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Epidemiology and Health Outcomes

Section edited by Bernard Jaar and Deputy Section Editor Laura Plantinga

The Epidemiology and Health Outcomes section considers manuscripts describing epidemiological studies relating to the field of nephrology. The section also considers systematic reviews and meta-analyses. Both qualitative and quantitative studies discussing health outcomes research and outcome measures are also considered by this section. Research related to clinical practice guidelines should be directed to the dedicated Guidelines and Policy section.

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  1. Patients receiving chronic hemodialysis treatments are at a higher risk of fracture compared to the general population. While the use of heparin during dialysis is crucial to avoid thrombosis of the extracorpo...

    Authors: Hind Harrak, Emilie René, Noor Alsalemi, Naoual Elftouh and Jean-Philippe Lafrance

    Citation: BMC Nephrology 2020 21:261

    Content type: Research article

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  2. The impact of anemia treatment with erythropoietin stimulating agents (ESA) on health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients is controversial, particularly regarding optimal h...

    Authors: Murilo Guedes, Camila R. Guetter, Lucas H. O. Erbano, Andre G. Palone, Jarcy Zee, Bruce M. Robinson, Ronald Pisoni, Thyago Proença de Moraes, Roberto Pecoits-Filho and Cristina P. Baena

    Citation: BMC Nephrology 2020 21:259

    Content type: Research article

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  3. Renal replacement therapy (RRT) places a burden on patients, and geographical relocation for easier access to healthcare facilities is a necessity for some. Incidence and factors associated with relocation has...

    Authors: Hicham I Cheikh Hassan, Jenny HC Chen and Karumathil Murali

    Citation: BMC Nephrology 2020 21:249

    Content type: Research article

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  4. Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus (SLE) that affects approximately 40% of patients. Pathogenic immune complexes that are characteristic of LN deposit in the kidney an...

    Authors: Rachael D. Wright, Fariba Bannerman, Michael W. Beresford and Louise Oni

    Citation: BMC Nephrology 2020 21:245

    Content type: Research article

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  5. Several studies have reported that lower body mass index (BMI) is associated with high mortality in patients with chronic kidney disease (CKD). Rate of infection-related death in CKD patients is increasing. Ho...

    Authors: Tae Yamamoto, Masaaki Nakayama, Mariko Miyazaki, Hiroshi Sato, Masato Matsushima, Toshinobu Sato and Sadayoshi Ito

    Citation: BMC Nephrology 2020 21:244

    Content type: Research article

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  6. The extension of the interdialytic interval due to due to dialysis session non-attendance varies according to which session of the week the patient misses. The impact of this on subsequent hospitalization and ...

    Authors: James Fotheringham, Michael T. Smith, Marc Froissart, Florian Kronenberg, Peter Stenvinkel, Jürgen Floege, Kai-Uwe Eckardt and David C. Wheeler

    Citation: BMC Nephrology 2020 21:218

    Content type: Research article

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  7. There are a growing number of studies on ethnic differences in progression and mortality for pre-dialysis chronic kidney disease (CKD), but this literature has yet to be synthesised, particularly for studies o...

    Authors: Hilda O. Hounkpatin, Simon D. S. Fraser, Rory Honney, Gavin Dreyer, Alison Brettle and Paul J. Roderick

    Citation: BMC Nephrology 2020 21:217

    Content type: Research article

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  8. There is mounting evidence that individuals with kidney disease and kidney stones have an abnormal gut microbiota composition. No studies to date have summarised the evidence to categorise how the gut microbio...

    Authors: Jordan Stanford, Karen Charlton, Anita Stefoska-Needham, Rukayat Ibrahim and Kelly Lambert

    Citation: BMC Nephrology 2020 21:215

    Content type: Research article

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  9. Physical inactivity and sedentary behaviour (too much sitting) can contribute to renal dysfunction. However, the potential benefits of behavioural change (e.g. replacing sedentary behaviour with physical activ...

