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Clinical Research

The Clinical Research section considers both interventional and non-interventional clinical research studies, including, but not limited to, controlled trials and case-control studies. This section does not consider basic experimental research, large epidemiological studies, or case reports. Systematic reviews, meta-analyses and epidemiological studies should be directed to the Epidemiology and Health Outcomes section, and case reports should be directed to our dedicated Case Reports section. 

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  1. Serum anti-phospholipase A2 receptor (PLA2R) antibody was correlated with disease activity of membranous nephropathy(MN). The predictive value of antibody titer changes on immunosuppressive response remains un...

    Authors: Chao Li, Hang Li, Yu-bing Wen, Xue-mei Li and Xue-wang Li

    Citation: BMC Nephrology 2018 19:354

    Content type: Research article

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  2. Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim o...

    Authors: Nordeval Cavalcante Araújo and José Hermógenes Rocco Suassuna

    Citation: BMC Nephrology 2018 19:351

    Content type: Research article

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  3. Nephrolithiasis is a global healthcare problem with a current lifetime risk of 18.8% in men and 9.4% in women. Given the high cost of medical treatments and surgical interventions as well as the morbidity rela...

    Authors: Nasser A. Dhayat, Nicolas Faller, Olivier Bonny, Nilufar Mohebbi, Alexander Ritter, Lisa Pellegrini, Giulia Bedino, Carlo Schönholzer, Reto M. Venzin, Carina Hüsler, Irene Koneth, Rosaria Del Giorno, Luca Gabutti, Patrizia Amico, Michael Mayr, Urs Odermatt…

    Citation: BMC Nephrology 2018 19:349

    Content type: Study protocol

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  4. Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the ...

    Authors: Antonio Mirijello, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Giuspina T. Russo, Pietro Guida, Roberto Pontremoli and Salvatore De Cosmo

    Citation: BMC Nephrology 2018 19:347

    Content type: Research article

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  5. Chronic Kidney Disease (CKD), the worldwide Public Health problem, is also one of the rising non-communicable diseases in low and middle-income countries. Its early detection and treatment using readily availa...

    Authors: Tamiru Adugna, Hailu Merga and Esayas Kebede Gudina

    Citation: BMC Nephrology 2018 19:345

    Content type: Research article

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  6. Patient experience in hemodialysis (HD) is measured twice yearly in all in-center HD patients in the United States using the In-Center Hemodialysis Consumer Assessment of Healthcare Providers and Systems (ICH ...

    Authors: Taimur Dad, Hocine Tighiouart, Eduardo Lacson Jr, Klemens B. Meyer, Daniel E. Weiner and Michelle M. Richardson

    Citation: BMC Nephrology 2018 19:340

    Content type: Research article

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  7. IgA vasculitis (IgAV, formerly Henoch-Schönlein purpura) is a type of systemic vasculitis. This study aimed to explore the clinicopathological features, treatment and renal outcomes of adult IgAV-related nephr...

    Authors: Xiao Huang, Jing Wu, Xiao-mei Wu, Ya-xin Hao, Cai-hong Zeng, Zhi-hong Liu and Zheng Tang

    Citation: BMC Nephrology 2018 19:334

    Content type: Research article

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  8. Kidney diseases have emerged as significant cause of morbidity and mortality in HIV subject on antiretroviral therapy (ART). In Ghana, routine follow up of HIV positive clients is by estimation of serum creati...

    Authors: Dorcas Obiri-Yeboah, Yaw Asante Awuku, Wonderful Alofa, Alice Charwudzi, Ebenezer Aniakwa-Bonsu, Evans Obboh and Paul Nsiah

    Citation: BMC Nephrology 2018 19:333

    Content type: Research article

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  9. Human immunodeficiency virus (HIV) is associated with diverse glomerular diseases. Characteristics of minimal change nephrotic syndrome (MCNS) in this setting have been little studied, and the specific feature...

    Authors: Romain ARRESTIER, Anne-Pascale SATIE, Shao-yu ZHANG, Emmanuelle PLAISIER, Corinne ISNARD-BAGNIS, Philippe GATAULT, Quentin RAIMBOURG, David BUOB, Flavia VOCILA, Anne-Elisabeth HENG, Helene FRANCOIS, Anissa MOKTEFI, Guillaume CANAUD, Marie MATIGNON, Nathalie DEJUCQ-RAINSFORD, Isabelle BROCHERIOU…

    Citation: BMC Nephrology 2018 19:331

    Content type: Research article

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  10. In a previous study we showed that troponin I (TnI) > 0.42 ng/mL predicted the need of dialysis in a group of 29 septic patients admitted to the intensive care unit (ICU). We aimed to confirm such finding in a...

