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BMC Nephrology

Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Content type: Research article

    Proteinuria is well recognised as a marker of chronic kidney disease (CKD), as a risk factor for progression of CKD among those with known CKD, and as a risk factor for cardiovascular events and death among bo...

    Authors: Tracey Ying, Philip Clayton, Chetana Naresh and Steven Chadban

    Citation: BMC Nephrology 2018 19:55

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  2. Content type: Research article

    C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family and have been implicated to be involved in maintaining vascular homeostasis and acting as a cardiac chronotropic agent in experime...

    Authors: Lulu Wang, Wenjin Liu, Yanting Yu, Lei Jiang and Junwei Yang

    Citation: BMC Nephrology 2018 19:50

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  3. Content type: Study protocol

    Rural areas in the state of New Mexico have been the “ground-zero” for the epidemic of diabetic Chronic Kidney Disease (CKD) in the United States. However, there is limited research about risk factors of diabe...

    Authors: Antonin Jaros, Hafiz A. Sroya, Venita K. Wolfe, Vikas Ghai, Maria-Eleni Roumelioti, Kamran Shaffi, Kai Wang, Vernon Shane Pankratz, Mark L. Unruh and Christos Argyropoulos

    Citation: BMC Nephrology 2018 19:47

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  4. Content type: Research article

    Acute kidney injury (AKI) is often observed in critically ill patients and is associated with high morbidity and mortality. Non-recovery from AKI has a negative impact on the prognosis of affected patients and...

    Authors: Fabienne Aregger, Dominik E. Uehlinger, Gerhard Fusch, Aldin Bahonjic, Rene Pschowski, Michael Walter and Joerg C. Schefold

    Citation: BMC Nephrology 2018 19:44

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  5. Content type: Research article

    The risk of chronic kidney disease (CKD) is known to be elevated in patients with diabetes mellitus but the risk of young adults aged 18 to 40 years with impaired glucose tolerance/impaired fasting glucose (IG...

    Authors: Ferozkhan Jadhakhan, Tom Marshall, Ronan Ryan and Paramjit Gill

    Citation: BMC Nephrology 2018 19:42

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  6. Content type: Study protocol

    Surveys using traditional measures of nutritional status indicate that muscle wasting is common among persons with end-stage kidney disease (ESKD). Up to 75% of adults undergoing maintenance dialysis show some...

    Authors: Joanne Reid, Helen R. Noble, Gary Adamson, Andrew Davenport, Ken Farrington, Denis Fouque, Kamyar Kalantar-Zadeh, John Mallett, C. McKeaveney, S. Porter, David S. Seres, Joanne Shields, Adrian Slee, Miles D. Witham and Alexander P. Maxwell

    Citation: BMC Nephrology 2018 19:38

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  7. Content type: Technical advance

    Precise renal histopathological diagnosis will guide therapy strategy in patients with lupus nephritis. Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) has been applicable noninvasive tech...

    Authors: Huilan Shi, Junya Jia, Dong Li, Li Wei, Wenya Shang and Zhenfeng Zheng

    Citation: BMC Nephrology 2018 19:33

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  8. Content type: Research article

    The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogen...

    Authors: Mehmet Oezkur, Attila Magyar, Phillip Thomas, Andreas Reif, Stefan Störk, Peter U. Heuschmann, Rainer G. Leyh and Martin Wagner

    Citation: BMC Nephrology 2018 19:34

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  9. Content type: Research article

    Anemia is highly prevalent in chronic kidney disease (CKD). Elevated hepcidin concentrations are an important mediator of disordered iron metabolism, a key mechanism underlying anemia of CKD. Vitamin D was rec...

    Authors: Bhupesh Panwar, Diane McCann, Gordana Olbina, Mark Westerman and Orlando M. Gutiérrez

    Citation: BMC Nephrology 2018 19:35

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  10. Content type: Research article

    The prognostic effect of gender on immunoglobulin A nephropathy (IgAN) is not clear. We explored gender-related differences in clinicopathological features and renal outcomes in IgAN.

    Authors: Wei Deng, Xiaojun Tan, Qian Zhou, Zhen Ai, Wenting Liu, Wei Chen, Xueqing Yu and Qiongqiong Yang

    Citation: BMC Nephrology 2018 19:31

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  11. Content type: Research article

    Obstetric-related acute kidney injury (AKI) is thought to be a key contributor to the overall burden of AKI in low resource settings, causing significant and preventable morbidity and mortality. However, epide...

