Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Research article

    The risk of diabetic renal function impairment in the first decade after diagnosed of diabetes mellitus is correlated with high variability of visit-to-visit systolic and diastolic blood pressure: a case control study

    The variability of visit-to-visit (VVV) in systolic blood pressure (SBP) and diastolic blood pressure (DBP) is proved as a predictor of renal function deterioration in patients with non-diabetic chronic kidney...

    Chi-Hsiao Yeh, Hsiu-Chin Yu, Tzu-Yen Huang, Pin-Fu Huang, Yao-Chang Wang, Tzu-Ping Chen and Shun-Ying Yin

    BMC Nephrology 2017 18:99

    Published on: 22 March 2017

  2. Research article

    Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy

    Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. T...

    In Mi Han, Chang-Yun Yoon, Dong Ho Shin, Youn Kyung Kee, Seung Gyu Han, Young Eun Kwon, Kyoung Sook Park, Mi Jung Lee, Hyung Jung Oh, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang and Tae-Hyun Yoo

    BMC Nephrology 2017 18:94

    Published on: 20 March 2017

  3. Research article

    Cardiovascular risk is similar in patients with glomerulonephritis compared to other types of chronic kidney disease: a matched cohort study

    Patients with chronic kidney disease (CKD) due to glomerulonephritis (GN) are thought to be at high risk for cardiovascular disease (CVD). However, no study has examined whether GN directly contributes to CV r...

    Holly L. Hutton, Adeera Levin, Jagbir Gill, Ognjenka Djurdjev, Mila Tang and Sean J. Barbour

    BMC Nephrology 2017 18:95

    Published on: 20 March 2017

  4. Research article

    Renal effects of metallothionein induction by zinc in vitro and in vivo

    Metallothionein (MTT) is an endogenous antioxidant that can be induced by both zinc (Zn) and ischemia. In kidneys, increased MTT expression exerts a putative protective role in diabetes and hypoxia. Our goal w...

    Moritz Schanz, Lea Schaaf, Juergen Dippon, Dagmar Biegger, Peter Fritz, Mark Dominik Alscher and Martin Kimmel

    BMC Nephrology 2017 18:91

    Published on: 16 March 2017

  5. Research article

    Clinical and laboratory parameters associated with acute kidney injury in patients with snakebite envenomation: a prospective observational study from Myanmar

    Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the occurrence of snakebite-re...

    Kyi-Phyu Aye, Vipa Thanachartwet, Chit Soe, Varunee Desakorn, Khin-Thida Thwin, Supat Chamnanchanunt, Duangjai Sahassananda, Thanom Supaporn and Visith Sitprija

    BMC Nephrology 2017 18:92

    Published on: 16 March 2017

  6. Research article

    Significance of clinical and morphological prognostic risk factors in IgA nephropathy: follow-up study of comparison patient groups with and without renoprotection

    IgA nephropathy (IgAN) is the most frequent glomerulonephritis in many countries including Estonia. There is no specific treatment for IgAN but renoprotection is indicated when proteinuria is >1 g/day. We aime...

    Živile Riispere, Anne Kuudeberg, Elviira Seppet, Kristin Sepp, Madis Ilmoja, Merike Luman, Külli Kõlvald, Asta Auerbach and Mai Ots-Rosenberg

    BMC Nephrology 2017 18:89

    Published on: 14 March 2017

  7. Research article

    Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects

    Tolvaptan is a selective vasopressin receptor antagonist. Nitric Oxide (NO) promotes renal water and sodium excretion, but the effect is unknown in the nephron’s principal cells. In a dose-response study, we m...

    Safa Al Therwani, Jeppe Bakkestrøm Rosenbæk, Frank Holden Mose, Jesper Nørgaard Bech and Erling Bjerregaard Pedersen

    BMC Nephrology 2017 18:86

    Published on: 13 March 2017

  8. Research article

    Abdominal aortic calcification on a plain X-ray and the relation with significant coronary artery disease in asymptomatic chronic dialysis patients

    Coronary artery disease (CAD) is common in asymptomatic chronic dialysis patients and plays an important role in their poor survival. Early identification of these high-risk patients could improve treatment an...

    M. K. de Bie, M. S. Buiten, J. I. Rotmans, M. Hogenbirk, M. J. Schalij, T. J. Rabelink and J. W. Jukema

    BMC Nephrology 2017 18:82

    Published on: 2 March 2017

  9. Research article

    Effectiveness of Integrated Care on Delaying Progression of stage 3-4 Chronic Kidney Disease in Rural Communities of Thailand (ESCORT study): a cluster randomized controlled trial

    In developing countries, renal specialists are scarce and physician-to-patient contact time is limited. While conventional hospital-based, physician-oriented approach has been the main focus of chronic kidney ...

    Teerayuth Jiamjariyapon, Atiporn Ingsathit, Krit Pongpirul, Kotcharat Vipattawat, Suphattra Kanchanakorn, Akhathai Saetie, Duangjit Kanistanon, Patimaporn Wongprompitak, Vinai Leesmidt, Watcharapong Watcharasaksilp, Wei Wang, Anil K. Chandraker and Kriang Tungsanga

    BMC Nephrology 2017 18:83

    Published on: 2 March 2017

  10. Technical advance

    A new prescription model for regional citrate anticoagulation in therapeutic plasma exchanges

    Regional citrate anticoagulation (RCA) is proposed for various extracorporeal purification techniques to overcome the risk of bleeding that might result from systemic anticoagulation. Yet, no individualized tr...

