Skip to main content

Immunology and Pathology

New Content Item

Section edited by Hayley Henderson

Page 2 of 2

  1. Caveolae are membrane invaginations measuring 50–100 nm. These organelles, composed of caveolin and cavin proteins, are important for cellular signaling and survival. Caveolae play incompletely defined roles i...

    Authors: Krzysztof M. Krawczyk, Jennifer Hansson, Helén Nilsson, Katarzyna K. Krawczyk, Karl Swärd and Martin E. Johansson

    Citation: BMC Nephrology 2017 18:320

    Content type: Research article

    Published on:

  2. Indoleamine 2, 3-dioxygenase (IDO) is an immunomodulatory molecule that has been implicated in several biological processes. Although IDO has been linked with some renal diseases, its role in renal fibrosis is...

    Authors: Luiz Henrique Gomes Matheus, Gislene Mendes Simão, Taíssa Altieri Amaral, Rodrigo Barbosa Oliveira Brito, Camila Soares Malta, Yves Silva Teles Matos, Alexandre Chagas Santana, Gabriela Gomes Cardoso Rodrigues, Maria Clara Albejante, Erna Elisabeth Bach, Maria Aparecida Dalboni, Cleber Pinto Camacho and Humberto Dellê

    Citation: BMC Nephrology 2017 18:287

    Content type: Research article

    Published on:

  3. The renal vasculature plays important roles in both homeostasis and pathology. In this study, we examined pathological changes in the renal microvascular in mouse models of kidney diseases.

    Authors: Md Abdul Masum, Osamu Ichii, Yaser Hosny Ali Elewa, Teppei Nakamura and Yasuhiro Kon

    Citation: BMC Nephrology 2017 18:280

    Content type: Research article

    Published on:

  4. The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be con...

    Authors: Wen-Pyng Wu, Yi-Giien Tsai, Tze-Yi Lin, Ming-Ju Wu and Ching-Yuang Lin

    Citation: BMC Nephrology 2017 18:225

    Content type: Research article

    Published on:

  5. Acute kidney injury (AKI) is a serious clinical problem with high rate of mortality and morbidity. Currently used prophylactic and therapeutic strategies to address AKI are limited and warrant further studies....

    Authors: Abdulrahman K. Al Asmari, Khalid Tariq Al Sadoon, Ali Ahmed Obaid, Deivakadatcham Yesunayagam and Mohammad Tariq

    Citation: BMC Nephrology 2017 18:41

    Content type: Research article

    Published on:

  6. Granulocyte colony-stimulating factor (G-CSF) can induce regulatory T cells (Tregs) as well as myeloid-derived suppressor cells (MDSCs). Despite the immune modulatory effects of G-CSF, results of G-CSF treatme...

    Authors: Ji-Jing Yan, Enkthuya Jambaldorj, Jae-Ghi Lee, Joon Young Jang, Jung Min Shim, Miyeun Han, Tai Yeon Koo, Curie Ahn and Jaeseok Yang

    Citation: BMC Nephrology 2016 17:175

    Content type: Research article

    Published on:

  7. Long-term outcomes after acute kidney injury (AKI) include incremental loss of function and progression towards chronic kidney disease (CKD); however, the pathogenesis of AKI to CKD remains largely unknown. Cl...

    Authors: Jia Guo, Qiunong Guan, Xiuheng Liu, Hao Wang, Martin E. Gleave, Christopher Y. C. Nguan and Caigan Du

    Citation: BMC Nephrology 2016 17:133

    Content type: Research article

    Published on:

  8. Amyloidosis leads to deposition of abnormal protein with beta-pleated sheet structure in specific compartments of the affected organs. The histological localization of these amyloid deposits determines the ove...

    Authors: Ekaterina Castano, Matthew B Palmer, Christine Vigneault, Randy Luciano, Serena Wong and Gilbert Moeckel

    Citation: BMC Nephrology 2015 16:64

    Content type: Research article

    Published on:

  9. The TNF-like weak inducer of apoptosis (TWEAK) contributes to kidney inflammation producing secretion by renal cells. The present study examined whether the level of TWEAK is associated with histologic finding...