    Authors: William R. Cooke, Ulla K. Hemmilä, Alison L. Craik, Chimwemwe J. Mandula, Priscilla Mvula, Ausbert Msusa, Gavin Dreyer and Rhys Evans

    Citation: BMC Nephrology 2018 19:25

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  12. Content type: Research article

    Accurate estimation of glomerular filtration rate (GFR) is important for diagnosis and risk stratification in chronic kidney disease and for selection of living donors. Ethnic differences have required correct...

    Authors: Vivek Kumar, Ashok Kumar Yadav, Yoshinari Yasuda, Masaru Horio, Vinod Kumar, Nancy Sahni, Krishan L. Gupta, Seiichi Matsuo, Harbir Singh Kohli and Vivekanand Jha

    Citation: BMC Nephrology 2018 19:22

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  13. Content type: Research article

    For patients unable to receive heparin anticoagulation during haemodialysis, saline flushes to reduce circuit clotting are often the norm. Regional citrate anticoagulation (RCA) although effective is not used ...

    Authors: Eng Kuang Lim, Ying-ying T Seow, Shun E Chen, Gao Yang, Min Er Liaw and Shimi Isaac

    Citation: BMC Nephrology 2018 19:16

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  14. Content type: Research article

    Therapeutic plasma exchange (TPE) is increasingly used throughout the world. Although the procedure itself is fairly standardized, it is yet unknown how the underlying disease entities influence the key coordi...

    Authors: Julius J. Schmidt, Firas Asper, Gunilla Einecke, Gabriele Eden, Carsten Hafer and Jan T. Kielstein

    Citation: BMC Nephrology 2018 19:12

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  15. Content type: Research article

    Recently there has been a progressive loss of specialty related skills for nephrologists. Among the skills we find the kidney biopsy that has a central role in diagnosis of renal parenchymal disease. One of th...

    Authors: Vittoria Esposito, Giulia Mazzon, Paola Baiardi, Massimo Torreggiani, Luca Semeraro, Davide Catucci, Marco Colucci, Alice Mariotto, Fabrizio Grosjean, Giacomo Bovio and Ciro Esposito

    Citation: BMC Nephrology 2018 19:14

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  16. Content type: Research article

    C3 glomerulopathy (C3G) is a rare, but severe glomerular disease with grim prognosis. The complex pathogenesis is just unfolding, and involves acquired as well as inherited dysregulation of the alternative pat...

    Authors: Thomas Welte, Frederic Arnold, Julia Kappes, Maximilian Seidl, Karsten Häffner, Carsten Bergmann, Gerd Walz and Elke Neumann-Haefelin

    Citation: BMC Nephrology 2018 19:7

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  17. Content type: Research article

    The United States is faced with an unprecedented epidemic of drug abuse. Every year thousands of Americans visit the emergency departments all over the country with illicit drug related complaints. These drugs...

    Authors: Kanaan Mansoor, Murad Kheetan, Saba Shahnawaz, Anna P. Shapiro, Eva Patton-Tackett, Larry Dial, Gary Rankin, Prasanna Santhanam, Antonios H. Tzamaloukas, Tibor Nadasdy, Joseph I. Shapiro and Zeid J. Khitan

    Citation: BMC Nephrology 2017 18:379

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  18. Content type: Research article

    In ANCA-associated vasculitis the acute phase of the disease is often preceded by prodromal symptoms. The aim of the present study was to analyze the relation between the duration of the prodromal phase and re...

    Authors: Eline Houben, Stefanie L. Groenland, Joost W. van der Heijden, Alexandre E. Voskuyl, Hiëronymus J. Doodeman and Erik L. Penne

    Citation: BMC Nephrology 2017 18:378

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  19. Content type: Research article

    High-dose methylprednisolone pulses were one of the main treatments for anti-neutrophil cytoplasmic autoantibody (ANCA) associated vasculitides (AAV) but had obvious side effects. We aimed to know the impact o...

    Authors: Yanhong Ma, Fei Han, Liangliang Chen, Hongya Wang, Haidongqing Han, Binfeng Yu, Ying Xu and Jianghua Chen

    Citation: BMC Nephrology 2017 18:381

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