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BMC Nephrology

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Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including controlled trials and case control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews and meta-analyses should be directed to the ‘Epidemiology and Health Outcomes’ section, and Case reports should be directed to our dedicated ‘Case Report’ section

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  1. Content type: Research article

    Accurate measurement of renal function is important: however, radiolabelled gold standard measurement of GFR is highly expensive and can only be used on a very limited scale. We aim to compare the performance ...

    Authors: Maisarah Jalalonmuhali, Soo Kun Lim, Mohammad Nazri Md Shah and Kok Peng Ng

    Citation: BMC Nephrology 2017 18:363

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  2. Content type: Research article

    Recent studies have demonstrated that red cell distribution width (RDW) is associated with cardiovascular (CV) events and mortality. Patients with chronic kidney disease (CKD) are often anemic and have high RD...

    Authors: Yueh-An Lu, Pei-Chun Fan, Cheng-Chia Lee, Victor Chien-Chia Wu, Ya-Chung Tian, Chih-Wei Yang, Yung-Chang Chen and Chih-Hsiang Chang

    Citation: BMC Nephrology 2017 18:361

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  3. Content type: Research article

    Whether persistent hematuria in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) during clinical remission reflects active disease or chronic glomerular injury is uncertain....

    Authors: Li Lv, Dong-Yuan Chang, Zhi-Ying Li, Min Chen, Zhao Hu and Ming-Hui Zhao

    Citation: BMC Nephrology 2017 18:354

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  4. Content type: Research article

    Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease in the Western world. Early and accurate identification of DKD offers the best chance of slowing the progression of kidney disease....

    Authors: Amanda Leong, Elif Ilhan Ekinci, Cattram Nguyen, Michele Milne, Mariam Hachem, Matthew Dobson, Richard J. MacIsaac and George Jerums

    Citation: BMC Nephrology 2017 18:355

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  5. Content type: Research article

    Collecting patient reported outcome measures (PROMs) via computer-based electronic data capture system may improve feasibility and facilitate implementation in clinical care. We report our initial experience a...

    Authors: Dorothy Wong, Shen Cao, Heather Ford, Candice Richardson, Dmitri Belenko, Evan Tang, Luca Ugenti, Eleanor Warsmann, Amanda Sissons, Yalinie Kulandaivelu, Nathaniel Edwards, Marta Novak, Madeline Li and Istvan Mucsi

    Citation: BMC Nephrology 2017 18:356

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  6. Content type: Research article

    Kidney stone disease is common in industrialized countries. Recently, it has attracted growing attention, because of its significant association with adverse renal outcomes, including end stage renal disease. ...

    Authors: Harald Seeger, Andrea Kaelin, Pietro M. Ferraro, Damian Weber, Philippe Jaeger, Patrice Ambuehl, William G. Robertson, Robert Unwin, Carsten A. Wagner and Nilufar Mohebbi

    Citation: BMC Nephrology 2017 18:349

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  7. Content type: Research article

    Acute kidney injury requiring renal replacement therapy (AKI-RRT) is associated with high morbidity, mortality and resource utilization. The type of vascular access placed for AKI-RRT is an important decision,...

    Authors: Mallika L. Mendu, Megan F. May, Arnaud D. Kaze, Dionne A. Graham, Salena Cui, Margaret E. Chen, Naomi Shin, Ayal A. Aizer and Sushrut S. Waikar

    Citation: BMC Nephrology 2017 18:351

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  8. Content type: Research article

    Differences in cystatin C and creatinine-based estimated glomerular filtration rate (eGFR) can lead to clinical uncertainty. Existing eGFR equations perform poorly in a subset of individuals. This study aims t...

    Authors: Helen Legrand, Karin Werner, Anders Christensson, Mats Pihlsgård and Sölve Elmståhl

    Citation: BMC Nephrology 2017 18:350

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  9. Content type: Research article

    Adult patients with minimal change nephrotic syndrome (MCNS) are often associated with acute kidney injury (AKI). To assess the mechanisms of AKI, we examined whether tubular cell injuries unique to MCNS patie...

