: BMC Nephrology 2015 16:212

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  31. Content type: Research article

    Intermedin (IMD) is a novel member of the calcitonin/calcitonin gene-related peptide family. Endoplasmic reticulum stress (ERS) has been implicated in the pathology of renal ischemia/reperfusion (IRI). In the ...

    Authors: Yanhong Wang, Jihua Tian, Xi Qiao, Xiaole Su, Yang Mi, Ruijing Zhang and Rongshan Li

    Citation: BMC Nephrology 2015 16:169

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  32. Content type: Research article

    Small non-coding RNA molecules (miRNAs) play a pivotal role in regulating gene expression in development. miRNAs regulate key processes at the cellular level and thereby influence organismal and tissue develop...

    Authors: Malte P Bartram, Claudia Dafinger, Sandra Habbig, Thomas Benzing, Bernhard Schermer and Roman-Ulrich Müller

    Citation: BMC Nephrology 2015 16:55

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  33. Content type: Research article

    Hyperlipidemia is thought to be a major risk factor for the progression of renal diseases in diabetes. Recent studies have shown that lipid profiles are commonly abnormal early on type 2 diabetes mellitus (T2D...

    Authors: Liang He, Lili Hao, Xin Fu, Mingshu Huang and Rui Li

    Citation: BMC Nephrology 2015 16:51

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  34. Content type: Research article

    Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reti...

    Authors: Zeng Si Wang, Fei Xiong, Xiao Hang Xie, Dan Chen, Jian Hua Pan and Li Cheng

    Citation: BMC Nephrology 2015 16:44

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  35. Content type: Research article

    Podocyte detachment and apoptosis are two risk factors causing podocyte loss, F-actin rearrangement is involved in detachment and apoptosis. However, the nature of events that promote detachment and apoptosis ...

    Authors: Rufeng Dai, Yi Lin, Haimei Liu, Jia Rao, Yihui Zhai, Xiliang Zha, Xiaoyan Fang and Hong Xu

    Citation: BMC Nephrology 2015 16:38

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  36. Content type: Research article

    Death receptors (DRs) play an important role in renal pathology. We have shown that DR3 is inducibly expressed on renal tubular epithelial cells in the setting of inflammatory injuries. In this study we invest...

    Authors: Jun Wang, Rafia S Al-Lamki, Xinwang Zhu, Hanzhe Liu, Jordan S Pober and John R Bradley

    Citation: BMC Nephrology 2014 15:178

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  37. Content type: Research article

    MicroRNAs have been demonstrated to play an important role in the pathogenesis of diabetic nephropathy (DN). In this study, we investigated both the repertoire of miRNAs in the kidneys of patients with DN and ...

    Authors: Youqun Huang, Yan Liu, Ling Li, Baihai Su, Lichuan Yang, Wenxin Fan, Qinghua Yin, Lijia Chen, Tianlei Cui, Jie Zhang, Yanrong Lu, Jingqiu Cheng, Ping Fu and Fang Liu

    Citation: BMC Nephrology 2014 15:142

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  38. Content type: Research article

    To evaluate the effects of contrast agents containing increasing concentrations of iodine on the renal oxygenation level determined by blood oxygenation level dependent (BOLD) magnetic resonance imaging (MRI) ...

    Authors: Jia-huan Wang, Ke Ren, Wen-ge Sun, Li Zhao, Hong-shan Zhong and Ke Xu

    Citation: BMC Nephrology 2014 15:140

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  39. Content type: Research article

    Intratracheal aspiration and sepsis are leading causes of acute lung injury that frequently necessitate mechanical ventilation (MV), which may aggravate lung injury thereby potentially increasing the risk of a...

    Authors: Jan Willem Kuiper, AB Johan Groeneveld, Jack J Haitsma, Lonneke Smeding, Mark PV Begieneman, Serge Jothy, Rosanna Vaschetto and Frans B Plötz

    Citation: BMC Nephrology 2014 15:126

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  40. Content type: Research article

    CLIC4, a member of the CLIC family of proteins, was recently demonstrated to translocate to the nucleus in differentiating keratinocytes where it potentiates TGFβ-driven gene regulation. Since TGFβ signaling i...

    Authors: John C Edwards, Jonathan Bruno, Phillip Key and Yao-Wen Cheng

    Citation: BMC Nephrology 2014 15:54

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  41. Content type: Research article

    The human glomerulus is the primary filtration unit of the kidney, and contains the Glomerular Filtration Barrier (GFB). The GFB had been thought to comprise 3 layers - the endothelium, the basement membrane a...

    Authors: Kenton P Arkill, Klaus Qvortrup, Tobias Starborg, Judith M Mantell, Carlo Knupp, C Charles Michel, Steve J Harper, Andy HJ Salmon, John M Squire, Dave O Bates and Chris R Neal

    Citation: BMC Nephrology 2014 15:24

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  42. Content type: Research article

    The purpose of this study was to determine whether AMPK influences the survival of primary cultures of mouse proximal tubular (MPT) cells subjected to metabolic stress. Previous studies, using an immortalized ...

    Authors: Wilfred Lieberthal, Meiyi Tang, Leiqing Zhang, Benoit Viollet, Vimal Patel and Jerrold S Levine

    Citation: BMC Nephrology 2013 14:251

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  43. Content type: Research article

    Chronic progressive mesangioproliferative nephropathy represents a major cause of end-stage renal disease worldwide. Until now, effective approaches to stop or even slow its progression are limited. We tested ...

    Authors: Yingrui Wang-Rosenke, Dymtro Khadzhynov, Tanja Loof, Alice Mika, Hiroshi Kawachi, Hans-H Neumayer and Harm Peters

    Citation: BMC Nephrology 2013 14:223

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  44. Content type: Research article

    Chronic exposure to low cadmium (Cd) levels produces urinary excretion of low molecular weight proteins, which is considered the critical effect of Cd exposure. However, the mechanisms involved in Cd-induced p...

    Authors: Mitzi Paola Santoyo-Sánchez, José Pedraza-Chaverri, Eduardo Molina-Jijón, Laura Arreola-Mendoza, Rafael Rodríguez-Muñoz and Olivier Christophe Barbier

    Citation: BMC Nephrology 2013 14:211

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  45. Content type: Research article

    Kidney injuries provoke considerable adjustment of renal physiology, metabolism, and architecture to nephron loss. Despite remarkable regenerative capacity of the renal tissue, these adaptations often lead to ...

    Authors: Larisa V Fedorova, Anita Tamirisa, David J Kennedy, Steven T Haller, Georgy Budnyy, Joseph I Shapiro and Deepak Malhotra

    Citation: BMC Nephrology 2013 14:209

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  46. Content type: Research article

    The renal distal nephron plays an important role in the maintenance of sodium balance, extra cellular volume and blood pressure. The degree of water transport, via aquaporin2 water channels (AQP2), and sodium ...

    Authors: Janni M Jensen, Frank H Mose, Jesper N Bech, Soren Nielsen and Erling B Pedersen

    Citation: BMC Nephrology 2013 14:202

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