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Epidemiology and Health Outcomes

The Epidemiology and Health Outcomes section considers manuscripts describing epidemiological studies relating to the field of nephrology. The section also considers systematic reviews and meta-analyses. Both qualitative and quantitative studies discussing health outcomes research and outcome measures are also considered by this section. Research related to clinical practice guidelines should be directed to the dedicated Guidelines and Policy section.

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  1. Acid-base imbalance might promote the progression of chronic kidney disease (CKD), but whether nutrient-derived dietary acid load increases the risk of albuminuria or even high normoalbuminuria is unclear.

    Authors: Keiko Kabasawa, Michihiro Hosojima, Ribeka Takachi, Kazutoshi Nakamura, Yumi Ito, Akihiko Saito, Norie Sawada, Shoichiro Tsugane, Junta Tanaka and Ichiei Narita

    Citation: BMC Nephrology 2019 20:194

    Content type: Research article

    Published on:

  2. Vitamin D deficiency is an important health concern because it is related to several comorbidities and mortality. However, its relationship with the risk of hematuria remains undetermined in the general popula...

    Authors: Hyunjin Ryu, Hyunjeong Cho, Yun Kyu Oh, Kwon Wook Joo, Yon Su Kim, Curie Ahn and Seung Seok Han

    Citation: BMC Nephrology 2019 20:187

    Content type: Research article

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  3. A classification tree model (CT-PIRP) was developed in 2013 to predict the annual renal function decline of patients with chronic kidney disease (CKD) participating in the PIRP (Progetto Insufficienza Renale P...

    Authors: Dino Gibertoni, Paola Rucci, Marcora Mandreoli, Mattia Corradini, Davide Martelli, Giorgia Russo, Elena Mancini and Antonio Santoro

    Citation: BMC Nephrology 2019 20:177

    Content type: Research article

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  4. Steroidal mineralocorticoid receptor antagonists (MRAs) are recommended for the treatment of heart failure (HF) and resistant hypertension, both common comorbidities in patients with diabetes and chronic kidne...

    Authors: Michael Blankenburg, Anne-Kathrin Fett, Seline Eisenring, Gabriele Haas and Alain Gay

    Citation: BMC Nephrology 2019 20:171

    Content type: Research article

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  5. As patients on daily hemodialysis (DHD) have heterogeneous profiles, DHD benefit in terms of survival is still debated. The aim of this study was to compare DHD practices in France and in Australia and New Zea...

    Authors: Adélaïde Pladys, Sahar Bayat, Cécile Couchoud, Cécile Vigneau and Stephen McDonald

    Citation: BMC Nephrology 2019 20:156

    Content type: Research article

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  6. Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation st...

    Authors: Naren Kumar Surendra, Mohd Rizal Abdul Manaf, Lai Seong Hooi, Sunita Bavanandan, Fariz Safhan Mohamad Nor, Shahnaz Shah Firdaus Khan, Loke Meng Ong and Abdul Halim Abdul Gafor

    Citation: BMC Nephrology 2019 20:151

    Content type: Research article

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  7. Fewer trainees are choosing to pursue nephrology. Only 60.1% of positions filled in the 2018 fellowship Match, which is concerning given the rising prevalence of end-stage kidney disease. Identifying factors i...

    Authors: Devika Nair, Kurtis A. Pivert, Adrian Baudy IV and Charuhas V. Thakar

    Citation: BMC Nephrology 2019 20:146

    Content type: Research article

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  8. Self-management intervention aims to facilitate an individual’s ability to make lifestyle changes. The effectiveness of this intervention in non-dialysis patients with chronic kidney disease (CKD) is limited. ...

    Authors: Suyuan Peng, Jiawei He, Jiasheng Huang, Longwei Lun, Jiahao Zeng, Shan Zeng, La Zhang, Xusheng Liu and Yifan Wu

    Citation: BMC Nephrology 2019 20:142

    Content type: Research article

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  9. The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represe...

    Authors: Hayley Bennett, Phil McEwan, Karina Hamilton and Karl O’Reilly

    Citation: BMC Nephrology 2019 20:136

    Content type: Research article

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  10. The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and...

    Authors: Gwang Sil Kim, Hyun Ho Oh, Sang Hyun Kim, Byung Ok Kim and Young Sup Byun

    Citation: BMC Nephrology 2019 20:130

    Content type: Research article

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  11. Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. However, little is k...

    Authors: Hyo Jin Kim, Joongyub Lee, Dong-Wan Chae, Kyu-Beck Lee, Su Ah Sung, Tae-Hyun Yoo, Seung Hyeok Han, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2019 20:119

    Content type: Research article

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  12. Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate es...

    Authors: Sachimi Kubo, Yoko Nishida, Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Takumi Hirata, Naomi Miyamatsu, Ayumi Tanabe, Aya Hirata, Yukako Tatsumi, Aya Kadota, Kazuyo Kuwabara, Tomofumi Nishikawa, Yoshihiro Miyamoto and Tomonori Okamura

    Citation: BMC Nephrology 2019 20:117

    Content type: Research article

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  13. Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the ...

    Authors: Nidhi Sukul, Junhui Zhao, Douglas S. Fuller, Angelo Karaboyas, Brian Bieber, James A. Sloand, Lalita Subramanian, David W. Johnson, Matthew J. Oliver, Kriang Tungsanga, Tadashi Tomo, Rachael L. Morton, Hal Morgenstern, Bruce M. Robinson and Jeffrey Perl

    Citation: BMC Nephrology 2019 20:116

    Content type: Research article

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  14. Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evalu...

    Authors: Philipp Russ, Martin Russwurm, Birgit Kortus-Goetze, Joachim Hoyer and Sahana Kamalanabhaiah

    Citation: BMC Nephrology 2019 20:114

    Content type: Research article

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  15. Health-related quality of life (HRQOL) is a key outcome for dialysis patients, and its assessment is mandated by the Centers for Medicaid and Medicare Services. The Kidney Disease Quality of Life (KDQOL-36™) s...

    Authors: Dena E. Cohen, Andrew Lee, Scott Sibbel, Deborah Benner, Steven M. Brunelli and Francesca Tentori

    Citation: BMC Nephrology 2019 20:112

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Nephrology 2019 20:461

    The Correspondence to this article has been published in BMC Nephrology 2019 20:447

  16. The Kidney Failure Risk Equation (KFRE) predicts risk of progression to kidney failure and is used to guide clinical decisions for patients with chronic kidney disease (CKD).

    Authors: Michelle D. Smekal, Helen Tam-Tham, Juli Finlay, Maoliosa Donald, Chandra Thomas, Robert G. Weaver, Robert R. Quinn, Kin Tam, Braden J. Manns, Marcello Tonelli, Aminu Bello, Navdeep Tangri and Brenda R. Hemmelgarn

    Citation: BMC Nephrology 2019 20:110

    Content type: Research article

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  17. Maximal conservative management (MCM) may be an appropriate alternative option for dialysis in some elderly patients with end-stage kidney disease (ESKD). Evidence about the impact of dialysis or MCM on qualit...

    Authors: I. N. van Loon, N. A. Goto, F. T. J. Boereboom, M. C. Verhaar, M. L. Bots and M. E. Hamaker

    Citation: BMC Nephrology 2019 20:108

    Content type: Research article

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  18. In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo mal...

    Authors: Martina Taborelli, Federica Toffolutti, Stefania Del Zotto, Elena Clagnan, Lucrezia Furian, Pierluca Piselli, Franco Citterio, Loris Zanier, Giuliano Boscutti and Diego Serraino

    Citation: BMC Nephrology 2019 20:107

    Content type: Research article

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  19. Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a...

    Authors: Inayat Ur Rehman, Pauline Siew Mei Lai, Soo Kun Lim, Learn Han Lee and Tahir Mehmood Khan

    Citation: BMC Nephrology 2019 20:102

    Content type: Research article

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  20. Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout its...

    Authors: Jasvinder A. Singh and John D. Cleveland

    Citation: BMC Nephrology 2019 20:93

    Content type: Research article

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  21. Real-world incidence, clinical consequences, and healthcare resource utilization (HRU) of hyperkalemia (HK) remain poorly characterized, particularly in patients with specific comorbidities.

