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Epidemiology and Health Outcomes

Section edited by Bernard Jaar and Deputy Section Editor Laura Plantinga

The Epidemiology and Health Outcomes section considers manuscripts describing epidemiological studies relating to the field of nephrology. The section also considers systematic reviews and meta-analyses. Both qualitative and quantitative studies discussing health outcomes research and outcome measures are also considered by this section. Research related to clinical practice guidelines should be directed to the dedicated Guidelines and Policy section.

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  1. Acute kidney injury (AKI) is common in cirrhotic patients and is associated with negative outcomes. The aim of this study was to evaluate the presence of AKI and its progression according to KDIGO (Kidney Dise...

    Authors: Paulo Ricardo Gessolo Lins, Wallace Stwart Carvalho Padilha, Carolina Frade Magalhaes Giradin Pimentel, Marcelo Costa Batista and Aécio Flávio Teixeira de Gois

    Citation: BMC Nephrology 2018 19:277

    Content type: Research article

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  2. Utilization of home hemodialysis (HHD) is low in Europe. The Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) is a multi-center study of HHD patients who have used a transportable hemodialysis ma...

    Authors: Shashidhar Cherukuri, Maria Bajo, Giacomo Colussi, Roberto Corciulo, Hafedh Fessi, Maxence Ficheux, Maria Slon, Eric Weinhandl and Natalie Borman

    Citation: BMC Nephrology 2018 19:262

    Content type: Research article

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  3. Estimates of the incidence of glomerulonephritis (GN) and end-stage renal disease (ESRD) in an Iraqi population are compared with the United States (US) and Jordan.

    Authors: Alaa A Ali, Dana A Sharif, Safa E Almukhtar, Kais Hasan Abd, Zana Sidiq M Saleem and Michael D Hughson

    Citation: BMC Nephrology 2018 19:257

    Content type: Research article

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  4. Chronic Kidney Disease (CKD) is common and its prevalence has increased steadily over several decades. Monitoring of rates and severity of CKD across populations is critical for policy development and resource...

    Authors: Mariette J Chartier, Navdeep Tangri, Paul Komenda, Randy Walld, Ina Koseva, Charles Burchill, Kari-Lynne McGowan and Allison Dart

    Citation: BMC Nephrology 2018 19:255

    Content type: Research article

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  5. Few investigations have evaluated the incremental usefulness of multiple biomarkers representing varying physiological pathways for predicting risk of renal outcomes in African Americans.

    Authors: Stanford E. Mwasongwe, Bessie Young, Aurelian Bidulescu, Mario Sims, Adolfo Correa and Solomon K. Musani

    Citation: BMC Nephrology 2018 19:239

    Content type: Research article

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  6. Iron deficiency is highly prevalent in chronic kidney disease (CKD) patients. In clinical practice, iron deficiency is defined based on a combination of two commonly used markers, ferritin and transferrin satu...

    Authors: Michele F. Eisenga, Ilja M. Nolte, Peter van der Meer, Stephan J. L. Bakker and Carlo A. J. M. Gaillard

    Citation: BMC Nephrology 2018 19:225

    Content type: Research article

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  7. To address a current paucity of European data, this study developed equations to predict risks of mortality, major adverse cardiac events (MACE) and renin angiotensin-aldosterone system inhibitor (RAASi) disco...

    Authors: Hans Furuland, Phil McEwan, Marc Evans, Cecilia Linde, Daniel Ayoubkhani, Ameet Bakhai, Eirini Palaka, Hayley Bennett and Lei Qin

    Citation: BMC Nephrology 2018 19:211

    Content type: Research article

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  8. Obesity emerged as the leading global health concern in 2017. Although higher body mass index (BMI) is a health risk in the general population, its implications for chronic kidney disease (CKD) are not entirel...

    Authors: Samuel Chan, Anne Cameron, Zaimin Wang, Sree K. Venuthurupalli, Ken S. Tan, Helen G. Healy and Wendy E. Hoy

    Citation: BMC Nephrology 2018 19:209

    Content type: Research article

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  9. Minimal change disease (MCD) is a common cause of the nephrotic syndrome in adults with limited evidence on its treatment and prognosis. We examined the presenting characteristics, treatments, and outcomes of ...

    Authors: Anthony Fenton, Stuart W. Smith and Peter Hewins

    Citation: BMC Nephrology 2018 19:207

    Content type: Research article

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  10. Chronic kidney disease (CKD) is often asymptomatic in its early stages but is indicated and is diagnosed with an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73m2. Certain sociodemographic groups are...

    Authors: Irene Ma, Maggie Guo, Daniel Muruve, Hallgrimur Benediktsson and Christopher Naugler

    Citation: BMC Nephrology 2018 19:198

    Content type: Research article

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  11. Dialysis is often initiated in the hospital during episodes of acute kidney injury and critical illness. Little is known about how patients or their surrogate decision makers feel about dialysis initiation in ...

    Authors: Amar D. Bansal, Nina R. O’Connor and David J. Casarett

    Citation: BMC Nephrology 2018 19:197

    Content type: Research article

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  12. Both dialysis facilities and hospitals are accountable for 30-day hospital readmissions among U.S. hemodialysis patients. We examined the association of post-hospitalization processes of care at hemodialysis f...

    Authors: Laura C. Plantinga, Tahsin Masud, Janice P. Lea, John M. Burkart, Christopher M. O’Donnell and Bernard G. Jaar

    Citation: BMC Nephrology 2018 19:186

    Content type: Research article

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  13. Knowing how chronic kidney disease (CKD) patients talk about their encounters with providers (i.e., their discourse) can inform the important clinical goal of engaging patients in their chronic disease self-ma...

    Authors: Ann E. Vandenberg, Katharina V. Echt, Theodore M. Johnson II and C. Barrett Bowling

    Citation: BMC Nephrology 2018 19:183

    Content type: Research article

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  14. There are conflicting reports on the impact of HIV in the era of combined antiretroviral (c-ART) on survival of patient with ESKD. We aimed to compare the one-year survival of HIV positive patients to that of ...

    Authors: Marie Patrice Halle, Anais Mfoula Edjomo, Hermine Fouda, Hilaire Djantio, Noel Essomba and Gloria Enow Ashuntantang

    Citation: BMC Nephrology 2018 19:166

    Content type: Research article

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  15. According to the literature the three stone diseases, sialolithiasis (SL), urolithiasis (UL) and cholelithiasis (CL) share comorbidities. We assess familial and spouse risks between these stone disease and com...

    Authors: Kari Hemminki, Otto Hemminki, Anni I. M. Koskinen, Asta Försti, Kristina Sundquist, Jan Sundquist and Xinjun Li

    Citation: BMC Nephrology 2018 19:158

    Content type: Research article

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  16. Hematuria is associated with chronic kidney disease (CKD), but has rarely been examined as a risk factor for CKD progression. We explored whether individuals with hematuria had worse outcomes compared to those...

    Authors: Paula F. Orlandi, Naohiko Fujii, Jason Roy, Hsiang-Yu Chen, L. Lee Hamm, James H. Sondheimer, Jiang He, Michael J. Fischer, Hernan Rincon-Choles, Geetha Krishnan, Raymond Townsend, Tariq Shafi, Chi-yuan Hsu, John W. Kusek, John T. Daugirdas and Harold I. Feldman

    Citation: BMC Nephrology 2018 19:150

    Content type: Research article

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  17. Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether fac...

    Authors: Alan S. Go, Jingrong Yang, Thida C. Tan, Claudia S. Cabrera, Bergur V. Stefansson, Peter J. Greasley and Juan D. Ordonez

    Citation: BMC Nephrology 2018 19:146

    Content type: Research article

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  18. This study describes the time trend of renal replacement therapy for end-stage renal disease (ESRD) in the Provence-Alpes Côte d’Azur region (PACA) between 2004 and 2015, and forecasts up to 2030.

    Authors: Anne-Claire Durand, Elisabeth Jouve, Jean-Christophe Delarozière, Mohamed Boucekine, Ghizlane Izaaryene, Adeline Crémades, Franck Mazoué, Bénédicte Devictor, Asmatullah Kakar, Roland Sambuc, Philippe Brunet and Stéphanie Gentile

    Citation: BMC Nephrology 2018 19:141

    Content type: Research article

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  19. Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20–25% of patients with chronic kidney disease and can lead...

    Authors: Lydia Namuyimbwa, Collins Atuheire, Joel Okullo and Robert Kalyesubula

    Citation: BMC Nephrology 2018 19:139

    Content type: Research article

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  20. A combination of safety concerns and labeling changes impacted use of erythropoiesis-stimulating agents (ESAs) in renal anemia. Data regarding contemporary utilization in pre-dialysis chronic kidney disease (C...

    Authors: Heide A. Stirnadel-Farrant, Jiacong Luo, Lata Kler, Borut Cizman, Delyth Jones, Steven M. Brunelli and Alexander R. Cobitz

    Citation: BMC Nephrology 2018 19:135

    Content type: Research article

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  21. The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. I...

    Authors: Benjamin J. Lee, Chi-yuan Hsu, Rishi V. Parikh, Thomas K. Leong, Thida C. Tan, Sophia Walia, Kathleen D. Liu, Raymond K. Hsu and Alan S. Go

    Citation: BMC Nephrology 2018 19:134

    Content type: Research article

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  22. Diabetic nephropathy requires periodic monitoring, dietary modification, and early intervention to prevent the disease severity within limited resource settings. To emphasize the importance of continuous care ...

    Authors: Yun Jung Jang, Yoon Soo Choy, Chung Mo Nam, Ki Tae Moon and Eun-Cheol Park

    Citation: BMC Nephrology 2018 19:127

    Content type: Research article

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  23. Accurate contemporary data on the burden of Chronic Kidney Disease (CKD) on the African continent are lacking. We determined the prevalence of CKD in adult populations living in Africa, and variations by stage...

    Authors: Arnaud D. Kaze, Titilayo Ilori, Bernard G. Jaar and Justin B. Echouffo-Tcheugui

    Citation: BMC Nephrology 2018 19:125

    Content type: Research article

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  24. People with chronic renal disease are insulin resistant. We hypothesized that in a healthy population, baseline renal function is associated with insulin sensitivity three years later.

    Authors: Soline Siméon, Ziad Massy, Kurt Højlund, Katarina Lalic, Francesca Porcellati, Jacqueline Dekker, John Petrie, Gemma Currie and Beverley Balkau

    Citation: BMC Nephrology 2018 19:124

    Content type: Research article

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  25. There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angio...

    Authors: Christopher E. Anderson, L. Lee Hamm, Gem Batuman, Damodar R. Kumbala, Chung-Shiuan Chen, Swapna G. Kallu, Ravi Siriki, Shilpa Gadde, Myra A. Kleinpeter, N. Kevin Krane, Eric E. Simon, Jiang He and Jing Chen

    Citation: BMC Nephrology 2018 19:117

    Content type: Research article

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  26. Chronic kidney disease of unknown origin (CKDu) in Sri Lanka is grouped with several other epidemics of similar nature across the world as Chronic Interstitial Nephritis in Agricultural Communities (CINAC). In...

    Authors: S. B. Agampodi, G. S. Amarasinghe, P. G. C. R. Naotunna, C. S. Jayasumana and S. H. Siribaddana

    Citation: BMC Nephrology 2018 19:115

    Content type: Research article

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  27. Analyzing the relationships between biomarkers representing distinct pathophysiologic pathways and microalbuminuria (MA) can strengthen the identifying ability for renal damage and illuminate previously unreco...

    Authors: Shihui Fu, Yi Guo, Zhao Zhang, Leiming Luo and Ping Ye

    Citation: BMC Nephrology 2018 19:93

    Content type: Research article

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  28. Accurately identifying cases of chronic kidney disease (CKD) from primary care data facilitates the management of patients, and is vital for surveillance and research purposes. Ontologies provide a systematic ...

    Authors: Nicholas I. Cole, Harshana Liyanage, Rebecca J. Suckling, Pauline A. Swift, Hugh Gallagher, Rachel Byford, John Williams, Shankar Kumar and Simon de Lusignan

    Citation: BMC Nephrology 2018 19:85

    Content type: Research article

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  29. Central venous catheters (CVC) are associated with substantial morbidity and mortality among patients undergoing haemodialysis (HD), yet they are frequently used as the primary vascular access for many patient...

    Authors: Wael F. Hussein, Husham Mohammed, Leonard Browne, Liam Plant and Austin G. Stack

    Citation: BMC Nephrology 2018 19:76

    Content type: Research article

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  30. Evidence indicates favorable effects of dialysate (DNa+) to serum sodium concentration (SNa+) alignment, however, results from larger sample populations are needed. For this reason, we conducted a retrospective p...

    Authors: Jochen G. Raimann, Linda H. Ficociello, Len A. Usvyat, Hanjie Zhang, Lisa Pacelli, Sandi Moore, Penny Sheppard, Qingqing Xiao, Yuedong Wang, Claudy Mullon, Paul Balter, Terry Sullivan and Peter Kotanko

    Citation: BMC Nephrology 2018 19:75

    Content type: Research article

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  31. Anemia is common in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients, but detailed information on prevalence and treatment is lacking.

    Authors: Wendy L. St. Peter, Haifeng Guo, Shaum Kabadi, David T. Gilbertson, Yi Peng, Trudy Pendergraft and Suying Li

    Citation: BMC Nephrology 2018 19:67

    Content type: Research article

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  32. Both diabetes and hemodialysis can seriously impair patients’ health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in he...

    Authors: Sohaib T. Khatib, Mohammad K. Hemadneh, Samer A. Hasan, Emad Khazneh and Sa’ed H. Zyoud

    Citation: BMC Nephrology 2018 19:49

    Content type: Research article

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  33. Chronic kidney disease (CKD) is considered a serious public health problem, both in Brazil and worldwide, with an increasing number of cases observed inrecent years. Especially, CKD has been reported to be hig...

    Authors: Natalino Salgado-Filho, Joyce Santos Lages, Dyego José Brito, João Victor Salgado, Gyl Eanes Silva, Alcione Miranda Santos, Francisco Chagas Monteiro-Júnior, Elisangela Milhomen Santos, Antônio Augusto Silva, Denizar Vianna Araújo and Ricardo Castro Sesso

    Citation: BMC Nephrology 2018 19:43

    Content type: Study protocol

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  34. The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat in...

    Authors: Ying Dong, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Jingyu Nie, Congyi Zheng, Jiali Wang, Lan Shao, Ye Tian and Runlin Gao

    Citation: BMC Nephrology 2018 19:40

    Content type: Research article

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  35. Renal angiomyolipomas (AMLs) are a major clinical feature in patients with tuberous sclerosis complex (TSC). Spontaneous bleeding can be life threatening, and appropriate information and proper surveillance an...

    Authors: I. Cockerell, M. Guenin, K. Heimdal, M. Bjørnvold, K. K. Selmer and O. Rouvière

    Citation: BMC Nephrology 2018 19:39

    Content type: Research article

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  36. Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. Th...

    Authors: Phil McEwan, Hayley Bennett Wilton, Albert C. M. Ong, Bjarne Ørskov, Richard Sandford, Francesco Scolari, Maria-Cristina V. Cabrera, Gerd Walz, Karl O’Reilly and Paul Robinson

    Citation: BMC Nephrology 2018 19:37

    Content type: Research article

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  37. Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid repr...

    Authors: Keith C. Norris, Karen E. Smoyer, Catherine Rolland, Jan Van der Vaart and Eliza Beth Grubb

    Citation: BMC Nephrology 2018 19:36

    Content type: Research article

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  38. The association of increased cancer risk with glomerulonephritis (GN) is well known, but controversy exists concerning which types of GN are involved, and the size of the association. A national registry surve...