    Authors: Yoshihide Fujigaki, Yoshifuru Tamura, Michito Nagura, Shigeyuki Arai, Tatsuru Ota, Shigeru Shibata, Fukuo Kondo, Yutaka Yamaguchi and Shunya Uchida

    Citation: BMC Nephrology 2017 18:339

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  10. Content type: Research article

    Estimating equations are recommended by clinical guidelines as the preferred method for assessment of glomerular filtration rate (GFR). The aim of the study was to compare population-based prevalence estimates...

    Authors: Pietro Trocchi, Matthias Girndt, Christa Scheidt-Nave, Silke Markau and Andreas Stang

    Citation: BMC Nephrology 2017 18:341

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  11. Content type: Research article

    Anaemia is a common complication of patients with antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. Nevertheless, the cause and degree of such cases of anaemia have not been elucidated in...

    Authors: Tetsuya Kawamura, Joichi Usui, Shuzo Kaneko, Ryoya Tsunoda, Eri Imai, Hirayasu Kai, Naoki Morito, Chie Saito, Michio Nagata and Kunihiro Yamagata

    Citation: BMC Nephrology 2017 18:337

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  12. Content type: Research article

    The requirement of continuous renal replacement therapy (CRRT) is increasing with the growing incidence of acute kidney injury (AKI). The decision to initiate CRRT is not difficult if an adequate medical histo...

    Authors: Harin Rhee, Gum Sook Jang, Miyeun Han, In Seong Park, Il Young Kim, Sang Heon Song, Eun Young Seong, Dong Won Lee, Soo Bong Lee and Ihm Soo Kwak

    Citation: BMC Nephrology 2017 18:332

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  13. Content type: Research article

    Chronic kidney disease (CKD) is a common comorbid condition in coronary heart disease (CHD). CKD predisposes the patient to acute kidney injury (AKI) during hospitalization. Data on awareness of kidney dysfunc...

    Authors: Martin Wagner, Christoph Wanner, Martin Schich, Kornelia Kotseva, David Wood, Katrin Hartmann, Georg Fette, Viktoria Rücker, Mehmet Oezkur, Stefan Störk and Peter U. Heuschmann

    Citation: BMC Nephrology 2017 18:321

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  14. Content type: Research article

    Acute Kidney Injury (AKI) has evoked much interest over the past decade and is reported to be associated with high inpatient mortality. Preventable death and increased readmission rates related to AKI have bee...

    Authors: Nerissa Jurawan, Tanya Pankhurst, Charles Ferro, Peter Nightingale, Jamie Coleman, David Rosser and Simon Ball

    Citation: BMC Nephrology 2017 18:317

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  15. Content type: Research article

    Even with abundant evidence for osmotic demyelination in patients with hyponatremia, the risk factors for overcorrection have not been fully investigated. Therefore the purpose of this study is to clarify the ...

    Authors: Sae Aratani, Masahiko Hara, Masahiko Nagahama, Fumika Taki, Miyuki Futatsuyama, Shuichi Tsuruoka and Yasuhiro Komatsu

    Citation: BMC Nephrology 2017 18:316

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  16. Content type: Research article

    Primary hyperoxaluria type 1 (PH1) is an autosomal recessive inherited disorder of glyoxylate metabolism in which excessive oxalates are formed by the liver and excreted by the kidneys. Calcium oxalate crystal...

    Authors: Houda Kanoun, Faiçal Jarraya, Bayen Maalej, Amina Lahiani, Hichem Mahfoudh, Fatma Makni, Jamil Hachicha and Faiza Fakhfakh

    Citation: BMC Nephrology 2017 18:303

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  17. Content type: Research article

    Accumulating evidences proved the important roles of circulating IgA1-containing immune complexes (cIgA1) in IgA nephropathy (IgAN). Galactose-deficient IgA1 (Gd-IgA1) and glycan-specific IgG antibody have bee...

    Authors: Yan-feng Zhao, Li Zhu, Li-jun Liu, Su-fang Shi, Ji-cheng Lv and Hong Zhang

    Citation: BMC Nephrology 2017 18:301

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  18. Content type: Research article

    Early detection and interventions have enabled patients with sickle cell disease (SCD) to live well into adulthood. Consequently, the chronicity of SCD allows for the insidious manifestation of multisystem com...

    Authors: Daveena Meeks, Arunraj Navaratnarajah, Emma Drasar, Ounali Jaffer, C. Jason Wilkins, Swee Lay Thein and Claire C. Sharpe

    Citation: BMC Nephrology 2017 18:298

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