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Epidemiology and Health Outcomes

Section edited by Bernard Jaar and Deputy Section Editor Laura Plantinga

The Epidemiology and Health Outcomes section considers manuscripts describing epidemiological studies relating to the field of nephrology. The section also considers systematic reviews and meta-analyses. Both qualitative and quantitative studies discussing health outcomes research and outcome measures are also considered by this section. Research related to clinical practice guidelines should be directed to the dedicated Guidelines and Policy section.

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  1. Analyzing the relationships between biomarkers representing distinct pathophysiologic pathways and microalbuminuria (MA) can strengthen the identifying ability for renal damage and illuminate previously unreco...

    Authors: Shihui Fu, Yi Guo, Zhao Zhang, Leiming Luo and Ping Ye

    Citation: BMC Nephrology 2018 19:93

    Content type: Research article

    Published on:

  2. Accurately identifying cases of chronic kidney disease (CKD) from primary care data facilitates the management of patients, and is vital for surveillance and research purposes. Ontologies provide a systematic ...

    Authors: Nicholas I. Cole, Harshana Liyanage, Rebecca J. Suckling, Pauline A. Swift, Hugh Gallagher, Rachel Byford, John Williams, Shankar Kumar and Simon de Lusignan

    Citation: BMC Nephrology 2018 19:85

    Content type: Research article

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  3. Central venous catheters (CVC) are associated with substantial morbidity and mortality among patients undergoing haemodialysis (HD), yet they are frequently used as the primary vascular access for many patient...

    Authors: Wael F. Hussein, Husham Mohammed, Leonard Browne, Liam Plant and Austin G. Stack

    Citation: BMC Nephrology 2018 19:76

    Content type: Research article

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  4. Evidence indicates favorable effects of dialysate (DNa+) to serum sodium concentration (SNa+) alignment, however, results from larger sample populations are needed. For this reason, we conducted a retrospective p...

    Authors: Jochen G. Raimann, Linda H. Ficociello, Len A. Usvyat, Hanjie Zhang, Lisa Pacelli, Sandi Moore, Penny Sheppard, Qingqing Xiao, Yuedong Wang, Claudy Mullon, Paul Balter, Terry Sullivan and Peter Kotanko

    Citation: BMC Nephrology 2018 19:75

    Content type: Research article

    Published on:

  5. Anemia is common in non-dialysis-dependent chronic kidney disease (NDD-CKD) patients, but detailed information on prevalence and treatment is lacking.

    Authors: Wendy L. St. Peter, Haifeng Guo, Shaum Kabadi, David T. Gilbertson, Yi Peng, Trudy Pendergraft and Suying Li

    Citation: BMC Nephrology 2018 19:67

    Content type: Research article

    Published on:

  6. Both diabetes and hemodialysis can seriously impair patients’ health related quality of life (HRQOL). This study seeks to obtain data which will help to address the factors associated with impaired HRQOL in he...

    Authors: Sohaib T. Khatib, Mohammad K. Hemadneh, Samer A. Hasan, Emad Khazneh and Sa’ed H. Zyoud

    Citation: BMC Nephrology 2018 19:49

    Content type: Research article

    Published on:

  7. Chronic kidney disease (CKD) is considered a serious public health problem, both in Brazil and worldwide, with an increasing number of cases observed inrecent years. Especially, CKD has been reported to be hig...

    Authors: Natalino Salgado-Filho, Joyce Santos Lages, Dyego José Brito, João Victor Salgado, Gyl Eanes Silva, Alcione Miranda Santos, Francisco Chagas Monteiro-Júnior, Elisangela Milhomen Santos, Antônio Augusto Silva, Denizar Vianna Araújo and Ricardo Castro Sesso

    Citation: BMC Nephrology 2018 19:43

    Content type: Study protocol

    Published on:

  8. The aim of the study was to assess the association between chronic kidney disease (CKD) and obesity in predicting CKD among Chinese adults, distinguishing between 5 different adiposity indices: visceral fat in...

    Authors: Ying Dong, Zengwu Wang, Zuo Chen, Xin Wang, Linfeng Zhang, Jingyu Nie, Congyi Zheng, Jiali Wang, Lan Shao, Ye Tian and Runlin Gao

    Citation: BMC Nephrology 2018 19:40

    Content type: Research article

    Published on:

  9. Renal angiomyolipomas (AMLs) are a major clinical feature in patients with tuberous sclerosis complex (TSC). Spontaneous bleeding can be life threatening, and appropriate information and proper surveillance an...

