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Clinical Research

Section edited by Amir Kazory

The Clinical Research section considers both interventional and non-interventional clinical research studies, including, but not limited to, controlled trials and case-control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews, meta-analyses and epidemiological studies should be directed to the Epidemiology and Health Outcomes section, and case reports should be directed to our dedicated Case Reports section. 

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  1. Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results...

    Authors: Claudio Bazzi, Virginia Rizza, Daniela Casellato, Rafid Tofik, Anna-Lena Berg, Maurizio Gallieni, Giuseppe D’Amico and Omran Bakoush

    Citation: BMC Nephrology 2014 15:74

    Content type: Research article

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  2. Left ventricular hypertrophy (LVH) is common in kidney transplant (KT) recipients. LVH is associated with a worse outcome, though m-TOR therapy may help to revert this complication. We therefore conducted a lo...

    Authors: Domingo Hernández, Pedro Ruiz-Esteban, Daniel Gaitán, Dolores Burgos, Auxiliadora Mazuecos, Rocío Collantes, Eva Briceño, Eulalia Palma, Mercedes Cabello, Miguel González-Molina and Manuel De Mora

    Citation: BMC Nephrology 2014 15:65

    Content type: Research article

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  3. The role of hyperuricemia in disease progression of autosomal dominant polycystic kidney disease (ADPKD) has not been defined well. We investigated the association of serum uric acid (sUA) with renal function ...

    Authors: Miyeun Han, Hayne Cho Park, Hyunsuk Kim, Hyung Ah Jo, Hyuk Huh, Joon Young Jang, Ah-Young Kang, Seung Hyup Kim, Hae Il Cheong, Duk-Hee Kang, Jaeseok Yang, Kook-Hwan Oh, Young-Hwan Hwang and Curie Ahn

    Citation: BMC Nephrology 2014 15:63

    Content type: Research article

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  4. Levetiracetam is a frequently used drug in the therapy of partial onset, myoclonic and generalized tonic-clonic seizures. The main route of elimination is via the kidneys, which eliminate 66% of the unchanged ...

    Authors: Svenja K Bahte, Marcus Hiss, Ralf Lichtinghagen and Jan T Kielstein

    Citation: BMC Nephrology 2014 15:49

    Content type: Case report

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  5. Urinary creatinine can be quantified by Jaffe or enzymatic assays and is commonly used as denominator of urinary excretion of electrolytes or protein. Paired analysis in pediatric and adult samples documented ...

    Authors: Karel Allegaert, Pieter Vermeersch, Anne Smits, Djalila Mekahli, Elena Levtchenko and Steven Pauwels

    Citation: BMC Nephrology 2014 15:62

    Content type: Research article

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  6. Carotid intima-media thickness (CIMT) and carotid atherosclerotic plaque (CAP) are well-known indicators of atherosclerosis. However, few studies have reported the value of CIMT and CAP for predicting renal ar...

    Authors: Yonggu Lee, Jeong-Hun Shin, Hwan-Cheol Park, Soon Gil Kim and Seong-il Choi

    Citation: BMC Nephrology 2014 15:60

    Content type: Research article

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  7. Dietary sodium restriction is a key management strategy in chronic kidney disease (CKD). Recent evidence has demonstrated short-term reduction in blood pressure (BP) and proteinuria with sodium restriction, ho...

    Authors: Katrina L Campbell, David W Johnson, Judith D Bauer, Carmel M Hawley, Nicole M Isbel, Michael Stowasser, Jonathan P Whitehead, Goce Dimeski and Emma McMahon

    Citation: BMC Nephrology 2014 15:57

    Content type: Research article

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  8. Osmotic demyelination syndrome (ODS) primarily occurs after rapid correction of severe hyponatremia. There are no proven effective therapies for ODS, but we describe the first case showing the successful treat...

    Authors: Kyung Yoon Chang, In-Hee Lee, Gi Jun Kim, Kangwon Cho, Hoon Suk Park and Hyung Wook Kim

    Citation: BMC Nephrology 2014 15:56

    Content type: Case report

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  9. Some studies but not others suggest angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) use prior to major surgery associates with a higher risk of postoperative acute kidney i...