    Authors: Daniel de Almeida Thiengo, Jorge P. Strogoff-de-Matos, Jocemir Ronaldo Lugon and Miguel Luis Graciano

    Citation: BMC Nephrology 2018 19:329

    Content type: Research article

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  11. The CKD-associated decline in soluble α-Klotho (α-Klotho) levels is considered detrimental. Some studies suggest a direct induction of α-Klotho concentrations by growth hormone (GH). In the present study, the ...

    Authors: Aaltje Y. Adema, Camiel L. M. de Roij van Zuijdewijn, Joost G. Hoenderop, Martin H. de Borst, Piet M. Ter Wee, Annemieke C. Heijboer and Marc G. Vervloet

    Citation: BMC Nephrology 2018 19:327

    Content type: Research article

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  12. Different methods to prevent contrast-associated acute kidney injury (CA-AKI) have been proposed in recent years. We performed a mixed treatment comparison to evaluate and rank suggested interventions.

    Authors: Khalid Ahmed, Terri McVeigh, Raminta Cerneviciute, Sara Mohamed, Mohammad Tubassam, Mohammad Karim and Stewart Walsh

    Citation: BMC Nephrology 2018 19:323

    Content type: Research article

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  13. The risk of early death is particularly high in patients over the age of 65 presenting with antineutrophil cytoplasmic antibody (ANCA)-associated renal vasculitis. We hypothesized that by combining disease sev...

    Authors: Dimitri Titeca-Beauport, Alexis Francois, Thierry Lobbedez, Dominique Guerrot, David Launay, Laurence Vrigneaud, Maité Daroux, Celine Lebas, Boris Bienvenu, Eric Hachulla, Momar Diouf and Gabriel Choukroun

    Citation: BMC Nephrology 2018 19:317

    Content type: Research article

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  14. Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum an...

    Authors: Richard J. Johnson, Santos E. Perez-Pozo, Julian Lopez Lillo, Felix Grases, Jesse D. Schold, Masanari Kuwabara, Yuka Sato, Ana Andres Hernando, Gabriela Garcia, Thomas Jensen, Christopher Rivard, Laura G. Sanchez-Lozada, Carlos Roncal and Miguel A. Lanaspa

    Citation: BMC Nephrology 2018 19:315

    Content type: Research article

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  15. Abdominal aortic calcification (AAC) has been known to be associated with cardiovascular mortality in hemodialysis. However, the association between AAC and future coronary artery disease (CAD) occurrence is n...

    Authors: Hung-Chih Chen, Wei-Ting Wang, Chieh-Ning Hsi, Che-Yi Chou, Hsuan-Jen Lin, Chiu-Ching Huang and Chiz-Tzung Chang

    Citation: BMC Nephrology 2018 19:313

    Content type: Research article

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  16. Iodinated contrast media may contribute to acute kidney injury. However, several recent works suggest that this toxicity is minimal in the clinical setting. Recently, urinary G1 cell-cycle arrest proteins tissue ...

    Authors: Emmanuelle Rouve, Karim Lakhal, Charlotte Salmon Gandonnière, Youenn Jouan, Laetitia Bodet-Contentin and Stephan Ehrmann

    Citation: BMC Nephrology 2018 19:308

    Content type: Research article

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  17. Knowledge on cross-talk between the heart and kidney has been established by basic and clinical research. Nevertheless, the effects of systolic and diastolic heart dysfunctions on the development of acute kidn...

    Authors: Jae Shin Choi, Seon Ha Baek, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Yon Su Kim, Sejoong Kim and Seung Seok Han

    Citation: BMC Nephrology 2018 19:292

    Content type: Research article

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  18. Laparoscopic abdominal surgery has been widely used to reduce the length of hospital stay and complications from open abdominal surgery. During the operation, the creation of pneumoperitoneum is used for bette...

