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Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Content type: Research article

    The risk of early death is particularly high in patients over the age of 65 presenting with antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We hypothesized that by combining disease sev...

    Authors: Dimitri Titeca-Beauport, Alexis Francois, Thierry Lobbedez, Dominique Guerrot, David Launay, Laurence Vrigneaud, Maité Daroux, Celine Lebas, Boris Bienvenu, Eric Hachulla, Momar Diouf and Gabriel Choukroun

    Citation: BMC Nephrology 2018 19:317

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  2. Content type: Research article

    Abdominal aortic calcification (AAC) has been known to be associated with cardiovascular mortality in hemodialysis. However, the association between AAC and future coronary artery disease (CAD) occurrence is n...

    Authors: Hung-Chih Chen, Wei-Ting Wang, Chieh-Ning Hsi, Che-Yi Chou, Hsuan-Jen Lin, Chiu-Ching Huang and Chiz-Tzung Chang

    Citation: BMC Nephrology 2018 19:313

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  3. Content type: Research article

    Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum an...

    Authors: Richard J. Johnson, Santos E. Perez-Pozo, Julian Lopez Lillo, Felix Grases, Jesse D. Schold, Masanari Kuwabara, Yuka Sato, Ana Andres Hernando, Gabriela Garcia, Thomas Jensen, Christopher Rivard, Laura G. Sanchez-Lozada, Carlos Roncal and Miguel A. Lanaspa

    Citation: BMC Nephrology 2018 19:315

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  4. Content type: Research article

    Iodinated contrast media may contribute to acute kidney injury. However, several recent works suggest that this toxicity is minimal in the clinical setting. Recently, urinary G1 cell-cycle arrest proteins tissue ...

    Authors: Emmanuelle Rouve, Karim Lakhal, Charlotte Salmon Gandonnière, Youenn Jouan, Laetitia Bodet-Contentin and Stephan Ehrmann

    Citation: BMC Nephrology 2018 19:308

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  5. Content type: Research article

    Knowledge on cross-talk between the heart and kidney has been established by basic and clinical research. Nevertheless, the effects of systolic and diastolic heart dysfunctions on the development of acute kidn...

    Authors: Jae Shin Choi, Seon Ha Baek, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Yon Su Kim, Sejoong Kim and Seung Seok Han

    Citation: BMC Nephrology 2018 19:292

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  6. Content type: Research article

    Laparoscopic abdominal surgery has been widely used to reduce the length of hospital stay and complications from open abdominal surgery. During the operation, the creation of pneumoperitoneum is used for bette...

    Authors: Nattachai Srisawat, Manasnun Kongwibulwut, Passisd Laoveeravat, Nuttha Lumplertgul, Pornlert Chatkaew, Pipat Saeyub, Krittayot Latthaprecha, Sadudee Peerapornratana, Khajohn Tiranathanagul, Somchai Eiam-Ong and Kriang Tungsanga

    Citation: BMC Nephrology 2018 19:289

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  7. Content type: Research article

    Autosomal dominant polycystic kidney disease (ADPKD) accounts for 8–10% of end-stage chronic kidney disease (CKD) patients worldwide. In the last decade, the advanced knowledge in genetics and molecular pathob...

    Authors: Antonio Pisani, Eleonora Riccio, Dario Bruzzese and Massimo Sabbatini

    Citation: BMC Nephrology 2018 19:282

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  8. Content type: Research article

    To achieve optimal health outcomes, people with chronic kidney disease must make changes in their everyday lives to self-manage their condition. This can be challenging, and there is a need for self-management...

    Authors: Kathryn Havas, Clint Douglas and Ann Bonner

    Citation: BMC Nephrology 2018 19:279

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  9. Content type: Research article

    Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship ...

    Authors: Moritz Wyler von Ballmoos, Donald S. Likosky, Michael Rezaee, Kevin Lobdell, Shama Alam, Devin Parker, Sherry Owens, Heather Thiessen-Philbrook, Todd MacKenzie and Jeremiah R. Brown

    Citation: BMC Nephrology 2018 19:280

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  10. Content type: Research article

    We investigated the impact of a transvenous cardiac implantable electronic device (CIED) placement on outcomes and arteriovenous vascular access (VA) patency among chronic hemodialysis patients.

    Authors: Seonjeong Jeong, Gi Byoung Nam, Jai Won Chang, Min-Ju Kim, Youngjin Han, Tae-Won Kwon and Yong-Pil Cho

    Citation: BMC Nephrology 2018 19:281

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  11. Content type: Research article

    Cyst infection is a common and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often refractory. Carbapenems are frequently needed to treat to patients with refractory cyst...