    Authors: James Goya Heaf, Alastair Hansen and Gunnar Hellmund Laier

    Citation: BMC Nephrology 2018 19:27

    Content type: Research article

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  39. Most estimates for End Stage Kidney Disease (ESKD) prevalence and incidence are based on renal replacement therapy (RRT) registers. However, not all people with ESKD will commence RRT and estimates based only ...

    Authors: Lin Li, Steven Guthridge, Shu Qin Li, Yuejen Zhao, Paul Lawton and Alan Cass

    Citation: BMC Nephrology 2018 19:15

    Content type: Research article

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  40. The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiven...

    Authors: Reem E. Hamoda, Jennifer C. Gander, Laura J. McPherson, Kimberly J. Arriola, Loren Cobb, Stephen O. Pastan, Laura Plantinga, Teri Browne, Erica Hartmann, Laura Mulloy, Carlos Zayas, Jenna Krisher and Rachel E. Patzer

    Citation: BMC Nephrology 2018 19:13

    Content type: Research article

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  41. For older adults receiving dialysis, health-related quality of life is not often considered in prognostication of death or future hospitalizations. To determine if routine health-related quality of life measur...

    Authors: Rasheeda K. Hall, Alison Luciano, Carl Pieper and Cathleen S. Colón-Emeric

    Citation: BMC Nephrology 2018 19:11

    Content type: Research article

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  42. Agricultural workers especially in sugarcane plantations have a high risk of chronic kidney disease (CKD). Little is known about CKD among sugarcane plantation workers in Cameroon. This study sought to evaluat...

    Authors: Martin E. Ekiti, Jean-Berthelot Zambo, Felix K. Assah, Valirie N. Agbor, Krystel Kekay and Gloria Ashuntantang

    Citation: BMC Nephrology 2018 19:10

    Content type: Research article

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  43. The Fried frailty phenotype, a measure of physiologic reserve defined by 5 components (exhaustion, unintentional weight loss, low physical activity, slow walking speed, and poor grip strength), is associated w...

    Authors: Sarah Van Pilsum Rasmussen, Jonathan Konel, Fatima Warsame, Hao Ying, Brian Buta, Christine Haugen, Elizabeth King, Sandra DiBrito, Ravi Varadhan, Leocadio Rodríguez-Mañas, Jeremy D. Walston, Dorry L. Segev and Mara A. McAdams-DeMarco

    Citation: BMC Nephrology 2018 19:8

    Content type: Research article

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  44. Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has...

    Authors: Hsien-Fu Chiu, Hung-chun Chen, Kuo-Cheng Lu and Kuo-Hsiung Shu

    Citation: BMC Nephrology 2018 19:6

    Content type: Research article

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  45. We aimed to describe clinical characteristics of patients with community-acquired acute kidney injury (CA-AKI), the effectiveness of initial management of CA-AKI, its prognosis and the impact of medication on ...

    Authors: Fabien Stucker, Belen Ponte, Victoria De la Fuente, Cyrielle Alves, Olivier Rutschmann, Sebastian Carballo, Nicolas Vuilleumier, Pierre-Yves Martin, Thomas Perneger and Patrick Saudan

    Citation: BMC Nephrology 2017 18:380

    Content type: Research article

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  46. Patients with CKD are at increased risk of potentially preventable hospital acquired complications (HACs). Understanding the economic consequences of preventable HACs, may define the scope and investment of in...

    Authors: Babak Bohlouli, Terri Jackson, Marcello Tonelli, Brenda Hemmelgarn and Scott Klarenbach

    Citation: BMC Nephrology 2017 18:375

    Content type: Research article

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  47. Systemic inflammation has been implicated in several chronic diseases. GlycA is a new nuclear mass resonance (NMR) spectroscopy-derived biomarker of systemic inflammation that reflects protein glycosylation. W...

    Authors: Silvia M. Titan, Roberto Pecoits-Filho, Sandhi M. Barreto, Antônio Alberto Lopes, Isabela J. Bensenor and Paulo A. Lotufo

    Citation: BMC Nephrology 2017 18:367

    Content type: Research article

    Published on: