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Immunology and Pathology

  1. Content type: Research article

    Lupus nephritis (LN) is an inflammation of the kidneys and is a major cause of mortality in systemic lupus erythaematosus (SLE) patients. In addition, Th17/Treg balance is one of the most important factors tha...

    Authors: Dongdong Fu, Soulixay Senouthai, Junjie Wang and Yanwu You

    Citation: BMC Nephrology 2019 20:350

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  2. Content type: Research article

    Though the roles of microRNAs (miRNAs) in renal diseases have been extensively investigated, a thorough screening and comparison of miRNAs among different types of chronic kidney disease (CKD) has never been p...

    Authors: Jianwen Yu, Chaolun Yu, Boya Feng, Xiaojiang Zhan, Ning Luo, Xueqing Yu and Qin Zhou

    Citation: BMC Nephrology 2019 20:336

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  3. Content type: Case report

    The nature of immunoglobulin M (IgM) nephropathy has been controversial for a long time, but it is now considered an independent disease like immunoglobulin A nephropathy. IgM nephropathy has been known to hav...

    Authors: Kyoung Sook Park, Ea Wha Kang and Jeong Hae Kie

    Citation: BMC Nephrology 2019 20:335

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  4. Content type: Research article

    It has been proposed that peroxisome proliferator-activated receptor-γ (PPARγ) agonists might reduce renal fibrosis, however, several studies had contradictory results. Moreover, the possible interaction of TGF-β

    Authors: Ágnes Németh, Miklós M. Mózes, Laurent Calvier, Georg Hansmann and Gábor Kökény

    Citation: BMC Nephrology 2019 20:245

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  5. Content type: Research article

    IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity a...

    Authors: Tong-dan Bi, Jian-nan Zheng, Jun-xiao Zhang, Long-shu Yang, Nan Liu, Li Yao and Lin-lin Liu

    Citation: BMC Nephrology 2019 20:244

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  6. Content type: Research article

    To evaluate renal expression of C4d, a complement component in the classical/mannose binding lectin (MBL) pathway, in patients with primary Sjögren’s syndrome (pSS)-associated renal impairments.

    Authors: Wenli Xia, Bixia Gao, Lin Duan, Yan Li, Yubing Wen, Limeng Chen, Xuemei Li, Falei Zheng and Mingxi Li

    Citation: BMC Nephrology 2019 20:189

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  7. Content type: Research article

    Angiopoietin-like-3 (Angptl3) knockout is known for its protective effects on podocyte injury and proteinuria in the early stage of adriamycin (ADR) nephropathy. The current study re-evaluated the renoprotecti...

    Authors: Rufeng Dai, Haimei Liu, Xinli Han, Junchao Liu, Yihui Zhai, Jia Rao, Qian Shen and Hong Xu

    Citation: BMC Nephrology 2019 20:185

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  8. Content type: Research article

    Meprin metalloproteases are abundantly expressed in the brush border membranes of kidney proximal tubules and small intestines. Meprins are also expressed in podocytes and leukocytes (monocytes and macrophages...

    Authors: Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner and Elimelda Moige Ongeri

    Citation: BMC Nephrology 2019 20:141

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  9. Content type: Research article

    To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims include...

    Authors: Yi Chen, Liyu Lin, Xuan Tao, Yankun Song, Jiong Cui and Jianxin Wan

    Citation: BMC Nephrology 2019 20:106

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  10. Content type: Research article

    IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Urinary micro-RNA (miRNA) level is increasingly reported to as non-invasive markers of various kidney diseases. We aim to identif...

    Authors: Cheuk-Chun Szeto, Gang Wang, Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Fernand Mac-Moune Lai, Kai-Ming Chow, Cathy Choi-Wan Luk, Ka-Bik Lai and Philip Kam-Tao Li

    Citation: BMC Nephrology 2019 20:77

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  11. Content type: Research article

    Acute kidney injury (AKI) is an underestimated, yet important, risk factor for the development of chronic kidney disease (CKD). Persistence of inflammation after a renal ischemic injury has been observed, both...

    Authors: Lies Moonen, Hilde Geryl, Patrick C. D’Haese and Benjamin A. Vervaet

    Citation: BMC Nephrology 2018 19:343

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  12. Content type: Research article

    Focal segmental glomerulosclerosis (FSGS) is the most common glomerular etiology of end-stage kidney disease (ESKD). Increasing evidence has indicated the reparative potential of mesenchymal stem cells (MSCs) ...

    Authors: Ru-chun Yang, Xiao-ling Zhu, Jun Wang, Feng Wan, Hua-qin Zhang, Yi Lin, Xuan-li Tang and Bin Zhu

    Citation: BMC Nephrology 2018 19:335

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  13. Content type: Research article

    The Oxford classification of IgA nephropathy (IgAN) defines histologic criteria (MEST-C) that provide prognostic information based on the kidney biopsy. There are few data on the predictive impact of this clas...

    Authors: Judith Isabel Schimpf, Till Klein, Christina Fitzner, Frank Eitner, Stefan Porubsky, Ralf-Dieter Hilgers, Jürgen Floege, Hermann-Josef Groene and Thomas Rauen

    Citation: BMC Nephrology 2018 19:328

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  14. Content type: Research article

    Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity in patients with IgAN remain...

    Authors: Guanhong Li, Wei Wu, Xinyao Zhang, Yuan Huang, Yubing Wen, Xuemei Li and Ruitong Gao

    Citation: BMC Nephrology 2018 19:326

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  15. Content type: Research article

    We recently reported on the enhanced tubular expression of two discrete isoforms of the MMP-2 (full length and N-terminal truncated, FL-MMP-2, NTT-MMP-2) in a murine model and human diabetic kidneys. In the pr...

    Authors: Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H. Lovett and Sang Heon Song

    Citation: BMC Nephrology 2018 19:248

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  16. Content type: Research article

    Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have r...

    Authors: Tamara Milagres, Fernando E. García-Arroyo, Miguel A. Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G. Sánchez-Lozada, Richard J. Johnson and Carlos Roncal-Jimenez

    Citation: BMC Nephrology 2018 19:180

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  17. Content type: Research article

    C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies...

    Authors: Takahiro Kanai, Yuko Akioka, Kenichiro Miura, Masataka Hisano, Junki Koike, Yutaka Yamaguchi and Motoshi Hattori

    Citation: BMC Nephrology 2018 19:82

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  18. Content type: Research article

    Chronic kidney disease (CKD) is characterized by sustained tissue damage and ongoing tubulo-interstitial inflammation and fibrosis. Pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and...

    Authors: Ingrid Stroo, Diba Emal, Loes M. Butter, Gwen J. Teske, Nike Claessen, Mark C. Dessing, Stephen E. Girardin, Sandrine Florquin and Jaklien C. Leemans

    Citation: BMC Nephrology 2018 19:78

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  19. Content type: Research article

    Accumulating evidence suggests that a decrease in brain-derived neurotrophic factor (BDNF) level induces a variety of psychiatric and neurological disorders. However, the expression and role of BDNF in the kid...

    Authors: Yuan Sheng Tao, Shang Guo Piao, Ying Shun Jin, Ji Zhe Jin, Hai Lan Zheng, Hai Yan Zhao, Sun Woo Lim, Chul Woo Yang and Can Li

    Citation: BMC Nephrology 2018 19:63

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  20. Content type: Technical advance

    The classical approach to the analysis of kidney biopsies is based on semi-quantitative scores of the amount of sclerosis, inflammatory infiltrate, fibrosis and vascular damage. However, advanced renal lesions...

    Authors: Michelangelo Nigro, Davide Viggiano, Vincenzo Ragone, Tiziana Trabace, Annamaria di Palma, Michele Rossini, Giovambattista Capasso, Loreto Gesualdo and Giuseppe Gigliotti

    Citation: BMC Nephrology 2018 19:62

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  21. Content type: Research article

    Necrotizing glomerular lesions are a feature of severe glomerulonephritis. Unlike apoptosis, cellular necrosis has the potential to release damage-associated proteins into the microenvironment, thereby potenti...

    Authors: N. R. Hill, H. T. Cook, C. D. Pusey and R. M. Tarzi

    Citation: BMC Nephrology 2018 19:61

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  22. Content type: Research article

    Uric acid (UA) plays important roles in inducing renal inflammation, intra-renal vasoconstriction and renal damage. Endothelin-1 (ET-1) is a well-known profibrotic factor in the kidney and is associated with f...

    Authors: Muhammad Mansyur Romi, Nur Arfian, Untung Tranggono, Wiwit Ananda Wahyu Setyaningsih and Dwi Cahyani Ratna Sari

    Citation: BMC Nephrology 2017 18:326

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  23. Content type: Research article

    We studied whether endothelin receptor antagonist and calcimimetic treatments influence renal damage and kidney renin-angiotensin (RA) components in adenine-induced chronic renal insufficiency (CRI).

    Authors: Suvi Törmänen, Ilkka Pörsti, Päivi Lakkisto, Ilkka Tikkanen, Onni Niemelä, Timo Paavonen, Jukka Mustonen and Arttu Eräranta

    Citation: BMC Nephrology 2017 18:323

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  24. Content type: Research article

    Caveolae are membrane invaginations measuring 50–100 nm. These organelles, composed of caveolin and cavin proteins, are important for cellular signaling and survival. Caveolae play incompletely defined roles i...

    Authors: Krzysztof M. Krawczyk, Jennifer Hansson, Helén Nilsson, Katarzyna K. Krawczyk, Karl Swärd and Martin E. Johansson

    Citation: BMC Nephrology 2017 18:320

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  25. Content type: Research article

    Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is...

    Authors: Luiz Henrique Gomes Matheus, Gislene Mendes Simão, Taíssa Altieri Amaral, Rodrigo Barbosa Oliveira Brito, Camila Soares Malta, Yves Silva Teles Matos, Alexandre Chagas Santana, Gabriela Gomes Cardoso Rodrigues, Maria Clara Albejante, Erna Elisabeth Bach, Maria Aparecida Dalboni, Cleber Pinto Camacho and Humberto Dellê

    Citation: BMC Nephrology 2017 18:287

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  26. Content type: Research article

    The renal vasculature plays important roles in both homeostasis and pathology. In this study, we examined pathological changes in the renal microvascular in mouse models of kidney diseases.

    Authors: Md Abdul Masum, Osamu Ichii, Yaser Hosny Ali Elewa, Teppei Nakamura and Yasuhiro Kon

    Citation: BMC Nephrology 2017 18:280

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  27. Content type: Research article

    The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be con...

    Authors: Wen-Pyng Wu, Yi-Giien Tsai, Tze-Yi Lin, Ming-Ju Wu and Ching-Yuang Lin

    Citation: BMC Nephrology 2017 18:225

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  28. Content type: Research article

    Acute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies....

    Authors: Abdulrahman K. Al Asmari, Khalid Tariq Al Sadoon, Ali Ahmed Obaid, Deivakadatcham Yesunayagam and Mohammad Tariq

    Citation: BMC Nephrology 2017 18:41

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  29. Content type: Research article

    Granulocyte colony-stimulating factor (G-CSF) can induce regulatory T cells (Tregs) as well as myeloid-derived suppressor cells (MDSCs). Despite the immune modulatory effects of G-CSF, results of G-CSF treatme...

    Authors: Ji-Jing Yan, Enkthuya Jambaldorj, Jae-Ghi Lee, Joon Young Jang, Jung Min Shim, Miyeun Han, Tai Yeon Koo, Curie Ahn and Jaeseok Yang

    Citation: BMC Nephrology 2016 17:175

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  30. Content type: Research article

    Long-term outcomes after acute kidney injury (AKI) include incremental loss of function and progression towards chronic kidney disease (CKD); however, the pathogenesis of AKI to CKD remains largely unknown. Cl...

    Authors: Jia Guo, Qiunong Guan, Xiuheng Liu, Hao Wang, Martin E. Gleave, Christopher Y. C. Nguan and Caigan Du

    Citation: BMC Nephrology 2016 17:133

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  31. Content type: Research article

    Amyloidosis leads to deposition of abnormal protein with beta-pleated sheet structure in specific compartments of the affected organs. The histological localization of these amyloid deposits determines the ove...

