Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Research article

    A low initial serum sodium level is associated with an increased risk of overcorrection in patients with chronic profound hyponatremia: a retrospective cohort analysis

    Even with abundant evidence for osmotic demyelination in patients with hyponatremia, the risk factors for overcorrection have not been fully investigated. Therefore the purpose of this study is to clarify the ...

    Sae Aratani, Masahiko Hara, Masahiko Nagahama, Fumika Taki, Miyuki Futatsuyama, Shuichi Tsuruoka and Yasuhiro Komatsu

    BMC Nephrology 2017 18:316

    Published on: 18 October 2017

  2. Research article

    Identification of compound heterozygous patients with primary hyperoxaluria type 1: clinical evaluations and in silico investigations

    Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder of glyoxylate metabolism in which excessive oxalates are formed by the liver and excreted by the kidneys. Calcium oxalate crystal...

    Houda Kanoun, Faiçal Jarraya, Bayen Maalej, Amina Lahiani, Hichem Mahfoudh, Fatma Makni, Jamil Hachicha and Faiza Fakhfakh

    BMC Nephrology 2017 18:303

    Published on: 2 October 2017

  3. Research article

    Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy

    Accumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have bee...

    Yan-feng Zhao, Li Zhu, Li-jun Liu, Su-fang Shi, Ji-cheng Lv and Hong Zhang

    BMC Nephrology 2017 18:301

    Published on: 29 September 2017

  4. Research article

    Increased prevalence of renal cysts in patients with sickle cell disease

    Early detection and interventions have enabled patients with sickle cell disease (SCD) to live well into adulthood. Consequently, the chronicity of SCD allows for the insidious manifestation of multisystem com...

    Daveena Meeks, Arunraj Navaratnarajah, Emma Drasar, Ounali Jaffer, C. Jason Wilkins, Swee Lay Thein and Claire C. Sharpe

    BMC Nephrology 2017 18:298

    Published on: 21 September 2017

  5. Study protocol

    Predictors of Acute Renal Injury Study (PARIS) among HIV-positive individuals: design and methods

    Acute kidney injury (AKI), which is common among HIV-positive individuals, may contribute to the excess burden of chronic kidney disease (CKD) in this patient population; however, conventional clinical methods...

    Celia P. Corona-Villalobos, Michael G. Shlipak, Adrienne Tin, Chirag Parikh, Richard D. Moore, Eric Vittinghoff, Jose Manuel Monroy-Trujillo, Mohamed G. Atta and Michelle M. Estrella

    BMC Nephrology 2017 18:289

    Published on: 7 September 2017

  6. Research article

    The dynamics of the metabolism of acetate and bicarbonate associated with use of hemodialysates in the ABChD trial: a phase IV, prospective, single center, single blind, randomized, cross-over, two week investigation

    In the United States, hemodialysis (HD) is generally performed via a bicarbonate dialysate. It is not known if small amounts of acid used in dialysate to buffer the bicarbonate can meaningfully contribute to o...

    William B. Smith, Sandy Gibson, George E. Newman, Kendra S. Hendon, Margarita Askelson, James Zhao, Jamil Hantash, Brigid Flanagan, John W. Larkin, Len A. Usvyat, Ravi I. Thadhani and Franklin W. Maddux

    BMC Nephrology 2017 18:273

    Published on: 29 August 2017

  7. Research article

    Effect of tolvaptan on renal handling of water and sodium, GFR and central hemodynamics in autosomal dominant polycystic kidney disease during inhibition of the nitric oxide system: a randomized, placebo-controlled, double blind, crossover study

    Tolvaptan slows progression of autosomal dominant polycystic kidney disease (ADPKD) by antagonizing the vasopressin-cAMP axis. Nitric oxide (NO) stimulates natriuresis and diuresis, but its role is unknown dur...

    Safa Al Therwani, My Emma Sofie Malmberg, Jeppe Bakkestroem Rosenbaek, Jesper Noergaard Bech and Erling Bjerregaard Pedersen

    BMC Nephrology 2017 18:268

    Published on: 15 August 2017

  8. Research article

    Diagnostic accuracy of contrast-enhanced ultrasound for characterization of kidney lesions in patients with and without chronic kidney disease

    Patients with chronic kidney disease are at increased risk of cystic kidney disease that requires imaging monitoring in many cases. However, these same patients often have contraindications to contrast-enhance...

    Emily Hueywen Chang, Wui Kheong Chong, Sandeep Kumar Kasoji, Julia Rose Fielding, Ersan Altun, Lee B. Mullin, Jung In Kim, Jason Peter Fine, Paul Alexander Dayton and Wendy Kimryn Rathmell

    BMC Nephrology 2017 18:266

    Published on: 9 August 2017

  9. Research article

    A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials

    To investigate the impact of timing the initiation of renal replacement therapy (RRT) on clinical outcomes in critically ill patients with acute kidney injury (AKI), focusing on the randomized controlled trial...

    Xiao-mei Yang, Guo-wei Tu, Ji-li Zheng, Bo Shen, Guo-guang Ma, Guang-wei Hao, Jian Gao and Zhe Luo

    BMC Nephrology 2017 18:264

    Published on: 7 August 2017

  10. Research article

    Urine neutrophil gelatinase-associated lipocalin to predict renal response after induction therapy in active lupus nephritis

    Tubulointerstitial injury is important to predict the progression of lupus nephritis (LN). Urine neutrophil gelatinase-associated lipocalin (NGAL) has been reported to detect worsening LN disease activity. Thu...

    Bancha Satirapoj, Chagriya Kitiyakara, Asada Leelahavanichkul, Yingyos Avihingsanon and Ouppatham Supasyndh

    BMC Nephrology 2017 18:263

    Published on: 4 August 2017

  11. Research article

    Predictive factors and prevalence of microalbuminuria in HIV-infected patients: a cross-sectional analysis

    Renal dysfunction is a common problem in the HIV+ population, due to the effect of both the HIV virus and the several classes of ARV drugs such as tenofovir (TDF). It is also known that the presence of renal d...

    Katia Falasca, Marta Di Nicola, Italo Porfilio, Claudio Ucciferri, Elisabetta Schiaroli, Chiara Gabrielli, Daniela Francisci and Jacopo Vecchiet

    BMC Nephrology 2017 18:255

    Published on: 28 July 2017

  12. Research article

    Multiple myeloma can be accurately diagnosed in acute kidney injury patients using a rapid serum free light chain test

    Acute kidney injury (AKI) is common in patients with multiple myeloma (MM). Whether serum free light chain (sFLC) measurements can distinguish between myeloma and other causes of AKI requires confirmation to g...

    Jennifer L. J. Heaney, John P. Campbell, Punit Yadav, Ann E. Griffin, Meena Shemar, Jennifer H. Pinney and Mark T. Drayson

    BMC Nephrology 2017 18:247

    Published on: 20 July 2017

  13. Research article

    Rhabdomyolysis in an HIV cohort: epidemiology, causes and outcomes

    The Literature on rhabdomyolysis in the HIV-positive population is sparse and limited. We aimed to explore the incidence, patient characteristics, etiologies and outcomes of rhabdomyolysis in a cohort of HIV-p...

    Sahar H. Koubar, Michelle M. Estrella, Rugmini Warrier, Richard D. Moore, Gregory M. Lucas, Mohamed G. Atta and Derek M. Fine

    BMC Nephrology 2017 18:242

    Published on: 17 July 2017

  14. Research article

    Performance of urinary neutrophil gelatinase-associated lipocalin, clusterin, and cystatin C in predicting diabetic kidney disease and diabetic microalbuminuria: a consecutive cohort study

    Tubular biomarkers have been regarded as emerging and promising markers for early diagnosis of diabetic kidney disease (DKD). The study was to determine the diagnostic capabilities of tubular biomarkers (urina...

    Xian-Fei Zeng, Dong-Xue Lu, Jun-Min Li, Yun Tan, Zhuo Li, Lei Zhou, Zeng-Qian Xi, Shu-Miao Zhang and Wei Duan

    BMC Nephrology 2017 18:233

    Published on: 12 July 2017

  15. Research article

    Response to immunosuppressive therapy in PLA2R- associated and non-PLA2R- associated idiopathic membranous nephropathy: a retrospective, multicenter cohort study

    According to renal M type phospholipase A2 receptor (PLA2R) immunohistochemistry, idiopathic membranous nephropathy (IMN) could be categorized into PLA2R-associated and non-PLA2R-associated IMN. We conducted a re...

    Jia Wang, Qionghong Xie, Zhuxing Sun, Ningxin Xu, Yan Li, Liang Wang, Shaojun Liu, Jun Xue and Chuan-Ming Hao

    BMC Nephrology 2017 18:227

    Published on: 10 July 2017

  16. Research article

    CKD-EPI creatinine-cystatin C glomerular filtration rate estimation equation seems more suitable for Chinese patients with chronic kidney disease than other equations

    The aim of this study was to identify the optimal equation that accurately estimates the glomerular filtration rate (GFR) and the chronic kidney disease (CKD) stage in the Chinese population.

    Xiao-Hua Chi, Gui-Ping Li, Quan-Shi Wang, Yong-Shuai Qi, Kai Huang, Qian Zhang and Yao-ming Xue

    BMC Nephrology 2017 18:226

    Published on: 10 July 2017

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