    Authors: Mitesh Shah, Arsh K Jain, Steven M Brunelli, Steven G Coca, Philip J Devereaux, Matthew T James, Jin Luo, Amber O Molnar, Marko Mrkobrada, Neesh Pannu, Chirag R Parikh, Michael Paterson, Salimah Shariff, Ron Wald, Michael Walsh, Richard Whitlock…

    Citation: BMC Nephrology 2014 15:53

    Content type: Research article

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  10. Many studies have shown that clinical characteristics and outcomes differ depending on pathologic variants of focal segmental glomerulosclerosis (FSGS). However, these are not well defined in Asian populations.

    Authors: Young Eun Kwon, Seung Hyeok Han, Jeong Hae Kie, Seong Yeong An, Yung Ly Kim, Kyoung Sook Park, Ki Heon Nam, Ah Young Leem, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Ea Wha Kang, Shin-Wook Kang, Kyu Hun Choi, Beom Jin Lim, Hyeon Joo Jeong…

    Citation: BMC Nephrology 2014 15:52

    Content type: Research article

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  11. No consensus exists on how to define abnormally rapid deterioration in renal function (Rapid Progression, RP). We developed an operational definition of RP in HIV-positive persons with baseline estimated glome...

    Authors: David A Kamara, Lene Ryom, Michael Ross, Ole Kirk, Peter Reiss, Philippe Morlat, Olivier Moranne, Christoph A Fux, Amanda Mocroft, Caroline Sabin, Jens D Lundgren and Colette J Smith

    Citation: BMC Nephrology 2014 15:51

    Content type: Research article

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  12. Patients on chronic dialysis are at increased risk of vitamin D deficiency. In observational studies plasma 25-hydroxyvitamin D (p-25(OH) D) levels are inversely correlated with plasma BNP and adverse cardiova...

    Authors: Frank H Mose, Henrik Vase, Thomas Larsen, Anne SP Kancir, Renata Kosierkiewic, Bartlomiej Jonczy, Annebirthe B Hansen, Anna E Oczachowska-Kulik, Ingrid M Thomsen, Jesper N Bech and Erling B Pedersen

    Citation: BMC Nephrology 2014 15:50

    Content type: Research article

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  13. Dose selection is an important step in pharmacokinetic (PK) studies of hemodialysis patients. We propose a simulation-based dose-selection method for PK studies of hemodialysis patients using a subpharmacologi...

    Authors: Dong Ki Kim, Jay Wook Lee, Kwang-Hee Shin, Sejoong Kim, Kook-Hwan Oh, Myounghee Kim, Kyung-Sang Yu, Jung Pyo Lee, Chun-Soo Lim, Yon Su Kim and Kwon Wook Joo

    Citation: BMC Nephrology 2014 15:46

    Content type: Research article

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  14. Podocytic infolding glomerulopathy (PIG) is a recently described condition causing rare pathological changes to the glomeruli, and has attracted considerable attention. PIG is characterized by specific changes...

    Authors: Makoto Harada, Yuji Kamijo, Takashi Ehara, Hisashi Shimojo, Hidekazu Shigematsu and Makoto Higuchi

    Citation: BMC Nephrology 2014 15:32

    Content type: Case report

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  15. We report a case of progressive Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) with life-threatening complications of both the underlying disease and induction immunosuppressive therapy. Here, for...

    Authors: Elena Ernst, Matthias Girndt and Rainer U Pliquett

    Citation: BMC Nephrology 2014 15:28

    Content type: Case report

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  16. Activated vitamin D is the mainstay of treatment for secondary hyperparathyroidism (SHPT) in chronic hemodialysis patients. However, the optimal route of administration is still debated. The aim of our study w...

    Authors: Myriam Lessard, Denis Ouimet, Martine Leblanc, Annie-Claire Nadeau-Fredette, Robert Bell, Jean-Philippe Lafrance, Vincent Pichette and Michel Vallée

    Citation: BMC Nephrology 2014 15:27

    Content type: Research article

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  17. During continuous venovenous haemofiltration (CVVH), regional anticoagulation with citrate may be superior to heparin in terms of biocompatibility, since heparin as opposed to citrate may activate complement (...