    Authors: Nattachai Srisawat, Manasnun Kongwibulwut, Passisd Laoveeravat, Nuttha Lumplertgul, Pornlert Chatkaew, Pipat Saeyub, Krittayot Latthaprecha, Sadudee Peerapornratana, Khajohn Tiranathanagul, Somchai Eiam-Ong and Kriang Tungsanga

    Citation: BMC Nephrology 2018 19:289

    Content type: Research article

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  19. Autosomal dominant polycystic kidney disease (ADPKD) accounts for 8–10% of end-stage chronic kidney disease (CKD) patients worldwide. In the last decade, the advanced knowledge in genetics and molecular pathob...

    Authors: Antonio Pisani, Eleonora Riccio, Dario Bruzzese and Massimo Sabbatini

    Citation: BMC Nephrology 2018 19:282

    Content type: Research article

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  20. We investigated the impact of a transvenous cardiac implantable electronic device (CIED) placement on outcomes and arteriovenous vascular access (VA) patency among chronic hemodialysis patients.

    Authors: Seonjeong Jeong, Gi Byoung Nam, Jai Won Chang, Min-Ju Kim, Youngjin Han, Tae-Won Kwon and Yong-Pil Cho

    Citation: BMC Nephrology 2018 19:281

    Content type: Research article

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  21. Previous research suggests that novel biomarkers may be used to identify patients at increased risk of acute kidney injury following cardiac surgery. The purpose of this study was to evaluate the relationship ...

    Authors: Moritz Wyler von Ballmoos, Donald S. Likosky, Michael Rezaee, Kevin Lobdell, Shama Alam, Devin Parker, Sherry Owens, Heather Thiessen-Philbrook, Todd MacKenzie and Jeremiah R. Brown

    Citation: BMC Nephrology 2018 19:280

    Content type: Research article

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  22. To achieve optimal health outcomes, people with chronic kidney disease must make changes in their everyday lives to self-manage their condition. This can be challenging, and there is a need for self-management...

    Authors: Kathryn Havas, Clint Douglas and Ann Bonner

    Citation: BMC Nephrology 2018 19:279

    Content type: Research article

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  23. Cyst infection is a common and serious complication of autosomal dominant polycystic kidney disease (ADPKD) that is often refractory. Carbapenems are frequently needed to treat to patients with refractory cyst...

    Authors: Satoshi Hamanoue, Tatsuya Suwabe, Yoshifumi Ubara, Koichi Kikuchi, Ryo Hazue, Koki Mise, Toshiharu Ueno, Kenmei Takaichi, Kana Matsumoto and Kunihiko Morita

    Citation: BMC Nephrology 2018 19:272

    Content type: Research article

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  24. The clinical course of Viridans streptococci (VS) peritonitis in patients undergoing peritoneal dialysis (PD) is rarely reported. This study examined the association of clinical factors with VS peritonitis.

    Authors: Ying Liu, Ben-Chung Cheng, Jien-Wei Liu, Chiao-Jung Chen, Li-Chueh Kuo, Wen Xiu Chang and Jin-Bor Chen

    Citation: BMC Nephrology 2018 19:271

    Content type: Research article

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  25. Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidit...

    Authors: Andrea Corsonello, Lisanne Tap, Regina Roller-Wirnsberger, Gerhard Wirnsberger, Carmine Zoccali, Tomasz Kostka, Agnieszka Guligowska, Francesco Mattace-Raso, Pedro Gil, Lara Guardado Fuentes, Itshak Meltzer, Ilan Yehoshua, Francesc Formiga-Perez, Rafael Moreno-González, Christian Weingart, Ellen Freiberger…

    Citation: BMC Nephrology 2018 19:260

    Content type: Study protocol

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  26. Poor nutritional status of patients with renal disease has been associated with worsening of renal function and poor health outcomes. Simply measuring weight and height for calculation of the body mass index d...

    Authors: Jutta Dierkes, Helene Dahl, Natasha Lervaag Welland, Kristina Sandnes, Kristin Sæle, Ingegjerd Sekse and Hans-Peter Marti

    Citation: BMC Nephrology 2018 19:259

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2018 19:375

  27. Vitamin D deficiency is common in patients with chronic kidney disease (CKD), and is associated with endothelial dysfunction and cardiovascular disease. We performed a meta-analysis to assess the effect of vit...

    Authors: Kristina Lundwall, Stefan H. Jacobson, Gun Jörneskog and Jonas Spaak

    Citation: BMC Nephrology 2018 19:247

    Content type: Research article

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  28. Increased monocyte chemoattractant protein-1 (MCP-1) and decreased epidermal growth factor (EGF) are promising biomarkers to predict progressive decline in kidney function in non-diabetic kidney diseases. We a...