    Authors: I. Cockerell, M. Guenin, K. Heimdal, M. Bjørnvold, K. K. Selmer and O. Rouvière

    Citation: BMC Nephrology 2018 19:39

    Content type: Research article

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  10. Autosomal dominant polycystic kidney disease (ADPKD) is the leading inheritable cause of end-stage renal disease (ESRD); however, the natural course of disease progression is heterogeneous between patients. Th...

    Authors: Phil McEwan, Hayley Bennett Wilton, Albert C. M. Ong, Bjarne Ørskov, Richard Sandford, Francesco Scolari, Maria-Cristina V. Cabrera, Gerd Walz, Karl O’Reilly and Paul Robinson

    Citation: BMC Nephrology 2018 19:37

    Content type: Research article

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  11. Albuminuria, elevated serum creatinine and low estimated glomerular filtration rate (eGFR) are pivotal indicators of kidney decline. Yet, it is uncertain if these and emerging biomarkers such as uric acid repr...

    Authors: Keith C. Norris, Karen E. Smoyer, Catherine Rolland, Jan Van der Vaart and Eliza Beth Grubb

    Citation: BMC Nephrology 2018 19:36

    Content type: Research article

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  12. The association of increased cancer risk with glomerulonephritis (GN) is well known, but controversy exists concerning which types of GN are involved, and the size of the association. A national registry surve...

    Authors: James Goya Heaf, Alastair Hansen and Gunnar Hellmund Laier

    Citation: BMC Nephrology 2018 19:27

    Content type: Research article

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  13. Most estimates for End Stage Kidney Disease (ESKD) prevalence and incidence are based on renal replacement therapy (RRT) registers. However, not all people with ESKD will commence RRT and estimates based only ...

    Authors: Lin Li, Steven Guthridge, Shu Qin Li, Yuejen Zhao, Paul Lawton and Alan Cass

    Citation: BMC Nephrology 2018 19:15

    Content type: Research article

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  14. The Reducing Disparities in Access to kidNey Transplantation Community Study (RaDIANT) was an End-Stage Renal Disease (ESRD) Network 6-developed, dialysis facility-level randomized trial testing the effectiven...

    Authors: Reem E. Hamoda, Jennifer C. Gander, Laura J. McPherson, Kimberly J. Arriola, Loren Cobb, Stephen O. Pastan, Laura Plantinga, Teri Browne, Erica Hartmann, Laura Mulloy, Carlos Zayas, Jenna Krisher and Rachel E. Patzer

    Citation: BMC Nephrology 2018 19:13

    Content type: Research article

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  15. For older adults receiving dialysis, health-related quality of life is not often considered in prognostication of death or future hospitalizations. To determine if routine health-related quality of life measur...

    Authors: Rasheeda K. Hall, Alison Luciano, Carl Pieper and Cathleen S. Colón-Emeric

    Citation: BMC Nephrology 2018 19:11

    Content type: Research article

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  16. Agricultural workers especially in sugarcane plantations have a high risk of chronic kidney disease (CKD). Little is known about CKD among sugarcane plantation workers in Cameroon. This study sought to evaluat...

    Authors: Martin E. Ekiti, Jean-Berthelot Zambo, Felix K. Assah, Valirie N. Agbor, Krystel Kekay and Gloria Ashuntantang

    Citation: BMC Nephrology 2018 19:10

    Content type: Research article

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  17. The Fried frailty phenotype, a measure of physiologic reserve defined by 5 components (exhaustion, unintentional weight loss, low physical activity, slow walking speed, and poor grip strength), is associated w...

    Authors: Sarah Van Pilsum Rasmussen, Jonathan Konel, Fatima Warsame, Hao Ying, Brian Buta, Christine Haugen, Elizabeth King, Sandra DiBrito, Ravi Varadhan, Leocadio Rodríguez-Mañas, Jeremy D. Walston, Dorry L. Segev and Mara A. McAdams-DeMarco

    Citation: BMC Nephrology 2018 19:8

    Content type: Research article

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  18. Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has...

    Authors: Hsien-Fu Chiu, Hung-chun Chen, Kuo-Cheng Lu and Kuo-Hsiung Shu

    Citation: BMC Nephrology 2018 19:6

    Content type: Research article

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  19. We aimed to describe clinical characteristics of patients with community-acquired acute kidney injury (CA-AKI), the effectiveness of initial management of CA-AKI, its prognosis and the impact of medication on ...

