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Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Content type: Research article

    There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patien...

    Authors: Mary C. Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos and Moro Salifu

    Citation: BMC Nephrology 2018 19:147

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  2. Content type: Research article

    Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical charact...

    Authors: Liu Yang, Honglang Xie, Zhengzhao Liu, Yinghua Chen, Jinquan Wang, Haitao Zhang, Yongchun Ge and Weixin Hu

    Citation: BMC Nephrology 2018 19:138

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  3. Content type: Research article

    Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropath...

    Authors: Joel Neugarten, Ladan Golestaneh and Nitin V. Kolhe

    Citation: BMC Nephrology 2018 19:131

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  4. Content type: Research article

    Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not full...

    Authors: Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian and Wei Fang

    Citation: BMC Nephrology 2018 19:119

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  5. Content type: Research article

    The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to as...

    Authors: Irene Ruderman, Edward R. Smith, Nigel D. Toussaint, Tim D. Hewitson and Stephen G. Holt

    Citation: BMC Nephrology 2018 19:113

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  6. Content type: Research article

    This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients.

    Authors: Jin-Bor Chen, Ben-Chung Cheng, Wen-Hao Liu, Shang-Chih Liao, Mao-Young Morgan Fu, Sin-Hua Moi and Cheng-Hong Yang

    Citation: BMC Nephrology 2018 19:109

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  7. Content type: Research article

    African Americans have persistently poor access to living donor kidney transplants (LDKT). We conducted a small randomized trial to provide preliminary evidence of the effect of informational decision support ...

    Authors: L. Ebony Boulware, Patti L. Ephraim, Jessica Ameling, LaPricia Lewis-Boyer, Hamid Rabb, Raquel C. Greer, Deidra C. Crews, Bernard G. Jaar, Priscilla Auguste, Tanjala S. Purnell, Julio A. Lamprea-Monteleagre, Tope Olufade, Luis Gimenez, Courtney Cook, Tiffany Campbell, Ashley Woodall…

    Citation: BMC Nephrology 2018 19:107

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  8. Content type: Research article

    Acute kidney injury (AKI) is a common post-cardiac surgery complication and influences patient morbidity and prognosis. This study was designed to identify preoperative candidate urine biomarkers in patients u...

    Authors: Michael L. Merchant, Michael E. Brier, Mark S. Slaughter, Jon B. Klein and Kenneth R. McLeish

    Citation: BMC Nephrology 2018 19:102

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  9. Content type: Research article

    We hypothesized that the use of actual body weight might lead to more frequent misdiagnosis of acute kidney injury (AKI) than when ideal body weight is used in underweight and/or obese patients. We examined wh...

    Authors: Shinshu Katayama, Kansuke Koyama, Yuya Goto, Toshitaka Koinuma, Ken Tonai, Jun Shima, Masahiko Wada and Shin Nunomiya

    Citation: BMC Nephrology 2018 19:101

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  10. Content type: Research article

    The transition from pre-dialysis chronic kidney disease (CKD) to renal replacement therapy (RRT) is a stressful event. Anxiety, depression and stress are frequent conditions in this population, and might play ...

    Authors: Cicero Italo L. Bezerra, Bruno C. Silva and Rosilene M. Elias

    Citation: BMC Nephrology 2018 19:98

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  11. Content type: Research article

    Increasing evidence has shown that albuminuria is related to serum uric acid. Little is known about whether this association may be interrelated via renal handling of uric acid. Therefore, we aim to study urin...

    Authors: Fengqin Li, Hui Guo, Jianan Zou, Weijun Chen, Yijun Lu, Xiaoli Zhang, Chensheng Fu, Jing Xiao and Zhibin Ye

    Citation: BMC Nephrology 2018 19:95

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  12. Content type: Research article

    Acute kidney injury (AKI), as defined by peak increase in serum creatinine, is independently associated with increased risk of mortality and length of stay. Studies have suggested that the duration of AKI may ...

    Authors: Swati Mehta, Kinsuk Chauhan, Achint Patel, Shanti Patel, Rachel Pinotti, Girish N. Nadkarni, Chirag R. Parikh and Steven G. Coca

    Citation: BMC Nephrology 2018 19:91

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  13. Content type: Research article

    Beta Trace Protein (BTP) is a promising marker of glomerular filtration rate (GFR). Equations to estimate GFR using BTP have been proposed. Very little is known about BTP’s production and metabolism. It has be...

    Authors: Debarati Chakraborty, Ayub Akbari, Greg A. Knoll, Jennifer A. Flemming, Catherine Lowe, Shareef Akbari and Christine A. White

    Citation: BMC Nephrology 2018 19:87

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  14. Content type: Research article

    The high cost, complexity of the available protocols, and metabolic complications are the major barriers that impede the clinical utilization of regional citrate anticoagulation (RCA) for sustained low efficie...

    Authors: Ming Wen, Claudius Küchle, Dominik Steubl, Robin Satanovskji, Uwe Heemann, Yana Suttmann, Susanne Angermann, Stephan Kemmner, Lisa Rehbehn, Monika Huber, Christine Hauser, Christoph Schmaderer, Anna-Lena Reichelt, Bernhard Haller and Lutz Renders

    Citation: BMC Nephrology 2018 19:79

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  15. Content type: Study protocol

    Aortic stenosis (AS) is common in patients on dialysis as well as in the general population. AS leads to difficulty with dialysis therapy because of unstable conditions such as intradialytic hypotension due to...

    Authors: Daijo Inaguma, Yuji Sasakawa, Noriko Suzuki, Eri Ito, Kazuo Takahashi, Hiroki Hayashi, Shigehisa Koide, Midori Hasegawa and Yukio Yuzawa

    Citation: BMC Nephrology 2018 19:80

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  16. Content type: Research article

    Proteinuria is well recognised as a marker of chronic kidney disease (CKD), as a risk factor for progression of CKD among those with known CKD, and as a risk factor for cardiovascular events and death among bo...

    Authors: Tracey Ying, Philip Clayton, Chetana Naresh and Steven Chadban

    Citation: BMC Nephrology 2018 19:55

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  17. Content type: Research article

    C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family and have been implicated to be involved in maintaining vascular homeostasis and acting as a cardiac chronotropic agent in experime...

    Authors: Lulu Wang, Wenjin Liu, Yanting Yu, Lei Jiang and Junwei Yang

    Citation: BMC Nephrology 2018 19:50

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  18. Content type: Study protocol

    Rural areas in the state of New Mexico have been the “ground-zero” for the epidemic of diabetic Chronic Kidney Disease (CKD) in the United States. However, there is limited research about risk factors of diabe...

    Authors: Antonin Jaros, Hafiz A. Sroya, Venita K. Wolfe, Vikas Ghai, Maria-Eleni Roumelioti, Kamran Shaffi, Kai Wang, Vernon Shane Pankratz, Mark L. Unruh and Christos Argyropoulos

    Citation: BMC Nephrology 2018 19:47

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  19. Content type: Research article

    The risk of chronic kidney disease (CKD) is known to be elevated in patients with diabetes mellitus but the risk of young adults aged 18 to 40 years with impaired glucose tolerance/impaired fasting glucose (IG...

    Authors: Ferozkhan Jadhakhan, Tom Marshall, Ronan Ryan and Paramjit Gill

    Citation: BMC Nephrology 2018 19:42

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