Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Research article

    C-terminal fragment of agrin (CAF) levels predict acute kidney injury after acute myocardial infarction

    Patients with acute myocardial infarction are at high risk for acute kidney injury. Novel biomarkers that can predict acute kidney injury in AMI may allow timely interventions. C-terminal fragment of agrin (CA...

    Spyridon Arampatzis, Georgios Chalikias, Vasilios Devetzis, Stavros Konstantinides, Uyen Huynh-Do and Dimitrios Tziakas

    BMC Nephrology 2017 18:202

    Published on: 24 June 2017

  2. Research article

    Membranous nephropathy: a retrospective observational study of membranous nephropathy in north east and central London

    Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. MN is a clinically heterogeneous disease and it is difficult to accurately predict outcomes (including end stage renal failure)...

    Sanjana Gupta, John Connolly, Ruth J Pepper, Stephen B Walsh, Magdi M Yaqoob, Robert Kleta and Neil Ashman

    BMC Nephrology 2017 18:201

    Published on: 21 June 2017

  3. Research article

    Effects of home-based exercise on pre-dialysis chronic kidney disease patients: a randomized pilot and feasibility trial

    Only a few research is available on the effects of home-based exercise training on pre-dialysis chronic kidney disease (CKD) patients. Therefore, we aimed to elucidate the effect of home-based exercise therapy...

    Koji Hiraki, Yugo Shibagaki, Kazuhiro P. Izawa, Chiharu Hotta, Akiko Wakamiya, Tsutomu Sakurada, Takashi Yasuda and Kenjiro Kimura

    BMC Nephrology 2017 18:198

    Published on: 17 June 2017

  4. Research article

    Metabolic syndrome is independently associated with a mildly reduced estimated glomerular filtration rate: a cross-sectional study

    Association between metabolic syndrome (MS) and mildly reduced estimated glomerular filtration rates (eGFRs) remains unclear. Therefore, we aimed to evaluate the association between MS and a mildly reduced eGF...

    Wen Hu, Xiao-Juan Wu, Yao-Jun Ni, Hai-Rong Hao, Wei-Nan Yu and Hong-Wen Zhou

    BMC Nephrology 2017 18:192

    Published on: 13 June 2017

  5. Research article

    The incidence, risk factors and in-hospital mortality of acute kidney injury in patients after abdominal aortic aneurysm repair surgery

    Acute kidney injury (AKI) is a severe complication associated with abdominal aortic aneurysm (AAA) repair. In this study, we evaluated the incidence, risk factors and in-hospital mortality of AKI in patients a...

    Ying Tang, Junzhe Chen, Kai Huang, Dan Luo, Peifen Liang, Min Feng, Wenxin Chai, Erik Fung, Hui Yao Lan and Anping Xu

    BMC Nephrology 2017 18:184

    Published on: 31 May 2017

  6. Research article

    Urinary TIMP-2 and IGFBP7 for the prediction of acute kidney injury following cardiac surgery

    Acute kidney injury (AKI) following cardiac surgery is common and associated with poor patient outcomes. Early risk assessment for development of AKI remains a challenge. The combination of urinary tissue inhi...

    Yimei Wang, Zhouping Zou, Jifu Jin, Jie Teng, Jiarui Xu, Bo Shen, Wuhua Jiang, Yamin Zhuang, Lan Liu, Zhe Luo, Chunsheng Wang and Xiaoqiang Ding

    BMC Nephrology 2017 18:177

    Published on: 30 May 2017

  7. Research article

    Serum micro-rna profiles in patients with autosomal dominant polycystic kidney disease according to hypertension and renal function

    Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder with unclear disease mechanism. Currently, overt hypertension and increased renal volume are the best predictors of renal fu...

    Ismail Kocyigit, Serpil Taheri, Elif Funda Sener, Eray Eroglu, Fahir Ozturk, Aydin Unal, Kezban Korkmaz, Gokmen Zararsiz, Murat Hayri Sipahioglu, Yusuf Ozkul, Bulent Tokgoz, Oktay Oymak, Tevfik Ecder and Jonas Axelsson

    BMC Nephrology 2017 18:179

    Published on: 30 May 2017

  8. Research article

    Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department

    The blood urea nitrogen to creatinine ratio (BCR) has been used since the early 1940s to help clinicians differentiate between prerenal acute kidney injury (PR AKI) and intrinsic AKI (I AKI). This ratio is sim...

    Guillaume Manoeuvrier, Kalyane Bach-Ngohou, Eric Batard, Damien Masson and David Trewick

    BMC Nephrology 2017 18:173

    Published on: 25 May 2017

  9. Research article

    Urinary neprilysin in the critically ill patient

    Critically ill patients in intensive care face hazardous conditions. Among these, acute kidney injury (AKI) is frequently seen as a result of sepsis. Early diagnosis of kidney injury is of the utmost importanc...

    Sahra Pajenda, Karl Mechtler and Ludwig Wagner

    BMC Nephrology 2017 18:172

    Published on: 25 May 2017

  10. Research article

    Clinical outcomes of linezolid and vancomycin in patients with nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus stratified by baseline renal function: a retrospective, cohort analysis

    The primary objective of this study is to assess whether baseline renal function impacts treatment outcomes of linezolid and vancomycin (with a dose-optimized regimen) for methicillin-resistant Staphylococcus aur...

