Cell Biology and Transport Physiology

Section edited by Robert Unwin

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  1. Research article

    Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells

    The distal convoluted tubule (DCT) is an important nephron site for parathyroid hormone (PTH) and calcitonin regulation of urinary divalent cation excretion. These hormones exert their effects on the DCT in su...

    Wararat Kittikulsuth, Peter A. Friedman, Alfred van Hoek, Yang Gao and Donald E. Kohan

    BMC Nephrology 2017 18:292

    Published on: 7 September 2017

  2. Research article

    CCL18 synergises with high concentrations of glucose in stimulating fibronectin production in human renal tubuloepithelial cells

    Diabetic nephropathy is the leading cause of end stage kidney disease worldwide. The pathogenesis of this disease remains elusive and multiple factors have been implicated. These include the effects of hypergl...

    Rosa M. Montero, Gurjeet Bhangal, Charles D. Pusey, Andrew H. Frankel and Frederick W. K. Tam

    BMC Nephrology 2016 17:139

    Published on: 29 September 2016

  3. Research article

    RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal

    Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA ...

    Zongshun Huang, Li Zhang, Yuanhan Chen, Hong Zhang, Chunping Yu, Fangjian Zhou, Zhiling Zhang, Lijuan Jiang, Ruizhao Li, Jianchao Ma, Zhuo Li, Yuxiong Lai, Ting Lin, Xinchen Zhao, Qianmei Zhang, Bin Zhang…

    BMC Nephrology 2016 17:66

    Published on: 7 July 2016

  4. Research article

    Mesangial cells from patients with IgA nephropathy have increased susceptibility to galactose-deficient IgA1

    IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, affecting close to a million people. Circulating galactose-deficient IgA (gd-IgA), present in patients with IgAN, form immune complex ...

    Kerstin Ebefors, Peidi Liu, Emelie Lassén, Johannes Elvin, Emma Candemark, Kristina Levan, Börje Haraldsson and Jenny Nyström

    BMC Nephrology 2016 17:40

    Published on: 5 April 2016

  5. Research article

    Changes in renal WT-1 expression preceding hypertension development

    Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable...

    Luciana Mazzei, Mercedes García, Juan Pablo Calvo, Mariana Casarotto, Miguel Fornés, María Angélica Abud, Darío Cuello-carrión, León Ferder and Walter Manucha

    BMC Nephrology 2016 17:34

    Published on: 24 March 2016

  6. Research article

    Resveratrol attenuates constitutive STAT3 and STAT5 activation through induction of PTPε and SHP-2 tyrosine phosphatases and potentiates sorafenib-induced apoptosis in renal cell carcinoma

    Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).

    Chulwon Kim, Sang Hyun Baek, Jae-Young Um, Bum Sang Shim and Kwang Seok Ahn

    BMC Nephrology 2016 17:19

    Published on: 25 February 2016

  7. Research article

    Effects of pyrrolidine dithiocarbamate on proliferation and nuclear factor-κB activity in autosomal dominant polycystic kidney disease cells

    Pyrrolidine dithiocarbamate (PDTC) reduces renal cyst growth in a rodent model of polycystic kidney disease (PKD) but the mechanism of action is not clear. Here, we investigated the hypothesis that PDTC reduce...

    Michelle H. T. Ta, David Liuwantara and Gopala K. Rangan

    BMC Nephrology 2015 16:212

    Published on: 15 December 2015

  8. Research article

    Loss of Dgcr8-mediated microRNA expression in the kidney results in hydronephrosis and renal malformation

    Small non-coding RNA molecules (miRNAs) play a pivotal role in regulating gene expression in development. miRNAs regulate key processes at the cellular level and thereby influence organismal and tissue develop...

    Malte P Bartram, Claudia Dafinger, Sandra Habbig, Thomas Benzing, Bernhard Schermer and Roman-Ulrich Müller

    BMC Nephrology 2015 16:55

    Published on: 14 April 2015

  9. Research article

    Severe hypertriglyceridemia and hypercholesterolemia accelerating renal injury: a novel model of type 1 diabetic hamsters induced by short-term high-fat / high-cholesterol diet and low-dose streptozotocin

    Hyperlipidemia is thought to be a major risk factor for the progression of renal diseases in diabetes. Recent studies have shown that lipid profiles are commonly abnormal early on type 2 diabetes mellitus (T2D...

    Liang He, Lili Hao, Xin Fu, Mingshu Huang and Rui Li

    BMC Nephrology 2015 16:51

    Published on: 11 April 2015

  10. Research article

    Astragaloside IV attenuates proteinuria in streptozotocin-induced diabetic nephropathy via the inhibition of endoplasmic reticulum stress

    Diabetic nephropathy (DN) is a major cause of Chronic Kidney Disease and End-Stage Renal Disease throughout the world; however, the reversibility of diabetic nephropathy remains controversial. Endoplasmic reti...

    Zeng Si Wang, Fei Xiong, Xiao Hang Xie, Dan Chen, Jian Hua Pan and Li Cheng

    BMC Nephrology 2015 16:44

    Published on: 31 March 2015

  11. Research article

    TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells

    Death receptors (DRs) play an important role in renal pathology. We have shown that DR3 is inducibly expressed on renal tubular epithelial cells in the setting of inflammatory injuries. In this study we invest...

    Jun Wang, Rafia S Al-Lamki, Xinwang Zhu, Hanzhe Liu, Jordan S Pober and John R Bradley

    BMC Nephrology 2014 15:178

    Published on: 16 November 2014

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