    Authors: Keisei Kosaki, Koichiro Tanahashi, Masahiro Matsui, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, David W. Dunstan, Neville Owen, Ai Shibata, Koichiro Oka and Seiji Maeda

    Citation: BMC Nephrology 2020 21:211

    Content type: Research article

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  10. Peritoneal dialysis (PD) is a home-based therapy performed by patients or their relatives in numerous cases, and the role of patients’ educational practices in the risk of peritonitis is not well assessed. Our...

    Authors: Hélène Bonnal, Clémence Bechade, Annabel Boyer, Thierry Lobbedez, Sonia Guillouët, Christian Verger, Maxence Ficheux and Antoine Lanot

    Citation: BMC Nephrology 2020 21:205

    Content type: Research article

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  11. Urological malignancy (UM) in patients with chronic kidney disease (CKD) is an added burden to their overall morbidity and mortality. UM is itself a common cause of CKD. Understanding the associations of UM wi...

    Authors: Rajkumar Chinnadurai, Noel W. Clarke and Philip A. Kalra

    Citation: BMC Nephrology 2020 21:202

    Content type: Research article

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  12. To examine the prevalence of chronic kidney disease (CKD) and its associations in a Russian population.

    Authors: Mukharram M. Bikbov, Rinat M. Zainullin, Gyulli M. Kazakbaeva, Timur R. Gilmanshin, Ellina M. Rakhimova, Iulia A. Rusakova, Natalia I. Bolshakova, Kamila R. Safiullina, Songhomitra Panda-Jonas, Dilya F. Yakupova, Nikolai A. Nikitin and Jost B. Jonas

    Citation: BMC Nephrology 2020 21:198

    Content type: Research article

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  13. Currently, there is limited epidemiology data on acute kidney injury (AKI) in Indonesia. Therefore, we assessed the incidence of AKI and the utilization of renal replacement therapy (RRT) in Indonesia.

    Authors: Jonny Jonny, Moch Hasyim, Vedora Angelia, Ayu Nursantisuryani Jahya, Lydia Permata Hilman, Venna Febrian Kusumaningrum and Nattachai Srisawat

    Citation: BMC Nephrology 2020 21:191

    Content type: Research article

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  14. There is a lack of empirical effort that systematically investigates the clustering of comorbidity among known risk factors (obesity, hypertension, diabetes, hypercholesterolemia, and elevated inflammation) of...

    Authors: Agus Surachman, Jonathan Daw, Bethany C. Bray, Lacy M. Alexander, Christopher L. Coe and David M. Almeida

    Citation: BMC Nephrology 2020 21:188

    Content type: Research article

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  15. Burnout syndrome in physicians is associated with adverse patient safety events, poorer quality of care and reduced patients’ satisfaction. There has been scarce information on the risk factors of burnout affe...

    Authors: Ewa Pawłowicz and Michał Nowicki

    Citation: BMC Nephrology 2020 21:177

    Content type: Research article

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  16. Impaired kidney function is the hallmark of chronic kidney disease (CKD), and is associated with increased risk of all-cause mortality in the elderly. In the present cross-sectional population-based study, we ...

    Authors: Horng-Jinh Chang, Kuan-Reng Lin, Meng-Te Lin and Junn-Liang Chang

    Citation: BMC Nephrology 2020 21:169

    Content type: Research article

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  17. Studies of progression of kidney dysfunction typically focus on renal replacement therapy or percentage decline in estimated glomerular filtration rate (eGFR) as outcomes. Our aim was to compare real-world pat...

    Authors: Gregory A. Nichols, Anouk Déruaz-Luyet, Kimberly G. Brodovicz, Teresa M. Kimes, A. Gabriela Rosales and Sibylle J. Hauske

    Citation: BMC Nephrology 2020 21:167

    Content type: Research article

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  18. Limited data suggest serum chloride levels associate with mortality in heart failure, chronic kidney disease (CKD), and pulmonary arterial hypertension. Randomized trials have also shown that administration of...

    Authors: Minesh Khatri, Joshua Zitovsky, Dale Lee, Kamal Nayyar, Melissa Fazzari and Candace Grant

    Citation: BMC Nephrology 2020 21:165

    Content type: Research article

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  19. Patients who were diagnosed with hematologic malignancies (HM) had a higher risk of acute kidney injury (AKI). This study applies the Bayesian networks (BNs) to investigate the interrelationships between AKI a...

    Authors: Yang Li, Xiaohong Chen, Yimei Wang, Jiachang Hu, Ziyan Shen and Xiaoqiang Ding

    Citation: BMC Nephrology 2020 21:162

    Content type: Research article

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  20. To measure health-related and care-related quality of life among informal caregivers of older people with end-stage kidney disease (ESKD), and to determine the association between caregiver quality of life and...

    Authors: Karan K. Shah, Fliss E. M. Murtagh, Kevin McGeechan, Susan M. Crail, Aine Burns and Rachael L. Morton

    Citation: BMC Nephrology 2020 21:160

    Content type: Research article

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  21. The oral health of patients undergoing renal replacement therapy (RRT) is insufficient. Poor oral health and its components can affect the oral health-related quality of life (OHRQoL) of these patients. The ai...

    Authors: Gerhard Schmalz, Susann Patschan, Daniel Patschan and Dirk Ziebolz

    Citation: BMC Nephrology 2020 21:154

    Content type: Research article

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  22. With the development and progression of genetic technology, preimplantation genetic testing (PGT) has made it possible to block the inheritance of autosomal dominant polycystic kidney disease (ADPKD) as early ...

    Authors: Mingji Sun, Cheng Xue, Yunhui Lu, Yiyi Ma, Ting Pan, Xiaoliu Wang, Li Fan, Jiandong Shen, Yan Hao, Danxia Zheng, Junhua Li, Mingxu Li, Yaping He and Changlin Mei

    Citation: BMC Nephrology 2020 21:147

    Content type: Research article

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  23. The relationship between kidney function and hearing loss has long been recognized, but evidence of this association mostly comes from small observational studies or other populations. The aim of this study is...

    Authors: Wenwen Liu, Qinqin Meng, Yafeng Wang, Chao Yang, Lili Liu, Huaiyu Wang, Zaiming Su, Guilan Kong, Yaohui Zhao and Luxia Zhang

    Citation: BMC Nephrology 2020 21:145

    Content type: Research article

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  24. Use of rituximab (RTX) for focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is widely described in children. Clinical evidence in adults is limited. The objective of this study was to...

    Authors: Panupong Hansrivijit, Wisit Cheungpasitporn, Charat Thongprayoon and Nasrollah Ghahramani

    Citation: BMC Nephrology 2020 21:134

    Content type: Research article

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  25. Although the prevalence of kidney disease is higher in those with reduced lung function, the longitudinal relationship between low lung function and future risk of chronic kidney disease (CKD) has not been wid...

    Authors: Suneela Zaigham, Anders Christensson, Per Wollmer and Gunnar Engström

    Citation: BMC Nephrology 2020 21:124

    Content type: Research article

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  26. Few chronic kidney disease (CKD) risk prediction models have been investigated in low- and middle-income areas worldwide. We developed new risk scores for predicting incident CKD in low- and middle-income rura...

    Authors: Jiangping Wen, Jie Hao, Ye Zhang, Kai Cao, Xiaohong Zhang, Jiang Li, Xinxin Lu and Ningli Wang

    Citation: BMC Nephrology 2020 21:120

    Content type: Research article

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  27. Little is known about the relationship between acute kidney injury (AKI) and outcomes after acute exacerbation of chronic obstructive pulmonary disease (AECOPD). We aimed to investigate associations between AK...

    Authors: Atsushi Hirayama, Tadahiro Goto and Kohei Hasegawa

    Citation: BMC Nephrology 2020 21:116

    Content type: Research article

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  28. This study was conducted to evaluate and update the current prevalence of and risk factors for chronic kidney disease (CKD) and diabetic kidney disease (DKD) in a central Chinese urban population.