    Authors: Louise Schilder, S Azam Nurmohamed, Pieter M ter Wee, Nanne J Paauw, Armand RJ Girbes, Albertus Beishuizen, Robert HJ Beelen and AB Johan Groeneveld

    Citation: BMC Nephrology 2014 15:19

    Content type: Research article

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  18. Recent studies in animal models have shown that statins can protect against renal failure independent of their lipid-lowering actions, and there is also an association between statin use and improved renal fun...

    Authors: Kefei Wu, Wenjing Lei, Jianwei Tian and Hongyan Li

    Citation: BMC Nephrology 2014 15:14

    Content type: Research article

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  19. Uncertainty exists regarding the optimal method to estimate glomerular filtration rate (GFR) for disease detection and monitoring. Widely used GFR estimates have not been validated in British ethnic minority p...

    Authors: Edmund J Lamb, Elizabeth A Brettell, Paul Cockwell, Neil Dalton, Jon J Deeks, Kevin Harris, Tracy Higgins, Philip A Kalra, Kamlesh Khunti, Fiona Loud, Ryan S Ottridge, Claire C Sharpe, Alice J Sitch, Paul E Stevens, Andrew J Sutton and Maarten W Taal

    Citation: BMC Nephrology 2014 15:13

    Content type: Study protocol

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  20. Hyperuricemia appeared to be a common symptom in IgA nephropathy (IgAN), even in those with normal eGFR. IgAN was characterized by variation of pathological features, especially variable tubulointerstitial les...

    Authors: Jingjing Zhou, Yuqing Chen, Ying Liu, Sufang Shi, Xueying Li, Suxia Wang and Hong Zhang

    Citation: BMC Nephrology 2014 15:11

    Content type: Research article

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  21. Detecting impaired glomerular filtration rate (GFR) is important in intensive care units (ICU) in order to diagnose acute kidney injuries and adjust the dose of renally excreted drugs. Whether serum Cystatin C...

    Authors: Pierre Delanaye, Etienne Cavalier, Jérôme Morel, Manolie Mehdi, Nicolas Maillard, Guillaume Claisse, Bernard Lambermont, Bernard E Dubois, Pierre Damas, Jean-Marie Krzesinski, Alexandre Lautrette and Christophe Mariat

    Citation: BMC Nephrology 2014 15:9

    Content type: Research article

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  22. Acute kidney injury in patients with acute pancreatitis carries a poor prognosis. Hemolytic uremic syndrome (HUS) is characterized by non-immune hemolytic anemia, thrombocytopenia, and renal failure caused by ...

    Authors: Peng Fu, Ai-hong Yuan, Chun-hua Wang, Xin Li and Hai-yang Wu

    Citation: BMC Nephrology 2014 15:1

    Content type: Case report

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  23. Anti-glomerular basement membrane (GBM) glomerulonephritis and systemic lupus erythematosus (SLE) are both disorders of the immune system; however, they are known as distinct diseases. Till now no clinical evi...

    Authors: Xiaoxia Liu, Yu Wu, Yuan Yang, Jue Wang, Ye Tao, Ping Fu and Zhangxue Hu

    Citation: BMC Nephrology 2013 14:277

    Content type: Case report

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  24. The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has...

    Authors: Hilde RH de Geus, Gijs Fortrie, Michiel GH Betjes, Ron HN van Schaik and AB Johan Groeneveld

    Citation: BMC Nephrology 2013 14:273

    Content type: Research article

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  25. Focal segmental glomerulosclerosis-like lesions have been proposed to be predictive factors for IgA nephropathy. This single center, retrospective cohort study was designed to clarify which clinical and pathol...

    Authors: Kunihiro Maeda, Shogo Kikuchi, Naoto Miura, Keisuke Suzuki, Wataru Kitagawa, Hiroyuki Morita, Shogo Banno and Hirokazu Imai

    Citation: BMC Nephrology 2013 14:272

    Content type: Research article

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  26. Estimation of Glomerular Filtration Rate (GFR) by equations such as Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) or Modification of Diet in Renal Disease (MDRD) is usually expressed as a Body Su...

    Authors: Belén Redal-Baigorri, Knud Rasmussen and James Goya Heaf

    Citation: BMC Nephrology 2013 14:271

    Content type: Research article

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  27. Contrast-induced acute kidney injury (CI-AKI) particularly in high risk patients with chronic kidney disease (CKD), increases morbidity and mortality. Neutrophil gelatinase-associated lipocalin (NGAL) is a pro...