    Authors: Bancha Satirapoj, Rattanawan Dispan, Piyanuch Radinahamed and Chagriya Kitiyakara

    Citation: BMC Nephrology 2018 19:246

    Content type: Research article

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  29. Evidence suggests that alkaline phosphatase attenuates inflammatory response in sepsis by lipopolysaccharide detoxification and adenosine triphosphate dephosphorylation. We sought to determine changes in alkal...

    Authors: Seung Don Baek, Jae-Young Kang, Hoon Yu, Seulgi Shin, Hyang-Sook Park, Mi-Soon Kim, Eun Kyoung Lee, So Mi Kim and Jai Won Chang

    Citation: BMC Nephrology 2018 19:243

    Content type: Research article

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  30. Anti-glomerular basement-membrane (anti-GBM) disease (or Goodpasture disease) is characterized by severe kidney and lung involvement. Prognoses have improved with treatments that combine plasma exchange and im...

    Authors: M. Heitz, P. L. Carron, G. Clavarino, T. Jouve, N. Pinel, F. Guebre-Egziabher and L. Rostaing

    Citation: BMC Nephrology 2018 19:241

    Content type: Research article

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  31. Corticosteroids are widely used to reduce the urine protein levels of patients with immunoglobulin A nephropathy (IgAN). However, their potential preventive effects on end-stage kidney disease (ESKD) are unclear.

    Authors: Ryoya Tsunoda, Joichi Usui, Junichi Hoshino, Takayuki Fujii, Satoshi Suzuki, Kenmei Takaichi, Yoshifumi Ubara and Kunihiro Yamagata

    Citation: BMC Nephrology 2018 19:222

    Content type: Research article

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  32. Nephrotoxicity is a major hazard complicating the use of platinum based drugs (PBD), which can hinder using higher doses protocols to maximize the therapeutic gain. Shortage of serum creatinine level as an acc...

    Authors: Mostafa Abdelsalam, Ekramy Elmorsy, Hassan Abdelwahab, Osman Algohary, Mahmoud Naguib, Ahmed Abd El Wahab, Ahmed Eldeeb, Ehab Eltoraby, Adel Abdelsalam, Alaa Sabry, Mohamed El-Metwally, Mohamed Akl, Nahla Anber, Maysaa El Sayed Zaki, Fahad Almutairi and Tamer Mansour

    Citation: BMC Nephrology 2018 19:219

    Content type: Research article

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  33. The clinical outcome varies considerably in primary membranous nephropathy (pMN). Risk factors for kidney prognosis include ageing, male gender, persistent heavy proteinuria, decreased eGFR at presentation, pe...

    Authors: Xiao-dan Zhang, Zhao Cui, Mu-fan Zhang, Jia Wang, Yi-miao Zhang, Zhen Qu, Xin Wang, Jing Huang, Fang Wang, Li-qiang Meng, Xu-yang Cheng, Su-xia Wang, Gang Liu and Ming-hui Zhao

    Citation: BMC Nephrology 2018 19:215

    Content type: Research article

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  34. With advancement of hemodialysis (HD) technique, late fistula failure (LFF) remains a problem significantly affecting life quality of patients. We attempt to identify factors affecting LFF in patients on chron...

    Authors: Cheng-Chieh Yen, Ching-Fang Tsai, Yueh-Yun Luo, Hsin-Yi Yang, Mei-Yin Liu, Peir-Haur Hung and Yueh-Han Hsu

    Citation: BMC Nephrology 2018 19:213

    Content type: Research article

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  35. Henoch-Schönlein purpura nephritis (HSPN) is a form of small vessel vasculitis associated with purpura and IgA deposition in the glomeruli. The International Study of Kidney Disease in Children (ISKDC) classif...

    Authors: Koji Inagaki, Ahmad Baseer Kaihan, Asaka Hachiya, Takaya Ozeki, Masahiko Ando, Sawako Kato, Yoshinari Yasuda and Shoichi Maruyama

    Citation: BMC Nephrology 2018 19:208

    Content type: Research article

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  36. Left ventricular hypertrophy (LVH) is one of the risk factors for cardiovascular (CV) disease and mortality. However, the relationship between socioeconomic status (SES) and LVH in chronic kidney disease remai...