    Sébastien Kissling, Cécile Legallais, Menno Pruijm, Daniel Teta, Bruno Vogt, Michel Burnier, Eric Rondeau and Christophe Ridel

    BMC Nephrology 2017 18:81

    Published on: 1 March 2017

    The Erratum to this article has been published in BMC Nephrology 2017 18:84

  11. Research article

    Simple, readily available clinical indices predict early and late mortality among patients with ANCA-associated vasculitis

    The early identification of patients with ANCA-associated vasculitis (AAV) who are at increased risk for inferior clinical outcome at the time of diagnosis might help to optimize the immunosuppressive therapy....

    Ágnes Haris, Kálmán Polner, József Arányi, Henrik Braunitzer, Ilona Kaszás, László Rosivall, Gábor Kökény and István Mucsi

    BMC Nephrology 2017 18:76

    Published on: 23 February 2017

  12. Research article

    NGAL expression during cardiopulmonary bypass does not predict severity of postoperative acute kidney injury

    Renal injury is a serious complication after cardiac surgery and therefore, early detection and much more prediction of postoperative kidney injury is desirable. Neutrophil gelatinase-associated lipocalin (NGA...

    Martin G. Friedrich, Ioannis Bougioukas, Johanna Kolle, Christian Bireta, Fawad A. Jebran, Marius Placzek and Theodor Tirilomis

    BMC Nephrology 2017 18:73

    Published on: 21 February 2017

  13. Research article

    Surfactant protein-D (SP-D) gene polymorphisms and serum level as predictors of susceptibility and prognosis of acute kidney injury in the Chinese population

    Injury to the kidney epithelial barrier is a characteristic feature of acute kidney injury (AKI). Serum surfactant protein-D (SP-D), a known biomarker of damaged alveolar epithelium, is also secreted by renal ...

    Jiao Liu, Guang Li, Lianghai Li, Zhiyong Liu, Qingshan Zhou, Guirong Wang and Dechang Chen

    BMC Nephrology 2017 18:67

    Published on: 17 February 2017

  14. Research article

    Prevalence and risk factors for Human T-Lymphotropic Virus Type 1 (HTLV-1) among maintenance hemodialysis patients

    Infection with the human T-cell lymphotropic virus type 1 (HTLV-1), although asymptomatic in most cases, can lead to potentially grave consequences, such as adult T-cell leukemia-lymphoma and HTLV-1-associated...

    Rilma F. S. Santos, Gildásio C. Conceição, Márcia S. Martins, Angiolina Kraychete, Maria A. C. Penalva, Edgar M. Carvalho, Antonio Alberto Lopes and Paulo Novis Rocha

    BMC Nephrology 2017 18:64

    Published on: 15 February 2017

  15. Research article

    The association between interleukin-19 concentration and diabetic nephropathy

    Interleukin-19 (IL-19) is a newly discovered cytokine belonging to the Interleukin-10(IL-10) family. IL-19 have indispensable functions in many inflammatory processes and also can induce the angiogenic potenti...

    Li Li, Xu-gan Jiang, Juan-Yu Hu, ZHeng-Qing Yu, Jian-Yong Xu, Fan Liu, Guang-Chun Zhao, Lei Zhang, Hui-Ming Gu, Si-Jing Zhang and Jin Meng

    BMC Nephrology 2017 18:65

    Published on: 15 February 2017

  16. Research article

    Urinary sediment miRNAs reflect tubulointerstitial damage and therapeutic response in IgA nephropathy

    Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. The clinical spectrum of IgAN varies from minor urinary abnormalities to rapidly progressive renal failure. Evaluation of th...

    Shuang Liang, Guang-Yan Cai, Zhi-Yu Duan, Shu-wen Liu, Jie Wu, Yang Lv, Kai Hou, Zuo-xiang Li, Xue-Guang Zhang and Xiang-Mei Chen

    BMC Nephrology 2017 18:63

    Published on: 15 February 2017

  17. Research article

    Acute kidney injury increases the risk of end-stage renal disease after cardiac surgery in an Asian population: a prospective cohort study

    Acute kidney injury (AKI) after cardiac surgery is associated with increased morbidity and mortality. The long-term association between AKI and end-stage renal disease (ESRD) in an Asian population is unknown....

    Sophia Tsong Huey Chew, Roderica Rui Ge Ng, Weiling Liu, Khuan Yew Chow and Lian Kah Ti

    BMC Nephrology 2017 18:60

    Published on: 13 February 2017

  18. Research article

    Efficacy and safety of calcineurin inhibitor treatment for IgA nephropathy: a meta-analysis

    IgA nephropathy is the most common progressive glomerular disease to end stage renal failure worldwide. Calcineurin inhibitors (CNIs) is a selective immunosuppressant widely used in organ transplantation. The ...

    Yu-Huan Song, Guang-Yan Cai, Yue-Fei Xiao, Yi-Ping Wang, Bao-Shi Yuan, Yuan-Yuan Xia, Si-Yang Wang, Pu Chen, Shu-Wen Liu and Xiang-Mei Chen

    BMC Nephrology 2017 18:61

    Published on: 13 February 2017

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