    Authors: Adis Tasanarong, Pisit Hutayanon and Dilok Piyayotai

    Citation: BMC Nephrology 2013 14:270

    Content type: Research article

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  28. Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate ...

    Authors: Yen-chung Lin, Nisha Bansal, Eric Vittinghoff, Alan S Go and Chi-yuan Hsu

    Citation: BMC Nephrology 2013 14:268

    Content type: Research article

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    The Erratum to this article has been published in BMC Nephrology 2014 15:85

  29. Chronic fluid overload is associated with higher mortality in dialysis patients; however, the link with cardiovascular morbidity has not formally been established and may be influenced by subclinical inflammat...

    Authors: Marlies Antlanger, Manfred Hecking, Michael Haidinger, Johannes Werzowa, Johannes J Kovarik, Gernot Paul, Manfred Eigner, Diana Bonderman, Walter H Hörl and Marcus D Säemann

    Citation: BMC Nephrology 2013 14:266

    Content type: Research article

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  30. Equations to estimate GFR have not been well validated in the elderly and may misclassify persons with chronic kidney disease (CKD). We measured GFR and compared the performance of the Modification of Diet in ...

    Authors: Marcelo B Lopes, Lara Q Araújo, Michelle T Passos, Sonia K Nishida, Gianna M Kirsztajn, Maysa S Cendoroglo and Ricardo C Sesso

    Citation: BMC Nephrology 2013 14:265

    Content type: Research article

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  31. Clinical outcomes of dialysis patients are variable, and improved knowledge of prognosis would inform decisions regarding patient management. We assessed the value of simple, chest X-ray derived measures of ca...

    Authors: Ethan Bohn, Navdeep Tangri, Brent Gali, Blair Henderson, Manish M Sood, Paul Komenda and Claudio Rigatto

    Citation: BMC Nephrology 2013 14:263

    Content type: Research article

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  32. The current treatment options for idiopathic membranous nephropathy (IMN) carry significant toxicity. In this prospective, observational pilot study, we used single time infusion of bone marrow derived autolog...

    Authors: Upal Sengupta, Vinod Kumar, Ashok K Yadav, Neelam Marwaha, Harbir S Kohli, Vinay Sakhuja and Vivekanand Jha

    Citation: BMC Nephrology 2013 14:262

    Content type: Research article

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  33. The mechanism for the development of thrombotic microangiopathy (TMA) during sepsis has only been partially elucidated. TMA is recognized as a disease caused by various factors, and may be involved in the emer...

    Authors: Yusuke Sakamaki, Konosuke Konishi, Koichi Hayashi, Akinori Hashiguchi, Matsuhiko Hayashi, Eiji Kubota, Takao Saruta and Hiroshi Itoh

    Citation: BMC Nephrology 2013 14:260

    Content type: Case report

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  34. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) has been widely integrated into clinical practice. Although useful in screening for CKD, its’ applica...

    Authors: Andrew A Udy, Fraser JA Morton, Sallyanne Nguyen-Pham, Paul Jarrett, Melissa Lassig-Smith, Janine Stuart, Rachel Dunlop, Therese Starr, Robert J Boots and Jeffrey Lipman

    Citation: BMC Nephrology 2013 14:250

    Content type: Research article

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  35. Placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A), soluble receptor for advanced glycation end products (sRAGE), extracellular newly identified receptor for RAGE binding protein (E...

    Authors: Oskar Zakiyanov, Vitezslav Kriha, Jan Vachek, Tomas Zima, Vladimir Tesar and Marta Kalousova

    Citation: BMC Nephrology 2013 14:245

    Content type: Research article

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  36. Disordered mineral metabolism is implicated in the pathogenesis of vascular calcification in hemodialysis (HD) patients. Fibroblast growth factor 23 (FGF-23) is the main regulator of phosphate metabolism. In t...

    Authors: Abdullah Ozkok, Cigdem Kekik, Gonca Emel Karahan, Tamer Sakaci, Alper Ozel, Abdulkadir Unsal and Alaattin Yildiz

    Citation: BMC Nephrology 2013 14:241

    Content type: Research article

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  37. Chloride administration has been found to be harmful to the kidney in critically ill patients. However the association between plasma chloride concentration and renal function has never been investigated.