    Ping Liu, Blair Capitano, Amy Stein and Ali A. El-Solh

    BMC Nephrology 2017 18:168

    Published on: 22 May 2017

  11. Research article

    Identification of chronic kidney disease patient characteristics influencing the renoprotective effects of febuxostat therapy: a retrospective follow-up study

    The ability of antihyperuricemic therapy to exert renoprotective effects in patients with chronic kidney disease (CKD) is controversial. In the present study, we studied patient characteristics that may mask f...

    Akinori Yamaguchi, Makoto Harada, Yosuke Yamada, Koji Hashimoto and Yuji Kamijo

    BMC Nephrology 2017 18:162

    Published on: 18 May 2017

  12. Research article

    Vitamin D receptor activation reduces inflammatory cytokines and plasma MicroRNAs in moderate chronic kidney disease – a randomized trial

    Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease (CVD), partly due to endothelial dysfunction and chronic inflammation. Vitamin D treatment in end stage renal disease is suggested to...

    Ladan Mansouri, Kristina Lundwall, Ali Moshfegh, Stefan H. Jacobson, Joachim Lundahl and Jonas Spaak

    BMC Nephrology 2017 18:161

    Published on: 16 May 2017

  13. Study protocol

    Exploring the utility and scalability of a telehomecare intervention for patients with chronic kidney disease undergoing peritoneal dialysis—a study protocol

    Chronic Kidney Disease (CKD) is a pressing global health concern that is placing increased strain on health care resources. CKD patients regularly receive peritoneal dialysis as a common CKD treatment. An emer...

    Lianne Jeffs, Arsh Kumar Jain, Rachel HiuTung Man, Nike Onabajo, Laura Desveaux, James Shaw, Jennifer Hensel, Payal Agarwal, Marianne Saragosa, Trevor Jamieson, Ivy Wong, Maria Maione and R. Sacha Bhatia

    BMC Nephrology 2017 18:155

    Published on: 10 May 2017

  14. Research article

    Renal replacement therapy in acute kidney injury from a Chinese cross-sectional study: patient, clinical, socioeconomic and health service predictors of treatment

    Renal replacement therapy (RRT) is important to support critically ill patients with acute kidney injury (AKI). This study, a part of a nation-wide survey for AKI conducted by the ISN AKF 0 by 25 China Consort...

    Fang Wang, Daqing Hong, Yafang Wang, Yunlin Feng, Li Wang and Li Yang

    BMC Nephrology 2017 18:152

    Published on: 4 May 2017

  15. Study protocol

    Physical performance and protein-energy wasting in patients treated with nocturnal haemodialysis compared to conventional haemodialysis: protocol of the DiapriFIT study

    Poor physical performance and protein-energy wasting (PEW) are health issues of major concern in haemodialysis patients. The conventional haemodialysis (CHD) regime, three times per week 3–5 h, is subject of d...

    Manouk Dam, Floor Neelemaat, Trudeke Struijk-Wielinga, Peter J. Weijs and Brigit C. van Jaarsveld

    BMC Nephrology 2017 18:144

    Published on: 1 May 2017

  16. Research article

    Diagnosis and outcomes of acute kidney injury using surrogate and imputation methods for missing preadmission creatinine values

    Missing preadmission serum creatinine (SCr) values are a common obstacle to assess acute kidney injury (AKI) diagnosis and outcomes. The Kidney Disease Improving Global Outcomes (KDIGO) guidelines suggest usin...

    Amélie Bernier-Jean, William Beaubien-Souligny, Rémi Goupil, François Madore, François Paquette, Stéphan Troyanov and Josée Bouchard

    BMC Nephrology 2017 18:141

    Published on: 28 April 2017

  17. Study protocol

    Cost-effectiveness of home telemonitoring in chronic kidney disease patients at different stages by a pragmatic randomized controlled trial (eNephro): rationale and study design

    Home telemonitoring has developed considerably over recent years in chronic diseases in order to improve communication between healthcare professionals and patients and to promote early detection of deteriorat...

    Nathalie Thilly, Jacques Chanliau, Luc Frimat, Christian Combe, Pierre Merville, Philippe Chauveau, Pierre Bataille, Raymond Azar, David Laplaud, Christian Noël and Michèle Kessler

    BMC Nephrology 2017 18:126

    Published on: 5 April 2017

  18. Research article

    Sleep apnea prevalence in chronic kidney disease - association with total body water and symptoms

    Sleep apnea is common and associated with poor outcome in severe chronic kidney disease, but validated screening tools are not available. Our objectives were to determine the prevalence of sleep apnea in this ...

    Hsin-Chia Huang, Giles Walters, Girish Talaulikar, Derek Figurski, Annette Carroll, Mark Hurwitz, Krishna Karpe and Richard Singer

    BMC Nephrology 2017 18:125

    Published on: 4 April 2017

  19. Research article

    Long-term clinical outcome for patients poisoned by the fungal nephrotoxin orellanine

    Accidental intake of mushrooms of the Cortinarius species (deadly webcap) may cause irreversible renal damage and the need for dialysis or transplantation. The species is found in forests of Northern Europe, Scan...

    Heidi Hedman, Johan Holmdahl, Johan Mölne, Kerstin Ebefors, Börje Haraldsson and Jenny Nyström

    BMC Nephrology 2017 18:121

    Published on: 3 April 2017

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