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Epidemiology and Health Outcomes

Section edited by Bernard Jaar and Deputy Section Editor Laura Plantinga

The Epidemiology and Health Outcomes section considers manuscripts describing epidemiological studies relating to the field of nephrology. The section also considers systematic reviews and meta-analyses. Both qualitative and quantitative studies discussing health outcomes research and outcome measures are also considered by this section. Research related to clinical practice guidelines should be directed to the dedicated Guidelines and Policy section.

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  1. Serum p-cresyl sulfate (PCS) associates with cardiovascular disease in patients with chronic kidney disease. PCS concentrations are determined by intestinal uptake of p-cresol, human metabolism to PCS and renal c...

    Authors: Ruben Poesen, Liesbeth Viaene, Kristin Verbeke, Patrick Augustijns, Bert Bammens, Kathleen Claes, Dirk Kuypers, Pieter Evenepoel and Björn Meijers

    Citation: BMC Nephrology 2014 15:87

    Content type: Research article

    Published on:

  2. Medication safety in patients with chronic kidney disease (CKD) is a growing concern. This is particularly relevant in older adults due to underlying CKD. Metformin use is contraindicated in patients with abno...

    Authors: Deborah L Huang, Itamar B Abrass and Bessie A Young

    Citation: BMC Nephrology 2014 15:86

    Content type: Research article

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  3. AKI is common among hospital in-patients and places a huge financial burden on the UK National Health Service, causing increased length of hospital stay and use of critical care services, with increased requir...

    Authors: Rachael Challiner, James P Ritchie, Catherine Fullwood, Paul Loughnan and Alastair J Hutchison

    Citation: BMC Nephrology 2014 15:84

    Content type: Research article

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  4. Asian patients undergoing kidney transplantation (KT) generally have better renal allograft survival and a lower burden of cardiovascular disease than those of other racial groups. The KNOW-KT aims to explore ...

    Authors: Jaeseok Yang, Joongyup Lee, Kyu Ha Huh, Jae Berm Park, Jang-Hee Cho, Sik Lee, Han Ro, Seung-Yeup Han, Young Hoon Kim, Jong Cheol Jeong, Byung-Joo Park, Duck Jong Han, Sung-Bae Park, Wookyung Chung, Sung Kwang Park, Chan-Duck Kim…

    Citation: BMC Nephrology 2014 15:77

    Content type: Study protocol

    Published on:

  5. This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics.

    Authors: Bernard G Jaar, Lili Zhang, Svetlana V Chembrovich, Stephen M Sozio, Tariq Shafi, Julia J Scialla, Gordon F Tomaselli, Joao A C Lima, Wen Hong Linda Kao, Rulan S Parekh and Lucy A Meoni

    Citation: BMC Nephrology 2014 15:68

    Content type: Research article

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  6. Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-prove...

    Authors: Qingjun Pan, Yaning Li, Ling Ye, Zhenzhen Deng, Lu Li, Yongmin Feng, Weijing Liu and Huafeng Liu

    Citation: BMC Nephrology 2014 15:67

    Content type: Research article

    Published on:

  7. The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR a...

    Authors: Tsung-Hsien Lin, Ho-Tsung Hsin, Chun-Li Wang, Wen-Ter Lai, Ai-Hsien Li, Chi-Tai Kuo, Juey-Jen Hwang, Fu-Tien Chiang, Shu-Chen Chang and Chee-Jen Chang

    Citation: BMC Nephrology 2014 15:66

    Content type: Research article

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  8. Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) globally. Diabetes and human immunodeficiency virus (HIV), both prevalent in South Africa, have not been reported as significant causes ...

    Authors: Nomandla D Madala, Gertrude P Thusi, Alain G H Assounga and Saraladevi Naicker

    Citation: BMC Nephrology 2014 15:61

    Content type: Research article

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  9. The appropriate exercise counseling for chronic kidney disease (CKD) patients is crucial to improve their prognosis. There have been few studies about exercise counseling by primary care physicians for CKD pat...