    Authors: Jia-Yu Duan, Guang-Cai Duan, Chong-Jian Wang, Dong-Wei Liu, Ying-Jin Qiao, Shao-Kang Pan, Deng-Ke Jiang, Yong Liu, Zi-Hao Zhao, Lu-Lu Liang, Fei Tian and Zhang-Suo Liu

    Citation: BMC Nephrology 2020 21:115

    Content type: Research article

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  29. High water hardness associated with high water fluoride and the geographical distribution of Chronic Kidney Disease of unknown etiology (CKDu) in Sri Lanka are well correlated. We undertook this study to obser...

    Authors: Thanusha Perera, Shirani Ranasinghe, Neil Alles and Roshitha Waduge

    Citation: BMC Nephrology 2020 21:103

    Content type: Research article

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  30. Little is known about the changes in disease makers and risk factors in patients with chronic kidney disease (CKD) under nephrological care in Africa. This study aimed to evaluate the baseline level of markers...

    Authors: Halle Marie Patrice, Kengne Andre Pascal, Kaze Folefack François, Djantio Hilaire, Doualla Marie Solange, Ashuntantang Enow Gloria and Choukem Siméon Pierre

    Citation: BMC Nephrology 2020 21:101

    Content type: Research article

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  31. Chronic kidney disease (CKD) is growing population health concern worldwide, and with early identification and effective management, kidney disease progression can be slowed or prevented. Most patients with ri...

    Authors: Elizabeth P. Neale, Justin Middleton and Kelly Lambert

    Citation: BMC Nephrology 2020 21:83

    Content type: Research article

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  32. In low-middle-income countries (LMICs), data regarding acute kidney injury (AKI) are scarce. AKI patients experience delayed diagnosis. This study aimed to evaluate whether delayed nephrologist consultation (N...

    Authors: Ginivaldo Victor Ribeiro do Nascimento, Marcela do Nascimento Silva, Juarez Duarte de Carvalho Neto, Ludgero Ribeiro Feitosa Filho and Jessica Duarte Antão

    Citation: BMC Nephrology 2020 21:94

    Content type: Research article

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  33. Chronic kidney disease (CKD) has been identified as a significant direct marker for cognitive decline, but controversy exists regarding the magnitude of the association of kidney function with cognitive declin...

    Authors: Laurien E. Zijlstra, Stella Trompet, Simon P. Mooijaart, Marjolijn van Buren, Naveed Sattar, David J. Stott and J. Wouter Jukema

    Citation: BMC Nephrology 2020 21:81

    Content type: Research article

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  34. Limited evidence has indicated that addition of a steroidal mineralocorticoid receptor antagonist (MRA) to the standard of care reduces proteinuria in patients with diabetic kidney disease (DKD); however, ther...

    Authors: Michael Blankenburg, Csaba P. Kovesdy, Anne-Kathrin Fett, Raymond G. Griner and Alain Gay

    Citation: BMC Nephrology 2020 21:61

    Content type: Research article

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  35. The use of peritoneal dialysis (PD) has increased substantially in the United States (US) in the past decade. This was likely spurred in large part by the implementation of the expanded prospective payment sys...

    Authors: Keiko I. Greenberg and Bernard G. Jaar

    Citation: BMC Nephrology 2020 21:39

    Content type: Commentary

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  36. Tissue derived biomarkers may offer utility as indicators of accumulated damage. Reduced thickness of retinal neuronal tissue and the vascular choroid have previously been associated with vascular damage and d...

    Authors: Euan N. Paterson, Meera L. Ravindran, Kayleigh Griffiths, Claire A. Le Velly, Chris C. Cardwell, Rachel V. McCarter, Patrick Nicol, Jay K. Chhablani, Mohammed Abdul Rasheed, Kiran Kumar Vupparaboina, Thomas J. MacGillivray, Mark Harbinson, Alexander P. Maxwell, Ruth E. Hogg and Gareth J. McKay

    Citation: BMC Nephrology 2020 21:37

    Content type: Research article

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  37. Hypothyroidism is highly prevalent in patients with chronic kidney disease (CKD) and has been associated with poorer clinical outcomes, including faster decline of kidney function. However, there is no consens...

    Authors: Alexandre Barbosa Câmara de Souza, Marcia Fernanda Arantes, Roberto Zatz, Rosilene Motta Elias, Roberto Iglesias Lopes and Etienne Macedo

    Citation: BMC Nephrology 2020 21:36

    Content type: Research article

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  38. To assess whether the agreement between fasting glucose and glycated proteins is affected by chronic kidney disease (CKD) in a community-based sample of 1621 mixed-ancestry South Africans.

    Authors: Cindy George, Tandi E. Matsha, Marizna Korf, Annalise E. Zemlin, Rajiv T. Erasmus and Andre P. Kengne

    Citation: BMC Nephrology 2020 21:32

    Content type: Research article

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  39. Glomerular filtration rate (GFR) is a valid indicator of kidney function. Different factors can affect GFR. The purpose of this study is to assess the direct and indirect effects of GFR-related factors using s...

    Authors: Parastoo Jamshidi, Farid Najafi, Shayan Mostafaei, Ebrahem Shakiba, Yahya Pasdar, Behrooz Hamzeh and Mehdi Moradinazar

    Citation: BMC Nephrology 2020 21:30

    Content type: Research article

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  40. Despite the high and rising burden of chronic kidney disease (CKD) in South Asia, factors that influence access to CKD care at the community level have not been studied previously, especially in the rural area...

    Authors: Tazeen Hasan Jafar, Chandrika Ramakrishnan, Oommen John, Abha Tewari, Benjamin Cobb, Helena Legido-Quigley, Yoon Sungwon and Vivekanand Jha

    Citation: BMC Nephrology 2020 21:26

    Content type: Research article

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  41. Record linkage is increasingly used in health research worldwide. Combining the patient information available in healthcare, administrative and clinical databases broadens the research perspectives, particular...

    Authors: Maxime Raffray, Sahar Bayat, Mathilde Lassalle and Cécile Couchoud

    Citation: BMC Nephrology 2020 21:25

    Content type: Technical advance

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  42. Estimating CKD prevalence is difficult. Information on CKD prevalence is rather scanty in Italy and available figures come from surveys in selected geographical areas. Administrative data have been already dem...

    Authors: Claudia Marino, Pietro Manuel Ferraro, Matteo Bargagli, Silvia Cascini, Nera Agabiti, Giovanni Gambaro and Marina Davoli

    Citation: BMC Nephrology 2020 21:23

    Content type: Research article

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  43. Chronic kidney disease (CKD) is a substantial cause of morbidity and mortality worldwide with disproportionate effects in sub-Saharan Africa (SSA). The optimal methods to estimate glomerular filtration rate (G...

    Authors: Robert Kalyesubula, June Fabian, Wisdom Nakanga, Robert Newton, Billy Ssebunnya, Josephine Prynn, Jaya George, Alisha N. Wade, Janet Seeley, Dorothea Nitsch, Christian Hansen, Moffat Nyirenda, Liam Smeeth, Saraladevi Naicker, Amelia C. Crampin and Laurie A. Tomlinson

    Citation: BMC Nephrology 2020 21:20

    Content type: Study protocol

    Published on:

  44. End stage kidney disease and hemodialysis dependence are associated with impairments in health-related quality of life (HRQOL), which may be related to vascular access (VA). Few HRQOL measures are VA-specific ...

    Authors: Robert J. Nordyke, Gina Nicholson, Shawn M. Gage, Ted Lithgow, Jonathan Himmelfarb, Matthew B. Rivara, Ron D. Hays, Karen Woo and John Devin Peipert

    Citation: BMC Nephrology 2020 21:16

    Content type: Research article

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