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Immunology and Pathology

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  1. A renal biopsy is needed to define active inflammatory infiltration and guide therapeutic management in drug-induced acute tubulointerstitial nephritis (D-ATIN). However, factors such as various contraindicati...

    Authors: Xi-zi Zheng, Yang-hui Gu, Tao Su, Xu-jie Zhou, Jun-wen Huang, Ping-ping Sun, Yan Jia, Da-min Xu, Su-xia Wang, Gang Liu and Li Yang

    Citation: BMC Nephrology 2020 21:514

    Content type: Research article

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  2. Anti-glomerular basement membrane disease (GBM) is an autoimmune disease caused by the deposition of circulating anti-GBM antibodies. Non-collagen region of α3 chain of type IV collagen (α3(IV)NC1) is one of t...

    Authors: Wen-jing Wang, Xiao-yu Jia, Zhao Cui, Yan Chen, Wei Wang, Jin-li Lou, Ming-hui Zhao and Sun Ying

    Citation: BMC Nephrology 2020 21:429

    Content type: Research article

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  3. Dipeptidyl peptidase-4 (DPP-4) is a serine protease that inhibits the degradation of glucagon-like peptide 1. DPP-4 inhibitors are used worldwide to treat type 2 diabetes mellitus and were recently shown to ha...

    Authors: Ayano Kubo, Teruo Hidaka, Maiko Nakayama, Yu Sasaki, Miyuki Takagi, Hitoshi Suzuki and Yusuke Suzuki

    Citation: BMC Nephrology 2020 21:402

    Content type: Research article

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  4. Membranous nephropathy (MN) has been recognized to occur in patients with human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. The prevalence of phospholipase A2 receptor (PLA2...

    Authors: Vivek Charu, Nicole Andeen, Vighnesh Walavalkar, Jessica Lapasia, Jin-Yon Kim, Andrew Lin, Richard Sibley, John Higgins, Megan Troxell and Neeraja Kambham

    Citation: BMC Nephrology 2020 21:401

    Content type: Research article

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  5. Immune checkpoint inhibitors (ICI) have become the standard of care in many oncological conditions but are associated with a spectrum of renal immune-related adverse events (IrAEs). We aimed to describe the sp...

    Authors: Sebastian Hultin, Kazi Nahar, Alexander M. Menzies, Georgina V. Long, Suran L. Fernando, Victoria Atkinson, Jonathan Cebon and Muh Geot Wong

    Citation: BMC Nephrology 2020 21:391

    Content type: Research article

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  6. Apolipoprotein L1, APOL1, is a trypanosome lytic factor present in human and certain other primates. APOL1 gene variants, present in individuals of recent sub-Saharan African descent, increase risk for glomerular...

    Authors: Hidefumi Wakashin, Jurgen Heymann, Hila Roshanravan, Parnaz Daneshpajouhnejad, Avi Rosenberg, Myung Kyun Shin, Maarten Hoek and Jeffrey B. Kopp

    Citation: BMC Nephrology 2020 21:371

    Content type: Research article

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  7. Lupus nephritis (LN) is one of most common types of secondary glomerulonephritis, which is characterized by longitudinal pathological changes. Microstructural lesions of LN will impact the motion of water mole...

    Authors: Huilan Shi, Yanyan Wang, Tiekun Yan, Junya Jia, Dong Li, Li Wei, Wenya Shang and Zhenfeng Zheng

    Citation: BMC Nephrology 2020 21:313

    Content type: Research article

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  8. Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide. Inflammatory mediators have been implicated in the pathogenesis of DN, thus considered an inflammatory disease. However, fur...

    Authors: Liliane Silvano Araújo, Bianca Gonçalves Silva Torquato, Crislaine Aparecida da Silva, Maria Luíza Gonçalves dos Reis Monteiro, Ana Luisa Monteiro dos Santos Martins, Marcos Vinícius da Silva, Marlene Antônia dos Reis and Juliana Reis Machado

    Citation: BMC Nephrology 2020 21:308

    Content type: Research article

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  9. Focal segmental glomerulosclerosis (FSGS) causes renal fibrosis and may lead to kidney failure. FSGS and its common complication, proteinuria, are challenging to treat. Corticosteroids are ineffective in many ...