    Authors: Ekaterina Castano, Matthew B Palmer, Christine Vigneault, Randy Luciano, Serena Wong and Gilbert Moeckel

    Citation: BMC Nephrology 2015 16:64

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  32. Content type: Research article

    The TNF-like weak inducer of apoptosis (TWEAK) contributes to kidney inflammation producing secretion by renal cells. The present study examined whether the level of TWEAK is associated with histologic finding...

    Authors: Yohei Sasaki, Yoshio Shimizu, Yusuke Suzuki, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Nephrology 2015 16:27

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  33. Content type: Research article

    Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and is associated with excessive cardiovascular morbidity and mortality. The angiotensin converting enzyme inhibitor (ACEI) benazepril h...

    Authors: Honglin Niu, Lei Nie, Maodong Liu, Yanqing Chi, Tao Zhang and Ying Li

    Citation: BMC Nephrology 2014 15:135

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  34. Content type: Research article

    IgA nephropathy (IgAN) may progress to renal failure for some patients without any clinical risk factors and it is not unusual to find severe pathologic damage in clinically mild IgAN. We therefore investigate...

    Authors: Peng-cheng Xu, Li Wei, Wen-ya Shang, Shun-li Tian, Dong-mei Gu, Tie-kun Yan and Shan Lin

    Citation: BMC Nephrology 2014 15:107

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  35. Content type: Research article

    Although serum under-O-glycosylated IgA1 in IgA nephropathy (IgAN) patients may deposit more preferentially in glomeruli than heavily-O-glycosylated IgA1, the relationship between the glomerular IgA deposition le...

    Authors: Kenji Satake, Yoshio Shimizu, Yohei Sasaki, Hiroyuki Yanagawa, Hitoshi Suzuki, Yusuke Suzuki, Satoshi Horikoshi, Shinichiro Honda, Kazuko Shibuya, Akira Shibuya and Yasuhiko Tomino

    Citation: BMC Nephrology 2014 15:89

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  36. Content type: Research article

    Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage. ...

    Authors: Seiji Nagamachi, Isao Ohsawa, Hiyori Suzuki, Nobuyuki Sato, Hiroyuki Inoshita, Atsuko Hisada, Daisuke Honda, Mamiko Shimamoto, Yoshio Shimizu, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Nephrology 2014 15:82

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  37. Content type: Research article

    Hypertension is a major risk factor for renal disease progression. However, the mechanisms by which hypertension aggravates the effects of diabetes on the kidney are incompletely understood. We tested the hypo...

    Authors: Stella P Hartono, Bruce E Knudsen, Lilach O Lerman, Stephen C Textor and Joseph P Grande

    Citation: BMC Nephrology 2014 15:58

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  38. Content type: Review

    The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cyt...

    Authors: Clare M Turner, Nishkantha Arulkumaran, Mervyn Singer, Robert J Unwin and Frederick WK Tam

    Citation: BMC Nephrology 2014 15:21

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  39. Content type: Case report

    Haemolytic-uremic syndrome (HUS) is a severe, life-threatening disease with symptoms such as haemolytic anaemia, renal failure, and a low platelet count. Possible aetiology includes bacterial infections, medic...

    Authors: Yi-Che Lee, Jyh-Seng Wang, Jeng-Chuan Shiang, Ming-Kai Tsai, Kai-Tai Deng, Min-Yu Chang, Hsi-Hao Wang, Li-Chun Ho, Yi-Ting Chen and Shih-Yuan Hung

    Citation: BMC Nephrology 2014 15:5

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  40. Content type: Research article

    Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure ...

    Authors: Marijan Saraga, Katarina Vukojević, Vjekoslav Krželj, Zvonimir Puretić, Ivana Bočina, Merica Glavina Durdov, Stefanie Weber, Bernd Dworniczak, Danica Galešić Ljubanović and Mirna Saraga-Babić

    Citation: BMC Nephrology 2014 15:3

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  41. Content type: Correspondence

    Most kidney disorders involve some degree of inflammation, i.e. induction of pro-inflammatory mediators and leukocyte recruitment. But what are the factors that determine inflammation as a trigger or a consequ...

    Authors: Hans-Joachim Anders

    Citation: BMC Nephrology 2013 14:138

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