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Clinical Research

The Clinical Research section considers both interventional and non-interventional clinical research studies, including, but not limited to, controlled trials and case-control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews, meta-analyses and epidemiological studies should be directed to the Epidemiology and Health Outcomes section, and case reports should be directed to our dedicated Case Reports section. 

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  1. Acute kidney injury in patients with acute pancreatitis carries a poor prognosis. Hemolytic uremic syndrome (HUS) is characterized by non-immune hemolytic anemia, thrombocytopenia, and renal failure caused by ...

    Authors: Peng Fu, Ai-hong Yuan, Chun-hua Wang, Xin Li and Hai-yang Wu

    Citation: BMC Nephrology 2014 15:1

    Content type: Case report

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  2. Anti-glomerular basement membrane (GBM) glomerulonephritis and systemic lupus erythematosus (SLE) are both disorders of the immune system; however, they are known as distinct diseases. Till now no clinical evi...

    Authors: Xiaoxia Liu, Yu Wu, Yuan Yang, Jue Wang, Ye Tao, Ping Fu and Zhangxue Hu

    Citation: BMC Nephrology 2013 14:277

    Content type: Case report

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  3. The predictive value of acute kidney injury (AKI) urinary biomarkers may depend on the time interval following tubular injury, thereby explaining in part the heterogeneous performance of these markers that has...

    Authors: Hilde RH de Geus, Gijs Fortrie, Michiel GH Betjes, Ron HN van Schaik and AB Johan Groeneveld

    Citation: BMC Nephrology 2013 14:273

    Content type: Research article

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  4. Focal segmental glomerulosclerosis-like lesions have been proposed to be predictive factors for IgA nephropathy. This single center, retrospective cohort study was designed to clarify which clinical and pathol...

    Authors: Kunihiro Maeda, Shogo Kikuchi, Naoto Miura, Keisuke Suzuki, Wataru Kitagawa, Hiroyuki Morita, Shogo Banno and Hirokazu Imai

    Citation: BMC Nephrology 2013 14:272

    Content type: Research article

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  5. Estimation of Glomerular Filtration Rate (GFR) by equations such as Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) or Modification of Diet in Renal Disease (MDRD) is usually expressed as a Body Su...

    Authors: Belén Redal-Baigorri, Knud Rasmussen and James Goya Heaf

    Citation: BMC Nephrology 2013 14:271

    Content type: Research article

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  6. Contrast-induced acute kidney injury (CI-AKI) particularly in high risk patients with chronic kidney disease (CKD), increases morbidity and mortality. Neutrophil gelatinase-associated lipocalin (NGAL) is a pro...

    Authors: Adis Tasanarong, Pisit Hutayanon and Dilok Piyayotai

    Citation: BMC Nephrology 2013 14:270

    Content type: Research article

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  7. Creatinine secretion, as quantified by the ratio of creatinine clearance (CrCl) to glomerular filtration rate (GFR), may introduce another source of error when using serum creatinine concentration to estimate ...

    Authors: Yen-chung Lin, Nisha Bansal, Eric Vittinghoff, Alan S Go and Chi-yuan Hsu

    Citation: BMC Nephrology 2013 14:268

    Content type: Research article

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    The Erratum to this article has been published in BMC Nephrology 2014 15:85

  8. Chronic fluid overload is associated with higher mortality in dialysis patients; however, the link with cardiovascular morbidity has not formally been established and may be influenced by subclinical inflammat...

    Authors: Marlies Antlanger, Manfred Hecking, Michael Haidinger, Johannes Werzowa, Johannes J Kovarik, Gernot Paul, Manfred Eigner, Diana Bonderman, Walter H Hörl and Marcus D Säemann

    Citation: BMC Nephrology 2013 14:266

    Content type: Research article

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  9. Equations to estimate GFR have not been well validated in the elderly and may misclassify persons with chronic kidney disease (CKD). We measured GFR and compared the performance of the Modification of Diet in ...

    Authors: Marcelo B Lopes, Lara Q Araújo, Michelle T Passos, Sonia K Nishida, Gianna M Kirsztajn, Maysa S Cendoroglo and Ricardo C Sesso

    Citation: BMC Nephrology 2013 14:265

    Content type: Research article

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  10. Clinical outcomes of dialysis patients are variable, and improved knowledge of prognosis would inform decisions regarding patient management. We assessed the value of simple, chest X-ray derived measures of ca...

    Authors: Ethan Bohn, Navdeep Tangri, Brent Gali, Blair Henderson, Manish M Sood, Paul Komenda and Claudio Rigatto

    Citation: BMC Nephrology 2013 14:263

    Content type: Research article

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  11. The current treatment options for idiopathic membranous nephropathy (IMN) carry significant toxicity. In this prospective, observational pilot study, we used single time infusion of bone marrow derived autolog...

    Authors: Upal Sengupta, Vinod Kumar, Ashok K Yadav, Neelam Marwaha, Harbir S Kohli, Vinay Sakhuja and Vivekanand Jha

    Citation: BMC Nephrology 2013 14:262

    Content type: Research article

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  12. The mechanism for the development of thrombotic microangiopathy (TMA) during sepsis has only been partially elucidated. TMA is recognized as a disease caused by various factors, and may be involved in the emer...

    Authors: Yusuke Sakamaki, Konosuke Konishi, Koichi Hayashi, Akinori Hashiguchi, Matsuhiko Hayashi, Eiji Kubota, Takao Saruta and Hiroshi Itoh

    Citation: BMC Nephrology 2013 14:260

    Content type: Case report

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  13. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimated glomerular filtration rate (eGFR) has been widely integrated into clinical practice. Although useful in screening for CKD, its’ applica...

    Authors: Andrew A Udy, Fraser JA Morton, Sallyanne Nguyen-Pham, Paul Jarrett, Melissa Lassig-Smith, Janine Stuart, Rachel Dunlop, Therese Starr, Robert J Boots and Jeffrey Lipman

    Citation: BMC Nephrology 2013 14:250

    Content type: Research article

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  14. Placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A), soluble receptor for advanced glycation end products (sRAGE), extracellular newly identified receptor for RAGE binding protein (E...

    Authors: Oskar Zakiyanov, Vitezslav Kriha, Jan Vachek, Tomas Zima, Vladimir Tesar and Marta Kalousova

    Citation: BMC Nephrology 2013 14:245

    Content type: Research article

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  15. Disordered mineral metabolism is implicated in the pathogenesis of vascular calcification in hemodialysis (HD) patients. Fibroblast growth factor 23 (FGF-23) is the main regulator of phosphate metabolism. In t...

    Authors: Abdullah Ozkok, Cigdem Kekik, Gonca Emel Karahan, Tamer Sakaci, Alper Ozel, Abdulkadir Unsal and Alaattin Yildiz

    Citation: BMC Nephrology 2013 14:241

    Content type: Research article

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  16. Chloride administration has been found to be harmful to the kidney in critically ill patients. However the association between plasma chloride concentration and renal function has never been investigated.

    Authors: Zhongheng Zhang, Xiao Xu, Haozhe Fan, Danyu Li and Hongsheng Deng

    Citation: BMC Nephrology 2013 14:235

    Content type: Research article

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  17. Because of the absorption of glucose in peritoneal dialysis (PD) solution, PD patients show an atherogenic lipid profile, which is predictive of poor survival in PD patients. Lipoprotein subclasses consist of ...

    Authors: Eiichiro Kanda, Masumi Ai, Asami Iwamoto, Mitsuyo Okazaki, Yoshitaka Maeda, Sei Sasaki and Masayuki Yoshida

    Citation: BMC Nephrology 2013 14:234

    Content type: Research article

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  18. Stress-induced cardiomyopathy (sCMP) is characterized by transient wall-motion abnormalities involving the left ventricular apex and mid-ventricle that are precipitated by emotional or physical stress. As the ...

    Authors: Min Ji Shin, Harin Rhee, Il Young Kim, Byeong Yun Yang, Sang Heon Song, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak, Jung Hyun Choi and Eun Young Seong

    Citation: BMC Nephrology 2013 14:213

    Content type: Research article

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  19. Peripheral artery disease (PAD) represents atherosclerotic disease and is a risk factor for death in peritoneal dialysis (PD) patients, who tend to show an atherogenic lipid profile. In this study, we investig...

    Authors: Eiichiro Kanda, Masumi Ai, Mitsuyo Okazaki, Yoshitaka Maeda, Sei Sasaki and Masayuki Yoshida

    Citation: BMC Nephrology 2013 14:212

    Content type: Research article

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  20. Renal biopsies provide important diagnostic and prognostic information in ANCA associated glomerulonephritis. A new classification for prognostication of pauci-immune glomerulonephritis (GN) based on four cate...

    Authors: Carla L Ellis, Rebecca L Manno, John P Havill, Lorraine C Racusen and Duvuru Geetha

    Citation: BMC Nephrology 2013 14:210

    Content type: Research article

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  21. Enhanced external counterpulsation (EECP) enhances coronary perfusion and reduces left ventricular afterload. However, the role of EECP on renal function in cardiac patients is unknown. Our aim was to assess r...

    Authors: Prajej Ruangkanchanasetr, Nithi Mahanonda, Ongkarn Raungratanaamporn, Piyanuj Ruckpanich, Chagriya Kitiyakara, Amnart Chaiprasert, Surawat Adirekkiat, Dollapas Punpanich, Somlak Vanavanan, Anchalee Chittamma and Thanom Supaporn

    Citation: BMC Nephrology 2013 14:193

    Content type: Research article

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  22. Accurate and precise estimates of glomerular filtration rate (GFR) are essential for clinical assessments, and many methods of estimation are available. We developed a radial basis function (RBF) network and a...

    Authors: Xun Liu, Yan-Ru Chen, Ning-shan Li, Cheng Wang, Lin-Sheng Lv, Ming Li, Xiao-Ming Wu and Tan-Qi Lou

    Citation: BMC Nephrology 2013 14:181

    Content type: Research article

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  23. The quality of life (QOL) of patients with autosomal dominant polycystic kidney disease (ADPKD) has not been investigated well. This study was performed to clarify the QOL of patients with ADPKD and to identif...

    Authors: Tatsuya Suwabe, Yoshifumi Ubara, Koki Mise, Masahiro Kawada, Satoshi Hamanoue, Keiichi Sumida, Noriko Hayami, Junichi Hoshino, Rikako Hiramatsu, Masayuki Yamanouchi, Eiko Hasegawa, Naoki Sawa and Kenmei Takaichi

    Citation: BMC Nephrology 2013 14:179

    Content type: Research article

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  24. Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified.

    Authors: Naoko Kinoshita-Katahashi, Hirotaka Fukasawa, Sayaka Ishigaki, Shinsuke Isobe, Shiro Imokawa, Yoshihide Fujigaki and Ryuichi Furuya

    Citation: BMC Nephrology 2013 14:171

    Content type: Case report

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  25. We established earlier the absolute renal risk (ARR) of dialysis/death (D/D) in primary IgA nephropathy (IgAN) which permitted accurate prospective prediction of final prognosis. This ARR was based on the pote...

    Authors: Hesham Mohey, Blandine Laurent, Christophe Mariat and Francois Berthoux

    Citation: BMC Nephrology 2013 14:169

    Content type: Research article

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  26. Some parenteral iron therapies have been found to be associated with hypophosphatemia. The mechanism of the decrease in serum phosphate is unknown. The aim of this study is to examine the effect of IV ferric c...

    Authors: Merche Prats, Ramon Font, Carmen García, Carmen Cabré, Manel Jariod and Alberto Martinez Vea

    Citation: BMC Nephrology 2013 14:167

    Content type: Research article

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  27. We previously demonstrated that lovastatin decreases cyst volume and improves kidney function in the Han:SPRD (Cy/+) rat model of ADPKD. Since endothelial dysfunction and inflammatory activity are evident in p...

    Authors: Jelena Klawitter, Iram Zafar, Jost Klawitter, Alexander T Pennington, Jacek Klepacki, Berenice Y Gitomer, Robert W Schrier, Uwe Christians and Charles L Edelstein

    Citation: BMC Nephrology 2013 14:165

    Content type: Research article

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  28. Thrombotic thrombocytopenic purpura (TTP) is frequently associated with renal abnormalities, but there have been few reports about renal abnormalities in patients with hereditary TTP. In particular, little is ...

    Authors: Koki Mise, Yoshifumi Ubara, Masanori Matsumoto, Keiichi Sumida, Rikako Hiramatsu, Eiko Hasegawa, Masayuki Yamanouchi, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenichi Ohashi, Koichi Kokame, Toshiyuki Miyata, Yoshihiro Fujimura and Kenmei Takaichi

    Citation: BMC Nephrology 2013 14:156

    Content type: Case report

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  29. The aim of this study was to describe the findings of renal biopsies from a large nephrology center in Iasi, Romania, performed between 2005 and 2010. We compared these findings with our previous ones, from 19...

    Authors: Carmen Volovăt, Irina Cãruntu, Camelia Costin, Alina Stefan, Raluca Popa, Simona Volovăt, Dimitrie Siriopol, Luminita Voroneanu, Ionut Nistor, Liviu Segall and Adrian Covic

    Citation: BMC Nephrology 2013 14:148

    Content type: Research article

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  30. Zinc-alpha2-glycoprotein (AZGP1) is a secreted protein which is synthesized in a variety of cell types. AZGP1 has functionally been implicated in lipid metabolism, the regulation of cell cycling and cancer pro...

    Authors: Inga Sörensen-Zender, Jan Beneke, Bernhard MW Schmidt, Jan Menne, Hermann Haller and Roland Schmitt

    Citation: BMC Nephrology 2013 14:145

    Content type: Research article

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  31. It is important to ensure an adequate sodium and volume balance in neurosurgical patients in order to avoid the worsening of brain injury.

    Authors: Valeria Corradetti, Pasquale Esposito, Teresa Rampino, Marilena Gregorini, Carmelo Libetta, Francesca Bosio, Teresa Valsania, Eleonora Francesca Pattonieri, Chiara Rocca, Stefania Bianzina and Antonio Dal Canton

    Citation: BMC Nephrology 2013 14:140

    Content type: Case report

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  32. Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication following coronary bypass graft (CABG) surgery. Multi-factorial causes of CSA-AKI involve oxidative stress and inflammation. Er...

    Authors: Adis Tasanarong, Soodkate Duangchana, Sangduen Sumransurp, Boonlawat Homvises and Opas Satdhabudha

    Citation: BMC Nephrology 2013 14:136

    Content type: Research article

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  33. Despite a confirmed association between restless legs syndrome (RLS) and end-stage renal disease (ESRD), there is no study on patients presenting with nephrotic syndrome (NS). To investigate the frequency of R...

    Authors: Alexandre Braga Libório, João Paulo Lima Santos, Natália Feitosa Arraes Minete, Cecília Alencar de Diógenes, Luiza de Andrade Braga Farias and Veralice Meireles Sales de Bruin

    Citation: BMC Nephrology 2013 14:113

    Content type: Research article

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  34. Chronic kidney disease (CKD) is known to expose the patient to a high risk of death due to cardiovascular and infective causes. In parallel, septic shock is a major challenge for cardiovascular and immune syst...

    Authors: Julien Maizel, Romain Deransy, Benedicte Dehedin, Edouard Secq, Elie Zogheib, Elisabeth Lewandowski, Chritstophe Tribouilloy, Ziad A Massy, Gabriel Choukroun and Michel Slama

    Citation: BMC Nephrology 2013 14:77

    Content type: Research article

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  35. The Chimney graft (CG) procedure is one of the novel modification techniques of the endovascular aneurysm repair (EVAR) surgery to treat suprarenal and juxtarenal abdominal aortic aneurysms. Other indications ...

    Authors: Amir Gal-Oz, Yehuda G Wolf, Galia Rosen, Haggai Sharon, Idit F Schwartz and Gil Chernin

    Citation: BMC Nephrology 2013 14:71

    Content type: Case report

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  36. Pulmonary renal syndrome (PRS), denoting the presence of diffuse alveolar hemorrhage and glomerulonephritis as manifestations of systemic autoimmune disease, is very rare in childhood. The coexistence of circu...

    Authors: Radovan Bogdanović, Predrag Minić, Jasmina Marković-Lipkovski, Nataša Stajić, Nataša Savić and Milan Rodić

    Citation: BMC Nephrology 2013 14:66

    Content type: Case report

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  37. Steroid-sensitive idiopathic nephrotic syndrome (SSINS) is most often encountered in sporadic cases of minimal change disease (MCD). Only rare cases of familial forms of MCD have been reported and most of them...

    Authors: Hassib Chehade, Francois Cachat, Eric Girardin, Samuel Rotman, Antonio Jorge Correia, Florence Fellmann and Olivier Bonny

    Citation: BMC Nephrology 2013 14:65

    Content type: Case report

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Thank you.

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