    Authors: Kyle Hayes, Elizabeth Warner, Chris Bollinger, Dale Wright and Richard M. Fitch

    Citation: BMC Nephrology 2020 21:226

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2020 21:278

  10. Chronic kidney disease (CKD) is characterized by inflammation, injury and fibrosis. Dysregulated innate immune responses mediated by macrophages play critical roles in progressive renal injury. The differentia...

    Authors: Hewang Lee, Michael B. Fessler, Peng Qu, Jurgen Heymann and Jeffrey B. Kopp

    Citation: BMC Nephrology 2020 21:270

    Content type: Review

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  11. C3 glomerulonephritis is a recently described entity with heterogeneous histopathological features. This study was conducted to assess the effect of reclassification of C3 glomerulopathies on renal outcomes, m...

    Authors: P. Puri, G. D. Walters, M. N. Fadia, M. Konia, K. A. Gibson and S. H. Jiang

    Citation: BMC Nephrology 2020 21:265

    Content type: Research article

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  12. The seroprevalence of human Parvovirus B19 (PVB19) is 70–85% in adults worldwide. PVB19 is the etiologic agent of the fifth disease, is a cause of aplastic anemia, and can be associated with kidney injury. We ...

    Authors: Maëlis Kauffmann, Mickaël Bobot, Laurent Daniel, Julia Torrents, Yannick Knefati, Olivier Moranne, Stéphane Burtey, Christine Zandotti and Noémie Jourde-Chiche

    Citation: BMC Nephrology 2020 21:260

    Content type: Research article

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  13. Lupus nephritis is associated with increased risk of end-stage renal disease (ESRD) and all-cause mortality. We evaluated the clinical features and outcomes of patients with early and delayed lupus nephritis.

    Authors: Sung Soo Ahn, Juyoung Yoo, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee

    Citation: BMC Nephrology 2020 21:258

    Content type: Research article

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  14. The aim of the present study was to evaluate the association between the histology of active and chronic lesions and urinary protein and serum creatinine (SCr) levels, as common clinical endpoints in clinical ...

    Authors: Eri Katsuyama, Yoshia Miyawaki, Ken-ei Sada, Yosuke Asano, Keigo Hayashi, Yuriko Yamamura, Sumie Hiramatsu-Asano, Michiko Morishita, Keiji Ohashi, Haruki Watanabe, Takayuki Katsuyama, Mariko Narazaki, Yoshinori Matsumoto and Jun Wada

    Citation: BMC Nephrology 2020 21:208

    Content type: Research article

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  15. Previous study showed that purinergic P2X7 receptors (P2X7R) reach the highest expression in the first week after unilateral ureteral obstruction (UUO) in mice, and are involved in the process of inflammation,...

    Authors: José Monteiro Sad Pereira, André Luis Barreira, Conrado Rodrigues Gomes, Felipe Mateus Ornellas, Débora Santos Ornellas, Luiz Carlos Miranda, Lucio Ronaldo Cardoso, Robson Coutinho-Silva, Alberto Schanaider, Marcelo M. Morales, Maurilo Leite Jr and Christina Maeda Takiya

    Citation: BMC Nephrology 2020 21:206

    Content type: Research article

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  16. T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by ...

    Authors: Andrea Cove-Smith, Claire C. Sharpe, Michael J. Shattock and Bruce M. Hendry

    Citation: BMC Nephrology 2020 21:187

    Content type: Research article

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  17. Sphingosine-1-phosphate (S1P) is a bioactive metabolite of sphingolipids and produced by sphingosine kinases (SphK1 and SphK2). SphK1/S1P pathway is implicated in the progression of chronic kidney disease. How...

    Authors: Bingqing Lyu, Weili Wang, Xin-Ying Ji, Joseph K. Ritter and Ningjun Li

    Citation: BMC Nephrology 2020 21:173

    Content type: Research article

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  18. Light chain proximal tubulopathy (LCPT) is a rare paraproteinemic renal disease that has been mostly reported in Western patients. LCPT is characterized by the accumulation of immunoglobulin (Ig)-light chain (...

    Authors: Minsun Jung, Youngeun Lee, Hajeong Lee and Kyung Chul Moon

    Citation: BMC Nephrology 2020 21:146

    Content type: Research article

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  19. The relationships between digestive bacterial translocation, uremic toxins, oxidative stress and microinflammation in a population of chronic kidney disease (CKD) patients without metabolic nor inflammatory di...

    Authors: Valerie Olivier, Catherine Dunyach-Remy, Pierre Corbeau, Jean-Paul Cristol, Thibault Sutra, Stephane Burtey, Jean-Philippe Lavigne and Olivier Moranne

    Citation: BMC Nephrology 2020 21:141

    Content type: Research article

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  20. Increased leucine-rich α2-glycoprotein-1 (LRG1) has been observed in various inflammatory and autoimmune diseases. We aimed to explore the expression and role of LRG1 in lupus nephritis (LN).

    Authors: Yi Yang, Ran Luo, Yichun Cheng, Tingting Liu, Wei Dai, Yueqiang Li, Shuwang Ge and Gang Xu

    Citation: BMC Nephrology 2020 21:122

    Content type: Research article

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  21. (1–3)-β-D glucans (BG) are cellular components of yeasts and fungi. Elevated blood levels may be an adjunct in diagnosing invasive fungal infection, though can be high in dialysis patients without fungaemia. B...

    Authors: Jonathan Wong, Yonglong Zhang, Oscar Swift, Malcolm Finkelman, Ashish Patidar, Sivaramakrishnan Ramanarayanan, Enric Vilar and Ken Farrington

    Citation: BMC Nephrology 2020 21:118

    Content type: Research article

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  22. Chronic Kidney Disease of unknown etiology (CKDu) is prevalent in North Central Province (NCP) of Sri Lanka. Consumption of un-boiled dug well water has been identified as one of the causative factors. This in...

    Authors: M. G. Thammitiyagodage, N. R. de Silva, C. Rathnayake, R. Karunakaran, Kumara WGSS, M. M. Gunatillka, N. Ekanayaka, B. P. Galhena and M. I. Thabrew

    Citation: BMC Nephrology 2020 21:38

    Content type: Research article

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  23. Henoch-Schönlein purpura nephritis (HSPN), a small-vessel vasculitis, shares renal pathological features with immunoglobulin A nephropathy. Oxford classification of immunoglobulin A nephropathy pathology has b...

    Authors: Donghwan Yun, Dong Ki Kim, Kook-Hwan Oh, Kwon Wook Joo, Kyung Chul Moon, Yon Su Kim, Kyoungbun Lee and Seung Seok Han

    Citation: BMC Nephrology 2020 21:33

    Content type: Research article

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  24. IgA nephropathy (IgAN) involves mesangial matrix expansion, but the proteomic composition of this matrix is unknown. The present study aimed to characterize changes in extracellular matrix in IgAN.

    Authors: Flavia Teodora Ioana Paunas, Kenneth Finne, Sabine Leh, Tarig Al-Hadi Osman, Hans-Peter Marti, Frode Berven and Bjørn Egil Vikse

    Citation: BMC Nephrology 2019 20:410

    Content type: Research article

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  25. Lupus nephritis (LN) is an inflammation of the kidneys and is a major cause of mortality in systemic lupus erythaematosus (SLE) patients. In addition, Th17/Treg balance is one of the most important factors tha...

    Authors: Dongdong Fu, Soulixay Senouthai, Junjie Wang and Yanwu You

    Citation: BMC Nephrology 2019 20:350

    Content type: Research article

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  26. Though the roles of microRNAs (miRNAs) in renal diseases have been extensively investigated, a thorough screening and comparison of miRNAs among different types of chronic kidney disease (CKD) has never been p...

    Authors: Jianwen Yu, Chaolun Yu, Boya Feng, Xiaojiang Zhan, Ning Luo, Xueqing Yu and Qin Zhou

    Citation: BMC Nephrology 2019 20:336

    Content type: Research article

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  27. The nature of immunoglobulin M (IgM) nephropathy has been controversial for a long time, but it is now considered an independent disease like immunoglobulin A nephropathy. IgM nephropathy has been known to hav...

    Authors: Kyoung Sook Park, Ea Wha Kang and Jeong Hae Kie

    Citation: BMC Nephrology 2019 20:335

    Content type: Case report

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  28. It has been proposed that peroxisome proliferator-activated receptor-γ (PPARγ) agonists might reduce renal fibrosis, however, several studies had contradictory results. Moreover, the possible interaction of TGF-β

    Authors: Ágnes Németh, Miklós M. Mózes, Laurent Calvier, Georg Hansmann and Gábor Kökény

    Citation: BMC Nephrology 2019 20:245

    Content type: Research article

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  29. IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and is an important cause of end-stage renal disease (ESRD). Exploring novel biomarkers is necessary for predicting the disease activity a...

    Authors: Tong-dan Bi, Jian-nan Zheng, Jun-xiao Zhang, Long-shu Yang, Nan Liu, Li Yao and Lin-lin Liu

    Citation: BMC Nephrology 2019 20:244

    Content type: Research article

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  30. To evaluate renal expression of C4d, a complement component in the classical/mannose binding lectin (MBL) pathway, in patients with primary Sjögren’s syndrome (pSS)-associated renal impairments.

    Authors: Wenli Xia, Bixia Gao, Lin Duan, Yan Li, Yubing Wen, Limeng Chen, Xuemei Li, Falei Zheng and Mingxi Li

    Citation: BMC Nephrology 2019 20:189

    Content type: Research article

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  31. Angiopoietin-like-3 (Angptl3) knockout is known for its protective effects on podocyte injury and proteinuria in the early stage of adriamycin (ADR) nephropathy. The current study re-evaluated the renoprotecti...

    Authors: Rufeng Dai, Haimei Liu, Xinli Han, Junchao Liu, Yihui Zhai, Jia Rao, Qian Shen and Hong Xu

    Citation: BMC Nephrology 2019 20:185

    Content type: Research article

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  32. Meprin metalloproteases are abundantly expressed in the brush border membranes of kidney proximal tubules and small intestines. Meprins are also expressed in podocytes and leukocytes (monocytes and macrophages...

    Authors: Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner and Elimelda Moige Ongeri

    Citation: BMC Nephrology 2019 20:141

    Content type: Research article

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  33. To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims include...

    Authors: Yi Chen, Liyu Lin, Xuan Tao, Yankun Song, Jiong Cui and Jianxin Wan

    Citation: BMC Nephrology 2019 20:106

    Content type: Research article

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  34. IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Urinary micro-RNA (miRNA) level is increasingly reported to as non-invasive markers of various kidney diseases. We aim to identif...

    Authors: Cheuk-Chun Szeto, Gang Wang, Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Fernand Mac-Moune Lai, Kai-Ming Chow, Cathy Choi-Wan Luk, Ka-Bik Lai and Philip Kam-Tao Li

    Citation: BMC Nephrology 2019 20:77

    Content type: Research article

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  35. Acute kidney injury (AKI) is an underestimated, yet important, risk factor for the development of chronic kidney disease (CKD). Persistence of inflammation after a renal ischemic injury has been observed, both...

    Authors: Lies Moonen, Hilde Geryl, Patrick C. D’Haese and Benjamin A. Vervaet

    Citation: BMC Nephrology 2018 19:343

    Content type: Research article

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  36. Focal segmental glomerulosclerosis (FSGS) is the most common glomerular etiology of end-stage kidney disease (ESKD). Increasing evidence has indicated the reparative potential of mesenchymal stem cells (MSCs) ...

    Authors: Ru-chun Yang, Xiao-ling Zhu, Jun Wang, Feng Wan, Hua-qin Zhang, Yi Lin, Xuan-li Tang and Bin Zhu

    Citation: BMC Nephrology 2018 19:335

    Content type: Research article

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  37. The Oxford classification of IgA nephropathy (IgAN) defines histologic criteria (MEST-C) that provide prognostic information based on the kidney biopsy. There are few data on the predictive impact of this clas...

    Authors: Judith Isabel Schimpf, Till Klein, Christina Fitzner, Frank Eitner, Stefan Porubsky, Ralf-Dieter Hilgers, Jürgen Floege, Hermann-Josef Groene and Thomas Rauen

    Citation: BMC Nephrology 2018 19:328

    Content type: Research article

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  38. Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity in patients with IgAN remain...

    Authors: Guanhong Li, Wei Wu, Xinyao Zhang, Yuan Huang, Yubing Wen, Xuemei Li and Ruitong Gao

    Citation: BMC Nephrology 2018 19:326

    Content type: Research article

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  39. We recently reported on the enhanced tubular expression of two discrete isoforms of the MMP-2 (full length and N-terminal truncated, FL-MMP-2, NTT-MMP-2) in a murine model and human diabetic kidneys. In the pr...

    Authors: Il Young Kim, Sang Soo Kim, Hye Won Lee, Sun Sik Bae, Hong Koo Ha, Eun Soon Jung, Min Young Lee, Miyeun Han, Harin Rhee, Eun Young Seong, Dong Won Lee, Soo Bong Lee, David H. Lovett and Sang Heon Song

    Citation: BMC Nephrology 2018 19:248

    Content type: Research article

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  40. Increasing evidence suggests heat stress induced chronic kidney disease (CKD) may be mediated by endogenous fructose generation and may be exacerbated by rehydration by fructose-containing solutions. We have r...

    Authors: Tamara Milagres, Fernando E. García-Arroyo, Miguel A. Lanaspa, Gabriela Garcia, Takuji Ishimoto, Ana Andres-Hernando, Masanari Kuwabara, Thomas Jensen, Yuka Sato, Jason Glaser, Laura G. Sánchez-Lozada, Richard J. Johnson and Carlos Roncal-Jimenez

    Citation: BMC Nephrology 2018 19:180

    Content type: Research article

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  41. C1q nephropathy (C1qN) was first described as glomerular disease characterized by predominant meangial C1q deposits in patients with proteinuria and no evidence of systemic lupus erythematosus. Several studies...

    Authors: Takahiro Kanai, Yuko Akioka, Kenichiro Miura, Masataka Hisano, Junki Koike, Yutaka Yamaguchi and Motoshi Hattori

    Citation: BMC Nephrology 2018 19:82

    Content type: Research article

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  42. Chronic kidney disease (CKD) is characterized by sustained tissue damage and ongoing tubulo-interstitial inflammation and fibrosis. Pattern recognition receptors (PRRs) including Toll-like receptors (TLRs) and...

    Authors: Ingrid Stroo, Diba Emal, Loes M. Butter, Gwen J. Teske, Nike Claessen, Mark C. Dessing, Stephen E. Girardin, Sandrine Florquin and Jaklien C. Leemans

    Citation: BMC Nephrology 2018 19:78

    Content type: Research article

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  43. Accumulating evidence suggests that a decrease in brain-derived neurotrophic factor (BDNF) level induces a variety of psychiatric and neurological disorders. However, the expression and role of BDNF in the kid...

    Authors: Yuan Sheng Tao, Shang Guo Piao, Ying Shun Jin, Ji Zhe Jin, Hai Lan Zheng, Hai Yan Zhao, Sun Woo Lim, Chul Woo Yang and Can Li

    Citation: BMC Nephrology 2018 19:63

    Content type: Research article

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  44. The classical approach to the analysis of kidney biopsies is based on semi-quantitative scores of the amount of sclerosis, inflammatory infiltrate, fibrosis and vascular damage. However, advanced renal lesions...

    Authors: Michelangelo Nigro, Davide Viggiano, Vincenzo Ragone, Tiziana Trabace, Annamaria di Palma, Michele Rossini, Giovambattista Capasso, Loreto Gesualdo and Giuseppe Gigliotti

    Citation: BMC Nephrology 2018 19:62

    Content type: Technical advance

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  45. Necrotizing glomerular lesions are a feature of severe glomerulonephritis. Unlike apoptosis, cellular necrosis has the potential to release damage-associated proteins into the microenvironment, thereby potenti...

    Authors: N. R. Hill, H. T. Cook, C. D. Pusey and R. M. Tarzi

    Citation: BMC Nephrology 2018 19:61

    Content type: Research article

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