    Authors: Fabien Stucker, Belen Ponte, Victoria De la Fuente, Cyrielle Alves, Olivier Rutschmann, Sebastian Carballo, Nicolas Vuilleumier, Pierre-Yves Martin, Thomas Perneger and Patrick Saudan

    Citation: BMC Nephrology 2017 18:380

    Content type: Research article

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  20. Patients with CKD are at increased risk of potentially preventable hospital acquired complications (HACs). Understanding the economic consequences of preventable HACs, may define the scope and investment of in...

    Authors: Babak Bohlouli, Terri Jackson, Marcello Tonelli, Brenda Hemmelgarn and Scott Klarenbach

    Citation: BMC Nephrology 2017 18:375

    Content type: Research article

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  21. The most commonly used glomerular filtration rate estimating equations for drug dosing are Cockcroft-Gault (CG), Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration ...

    Authors: Hunduma Dinsa, Teshome Nedi and Alemseged Beyene Berha

    Citation: BMC Nephrology 2017 18:368

    Content type: Research article

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  22. Systemic inflammation has been implicated in several chronic diseases. GlycA is a new nuclear mass resonance (NMR) spectroscopy-derived biomarker of systemic inflammation that reflects protein glycosylation. W...

    Authors: Silvia M. Titan, Roberto Pecoits-Filho, Sandhi M. Barreto, Antônio Alberto Lopes, Isabela J. Bensenor and Paulo A. Lotufo

    Citation: BMC Nephrology 2017 18:367

    Content type: Research article

    Published on:

  23. Evidence on stages of renal impairment and related risk factors in Luxembourg is lacking. This study aimed to assess the prevalence of chronic kidney disease (CKD) and identify potential correlates among the g...

    Authors: Ala’a Alkerwi, Nicolas Sauvageot, Illiasse El Bahi, Charles Delagardelle, Jean Beissel, Stephanie Noppe, Paul J. Roderick, Jennifer S. Mindell and Saverio Stranges

    Citation: BMC Nephrology 2017 18:358

    Content type: Research article

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  24. For people requiring hemodialysis, infectious mortality is independently associated with geographic distance from a nephrologist. We aimed to determine if differential management of catheter-related blood stre...

    Authors: Stephanie Thompson, Natasha Wiebe, Scott Klarenbach, Rick Pelletier, Brenda R. Hemmelgarn, John S. Gill, Braden J. Manns and Marcello Tonelli

    Citation: BMC Nephrology 2017 18:357

    Content type: Research article

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  25. Hyperchloremia is common in critically ill septic patients. The impact of hyperchloremia on the incidence of acute kidney injury (AKI) is not well studied. We investigated the association between hyperchloremi...

    Authors: Lenar Yessayan, Javier A. Neyra, Fabrizio Canepa-Escaro, George Vasquez-Rios, Michael Heung and Jerry Yee

    Citation: BMC Nephrology 2017 18:346

    Content type: Research article

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  26. Chronic Kidney Disease (CKD) represents a great burden for the patient and the health system, particularly if diagnosed at late stages. Consequently, tools to identify patients at high risk of having CKD are n...

    Authors: Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Robert H. Gilman, Josefina Medina-Lezama, Julio A. Chirinos-Pacheco, Paola V. Muñoz-Retamozo, Liam Smeeth, William Checkley and Antonio Bernabe-Ortiz

    Citation: BMC Nephrology 2017 18:343

    Content type: Research article

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  27. Chronic kidney disease (CKD) is a leading cause of death before and after onset of end-stage renal disease (ESRD). Knowing treatments that can delay disease progression will lead to reduced mortality. We there...

    Authors: Phisitt Vejakama, Atiporn Ingsathit, Gareth J. McKay, Alexander P. Maxwell, Mark McEvoy, John Attia and Ammarin Thakkinstian

    Citation: BMC Nephrology 2017 18:342

    Content type: Research article

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  28. Predictive abilities of cardiovascular biomarkers to renal function decline are more significant in Chinese community-dwelling population without glomerular filtration rate (GFR) below 60 ml/min/1.73m2, and long-...

    Authors: Shihui Fu, Chunling Liu, Leiming Luo and Ping Ye

    Citation: BMC Nephrology 2017 18:331

    Content type: Research article

    Published on:

  29. The Australian Institute of Health and Welfare’s first report into acute kidney injury demonstrated a significant increase in the incidence of acute-tubulo interstitial nephritis, the ICD-10 code representing ...