    Authors: Satoshi Hamanoue, Tatsuya Suwabe, Yoshifumi Ubara, Koichi Kikuchi, Ryo Hazue, Koki Mise, Toshiharu Ueno, Kenmei Takaichi, Kana Matsumoto and Kunihiko Morita

    Citation: BMC Nephrology 2018 19:272

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  12. Content type: Research article

    The clinical course of Viridans streptococci (VS) peritonitis in patients undergoing peritoneal dialysis (PD) is rarely reported. This study examined the association of clinical factors with VS peritonitis.

    Authors: Ying Liu, Ben-Chung Cheng, Jien-Wei Liu, Chiao-Jung Chen, Li-Chueh Kuo, Wen Xiu Chang and Jin-Bor Chen

    Citation: BMC Nephrology 2018 19:271

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  13. Content type: Research article

    Poor nutritional status of patients with renal disease has been associated with worsening of renal function and poor health outcomes. Simply measuring weight and height for calculation of the body mass index d...

    Authors: Jutta Dierkes, Helene Dahl, Natasha Lervaag Welland, Kristina Sandnes, Kristin Sæle, Ingegjerd Sekse and Hans-Peter Marti

    Citation: BMC Nephrology 2018 19:259

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  14. Content type: Study protocol

    Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidit...

    Authors: Andrea Corsonello, Lisanne Tap, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Carmine Zoccali, Tomasz Kostka, Agnieszka Guligowska, Francesco Mattace-Raso, Pedro Gil, Lara Guardado Fuentes, Itshak Meltzer, Ilan Yehoshua, Francesc Formiga-Perez, Rafael Moreno-González, Christian Weingart, Ellen Freiberger…

    Citation: BMC Nephrology 2018 19:260

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  15. Content type: Research article

    Vitamin D deficiency is common in patients with chronic kidney disease (CKD), and is associated with endothelial dysfunction and cardiovascular disease. We performed a meta-analysis to assess the effect of vit...

    Authors: Kristina Lundwall, Stefan H. Jacobson, Gun Jörneskog and Jonas Spaak

    Citation: BMC Nephrology 2018 19:247

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  16. Content type: Research article

    Increased monocyte chemoattractant protein-1 (MCP-1) and decreased epidermal growth factor (EGF) are promising biomarkers to predict progressive decline in kidney function in non-diabetic kidney diseases. We a...

    Authors: Bancha Satirapoj, Rattanawan Dispan, Piyanuch Radinahamed and Chagriya Kitiyakara

    Citation: BMC Nephrology 2018 19:246

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  17. Content type: Research article

    Anti-glomerular basement-membrane (anti-GBM) disease (or Goodpasture disease) is characterized by severe kidney and lung involvement. Prognoses have improved with treatments that combine plasma exchange and im...

    Authors: M. Heitz, P. L. Carron, G. Clavarino, T. Jouve, N. Pinel, F. Guebre-Egziabher and L. Rostaing

    Citation: BMC Nephrology 2018 19:241

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  18. Content type: Research article

    Evidence suggests that alkaline phosphatase attenuates inflammatory response in sepsis by lipopolysaccharide detoxification and adenosine triphosphate dephosphorylation. We sought to determine changes in alkal...

    Authors: Seung Don Baek, Jae-Young Kang, Hoon Yu, Seulgi Shin, Hyang-Sook Park, Mi-Soon Kim, Eun Kyoung Lee, So Mi Kim and Jai Won Chang

    Citation: BMC Nephrology 2018 19:243

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  19. Content type: Research article

    Corticosteroids are widely used to reduce the urine protein levels of patients with immunoglobulin A nephropathy (IgAN). However, their potential preventive effects on end-stage kidney disease (ESKD) are unclear.

    Authors: Ryoya Tsunoda, Joichi Usui, Junichi Hoshino, Takayuki Fujii, Satoshi Suzuki, Kenmei Takaichi, Yoshifumi Ubara and Kunihiro Yamagata

    Citation: BMC Nephrology 2018 19:222

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  20. Content type: Research article

    Nephrotoxicity is a major hazard complicating the use of platinum based drugs (PBD), which can hinder using higher doses protocols to maximize the therapeutic gain. Shortage of serum creatinine level as an acc...

    Authors: Mostafa Abdelsalam, Ekramy Elmorsy, Hassan Abdelwahab, Osman Algohary, Mahmoud Naguib, Ahmed Abd El Wahab, Ahmed Eldeeb, Ehab Eltoraby, Adel Abdelsalam, Alaa Sabry, Mohamed El-Metwally, Mohamed Akl, Nahla Anber, Maysaa El Sayed Zaki, Fahad Almutairi and Tamer Mansour

    Citation: BMC Nephrology 2018 19:219

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  21. Content type: Research article

    The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, pe...

