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Epidemiology and Health Outcomes

Section edited by Bernard Jaar and Deputy Section Editor Laura Plantinga

The Epidemiology and Health Outcomes section considers manuscripts describing epidemiological studies relating to the field of nephrology. The section also considers systematic reviews and meta-analyses. Both qualitative and quantitative studies discussing health outcomes research and outcome measures are also considered by this section. Research related to clinical practice guidelines should be directed to the dedicated Guidelines and Policy section.

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  1. Content type: Research article

    The diagnostic value of serum M-type phospholipase A2 receptor antibody (sPLA2R-ab) expression in patients with primary membranous nephropathy (PMN) has been established. However, the association between sPLA2...

    Authors: Yufeng Liang, Jianxin Wan, Yongping Chen and Yangbin Pan

    Citation: BMC Nephrology 2019 20:360

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  2. Content type: Research article

    Evidences show that around 20% of biosimilar or originator erythropoiesis-stimulating agents (ESAs) users are hyporesponsive. Controversial post-marketing data exist on the predictors of ESA hyporesponsiveness...

    Authors: Ingrasciotta Ylenia, Lacava Viviana, Marcianò Ilaria, Giorgianni Francesco, Tripepi Giovanni, D’ Arrigo Graziella, Chinellato Alessandro, Tari Daniele Ugo, Santoro Domenico and Trifirò Gianluca

    Citation: BMC Nephrology 2019 20:359

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  3. Content type: Research article

    Chronic kidney disease (CKD) is often under-recognized and poorly documented via diagnoses, but the extent of under-recognition is not well understood among Medicare beneficiaries. The current study used claim...

    Authors: Clarissa J. Diamantidis, Sarah L. Hale, Virginia Wang, Valerie A. Smith, Sarah Hudson Scholle and Matthew L. Maciejewski

    Citation: BMC Nephrology 2019 20:357

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  4. Content type: Research article

    High blood pressure is the most significant risk factor for the development and progression of chronic kidney disease (CKD). Lowering blood pressure is a goal to prevent CKD progression. This study of adults w...

    Authors: Jianzhen Zhang, Helen G. Healy, Sree Krishna Venuthurupalli, Ken-Soon Tan, Zaimin Wang, Anne Cameron and Wendy E. Hoy

    Citation: BMC Nephrology 2019 20:348

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  5. Content type: Research article

    Neighborhood racial mix is associated with dialysis facility performance metrics and mortality outcomes in patients on hemodialysis. We explored the association of neighborhood racial mix with emergency depart...

    Authors: Ladan Golestaneh, Atessa Farzami, Chikeluba Madu, Tanya Johns, Michal L. Melamed and Keith C. Norris

    Citation: BMC Nephrology 2019 20:343

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  6. Content type: Research article

    Approximately 4–6% of incident end stage renal disease (ESRD) patients in the U.S. recover enough kidney function to discontinue dialysis but there is considerable geographic variation. We undertook this study...

    Authors: Zijin Chen, Benjamin J. Lee, Charles E. McCulloch, Nilka Ríos Burrows, Michael Heung, Raymond K. Hsu, Meda E. Pavkov, Neil R. Powe, Rajiv Saran, Vahakn Shahinian and Chi-yuan Hsu

    Citation: BMC Nephrology 2019 20:342

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  7. Content type: Research article

    Chronic Kidney Disease (CKD) of uncertain origin (CKDu) has affected North Central Province (Anuradhapura and Polonnaruwa districts) of Sri Lanka. The cause is still unknown. The objective of this study was to...

    Authors: Asanga Venura Ranasinghe, Gardiye Weligamage Gamini Priyantha Kumara, Ranamuka Henayage Karunarathna, Ambepitiyawaduge Pubudu De Silva, Korale Gedara Dilini Sachintani, Jayaprakara Mudiyanselage Chathurika Nayani Gunawardena, Sembu Kuttige Champika Ruwan Kumari, Mohamed Shali Fathima Sarjana, Janaka Sri Chandraguptha and Mannikawadumesthri Vipula Chandu De Silva

    Citation: BMC Nephrology 2019 20:338

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  8. Content type: Research article

    Immunosuppressive agents have been widely used in the treatment of IgA nephropathy (IgAN), but the efficacy and safety remain controversial. The recent STOP-IgAN and TESTING studies have again focused attentio...

    Authors: Zheng Zhang, Yue Yang, Shi-min Jiang and Wen-ge Li

    Citation: BMC Nephrology 2019 20:333

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  9. Content type: Research article

    A survival advantage associated with obesity has often been described in dialysis patients. The association of higher body mass index (BMI) with mortality and renal replacement therapy (RRT) in preterminal chr...

    Authors: Zaimin Wang, Jianzhen Zhang, Samuel Chan, Anne Cameron, Helen G. Healy, Sree K. Venuthurupalli, Ken-Soon Tan and Wendy E. Hoy

    Citation: BMC Nephrology 2019 20:329

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  10. Content type: Research article

    Studies have reported conflicting findings on the infection risk posed by intravenous iron supplementation among hemodialysis (HD) patients. We used a novel study design to assess associations between intraven...

    Authors: Chieh-Li Yen, Yu-Sheng Lin, Yueh-An Lu, Hsin-Fu Lee, Cheng-Chia Lee, Ying-Chang Tung, George Kuo, Lung-Sheng Wu, Ya-Chung Tian and Pao-Hsien Chu

    Citation: BMC Nephrology 2019 20:327

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  11. Content type: Research article

    Patients with cardiovascular disease are at an increased risk of chronic kidney disease (CKD). However, data on incident CKD in patients with multiple vascular comorbidities are insufficient. In this study, we...

    Authors: Saif Al-Shamsi, Abderrahim Oulhaj, Dybesh Regmi and Romona D. Govender

    Citation: BMC Nephrology 2019 20:325

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  12. Content type: Research article

    Patients suffering from acute kidney injury (AKI) were associated with impaired sodium and potassium homeostasis. We aimed to investigate how admission serum sodium and potassium independently and jointly modi...

    Authors: Xu-ping Gao, Chen-fei Zheng, Min-qi Liao, Hong He, Yan-hua Liu, Chun-xia Jing, Fang-fang Zeng and Qing-shan Chen

    Citation: BMC Nephrology 2019 20:311

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  13. Content type: Research article

    The benefits and risks of antiplatelet therapy for patients with chronic kidney disease (CKD) remain controversial. We undertook a systematic review and meta-analysis to investigate the effects of antiplatelet...

    Authors: Xiaole Su, Bingjuan Yan, Lihua Wang, Jicheng Lv, Hong Cheng and Yipu Chen

    Citation: BMC Nephrology 2019 20:309

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  14. Content type: Research article

    The Southern Community Cohort Study is a prospective study of low socioeconomic status (SES) blacks and whites from the southeastern US, where the burden of end-stage renal disease (ESRD) and its risk factors ...

    Authors: Fabian Bock, Thomas G. Stewart, Cassianne Robinson-Cohen, Jennifer Morse, Edmond K. Kabagambe, Kerri L. Cavanaugh, Kelly A. Birdwell, Adriana M. Hung, Khaled Abdel-Kader, Edward D. Siew, Elvis A. Akwo, William J. Blot, T. Alp Ikizler and Loren Lipworth

    Citation: BMC Nephrology 2019 20:308

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  15. Content type: Research article

    Chronic Kidney Disease (CKD) is a growing public health problem. Many risk factors were identified and interventions were applied accordingly, but the incidence of end-stage renal disease continued increasing....

    Authors: Chung-Yen Lu, Yin-Cheng Chen, Yu-Wen Lu, Chih-Hsin Muo and Ray-E Chang

    Citation: BMC Nephrology 2019 20:304

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  16. Content type: Research article

    Chronic Kidney Disease in certain part of Sri Lanka and increasing burden of CKD in some other countries is a global public health problem. While the underlying causes of majority of cases are unknown, effecti...

    Authors: Nalaka Herath, Rajeewa Dassanayake, Manjula Dissanayake, Chamara Janitha, Kosala Weerakoon, Chalaka Kumarasinghe, Terence Gamini de Silva and Suneth Agampodi

    Citation: BMC Nephrology 2019 20:298

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  17. Content type: Research article

    Acute kidney injury (AKI) is a major global health problem. We aim to evaluate the epidemiology, risk factors and outcomes of AKI episodes in our single centre.

    Authors: Su Hooi Teo, Kian-Guan Lee, Riece Koniman, Alvin Ren Kwang Tng, Zhong Hong Liew, Thin Thiri Naing, Huihua Li, Ru Yu Tan, Han Khim Tan, Hui Lin Choong, W. Y. Marjorie Foo and Manish Kaushik

    Citation: BMC Nephrology 2019 20:282

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  18. Content type: Research article

    Chronic kidney disease (CKD) and end stage renal disease (ESRD) are not well characterized in prostate cancer patients. This study aimed to examine the clinical characteristics and postsurgical outcomes of pat...

    Authors: Chen Ning, Xinyi Hu, Fangming Liu, Jun Lin, Jian Zhang, Zhipeng Wang and Yichen Zhu

    Citation: BMC Nephrology 2019 20:278

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  19. Content type: Research article

    Palliative care has improved the quality of end-of-life (EOL) care and lowered the health care cost of cancer, and these benefits should be extended to patients with other serious illnesses including end-stage...

    Authors: Jui-Kun Chiang, Jean-Shi Chen and Yee-Hsin Kao

    Citation: BMC Nephrology 2019 20:265

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  20. Content type: Research article

    There is limited evidence on the relationship between social support and renal outcomes in African Americans. We sought to determine the association of social support with prevalent chronic kidney disease (CKD...

    Authors: Rasheeda K. Hall, Clemontina A. Davenport, Mario Sims, Cathleen Colón-Emeric, Tiffany Washington, Jennifer St. Clair Russell, Jane Pendergast, Nrupen Bhavsar, Julia Scialla, Crystal C. Tyson, Wei Wang, Yuan-I Min, Bessie Young, L. Ebony Boulware and Clarissa J. Diamantidis

    Citation: BMC Nephrology 2019 20:262

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  21. Content type: Research article

    Epidemiologic studies has shown an association of albuminuria and low estimated glomerular filtration rate (eGFR) with dementia, but the findings are inconsistent. This study examines the association between e...

    Authors: Jessica Mira Gabin, Solfrid Romundstad, Ingvild Saltvedt and Jostein Holmen

    Citation: BMC Nephrology 2019 20:261

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  22. Content type: Research article

    The International Classification of Diseases (ICD) coding system is the industry standard tool for billing, disease classification, and epidemiology purposes. However, ICD codes are often not assigned or incor...

    Authors: Kabir Jalal, Edwin J. Anand, Rocco Venuto, Joe Eberle and Pradeep Arora

    Citation: BMC Nephrology 2019 20:260

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  23. Content type: Research article

    The development of large-scale chronic kidney disease (CKD) cohorts within the Veterans Affairs (VA) system has been limited by several factors, including the high proportion of missing race data etc. The goal...

    Authors: Mukoso N. Ozieh, Mulugeta Gebregziabher, Ralph C. Ward, David J. Taber and Leonard E. Egede

    Citation: BMC Nephrology 2019 20:241

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  24. Content type: Research article

    Body mass index (BMI) is associated with renal disease progression in unspecified CKD. The relationship between BMI and primary glomerular disease (GN) may be more complex. We aimed to evaluate the association...

    Authors: Benjamin M. P. Elyan, Jennifer S. Lees, Keith A. Gillis, Bruce Mackinnon, Jonathan G. Fox, Colin C. Geddes and Emily P. McQuarrie

    Citation: BMC Nephrology 2019 20:237

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  25. Content type: Research article

    Maintenance dialysis is a costly and resource intense activity. In Australia, inadequate health infrastructure and poor access to technically skilled staff can limit service provision in remote areas where man...

    Authors: G. Gorham, K. Howard, Y. Zhao, A. M. S. Ahmed, P. D. Lawton, C. Sajiv, S. W. Majoni, P. Wood, T. Conlon, S. Signal, S. L. Robinson, S. Brown and A. Cass

    Citation: BMC Nephrology 2019 20:231

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  26. Content type: Study protocol

    Maternal kidney disease (acute kidney injury (AKI), advanced chronic kidney disease (CKD), dependence on dialysis or a kidney transplant) has a substantial impact on pregnancy, with risks of significant perina...

    Authors: Nadom Safi, Elizabeth Sullivan, Zhuoyang Li, Mark Brown, William Hague, Stephen McDonald, Michael J. Peek, Angela Makris, Angela M. O’Brien and Shilpanjali Jesudason

    Citation: BMC Nephrology 2019 20:230

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  27. Content type: Research article

    Anabolic-androgenic steroids and growth hormone are among the most commonly used supplements by sportsmen and sportswomen. The aim of this systematic review is to collect and report available data about renal ...

    Authors: Dorna Davani-Davari, Iman Karimzadeh and Hossein Khalili

    Citation: BMC Nephrology 2019 20:198

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  28. Content type: Research article

    Acid-base imbalance might promote the progression of chronic kidney disease (CKD), but whether nutrient-derived dietary acid load increases the risk of albuminuria or even high normoalbuminuria is unclear.

    Authors: Keiko Kabasawa, Michihiro Hosojima, Ribeka Takachi, Kazutoshi Nakamura, Yumi Ito, Akihiko Saito, Norie Sawada, Shoichiro Tsugane, Junta Tanaka and Ichiei Narita

    Citation: BMC Nephrology 2019 20:194

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  29. Content type: Research article

    Vitamin D deficiency is an important health concern because it is related to several comorbidities and mortality. However, its relationship with the risk of hematuria remains undetermined in the general popula...

    Authors: Hyunjin Ryu, Hyunjeong Cho, Yun Kyu Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn and Seung Seok Han

    Citation: BMC Nephrology 2019 20:187

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  30. Content type: Research article

    A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale P...

    Authors: Dino Gibertoni, Paola Rucci, Marcora Mandreoli, Mattia Corradini, Davide Martelli, Giorgia Russo, Elena Mancini and Antonio Santoro

    Citation: BMC Nephrology 2019 20:177

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  31. Content type: Research article

    Steroidal mineralocorticoid receptor antagonists (MRAs) are recommended for the treatment of heart failure (HF) and resistant hypertension, both common comorbidities in patients with diabetes and chronic kidne...

    Authors: Michael Blankenburg, Anne-Kathrin Fett, Seline Eisenring, Gabriele Haas and Alain Gay

    Citation: BMC Nephrology 2019 20:171

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  32. Content type: Research article

    As patients on daily hemodialysis (DHD) have heterogeneous profiles, DHD benefit in terms of survival is still debated. The aim of this study was to compare DHD practices in France and in Australia and New Zea...

    Authors: Adélaïde Pladys, Sahar Bayat, Cécile Couchoud, Cécile Vigneau and Stephen McDonald

    Citation: BMC Nephrology 2019 20:156

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  33. Content type: Research article

    Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation st...

    Authors: Naren Kumar Surendra, Mohd Rizal Abdul Manaf, Lai Seong Hooi, Sunita Bavanandan, Fariz Safhan Mohamad Nor, Shahnaz Shah Firdaus Khan, Loke Meng Ong and Abdul Halim Abdul Gafor

    Citation: BMC Nephrology 2019 20:151

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  34. Content type: Research article

    Fewer trainees are choosing to pursue nephrology. Only 60.1% of positions filled in the 2018 fellowship Match, which is concerning given the rising prevalence of end-stage kidney disease. Identifying factors i...

    Authors: Devika Nair, Kurtis A. Pivert, Adrian Baudy IV and Charuhas V. Thakar

    Citation: BMC Nephrology 2019 20:146

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  35. Content type: Research article

    Self-management intervention aims to facilitate an individual’s ability to make lifestyle changes. The effectiveness of this intervention in non-dialysis patients with chronic kidney disease (CKD) is limited. ...

    Authors: Suyuan Peng, Jiawei He, Jiasheng Huang, Longwei Lun, Jiahao Zeng, Shan Zeng, La Zhang, Xusheng Liu and Yifan Wu

    Citation: BMC Nephrology 2019 20:142

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  36. Content type: Research article

    The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represe...

    Authors: Hayley Bennett, Phil McEwan, Karina Hamilton and Karl O’Reilly

    Citation: BMC Nephrology 2019 20:136

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  37. Content type: Research article

    The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and...

    Authors: Gwang Sil Kim, Hyun Ho Oh, Sang Hyun Kim, Byung Ok Kim and Young Sup Byun

    Citation: BMC Nephrology 2019 20:130

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  38. Content type: Research article

    Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. However, little is k...

    Authors: Hyo Jin Kim, Joongyub Lee, Dong-Wan Chae, Kyu-Beck Lee, Su Ah Sung, Tae-Hyun Yoo, Seung Hyeok Han, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2019 20:119

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  39. Content type: Research article

    Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate es...

    Authors: Sachimi Kubo, Yoko Nishida, Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Takumi Hirata, Naomi Miyamatsu, Ayumi Tanabe, Aya Hirata, Yukako Tatsumi, Aya Kadota, Kazuyo Kuwabara, Tomofumi Nishikawa, Yoshihiro Miyamoto and Tomonori Okamura

    Citation: BMC Nephrology 2019 20:117

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  40. Content type: Research article

    Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the ...

    Authors: Nidhi Sukul, Junhui Zhao, Douglas S. Fuller, Angelo Karaboyas, Brian Bieber, James A. Sloand, Lalita Subramanian, David W. Johnson, Matthew J. Oliver, Kriang Tungsanga, Tadashi Tomo, Rachael L. Morton, Hal Morgenstern, Bruce M. Robinson and Jeffrey Perl

    Citation: BMC Nephrology 2019 20:116

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  41. Content type: Research article

    Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evalu...

    Authors: Philipp Russ, Martin Russwurm, Birgit Kortus-Goetze, Joachim Hoyer and Sahana Kamalanabhaiah

    Citation: BMC Nephrology 2019 20:114

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  42. Content type: Research article

    Health-related quality of life (HRQOL) is a key outcome for dialysis patients, and its assessment is mandated by the Centers for Medicaid and Medicare Services. The Kidney Disease Quality of Life (KDQOL-36™) s...

    Authors: Dena E. Cohen, Andrew Lee, Scott Sibbel, Deborah Benner, Steven M. Brunelli and Francesca Tentori

    Citation: BMC Nephrology 2019 20:112

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  43. Content type: Research article

    The Kidney Failure Risk Equation (KFRE) predicts risk of progression to kidney failure and is used to guide clinical decisions for patients with chronic kidney disease (CKD).

    Authors: Michelle D. Smekal, Helen Tam-Tham, Juli Finlay, Maoliosa Donald, Chandra Thomas, Robert G. Weaver, Robert R. Quinn, Kin Tam, Braden J. Manns, Marcello Tonelli, Aminu Bello, Navdeep Tangri and Brenda R. Hemmelgarn

    Citation: BMC Nephrology 2019 20:110

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  44. Content type: Research article

    Maximal conservative management (MCM) may be an appropriate alternative option for dialysis in some elderly patients with end-stage kidney disease (ESKD). Evidence about the impact of dialysis or MCM on qualit...

    Authors: I. N. van Loon, N. A. Goto, F. T. J. Boereboom, M. C. Verhaar, M. L. Bots and M. E. Hamaker

    Citation: BMC Nephrology 2019 20:108

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  45. Content type: Research article

    In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo mal...

    Authors: Martina Taborelli, Federica Toffolutti, Stefania Del Zotto, Elena Clagnan, Lucrezia Furian, Pierluca Piselli, Franco Citterio, Loris Zanier, Giuliano Boscutti and Diego Serraino

    Citation: BMC Nephrology 2019 20:107

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  46. Content type: Research article

    Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a...

    Authors: Inayat Ur Rehman, Pauline Siew Mei Lai, Soo Kun Lim, Learn Han Lee and Tahir Mehmood Khan

    Citation: BMC Nephrology 2019 20:102

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