    Authors: Gregory J. Wilson, Adrian L. Kark, Leo P. Francis, Wendy Hoy, Helen G. Healy and Andrew J. Mallett

    Citation: BMC Nephrology 2017 18:329

    Content type: Research article

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  30. Hyponatremia (serum sodium concentration < 135 mmol/L) is the most common electrolyte abnormality and is a predictor of the mortality of hospitalized patients in Western countries. However, hyponatremia data a...

    Authors: Jinling Hao, Yang Li, Xuehan Zhang, Cheng Pang, Yi Wang, Sagar U. Nigwekar, Ling Qiu and Limeng Chen

    Citation: BMC Nephrology 2017 18:328

    Content type: Research article

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  31. The differential diagnosis of thrombotic microangiopathy (TMA) is complex however the rapid diagnosis of the underlying condition is vital to inform urgent treatment decisions. A survey was devised with the ob...

    Authors: T. Sakari Jokiranta, Ondrej Viklicky, Saleh Al Shorafa, Rosanna Coppo, Christoph Gasteyger, Manuel Macia, Tatiana Pankratenko, Mohan Shenoy, Oğuz Soylemezoglu, Michel Tsimaratos, Jack Wetzels and Hermann Haller

    Citation: BMC Nephrology 2017 18:324

    Content type: Research article

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  32. Efficient and safe delivery of care to dialysis patients is essential. Concerns have been raised regarding the ability of accountable care organizations to adequately serve this high-risk population. Little is...

    Authors: Bjorg Thorsteinsdottir, Priya Ramar, LaTonya J. Hickson, Megan S. Reinalda, Robert C. Albright, Jon C. Tilburt, Amy W. Williams, Paul Y. Takahashi, Molly M. Jeffery and Nilay D. Shah

    Citation: BMC Nephrology 2017 18:322

    Content type: Research article

    Published on:

  33. This study aimed to compare clinical features and health-related quality of life (HRQoL) in the Chinese chronic kidney disease (CKD) 3 population and determined the necessity of the subdivision of CKD3 in Chin...

    Authors: Zhangzhe Peng, Jinwei Wang, Qiongjing Yuan, Xiangcheng Xiao, Hui Xu, Yanyun Xie, Wei Wang, Ling Huang, Yong Zhong, Xiang Ao, Luxia Zhang, Minghui Zhao, Lijian Tao and Qiaoling Zhou

    Citation: BMC Nephrology 2017 18:311

    Content type: Research article

    Published on:

  34. Arrhythmia-related complications and sudden death are common in dialysis patients. However, routine cardiac monitoring has so far not been feasible. Miniaturization of implantable cardiac monitors offers a new...

    Authors: Naya El Hage, Bernard G. Jaar, Alan Cheng, Chloe Knight, Elena Blasco-Colmenares, Luis Gimenez, Eliseo Guallar and Tariq Shafi

    Citation: BMC Nephrology 2017 18:309

    Content type: Research article

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  35. Chronic kidney disease (CKD) has become a major public health issue worldwide in the past few years. Pruritus is a common, well-recognized complication often seen in patients with chronic renal failure. For as...

    Authors: Inayat Ur Rehman and Tahir Mehmood Khan

    Citation: BMC Nephrology 2017 18:302

    Content type: Research article

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  36. A balanced diet is essential to slowing the progression of chronic kidney disease (CKD) and managing the symptoms. Currently, no tool is available to easily and quickly assess energy and macronutrient intake i...

    Authors: Aurélie Affret, Sandra Wagner, Douae El Fatouhi, Courtney Dow, Emmanuelle Correia, Maryvonne Niravong, Françoise Clavel-Chapelon, Julie De Chefdebien, Denis Fouque, Bénédicte Stengel, Marie-Christine Boutron-Ruault and Guy Fagherazzi

    Citation: BMC Nephrology 2017 18:297

    Content type: Research article

    Published on:

  37. Low and high blood potassium levels are common and were both associated with poor outcomes in patients with chronic kidney disease (CKD). Whether such relationships may be altered in CKD patients receiving opt...

    Authors: Sandra Wagner, Marie Metzger, Martin Flamant, Pascal Houillier, Jean-Philippe Haymann, François Vrtovsnik, Eric Thervet, Jean-Jacques Boffa, Ziad A. Massy, Bénédicte Stengel and Patrick Rossignol

    Citation: BMC Nephrology 2017 18:295

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Nephrology 2017 18:308

  38. Diabetes-related end stage renal disease (DM-ESRD) is a devastating consequence of the type 2 diabetes epidemic, both of which disproportionately affect Indigenous peoples. Projecting case numbers and costs in...

    Authors: Amy Gao, Nathaniel D. Osgood, Ying Jiang and Roland F. Dyck

    Citation: BMC Nephrology 2017 18:283

    Content type: Research article

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  39. Care coordination is a challenge for patients with kidney disease, who often see multiple providers to manage their associated complex chronic conditions. Much of the focus has been on primary care physician (...

    Authors: Virginia Wang, Clarissa J. Diamantidis, JaNell Wylie and Raquel C. Greer

    Citation: BMC Nephrology 2017 18:274

    Content type: Research article

    Published on:

  40. Periodontal disease occurs relatively prevalently in people with chronic kidney disease (CKD), but it remains indeterminate whether periodontal disease is an independent risk factor for premature death in this...

    Authors: Jian Zhang, Hong Jiang, Min Sun and Jianghua Chen

    Citation: BMC Nephrology 2017 18:269

    Content type: Research article

    Published on:

  41. Objective of the study is to assess prevalence and survival among end stage renal disease patients with restless legs syndrome (RLS) within a national database (USRDS).

    Authors: Joseph J. DeFerio, Usha Govindarajulu, Amarpali Brar, Daniel Cukor, Kathleen G. Lee and Moro O. Salifu

    Citation: BMC Nephrology 2017 18:258

    Content type: Research article

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  42. Since diabetes mellitus (DM) is the leading cause of end stage renal disease (ESRD), this study aimed to develop a 5-year ESRD risk prediction model among Chinese patients with Type 2 DM (T2DM) in primary care.

    Authors: Eric Yuk Fai Wan, Daniel Yee Tak Fong, Colman Siu Cheung Fung, Esther Yee Tak Yu, Weng Yee Chin, Anca Ka Chun Chan and Cindy Lo Kuen Lam

    Citation: BMC Nephrology 2017 18:257

    Content type: Research article

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  43. Non-steroidal anti-inflammatory drugs (NSAIDs) are a common cause of adverse drug events (ADEs), but renal risks of NSAIDs are less well quantified than gastrointestinal and cardiac risks. This paper reports a...

    Authors: Xinyu Zhang, Peter T Donnan, Samira Bell and Bruce Guthrie

    Citation: BMC Nephrology 2017 18:256

    Content type: Research article

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  44. Patient engagement and patient-centered care are critical in optimally managing patients with end-stage renal disease (ESRD). Understanding patient preferences is a key element of patient-centered care and sha...

    Authors: Brett Hauber, John Caloyeras, Joshua Posner, Deborah Brommage, Vasily Belozeroff and Kerry Cooper

    Citation: BMC Nephrology 2017 18:254

    Content type: Research article

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  45. Patient engagement in end-stage renal disease (ESRD) is expected to result in a more patient-centered approach to care that aligns with patients’ values, preferences, and goals for treatment. Nevertheless, no ...

    Authors: Brett Hauber, John Caloyeras, Joshua Posner, Deborah Brommage, Spiros Tzivelekis and Allan Pollock

    Citation: BMC Nephrology 2017 18:253

    Content type: Research article

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  46. Hemodialysis (HD) patients have increased risk of cardiovascular disease (CVD). Impaired stem cell health and adipocytokine metabolism may play important roles in the complex pathophysiological mechanisms of C...

    Authors: Abdullah Ozkok, Riza Atas, Suzan Adin Cinar, Akar Yilmaz, Esin Aktas, Gunnur Deniz and Alaattin Yildiz

    Citation: BMC Nephrology 2017 18:250

    Content type: Research article

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  47. Chronic Kidney Disease (CKD) is a worldwide public health problem. There are few studies in Latin America, especially in primary care settings. Our objective was to determine the prevalence, stages, and associ...

    Authors: Percy Herrera-Añazco, Alvaro Taype-Rondan, María Lazo-Porras, E. Alberto Quintanilla, Victor Manuel Ortiz-Soriano and Adrian V. Hernandez

    Citation: BMC Nephrology 2017 18:246

    Content type: Research article

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  48. The epidemiology and outcomes of acute kidney injury (AKI) in prevalent non-renal solid organ transplant recipients is unknown.

    Authors: Girish N. Nadkarni, Kinsuk Chauhan, Achint Patel, Aparna Saha, Priti Poojary, Sunil Kamat, Shanti Patel, Rocco Ferrandino, Ioannis Konstantinidis, Pranav S. Garimella, Madhav C. Menon and Charuhas V. Thakar

    Citation: BMC Nephrology 2017 18:244

    Content type: Research article

    Published on:

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As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Thank you.

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