    Authors: Eunjeong Kang, Joongyub Lee, Hyo Jin Kim, Miyeun Han, Soo Wan Kim, Kyu-Beck Lee, Suah Sung, Tae-Hyun Yoo, Wookyung Chung, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2018 19:203

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2018 19:217

  37. Volume overload poses a major risk in hemodialysis patients but simple detection methods are lacking. We propose a novel marker, the Interdialytic Creatinine Rise (IDCR), readily calculated as the change in se...

    Authors: Ljubomir M. Ilic, Roger B. Davis, Robert S. Brown and Stewart H. Lecker

    Citation: BMC Nephrology 2018 19:202

    Content type: Research article

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  38. Microalbuminuria signifies the onset of diabetic nephropathy, but normoalbuminuric patients with diabetes who have a low Glomerular Filtration Rate (GFR) are not uncommon. The purpose of the study was to estim...

    Authors: Polwatta Liyanage Gayani Chandima Liyanage, Sarath Lekamwasam, Thilak Priyantha Weerarathna and Dodanduwa Waduge Shyamal Yashodara Srikantha

    Citation: BMC Nephrology 2018 19:200

    Content type: Research article

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  39. Genitourinary tuberculosis (GUTB) is a type of extrapulmonary TB that exerts a deleterious effect on renal function by promoting renal calcification and ureteric stricture. Therefore, we investigated the risk ...

    Authors: Eun Jin Kim, Woonji Lee, Woo Yong Jeong, Hen Choi, In Young Jung, Jin Young Ahn, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Hwa Choi, Young Goo Song and June Myung Kim

    Citation: BMC Nephrology 2018 19:193

    Content type: Research article

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  40. Increased plasma level of lipoprotein(a) (Lpa) is a risk factor of cardiovascular diseases. This study aimed to explore the role of Lpa in the progression of atherosclerosis in patients with end-stage renal di...

    Authors: Kun Ling Ma, Tie Kai Gong, Ze Bo Hu, Yang Zhang, Gui Hua Wang, Liang Liu, Pei Pei Chen, Jian Lu, Chen Chen Lu and Bi Cheng Liu

    Citation: BMC Nephrology 2018 19:192

    Content type: Research article

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  41. Soluble urokinase-type plasminogen activator receptor (suPAR) has emerged as a new sepsis biomarker. It is not known whether suPAR has a role in critically ill patients with severe acute kidney injury (AKI).

    Authors: Anna Hall, Siobhan Crichton, Matt Varrier, Danielle E. Bear and Marlies Ostermann

    Citation: BMC Nephrology 2018 19:191

    Content type: Research article

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  42. Investigations on the role of the time-mean serum uric acid (SUA) value in determining the risk of chronic kidney disease (CKD) are limited. We investigated whether the time-mean SUA value indicates the risk o...

    Authors: Meiyu Ye, Kang Hu, Juan Jin, Diandian Wu, Peiying Hu and Qiang He

    Citation: BMC Nephrology 2018 19:190

    Content type: Research article

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  43. Ongoing efforts are focused on shortening ischemia intervals as much as possible during partial nephrectomy to preserve renal function. Off-clamp partial nephrectomy (off-PN) has been a common strategy for to ...

    Authors: Wen Deng, Xiaoqiang Liu, Jieping Hu, Luyao Chen and Bin Fu

    Citation: BMC Nephrology 2018 19:188

    Content type: Research article

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  44. Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR a...

    Authors: Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Nephrology 2018 19:187

    Content type: Research article

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  45. Idiopathic membranous nephropathy (IMN) is one of the most common adult nephrotic syndromes. Some patients with this disorder require immunosuppressive therapy. This retrospective case series was performed to ...

    Authors: Shun-Lai Shang, Guang-Yan Cai, Shu-wei Duan, Ping Li, Qing-Gang Li and Xiang-Mei Chen

    Citation: BMC Nephrology 2018 19:182

    Content type: Research article

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  46. Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light ...

    Authors: Punit Yadav, Paul Cockwell, Mark Cook, Jennifer Pinney, Hannah Giles, Yu Sandar Aung, David Cairns, Roger G. Owen, Faith E. Davies, Graham H. Jackson, J. Anthony Child, Gareth J. Morgan and Mark T. Drayson

    Citation: BMC Nephrology 2018 19:178

    Content type: Research article

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Thank you.

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