    Authors: Zhongheng Zhang, Xiao Xu, Haozhe Fan, Danyu Li and Hongsheng Deng

    Citation: BMC Nephrology 2013 14:235

    Content type: Research article

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  38. Because of the absorption of glucose in peritoneal dialysis (PD) solution, PD patients show an atherogenic lipid profile, which is predictive of poor survival in PD patients. Lipoprotein subclasses consist of ...

    Authors: Eiichiro Kanda, Masumi Ai, Asami Iwamoto, Mitsuyo Okazaki, Yoshitaka Maeda, Sei Sasaki and Masayuki Yoshida

    Citation: BMC Nephrology 2013 14:234

    Content type: Research article

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  39. Stress-induced cardiomyopathy (sCMP) is characterized by transient wall-motion abnormalities involving the left ventricular apex and mid-ventricle that are precipitated by emotional or physical stress. As the ...

    Authors: Min Ji Shin, Harin Rhee, Il Young Kim, Byeong Yun Yang, Sang Heon Song, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Jung Hyun Choi and Eun Young Seong

    Citation: BMC Nephrology 2013 14:213

    Content type: Research article

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  40. Peripheral artery disease (PAD) represents atherosclerotic disease and is a risk factor for death in peritoneal dialysis (PD) patients, who tend to show an atherogenic lipid profile. In this study, we investig...

    Authors: Eiichiro Kanda, Masumi Ai, Mitsuyo Okazaki, Yoshitaka Maeda, Sei Sasaki and Masayuki Yoshida

    Citation: BMC Nephrology 2013 14:212

    Content type: Research article

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  41. Renal biopsies provide important diagnostic and prognostic information in ANCA associated glomerulonephritis. A new classification for prognostication of pauci-immune glomerulonephritis (GN) based on four cate...

    Authors: Carla L Ellis, Rebecca L Manno, John P Havill, Lorraine C Racusen and Duvuru Geetha

    Citation: BMC Nephrology 2013 14:210

    Content type: Research article

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  42. Enhanced external counterpulsation (EECP) enhances coronary perfusion and reduces left ventricular afterload. However, the role of EECP on renal function in cardiac patients is unknown. Our aim was to assess r...

    Authors: Prajej Ruangkanchanasetr, Nithi Mahanonda, Ongkarn Raungratanaamporn, Piyanuj Ruckpanich, Chagriya Kitiyakara, Amnart Chaiprasert, Surawat Adirekkiat, Dollapas Punpanich, Somlak Vanavanan, Anchalee Chittamma and Thanom Supaporn

    Citation: BMC Nephrology 2013 14:193

    Content type: Research article

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  43. Accurate and precise estimates of glomerular filtration rate (GFR) are essential for clinical assessments, and many methods of estimation are available. We developed a radial basis function (RBF) network and a...

    Authors: Xun Liu, Yan-Ru Chen, Ning-shan Li, Cheng Wang, Lin-Sheng Lv, Ming Li, Xiao-Ming Wu and Tan-Qi Lou

    Citation: BMC Nephrology 2013 14:181

    Content type: Research article

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  44. The quality of life (QOL) of patients with autosomal dominant polycystic kidney disease (ADPKD) has not been investigated well. This study was performed to clarify the QOL of patients with ADPKD and to identif...

    Authors: Tatsuya Suwabe, Yoshifumi Ubara, Koki Mise, Masahiro Kawada, Satoshi Hamanoue, Keiichi Sumida, Noriko Hayami, Junichi Hoshino, Rikako Hiramatsu, Masayuki Yamanouchi, Eiko Hasegawa, Naoki Sawa and Kenmei Takaichi

    Citation: BMC Nephrology 2013 14:179

    Content type: Research article

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  45. Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified.

    Authors: Naoko Kinoshita-Katahashi, Hirotaka Fukasawa, Sayaka Ishigaki, Shinsuke Isobe, Shiro Imokawa, Yoshihide Fujigaki and Ryuichi Furuya

    Citation: BMC Nephrology 2013 14:171

    Content type: Case report

    Published on:

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