    Authors: Laura Horne, Akhtar Ashfaq, Sharon MacLachlan, Marvin Sinsakul, Lei Qin, Robert LoCasale and James B. Wetmore

    Citation: BMC Nephrology 2019 20:85

    Content type: Research article

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  22. People with Chronic Kidney Disease (CKD) often present with prevalent gait impairment and high fall rates, particularly in advanced CKD stages. Gait impairment and its consequences is associated with increased...

    Authors: Damiano D. Zemp, Olivier Giannini, Pierluigi Quadri and Eling D. de Bruin

    Citation: BMC Nephrology 2019 20:83

    Content type: Research article

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  23. DOPPS reported that thousands of life-years could be gained in the US and Europe over 5 years by correcting six modifiable haemodialysis practices. We estimated potential life-years gained across 10 European c...

    Authors: Christian Combe, Johannes Mann, David Goldsmith, Frank Dellanna, Philippe Zaoui, Gérard London, Kris Denhaerynck, Andriy Krendyukov, Ivo Abraham and Karen MacDonald

    Citation: BMC Nephrology 2019 20:81

    Content type: Research article

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  24. Electronic health record (EHR) based chronic kidney disease (CKD) registries are central to population health strategies to improve CKD care. In 2015, Partners Healthcare System (PHS), encompassing multiple ac...

    Authors: Mallika L. Mendu, Salman Ahmed, Jason K. Maron, Sandhya K. Rao, Sreekanth K. Chaguturu, Megan F. May, Walter P. Mutter, Kelly A. Burdge, David J. R. Steele, David B. Mount, Sushrut S. Waikar, Jeffrey B. Weilburg and Thomas D. Sequist

    Citation: BMC Nephrology 2019 20:72

    Content type: Research article

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  25. Epidemiologic data of acute kidney injury (AKI) during pregnancy is lacking in China. This study aims to determine the effect of pregnancy on the risk of AKI among hospitalized women of childbearing age, and t...

    Authors: Diankun Liu, Wenjuan He, Yanqin Li, Mengqi Xiong, Long Wang, Jingxin Huang, Ling Jia, Shuling Yuan and Sheng Nie

    Citation: BMC Nephrology 2019 20:67

    Content type: Research article

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  26. Circulating C3 has been associated with diabetes and hypertension, which are the leading causes of chronic kidney disease (CKD). C3 activation is considered to contribute to several renal diseases. Here we exa...

    Authors: Xue Bao, Yan Borné, Iram Faqir Muhammad, Christina-Alexandra Schulz, Margaretha Persson, Marju Orho-Melander, Kaijun Niu, Anders Christensson and Gunnar Engström

    Citation: BMC Nephrology 2019 20:61

    Content type: Research article

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  27. The incidence of Acute Kidney Injury (AKI) continues to increase in the UK, with associated mortality rates remaining significant. Approximately one fifth of hospital admissions are associated with AKI and app...

    Authors: Anastasios Argyropoulos, Stuart Townley, Paul M. Upton, Stephen Dickinson and Adam S. Pollard

    Citation: BMC Nephrology 2019 20:56

    Content type: Research article

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  29. Adherence to the diet prescription for chronic kidney disease is suboptimal. Interventions to improve dietary adherence suggest that improving communication between the patient and the health professional is f...

    Authors: Kelly Lambert, Tsz Kwan Lau, Sarah Davison, Holly Mitchell, Alex Harman and Mandy Carrie

    Citation: BMC Nephrology 2019 20:48

    Content type: Research article

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  30. Pruritus is a distressing, life-limiting symptom in chronic renal failure, affecting 40% of patients. This study aimed to determine uremic pruritus prevalence and investigate the multidimensional impact on hem...

    Authors: Nese Altınok Ersoy and İmatullah Akyar

    Citation: BMC Nephrology 2019 20:42

    Content type: Research article

    Published on:

  31. Older people with advanced kidney disease require information and support from clinicians when deciding whether to have dialysis or conservative (non-dialysis) care. There is evidence that communication practi...

    Authors: Lucy Ellen Selman, Katherine Bristowe, Irene J. Higginson and Fliss E. M. Murtagh

    Citation: BMC Nephrology 2019 20:38

    Content type: Research article

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  32. Innovative care models such as public-private partnerships (PPPs) may help meet the challenge of providing cost-effective high-quality care for the steadily growing and complex chronic kidney disease populatio...

    Authors: L. A. Pedrini, A. C. Winter, F. Cerino, A. M. Zawada, M. Garbelli, A. Feuersenger, A. Feliciani, P. Ruggiero, S. Civardi, C. Amato, B. Canaud, S. Stuard, A. Karch and A. Gauly

    Citation: BMC Nephrology 2019 20:35

    Content type: Research article

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  33. Electronic health records (EHR) detect the onset of acute kidney injury (AKI) in hospitalized patients, and may identify those at highest risk of mortality and renal replacement therapy (RRT), for earlier targ...

    Authors: Sanmay Low, Anantharaman Vathsala, Tanusya Murali Murali, Long Pang, Graeme MacLaren, Wan-Ying Ng, Sabrina Haroon, Amartya Mukhopadhyay, Shir-Lynn Lim, Bee-Hong Tan, Titus Lau and Horng-Ruey Chua

    Citation: BMC Nephrology 2019 20:32

    Content type: Research article

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  34. People with chronic kidney disease (CKD) are at an increased risk of developing hyperkalaemia due to their declining kidney function. In addition, these patients are often required to reduce or discontinue gui...

    Authors: Marc Evans, Eirini Palaka, Hans Furuland, Hayley Bennett, Cecilia Linde, Lei Qin, Phil McEwan and Ameet Bakhai

    Citation: BMC Nephrology 2019 20:31

    Content type: Research article

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  35. After two-years of follow-up of 263 apparently healthy 18- to 30-year-old men in communities affected by Mesoamerican nephropathy (MeN), we identified three distinct case groups: a subgroup with (i) establishe...

    Authors: Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Neil Pearce, Ben Caplin and Dorothea Nitsch

    Citation: BMC Nephrology 2019 20:21

    Content type: Research article

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  37. Use of routine medical care (RMC) is advocated to address ethnic/racial disparities in chronic kidney disease (CKD) risks, but use is less frequent among African Americans. Factors associated with low RMC use ...

    Authors: Clarissa J. Diamantidis, Clemontina A. Davenport, Joseph Lunyera, Nrupen Bhavsar, Julia Scialla, Rasheeda Hall, Crystal Tyson, Mario Sims, Tara Strigo, Neil R. Powe and L. Ebony Boulware

    Citation: BMC Nephrology 2019 20:11

    Content type: Research article

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  38. There is a paucity of specific data on early stages of chronic kidney disease (CKD) among Asian Americans (AAs). The objective of this study was to examine the independent association of Asian race/ethnicity a...

    Authors: Merle Kataoka-Yahiro, James Davis, Krupa Gandhi, Connie M. Rhee and Victoria Page

    Citation: BMC Nephrology 2019 20:10

    Content type: Research article

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  39. Experimental studies have shown that exposure to incense burning may have deleterious effects on kidney function and architecture. However, the association between chronic exposure to incense smoke and risk of...

    Authors: Ting-Ting Geng, Tazeen Hasan Jafar, Jian-Min Yuan and Woon-Puay Koh

    Citation: BMC Nephrology 2019 20:9

    Content type: Research article

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  40. The optimal treatment algorithm for iron therapy and the use of erythropoiesis-stimulating agents (ESA) in anemic hemodialysis (HD) patients has not been established. Hemoglobin (Hb) target levels can be achie...

    Authors: Maciej Drozdz, André Weigert, Fatima Silva, João Frazão, Abdulkareem Alsuwaida, Mahesh Krishnan, Werner Kleophas, Szymon Brzosko, Fredrik K. Johansson and Stefan H. Jacobson

    Citation: BMC Nephrology 2019 20:5

    Content type: Research article

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  41. Estimated glomerular filtration rate (eGFR) is the clinical standard for assessing kidney function and staging chronic kidney disease. Automated reporting of eGFR using the Modification of Diet in Renal Diseas...

    Authors: Kristine E. Lynch, Ji won Chang, Michael E. Matheny, Alexander Goldfarb, Olga Efimova, Gregorio Coronado and Scott L. DuVall

    Citation: BMC Nephrology 2018 19:380

    Content type: Research article

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  42. Recent studies have shown associations between contrast-induced acute kidney injury (CI-AKI) and increased risk of adverse clinical outcomes in acute coronary syndrome (ACS) patients undergoing percutaneous co...

    Authors: Yi Yang, Kaisha C. George, Ran Luo, Yichun Cheng, Weifeng Shang, Shuwang Ge and Gang Xu

    Citation: BMC Nephrology 2018 19:374

    Content type: Research article

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  43. IgA nephropathy (IgAN) is one of the most common forms of idiopathic glomerular diseases and might lead to end-stage kidney disease. Accurate and non-invasive biomarkers for early diagnosis are required for ea...

    Authors: Zhengguang Guo, Zhao Wang, Chen Lu, Shufen Yang, Haidan Sun, Reziw, Yu Guo, Wei Sun and Hua Yue

    Citation: BMC Nephrology 2018 19:358

    Content type: Research article

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  44. The effect of chronic hepatitis B virus (HBV) infection on the risk of chronic kidney disease (CKD) is controversial. We examined the prospective association between hepatitis B surface antigen (HBsAg) serolog...

    Authors: Yun Soo Hong, Seungho Ryu, Yoosoo Chang, Miguel Caínzos-Achirica, Min-Jung Kwon, Di Zhao, Tariq Shafi, Mariana Lazo, Roberto Pastor-Barriuso, Hocheol Shin, Juhee Cho and Eliseo Guallar

    Citation: BMC Nephrology 2018 19:353

    Content type: Research article

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  45. Surgery is one of the leading causes of acute kidney injury (AKI) in hospitalized patients. Major abdominal surgery has the second higher incidences of AKI, after cardiac surgery. AKI results from a complex in...

    Authors: Joana Gameiro, José Agapito Fonseca, Joana Monteiro Dias, Joana Milho, Rosário Rosa, Sofia Jorge and José António Lopes

    Citation: BMC Nephrology 2018 19:320

    Content type: Research article

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  46. The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovas...

    Authors: Haesuk Park, Xinyue Liu, Linda Henry, Jeffrey Harman and Edward A. Ross

    Citation: BMC Nephrology 2018 19:318

    Content type: Research article

    Published on:

  47. Patients with end stage renal disease have a high all-cause and cardiovascular mortality. Secondary hyperparathyroidism and vitamin D deficiency are considered part of the mechanism for the excess mortality ob...

    Authors: Jo-Yen Chao, Hsu-Chih Chien, Te-Hui Kuo, Yu-Tzu Chang, Chung-Yi Li, Ming-Cheng Wang and Yea-Huei Kao Yang

    Citation: BMC Nephrology 2018 19:309

    Content type: Research article

    Published on:

  49. Patients on hemodialysis are at high risk for hepatitis C virus (HCV) infection if measures for effective control of HCV infection in the hemodialysis environment are not implemented. Whereas in developed coun...

    Authors: Xhevat Jakupi, Jana Mlakar, Maja M. Lunar, Katja Seme, Ibrahim Rudhani, Lul Raka, Adriana Vince and Mario Poljak

    Citation: BMC Nephrology 2018 19:304

    Content type: Research article

    Published on:

  50. Recent studies have suggested that cardiometabolic index (CMI), a novel estimate of visceral adipose tissue, could be of use in the evaluation of cardiovascular risk factors. However, the potential utility and...

    Authors: Hao-Yu Wang, Wen-Rui Shi, Xin Yi, Shu-Ze Wang, Si-Yuan Luan and Ying-Xian Sun

    Citation: BMC Nephrology 2018 19:294

    Content type: Research article

    Published on:

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