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Immunology and Pathology

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Section edited by Hayley Henderson

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  1. Amyloidosis leads to deposition of abnormal protein with beta-pleated sheet structure in specific compartments of the affected organs. The histological localization of these amyloid deposits determines the ove...

    Authors: Ekaterina Castano, Matthew B Palmer, Christine Vigneault, Randy Luciano, Serena Wong and Gilbert Moeckel

    Citation: BMC Nephrology 2015 16:64

    Content type: Research article

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  2. The TNF-like weak inducer of apoptosis (TWEAK) contributes to kidney inflammation producing secretion by renal cells. The present study examined whether the level of TWEAK is associated with histologic finding...

    Authors: Yohei Sasaki, Yoshio Shimizu, Yusuke Suzuki, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Nephrology 2015 16:27

    Content type: Research article

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  3. Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and is associated with excessive cardiovascular morbidity and mortality. The angiotensin converting enzyme inhibitor (ACEI) benazepril h...

    Authors: Honglin Niu, Lei Nie, Maodong Liu, Yanqing Chi, Tao Zhang and Ying Li

    Citation: BMC Nephrology 2014 15:135

    Content type: Research article

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  4. IgA nephropathy (IgAN) may progress to renal failure for some patients without any clinical risk factors and it is not unusual to find severe pathologic damage in clinically mild IgAN. We therefore investigate...

    Authors: Peng-cheng Xu, Li Wei, Wen-ya Shang, Shun-li Tian, Dong-mei Gu, Tie-kun Yan and Shan Lin

    Citation: BMC Nephrology 2014 15:107

    Content type: Research article

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  5. Although serum under-O-glycosylated IgA1 in IgA nephropathy (IgAN) patients may deposit more preferentially in glomeruli than heavily-O-glycosylated IgA1, the relationship between the glomerular IgA deposition le...

    Authors: Kenji Satake, Yoshio Shimizu, Yohei Sasaki, Hiroyuki Yanagawa, Hitoshi Suzuki, Yusuke Suzuki, Satoshi Horikoshi, Shinichiro Honda, Kazuko Shibuya, Akira Shibuya and Yasuhiko Tomino

    Citation: BMC Nephrology 2014 15:89

    Content type: Research article

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  6. Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage. ...

    Authors: Seiji Nagamachi, Isao Ohsawa, Hiyori Suzuki, Nobuyuki Sato, Hiroyuki Inoshita, Atsuko Hisada, Daisuke Honda, Mamiko Shimamoto, Yoshio Shimizu, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Nephrology 2014 15:82

    Content type: Research article

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  7. Hypertension is a major risk factor for renal disease progression. However, the mechanisms by which hypertension aggravates the effects of diabetes on the kidney are incompletely understood. We tested the hypo...

    Authors: Stella P Hartono, Bruce E Knudsen, Lilach O Lerman, Stephen C Textor and Joseph P Grande

    Citation: BMC Nephrology 2014 15:58

    Content type: Research article

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  8. The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cyt...

    Authors: Clare M Turner, Nishkantha Arulkumaran, Mervyn Singer, Robert J Unwin and Frederick WK Tam

    Citation: BMC Nephrology 2014 15:21

    Content type: Review

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  9. Haemolytic-uremic syndrome (HUS) is a severe, life-threatening disease with symptoms such as haemolytic anaemia, renal failure, and a low platelet count. Possible aetiology includes bacterial infections, medic...

    Authors: Yi-Che Lee, Jyh-Seng Wang, Jeng-Chuan Shiang, Ming-Kai Tsai, Kai-Tai Deng, Min-Yu Chang, Hsi-Hao Wang, Li-Chun Ho, Yi-Ting Chen and Shih-Yuan Hung

    Citation: BMC Nephrology 2014 15:5

    Content type: Case report

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  10. Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure ...

    Authors: Marijan Saraga, Katarina Vukojević, Vjekoslav Krželj, Zvonimir Puretić, Ivana Bočina, Merica Glavina Durdov, Stefanie Weber, Bernd Dworniczak, Danica Galešić Ljubanović and Mirna Saraga-Babić

    Citation: BMC Nephrology 2014 15:3

    Content type: Research article

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  11. Most kidney disorders involve some degree of inflammation, i.e. induction of pro-inflammatory mediators and leukocyte recruitment. But what are the factors that determine inflammation as a trigger or a consequ...

    Authors: Hans-Joachim Anders

    Citation: BMC Nephrology 2013 14:138

    Content type: Correspondence

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