    Authors: Xiao-dan Zhang, Zhao Cui, Mu-fan Zhang, Jia Wang, Yi-miao Zhang, Zhen Qu, Xin Wang, Jing Huang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Su-xia Wang, Gang Liu and Ming-hui Zhao

    Citation: BMC Nephrology 2018 19:215

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  22. Content type: Research article

    With advancement of hemodialysis (HD) technique, late fistula failure (LFF) remains a problem significantly affecting life quality of patients. We attempt to identify factors affecting LFF in patients on chron...

    Authors: Cheng-Chieh Yen, Ching-Fang Tsai, Yueh-Yun Luo, Hsin-Yi Yang, Mei-Yin Liu, Peir-Haur Hung and Yueh-Han Hsu

    Citation: BMC Nephrology 2018 19:213

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  23. Content type: Research article

    Henoch-Schönlein purpura nephritis (HSPN) is a form of small vessel vasculitis associated with purpura and IgA deposition in the glomeruli. The International Study of Kidney Disease in Children (ISKDC) classif...

    Authors: Koji Inagaki, Ahmad Baseer Kaihan, Asaka Hachiya, Takaya Ozeki, Masahiko Ando, Sawako Kato, Yoshinari Yasuda and Shoichi Maruyama

    Citation: BMC Nephrology 2018 19:208

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  24. Content type: Research article

    Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remai...

    Authors: Eunjeong Kang, Joongyub Lee, Hyo Jin Kim, Miyeun Han, Soo Wan Kim, Kyu-Beck Lee, Suah Sung, Tae-Hyun Yoo, Wookyung Chung, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2018 19:203

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    The Correction to this article has been published in BMC Nephrology 2018 19:217

  25. Content type: Research article

    Volume overload poses a major risk in hemodialysis patients but simple detection methods are lacking. We propose a novel marker, the Interdialytic Creatinine Rise (IDCR), readily calculated as the change in se...

    Authors: Ljubomir M. Ilic, Roger B. Davis, Robert S. Brown and Stewart H. Lecker

    Citation: BMC Nephrology 2018 19:202

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  26. Content type: Research article

    Microalbuminuria signifies the onset of diabetic nephropathy, but normoalbuminuric patients with diabetes who have a low Glomerular Filtration Rate (GFR) are not uncommon. The purpose of the study was to estim...

    Authors: Polwatta Liyanage Gayani Chandima Liyanage, Sarath Lekamwasam, Thilak Priyantha Weerarathna and Dodanduwa Waduge Shyamal Yashodara Srikantha

    Citation: BMC Nephrology 2018 19:200

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  27. Content type: Research article

    Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk ...

    Authors: Eun Jin Kim, Woonji Lee, Woo Yong Jeong, Hen Choi, In Young Jung, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Hwa Choi, Young Goo Song and June Myung Kim

    Citation: BMC Nephrology 2018 19:193

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  28. Content type: Research article

    Increased plasma level of lipoprotein(a) (Lpa) is a risk factor of cardiovascular diseases. This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal di...

    Authors: Kun Ling Ma, Tie Kai Gong, Ze Bo Hu, Yang Zhang, Gui Hua Wang, Liang Liu, Pei Pei Chen, Jian Lu, Chen Chen Lu and Bi Cheng Liu

    Citation: BMC Nephrology 2018 19:192

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  29. Content type: Research article

    Soluble urokinase-type plasminogen activator receptor (suPAR) has emerged as a new sepsis biomarker. It is not known whether suPAR has a role in critically ill patients with severe acute kidney injury (AKI).

    Authors: Anna Hall, Siobhan Crichton, Matt Varrier, Danielle E. Bear and Marlies Ostermann

    Citation: BMC Nephrology 2018 19:191

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  30. Content type: Research article

    Investigations on the role of the time-mean serum uric acid (SUA) value in determining the risk of chronic kidney disease (CKD) are limited. We investigated whether the time-mean SUA value indicates the risk o...

    Authors: Meiyu Ye, Kang Hu, Juan Jin, Diandian Wu, Peiying Hu and Qiang He

    Citation: BMC Nephrology 2018 19:190

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  31. Content type: Research article

    Ongoing efforts are focused on shortening ischemia intervals as much as possible during partial nephrectomy to preserve renal function. Off-clamp partial nephrectomy (off-PN) has been a common strategy for to ...

    Authors: Wen Deng, Xiaoqiang Liu, Jieping Hu, Luyao Chen and Bin Fu

    Citation: BMC Nephrology 2018 19:188

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  32. Content type: Research article

    Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR a...

    Authors: Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Nephrology 2018 19:187

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  33. Content type: Research article

    Idiopathic membranous nephropathy (IMN) is one of the most common adult nephrotic syndromes. Some patients with this disorder require immunosuppressive therapy. This retrospective case series was performed to ...

    Authors: Shun-Lai Shang, Guang-Yan Cai, Shu-wei Duan, Ping Li, Qing-Gang Li and Xiang-Mei Chen

    Citation: BMC Nephrology 2018 19:182

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  34. Content type: Research article

    Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light ...

    Authors: Punit Yadav, Paul Cockwell, Mark Cook, Jennifer Pinney, Hannah Giles, Yu Sandar Aung, David Cairns, Roger G. Owen, Faith E. Davies, Graham H. Jackson, J. Anthony Child, Gareth J. Morgan and Mark T. Drayson

    Citation: BMC Nephrology 2018 19:178

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  35. Content type: Research article

    Echocardiographic characteristics across the spectrum of chronic kidney disease (CKD) have not been well described. We assessed the echocardiographic characteristics of patients with preserved renal function a...

    Authors: Thomas A. Mavrakanas, Aisha Khattak, Karandeep Singh and David M. Charytan

    Citation: BMC Nephrology 2018 19:176

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  36. Content type: Research article

    The management of proliferative lupus nephritis (LN) comprises timely and coordinated immunosuppressive therapy. This study aimed to evaluate and compare the effectiveness and safety profile of low dose mycoph...

    Authors: Arun Sedhain, Rajani Hada, Rajendra K. Agrawal, Gandhi R. Bhattarai and Anil Baral

    Citation: BMC Nephrology 2018 19:175

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  37. Content type: Research article

    Current guidelines regarding plasma-sampling techniques for glomerular filtration rate (GFR) determination are inconsistent. Single-sample methods are commonly believed not to be precise enough to meet clinica...

    Authors: Yong Zhang, Zhun Sui, Ze Yu, Tai Feng Li, Wan Yu Feng and Li Zuo

    Citation: BMC Nephrology 2018 19:174

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  38. Content type: Research article

    Chronic kidney disease (CKD) poses a substantial health burden in sub-Saharan Africa, with risk factors ranging from communicable to non-communicable diseases. Hyperuricemia has been recently identified as a f...

    Authors: Marie Doualla, Marie Patrice Halle, Jude Moutchia, Steve Tegang and Gloria Ashuntantang

    Citation: BMC Nephrology 2018 19:169

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  39. Content type: Research article

    Organ donation after brain death (DBD) is the standard strategy for organ transplantation; however, the concept of brain death is not universally accepted due to cultural beliefs and barriers amongst billions ...

    Authors: Qipeng Sun, Honglan Zhou, Ronghua Cao, Minzhuan Lin, Xuefeng Hua, Liangqing Hong, Zhengyu Huang, Ning Na, Ruiming Cai, Gang Wang, Fanhang Meng and Qiquan Sun

    Citation: BMC Nephrology 2018 19:164

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  40. Content type: Research article

    Acute kidney injury (AKI) following cardiac surgery is a frequent complication and several risk factors increasing its incidence have already been characterized. This study evaluates the influence of preoperat...

    Authors: T. Kaufeld, K. A. Foerster, T. Schilling, J. T. Kielstein, J. Kaufeld, M. Shrestha, H. G. Haller, A. Haverich and B. M. W. Schmidt

    Citation: BMC Nephrology 2018 19:161

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  41. Content type: Research article

    The Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury (AKI) guidelines assign the same stage of AKI to patients whether they fulfil urine output criteria, serum creatinine criteria or both ...

    Authors: Samuel H. Howitt, Stuart W. Grant, Camila Caiado, Eric Carlson, Dowan Kwon, Ioannis Dimarakis, Ignacio Malagon and Charles McCollum

    Citation: BMC Nephrology 2018 19:149

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  42. Content type: Research article

    There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patien...

    Authors: Mary C. Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos and Moro Salifu

    Citation: BMC Nephrology 2018 19:147

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  43. Content type: Research article

    Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical charact...

    Authors: Liu Yang, Honglang Xie, Zhengzhao Liu, Yinghua Chen, Jinquan Wang, Haitao Zhang, Yongchun Ge and Weixin Hu

    Citation: BMC Nephrology 2018 19:138

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  44. Content type: Research article

    Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropath...

    Authors: Joel Neugarten, Ladan Golestaneh and Nitin V. Kolhe

    Citation: BMC Nephrology 2018 19:131

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  45. Content type: Research article

    Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not full...

    Authors: Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian and Wei Fang

    Citation: BMC Nephrology 2018 19:119

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  46. Content type: Research article

    The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to as...

    Authors: Irene Ruderman, Edward R. Smith, Nigel D. Toussaint, Tim D. Hewitson and Stephen G. Holt

    Citation: BMC Nephrology 2018 19:113

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  47. Content type: Research article

    This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients.

    Authors: Jin-Bor Chen, Ben-Chung Cheng, Wen-Hao Liu, Shang-Chih Liao, Mao-Young Morgan Fu, Sin-Hua Moi and Cheng-Hong Yang

    Citation: BMC Nephrology 2018 19:109

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