    Authors: Yoshiyuki Morishita, Akihiko Numata, Atushi Miki, Mari Okada, Kenichi Ishibashi, Fumi Takemoto, Yasuhiro Ando, Shigeaki Muto, Daisuke Nagata and Eiji Kusano

    Citation: BMC Nephrology 2014 15:48

    Content type: Research article

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  10. Chronic kidney disease (CKD) is a progressive and usually irreversible disease. Different types of outcomes are of interest in the course of CKD such as time-to-dialysis, transplantation or decline of the glom...

    Authors: Julie Boucquemont, Georg Heinze, Kitty J Jager, Rainer Oberbauer and Karen Leffondre

    Citation: BMC Nephrology 2014 15:45

    Content type: Research article

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  11. Increasing evidence suggests that aldosterone promotes renal damage. Since data on the association between aldosterone and renal function in the general population are sparse, we chose to address this issue. W...

    Authors: Anke Hannemann, Rainer Rettig, Kathleen Dittmann, Henry Völzke, Karlhans Endlich, Matthias Nauck and Henri Wallaschofski

    Citation: BMC Nephrology 2014 15:44

    Content type: Research article

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  12. Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India.

    Authors: Youssef MK Farag, Bharati V Mittal, Sai Ram Keithi-Reddy, Vidya N Acharya, Alan F Almeida, Anil C, Ballal HS, Gaccione P, Issacs R, Sanjiv Jasuja, Kirpalani AL, Kher V, Modi GK, Georgy Nainan, Jai Prakash, Mohan M Rajapurkar…

    Citation: BMC Nephrology 2014 15:42

    Content type: Research article

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  13. Residing remotely from health care resources appears to impact quality of care delivery. It remains unclear if there are differences in vascular access based on distance of one’s residence to dialysis centre a...

    Authors: Lisa M Miller, Lavern M Vercaigne, Louise Moist, Charmaine E Lok, Navdeep Tangri, Paul Komenda, Claudio Rigatto, Julie Mojica and Manish M Sood

    Citation: BMC Nephrology 2014 15:40

    Content type: Research article

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  14. An analysis of intracranial hemorrhage (ICH) in a national sample of autosomal dominant polycystic kidney disease (ADPKD) patients receiving long-term dialysis has not been reported. It is often assumed that p...

    Authors: David J Yoo, Lawrence Agodoa, Christina M Yuan, Kevin C Abbott and Robert Nee

    Citation: BMC Nephrology 2014 15:39

    Content type: Research article

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  15. About 1% of patients admitted to the Emergency Department (ED) have hypernatremia, a condition associated with a mortality rate of 20 to 60%. Management recommendations originate from intensive care unit studi...

    Authors: Stanislas Bataille, Camille Baralla, Dominique Torro, Christophe Buffat, Yvon Berland, Marc Alazia, Anderson Loundou, Pierre Michelet and Henri Vacher-Coponat

    Citation: BMC Nephrology 2014 15:37

    Content type: Research article

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  16. The prevalence of chronic kidney disease (CKD) and metabolic diseases has increased at different rates in different regions in China. The aim of our study was to estimate the prevalence of CKD and to analyze a...

    Authors: Bo Lin, Lina Shao, Qun Luo, Lingxia Ou-yang, Fangfang Zhou, Biao Du, Qiang He, Jianyong Wu, Nan Xu and Jianghua Chen

    Citation: BMC Nephrology 2014 15:36

    Content type: Research article

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  17. Children and adolescents with end-stage renal disease (ESRD) in sub-Saharan Africa may have the worst outcomes globally. Barriers to management include late presentation, poor socioeconomic conditions, absence...

    Authors: Adanze O Asinobi, Adebowale D Ademola, Oluwatoyin O Ogunkunle and Susan A Mott

    Citation: BMC Nephrology 2014 15:25

    Content type: Research article

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  18. Cardiovascular disease is a major cause of death in patients with stage 4–5 Chronic Kidney disease (CKD, eGFR < 30). There are only limited data on the risk factors predicting these complications in CKD patien...

    Authors: Ahmad Farshid, Rajeev Pathak, Bruce Shadbolt, Leonard Arnolda and Girish Talaulikar

    Citation: BMC Nephrology 2013 14:280

    Content type: Research article

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  19. Hyponatremia is associated with increased mortality in chronic kidney disease with and without end-stage renal disease (ESRD). Increasing evidence suggests that hyponatremia is not only a marker of severe unde...

    Authors: Shintaro Mandai, Michio Kuwahara, Yuri Kasagi, Keita Kusaka, Tomomi Tanaka, Satomi Shikuma, Wataru Akita and Sei Sasaki

    Citation: BMC Nephrology 2013 14:276

    Content type: Research article

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  20. Dyspepsia is common among end-stage renal disease (ESRD) patients and its association with delayed gastric emptying is not well established. We assessed the association of dyspepsia with gastric emptying time ...

    Authors: Luiz Derwal Salles Junior, Paulo Roberto Santos, Armênio Aguiar dos Santos and Marcellus Henrique Loiola Ponte de Souza

    Citation: BMC Nephrology 2013 14:275

    Content type: Research article

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  21. Few population-based studies have examined the relationship between glycemic status and chronic kidney disease (CKD) in China. We examined the prevalence of CKD across categories of glycemia [diagnosed diabete...

    Authors: Yi Zhou, Justin B Echouffo-Tcheugui, Jian-jun Gu, Xiao-nan Ruan, Gen-ming Zhao, Wang-hong Xu, Li-ming Yang, Hong Zhang, Hua Qiu, K M Venkat Narayan and Qiao Sun

    Citation: BMC Nephrology 2013 14:253

    Content type: Research article

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  22. Low 24-hour urine volume (24UV) may be a significant risk factor for decline in kidney function. We therefore aimed to study associated markers and possible determinants of 24UV in a sample of the Swiss popula...

    Authors: Tobias Schoen, Jonas Blum, Fred Paccaud, Michel Burnier, Murielle Bochud and David Conen

    Citation: BMC Nephrology 2013 14:246

    Content type: Research article

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  23. Urban migration is associated with an increased risk of hypertension, obesity and diabetes in Indian migrants. This study assessed the relationship between internal migration and renal function in the Hyderaba...

    Authors: Phillippa K Bailey, Charles RV Tomson, Sanjay Kinra, Shah Ebrahim, KV Radhakrishna, Hannah Kuper, Dorothea Nitsch and Yoav Ben-Shlomo

    Citation: BMC Nephrology 2013 14:240

    Content type: Research article

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  24. Renal disease is a known contributor to mortality in adults with sickle cell disease (SCD) and renal abnormalities are evident in childhood. Hyperfiltration (evidenced by elevated glomerular filtration rate, G...

    Authors: Prasad Bodas, Alex Huang, Mary Ann O’Riordan, John R Sedor and Katherine MacRae Dell

    Citation: BMC Nephrology 2013 14:237

    Content type: Research article

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  25. Glomerulonephritis (GN) is a group of rare kidney diseases with a substantial health burden and high risk of progression to end-stage renal disease. Research in GN has been limited by poor availability of larg...

    Authors: Sean Barbour, Monica Beaulieu, Jagbir Gill, Ognjenka Djurdjev, Heather Reich and Adeera Levin

    Citation: BMC Nephrology 2013 14:236

    Content type: Database

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  26. Cardiac troponin T is independently associated with cardiovascular events and mortality in patients with chronic kidney disease (CKD). Serum levels of high sensitivity cardiac troponin T (hs-TnT) reflect subcl...

    Authors: Ruth F Dubin, Yongmei Li, Jiang He, Bernard G Jaar, Radhakrishna Kallem, James P Lash, Gail Makos, Sylvia E Rosas, Elsayed Z Soliman, Ray R Townsend, Wei Yang, Alan S Go, Martin Keane, Christopher deFilippi, Rakesh Mishra, Myles Wolf…

    Citation: BMC Nephrology 2013 14:229

    Content type: Research article

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  27. Frailty is a condition characterized by a decline in physical function and functional capacity. Common symptoms of frailty, such as weakness and exhaustion, are prevalent in patients with chronic kidney diseas...

    Authors: Simon R Walker, Kamalpreet Gill, Kerry Macdonald, Paul Komenda, Claudio Rigatto, Manish M Sood, Clara J Bohm, Leroy J Storsley and Navdeep Tangri

    Citation: BMC Nephrology 2013 14:228

    Content type: Research article

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  28. Patients undergoing hemodialysis are at high risk of falls, with subsequent complications including fractures, loss of independence, hospitalization, and institutionalization. Factors associated with falls are...

    Authors: Mara A McAdams-DeMarco, Sunitha Suresh, Andrew Law, Megan L Salter, Luis F Gimenez, Bernard G Jaar, Jeremy D Walston and Dorry L Segev

    Citation: BMC Nephrology 2013 14:224

    Content type: Research article

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  29. Vitamin D insufficiency is associated with proteinuria and could be a risk factor for end-stage renal disease (ESRD). However, few studies have examined the significance of vitamin D insufficiency as a contrib...

    Authors: Bancha Satirapoj, Pokkrong Limwannata, Amnart Chaiprasert, Ouppatham Supasyndh and Panbuppa Choovichian

    Citation: BMC Nephrology 2013 14:206

    Content type: Research article

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  30. Responsiveness to erythropoiesis-stimulating agents (ESAs) varies widely among dialysis patients. ESA resistance has been associated with mortality in hemodialysis (HD) patients, but in peritoneal dialysis (PD...

    Authors: Marit M Suttorp, Tiny Hoekstra, Joris I Rotmans, Ilka Ott, Moshe Mittelman, Raymond T Krediet and Friedo W Dekker

    Citation: BMC Nephrology 2013 14:200

    Content type: Research article

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  31. Chronic kidney disease (CKD) is a known risk factor for cardiovascular events and all-cause mortality. We investigate the relationship between CKD stage, proteinuria, hypertension and these adverse outcomes in...

    Authors: Andrew P McGovern, Benjamin Rusholme, Simon Jones, Jeremy N van Vlymen, Harshana Liyanage, Hugh Gallagher, Charles RV Tomson, Kamlesh Khunti, Kevin Harris and Simon de Lusignan

    Citation: BMC Nephrology 2013 14:198

    Content type: Research article

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  32. There is a paucity of information about the views of dialysis nurses towards dialysis modality selection, yet nurses often have the most direct contact time with patients. We conducted a survey to better under...

    Authors: Karthik K Tennankore, Jay Hingwala, Diane Watson, Joanne M Bargman and Christopher T Chan

    Citation: BMC Nephrology 2013 14:192

    Content type: Research article

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  33. In the general population, reported levels of oxidative stress and antioxidant potential seem to vary. The aim of this study was to investigate the levels of oxidant status markers in relation to estimated glo...

    Authors: Yuko Ishizaka, Minoru Yamakado, Akiko Toda, Mizuki Tani and Nobukazu Ishizaka

    Citation: BMC Nephrology 2013 14:191

    Content type: Research article

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  34. Hepatitis C virus (HCV) infection and chronic kidney disease (CKD) have high prevalences in Taiwan and worldwide, but the role of HCV infection in causing CKD remains uncertain. This cohort study aimed to expl...

    Authors: Yi-Chun Chen, Wen-Yen Chiou, Shih-Kai Hung, Yu-Chieh Su and Shang-Jyh Hwang

    Citation: BMC Nephrology 2013 14:187

    Content type: Research article

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  35. Some 7-10% of patients on replacement renal therapy (RRT) are receiving it because of autosomal dominant polycystic kidney disease (ADPKD). The age at initiation of RRT is expected to increase over time.

    Authors: Víctor Martínez, Jordi Comas, Emma Arcos, Joan Manel Díaz, Salomé Muray, Juan Cabezuelo, José Ballarín, Elisabet Ars and Roser Torra

    Citation: BMC Nephrology 2013 14:186

    Content type: Research article

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  36. The number of adults with diabetes mellitus is increasing worldwide, particularly in Asia and Africa. In sub-Saharan Africa, renal complications of diabetes may go unrecognized due to limited diagnostic resour...

    Authors: Mubarakali N Janmohamed, Samuel E Kalluvya, Andreas Mueller, Rodrick Kabangila, Luke R Smart, Jennifer A Downs and Robert N Peck

    Citation: BMC Nephrology 2013 14:183

    Content type: Research article

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  37. This study describes chronic kidney disease of uncertain aetiology (CKDu), which cannot be attributed to diabetes, hypertension or other known aetiologies, that has emerged in the North Central region of Sri L...

    Authors: Nihal Jayatilake, Shanthi Mendis, Palitha Maheepala and Firdosi R Mehta

    Citation: BMC Nephrology 2013 14:180

    Content type: Research article

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  38. The number of individuals suffering from chronic kidney disease (CKD) is increasing. Therefore, early identification of modifiable predictors of CKD is highly desirable. Previous studies suggest an association...

    Authors: Gabriele Nagel, Emanuel Zitt, Raphael Peter, Alfonso Pompella, Hans Concin and Karl Lhotta

    Citation: BMC Nephrology 2013 14:177

    Content type: Research article

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  39. The number of elderly people over the age of 65 commencing dialysis in NZ has increased by almost 400% in the past decade. Few data are available about health related outcomes and survival on dialysis in the e...

    Authors: Robert Walker, Sarah Derrett, John Campbell, Mark R Marshall, Andrew Henderson, John Schollum, Sheila Williams and Bronwen McNoe

    Citation: BMC Nephrology 2013 14:175

    Content type: Study protocol

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  40. About 39,000 patients were newly prescribed renal replacement therapy in Japan in 2011, resulting in a total of more than 300,000 patients being treated with dialysis. This high prevalence of treated end stage...

    Authors: Soichiro Iimori, Yumi Noda, Tomokazu Okado, Shotaro Naito, Takayuki Toda, Yoshiko Chida, Michio Kuwahara, Ryoichi Ando, Yasuhide Nishio, Yoshitaka Maeda, Hiroyuki Tanaka, Teiichi Tamura, Shigeaki Kimoto, Eiichiro Kanda, Seiji Inoshita, Momono Yoshikawa…

    Citation: BMC Nephrology 2013 14:152

    Content type: Research article

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  41. Increasing evidence suggests a mechanistic link between the glycemic environment and renal and cardiovascular events, even below the threshold for diabetes. We aimed to assess the association between HbA1c and...

    Authors: Domingo Hernandez, Ana Espejo-Gil, M Rosa Bernal-Lopez, Jose Mancera-Romero, Antonio J Baca-Osorio, Francisco J Tinahones, Ana M Armas-Padron, Pedro Ruiz-Esteban, Armando Torres and Ricardo Gomez-Huelgas

    Citation: BMC Nephrology 2013 14:151

    Content type: Research article

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  42. Individuals with end-stage renal disease (ESRD) have excess risk of various cancer types. However, the total burden of human papillomavirus-related cancers remains unknown.

    Authors: Lars Skov Dalgaard, Ulrik Fassel, Lars Jørgen Østergaard, Bente Jespersen, Ole Schmeltz Søgaard and Søren Jensen-Fangel

    Citation: BMC Nephrology 2013 14:137

    Content type: Research article

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  43. For chronic kidney disease (CKD) patients, national treatment guidelines recommend a low-density lipoprotein cholesterol (LDL-C) goal <100 mg/dL and blood pressure (BP) target <130/80 mmHg. This analysis asses...

    Authors: Andreas Kuznik, Jack Mardekian and Lisa Tarasenko

    Citation: BMC Nephrology 2013 14:132

    Content type: Research article

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COVID-19 Announcement

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time. Thank you.

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