    Authors: Yohei Sasaki, Yoshio Shimizu, Yusuke Suzuki, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Nephrology 2015 16:27

    Content type: Research article

    Published on:

  10. Diabetic nephropathy (DN) is the leading cause of chronic kidney disease and is associated with excessive cardiovascular morbidity and mortality. The angiotensin converting enzyme inhibitor (ACEI) benazepril h...

    Authors: Honglin Niu, Lei Nie, Maodong Liu, Yanqing Chi, Tao Zhang and Ying Li

    Citation: BMC Nephrology 2014 15:135

    Content type: Research article

    Published on:

  11. IgA nephropathy (IgAN) may progress to renal failure for some patients without any clinical risk factors and it is not unusual to find severe pathologic damage in clinically mild IgAN. We therefore investigate...

    Authors: Peng-cheng Xu, Li Wei, Wen-ya Shang, Shun-li Tian, Dong-mei Gu, Tie-kun Yan and Shan Lin

    Citation: BMC Nephrology 2014 15:107

    Content type: Research article

    Published on:

  12. Although serum under-O-glycosylated IgA1 in IgA nephropathy (IgAN) patients may deposit more preferentially in glomeruli than heavily-O-glycosylated IgA1, the relationship between the glomerular IgA deposition le...

    Authors: Kenji Satake, Yoshio Shimizu, Yohei Sasaki, Hiroyuki Yanagawa, Hitoshi Suzuki, Yusuke Suzuki, Satoshi Horikoshi, Shinichiro Honda, Kazuko Shibuya, Akira Shibuya and Yasuhiko Tomino

    Citation: BMC Nephrology 2014 15:89

    Content type: Research article

    Published on:

  13. Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage. ...

    Authors: Seiji Nagamachi, Isao Ohsawa, Hiyori Suzuki, Nobuyuki Sato, Hiroyuki Inoshita, Atsuko Hisada, Daisuke Honda, Mamiko Shimamoto, Yoshio Shimizu, Satoshi Horikoshi and Yasuhiko Tomino

    Citation: BMC Nephrology 2014 15:82

    Content type: Research article

    Published on:

  14. Hypertension is a major risk factor for renal disease progression. However, the mechanisms by which hypertension aggravates the effects of diabetes on the kidney are incompletely understood. We tested the hypo...

    Authors: Stella P Hartono, Bruce E Knudsen, Lilach O Lerman, Stephen C Textor and Joseph P Grande

    Citation: BMC Nephrology 2014 15:58

    Content type: Research article

    Published on:

  15. The inflammasome is a large, multiprotein complex that drives proinflammatory cytokine production in response to infection and tissue injury. Pattern recognition receptors that are either membrane bound or cyt...

    Authors: Clare M Turner, Nishkantha Arulkumaran, Mervyn Singer, Robert J Unwin and Frederick WK Tam

    Citation: BMC Nephrology 2014 15:21

    Content type: Review

    Published on:

  16. Haemolytic-uremic syndrome (HUS) is a severe, life-threatening disease with symptoms such as haemolytic anaemia, renal failure, and a low platelet count. Possible aetiology includes bacterial infections, medic...

    Authors: Yi-Che Lee, Jyh-Seng Wang, Jeng-Chuan Shiang, Ming-Kai Tsai, Kai-Tai Deng, Min-Yu Chang, Hsi-Hao Wang, Li-Chun Ho, Yi-Ting Chen and Shih-Yuan Hung

    Citation: BMC Nephrology 2014 15:5

    Content type: Case report

    Published on:

  17. Nephrotic syndrome (NS) is pathological condition characterized by heavy proteinuria. Our study investigates hypothesis that change in cell proliferation of proximal tubules influences primary cilia structure ...

    Authors: Marijan Saraga, Katarina Vukojević, Vjekoslav Krželj, Zvonimir Puretić, Ivana Bočina, Merica Glavina Durdov, Stefanie Weber, Bernd Dworniczak, Danica Galešić Ljubanović and Mirna Saraga-Babić

    Citation: BMC Nephrology 2014 15:3

    Content type: Research article

    Published on:

  18. Most kidney disorders involve some degree of inflammation, i.e. induction of pro-inflammatory mediators and leukocyte recruitment. But what are the factors that determine inflammation as a trigger or a consequ...

    Authors: Hans-Joachim Anders

    Citation: BMC Nephrology 2013 14:138

    Content type: Correspondence

    Published on: