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BMC Nephrology

Mineral Metabolism and Bone Disease

Section edited by Adrian Covic

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  1. Content type: Research article

    Vascular calcification is a major contributing factor to mortality in end stage renal disease (ESRD). Despite the efficacy of phosphate binders to improve hyperphosphatemia, data on vascular calcification are ...

    Authors: A. Neradova, S. P. Schumacher, I. Hubeek, P. Lux, L. J. Schurgers and M. G. Vervloet

    Citation: BMC Nephrology 2017 18:149

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  2. Content type: Research article

    The clinical effect of bisphosphonate treatment has not been clearly evaluated by kidney function in Japanese Chronic Kidney Disease (CKD) patients with osteoporosis. This study analyzed the data from three ri...

    Authors: Takashi Shigematsu, Ryoichi Muraoka, Toshitsugu Sugimoto and Yoshiki Nishizawa

    Citation: BMC Nephrology 2017 18:66

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  3. Content type: Research article

    Intravenous iron affects serum levels of intact fibroblast growth factor-23 (iFGF23) and its cleavage product c-terminal FGF23 (cFGF23) in iron-deficient people with normal renal function. We hypothesized that...

    Authors: Matthew A. Roberts, Louis Huang, Darren Lee, Robert MacGinley, Stefanie M. A. Troster, Annette B. Kent, Sukhvinder S. Bansal, Iain C. Macdougall and Lawrence P. McMahon

    Citation: BMC Nephrology 2016 17:177

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  4. Content type: Research article

    The regulation of fibroblast growth factor-23 (FGF23) secretion in patients with chronic kidney disease (CKD) is incompletely understood. An in vitro study showed that metabolic acidosis increased FGF23 in mouse ...

    Authors: Wei Chen, Michal L. Melamed, Thomas H. Hostetter, Carolyn Bauer, Amanda C. Raff, Anthony L. Almudevar, Amy Lalonde, Susan Messing and Matthew K. Abramowitz

    Citation: BMC Nephrology 2016 17:114

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  5. Content type: Research article

    Cardiovascular calcifications can be prevented by vitamin K and are accelerated by vitamin K antagonists. These effects are believed to be mainly mediated by the vitamin K-dependent matrix Gla protein. Another...

    Authors: Nadine Kaesler, Svenja Immendorf, Chun Ouyang, Marjolein Herfs, Nadja Drummen, Peter Carmeliet, Cees Vermeer, Jürgen Floege, Thilo Krüger and Georg Schlieper

    Citation: BMC Nephrology 2016 17:52

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  6. Content type: Research article

    Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is stil...

    Authors: Hsin-Hung Lin, Hung-Hsiang Liou, Ming-Shiou Wu and Chiu-Ching Huang

    Citation: BMC Nephrology 2016 17:33

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  7. Content type: Research article

    Removal of phosphate by peritoneal dialysis is insufficient to maintain normal serum phosphate levels such that most patients must take phosphate binders with their meals. However, phosphate ‘counting’ is comp...

    Authors: Simon Leung, Brendan McCormick, Jessica Wagner, Mohan Biyani, Susan Lavoie, Rameez Imtiaz and Deborah Zimmerman

    Citation: BMC Nephrology 2015 16:205

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  8. Content type: Research article

    Hyperphosphataemia is linked to cardiovascular disease and mortality in chronic kidney disease (CKD). Outcome in CKD is also affected by socioeconomic status. The objective of this study was to assess the asso...

    Authors: Marit D. Solbu, Peter C. Thomson, Sarah Macpherson, Mark D. Findlay, Kathryn K Stevens, Rajan K. Patel, Sandosh Padmanabhan, Alan G Jardine and Patrick B. Mark

    Citation: BMC Nephrology 2015 16:194

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  9. Content type: Research article

    Understanding the regulation of mineral homeostasis and function of the skeleton as buffer for Calcium and Phosphate has regained new interest with introduction of the syndrome “Chronic Kidney Disease-Mineral ...

    Authors: Anders Nordholm, Maria L Mace, Eva Gravesen, Klaus Olgaard and Ewa Lewin

    Citation: BMC Nephrology 2015 16:29

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  10. Content type: Research article

    Polycystic kidney disease (PKD), a genetic disorder characterized by multiple cysts and renal failure at an early age. In children, kidney disease is often accompanied by disordered mineral metabolism, failure...

    Authors: Kaitlin H Maditz, Brenda J Smith, Matthew Miller, Chris Oldaker and Janet C Tou

    Citation: BMC Nephrology 2015 16:13

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  11. Content type: Research article

    Dialysis patients suffer from a high burden of cardiovascular disease (CVD). Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous studies suggested that besides FGF-23, lo...

    Authors: Maurits S Buiten, Mihály K de Bie, Annet Bouma-de Krijger, Bastiaan van Dam, Friedo W Dekker, J Wouter Jukema, Ton J Rabelink and Joris I Rotmans

    Citation: BMC Nephrology 2014 15:197

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  12. Content type: Research article

    Sclerostin (Scl) has recently emerged as a novel marker of bone remodeling and vascular calcification. However, whether high circulating Scl is also a risk factor for death is not well established. The purpose...

    Authors: Flávia Letícia Carvalho Gonçalves, Rosilene M Elias, Luciene M dos Reis, Fabiana G Graciolli, Fernando Godinho Zampieri, Rodrigo B Oliveira, Vanda Jorgetti and Rosa MA Moysés

    Citation: BMC Nephrology 2014 15:190

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  13. Content type: Research article

    Mineral disorders are associated with adverse renal outcomes in chronic kidney disease (CKD) patients. Previous studies have associated hypercalcemia and hypocalcemia with mortality; however, the association b...

    Authors: Lee-Moay Lim, Hung-Tien Kuo, Mei-Chuan Kuo, Yi-Wen Chiu, Jia-Jung Lee, Shang-Jyh Hwang, Jer-Chia Tsai, Chi-Chih Hung and Hung-Chun Chen

    Citation: BMC Nephrology 2014 15:183

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  14. Content type: Case report

    Demineralisation and bone density loss during immobilisation are known phenomena. However information concerning the extent of calcium loss during immobilisation remains inconsistent within literature. This ma...

    Authors: Matthias Klingele, Sarah Seiler, Aaron Poppleton, Philip Lepper, Danilo Fliser and Roland Seidel

    Citation: BMC Nephrology 2014 15:163

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  15. Content type: Research article

    Matrix Gla protein (MGP) is known to act as a potent local inhibitor of vascular calcifications. However, in order to be active, MGP must be phosphorylated and carboxylated, with this last process being depend...

    Authors: Pierre Delanaye, Jean-Marie Krzesinski, Xavier Warling, Martial Moonen, Nicole Smelten, Laurent Médart, Hans Pottel and Etienne Cavalier

    Citation: BMC Nephrology 2014 15:145

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  16. Content type: Research article

    AMG 416 is a novel peptide agonist of the calcium-sensing receptor (CaSR). This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approv...

    Authors: Sarah Walter, Amos Baruch, Shawn T Alexander, Julie Janes, Eiketsu Sho, Jin Dong, Qun Yin, Derek Maclean, Dirk B Mendel, Felix Karim and Randolph M Johnson

    Citation: BMC Nephrology 2014 15:81

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  17. Content type: Research article

    High levels of circulating fibroblast growth factor 23 (FGF23) are associated with chronic kidney disease (CKD) progression and high mortality. In the Phosphate Reduction Evaluation of FGF23 in Early CKD Treat...

    Authors: Pablo Ureña-Torres, Dominique Prié, Karim Keddad, Peter Preston, Paul Wilde, Hong Wan and J Brian Copley

    Citation: BMC Nephrology 2014 15:71

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  18. Content type: Research article

    Experimental models are important to the understanding of the pathophysiology of, as well as the effects of therapy on, certain diseases. In the case of chronic kidney disease-mineral bone disorder, there are ...

    Authors: Guaraciaba O Ferrari, Juliana C Ferreira, Raquel T Cavallari, Katia R Neves, Luciene M dos Reis, Wagner V Dominguez, Elizabeth C Oliveira, Fabiana G Graciolli, Jutta Passlick-Deetjen, Vanda Jorgetti and Rosa MA Moysés

    Citation: BMC Nephrology 2014 15:69

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  19. Content type: Research article

    Previous studies have shown that treatment with ergocalciferol in patients with CKD stage 3 + 4 is not effective with less than 33% of patients achieving a 25-OH vitamin D target of >30 ng/ml. The aim of this ...

    Authors: Amay Parikh, Herbert S Chase, Linda Vernocchi and Leonard Stern

    Citation: BMC Nephrology 2014 15:47

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  20. Content type: Research article

    High iron load might have a number of toxic effects in the organism. Recently intravenous (iv) iron has been proposed to induce elevation of fibroblast growth factor 23 (FGF23), hypophosphatemia and osteomalac...

    Authors: Eva Gravesen, Jacob Hofman-Bang, Maria L Mace, Ewa Lewin and Klaus Olgaard

    Citation: BMC Nephrology 2013 14:281

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BMC Nephrology

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