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Pre-dialysis care and dialysis

The Pre-dialysis Care and Dialysis section considers clinical research relating to the care of patients both before and during dialysis and their post-dialysis outcomes. Articles may describe interventional and non-interventional studies as well as qualitative studies. Systematic reviews, meta-analyses and large epidemiological studies should be directed to the Epidemiology and Health Outcomes section. This section does not consider case reports and these should be directed to the dedicated Case Reports section.

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  1. Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardio...

    Authors: Samuel A. Headley, Donna J. Chapman, Michael J. Germain, Elizabeth E. Evans, Jasmin Hutchinson, Karen L. Madsen, Talat Alp Ikizler, Emily M. Miele, Kristyn Kirton, Elizabeth O’Neill, Allen Cornelius, Brian Martin, Bradley Nindl and Nosratola D. Vaziri

    Citation: BMC Nephrology 2020 21:517

    Content type: Study protocol

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  2. End-stage renal disease (ESRD) patients are at a substantially higher risk for developing cognitive impairment compared with the healthy population. Dialysis is an essential way to maintain the life of ESRD pa...

    Authors: Shaohui Ma, Ming Zhang, Yang Liu, Dun Ding, Peng Li, Xueying Ma, Hongjuan Liu and Junya Mu

    Citation: BMC Nephrology 2020 21:515

    Content type: Research article

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  3. In this study, we focused on the role of overhydration (OH) and low serum prealbumin concentration in predicting peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 3-year period.

    Authors: Quyen Dao Bui Quy, Tuan Pham Ngoc Huy, Loc Nguyen Duc, My Pham Van, Dung Nguyen Huu, Toan Nguyen Duy, Tien Tran Viet, Quyet Do and Thang Le Viet

    Citation: BMC Nephrology 2020 21:512

    Content type: Research article

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  4. optimal management of end-stage renal disease (ESRD) in hemodialysis (HD) patients should be more studied because it is a serious risk factor for mortality, being considered an unquestionable global priority.

    Authors: Emily de Souza Ferreira, Tiago Ricardo Moreira, Rodrigo Gomes da Silva, Glauce Dias da Costa, Luciana Saraiva da Silva, Samantha Bicalho de Oliveira Cavalier, Beatriz Oliveira Silva, Heloísa Helena Dias, Luiza Delazari Borges, Juliana Costa Machado and Rosângela Minardi Mitre Cotta

    Citation: BMC Nephrology 2020 21:502

    Content type: Research article

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  5. Haemodialysis can negatively impact quality of life and mental health. Arts-based interventions used successfully in other settings to improve health and well-being, could help address the impact of haemodialy...

    Authors: Claire Carswell, Joanne Reid, Ian Walsh, William Johnston, Helen McAneney, Robert Mullan, Jenny B. Lee, Hugh Nelson, Michael Matthews, Elizabeth Weatherup, Andrea Spencer, Jean Michelo, Anne Quail, Grainne Kielty, Alistair Mackenzie, Jenny Elliott…

    Citation: BMC Nephrology 2020 21:497

    Content type: Research article

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  6. Critically ill coronavirus disease 2019 (COVID-19) patients have a high risk of acute kidney injury (AKI) that requires renal replacement therapy (RRT). A state of hypercoagulability reduces circuit life spans...

    Authors: Frederic Arnold, Lukas Westermann, Siegbert Rieg, Elke Neumann-Haefelin, Paul Marc Biever, Gerd Walz, Johannes Kalbhenn and Yakup Tanriver

    Citation: BMC Nephrology 2020 21:486

    Content type: Research article

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  7. The purpose of this study was to explore the effect of changing treatment to high-flux hemodialysis (HFHD) on mortality rate in patients with long-term low flux hemodialysis (LFHD).

    Authors: Shuxin Liu, Hong Liu, Zhihong Wang, Lanbo Teng, Cui Dong, Tingting Gui and Yu Zhang

    Citation: BMC Nephrology 2020 21:485

    Content type: Research article

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  8. Hepatitis C virus (HCV) infects more than 71 million people worldwide and chronic HCV infection increases the risk of liver cirrhosis and failure. Haemodialysis (HD) is one of the renal replacement therapies w...

    Authors: Xue Zheng Wong, Chye Chung Gan, Rosmawati Mohamed, Rosnawati Yahya, Shubash Ganapathy, Soek Siam Tan and Soo Kun Lim

    Citation: BMC Nephrology 2020 21:480

    Content type: Research article

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  9. We questioned whether the introduction of a subjective evaluation of patient-specific goals, could be used as a valid method to assess the effectiveness of inpatient rehabilitation.

    Authors: Takahiro Shimoda, Helen Alston, Angelique Chai and Sarbjit V. Jassal

    Citation: BMC Nephrology 2020 21:466

    Content type: Research article

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  10. Renal replacement therapy (RRT) is usually indicated for patients with chronic kidney disease (CKD) with glomerular filtration rate below 10 ml/ml/min/1.73m2. However, the need for RRT and timing of dialysis init...

    Authors: Venceslau A. Coelho, Giovani GN. Santos, Carla M. Avesani, Cicero Italo L. Bezerra, Luana Cristina A. Silva, Julia C. Lauar, Bengt Lindholm, Peter Stenvinkel, Wilson Jacob-Filho, Irene L. Noronha, Roberto Zatz, Rosa M. A. Moysés and Rosilene M. Elias

    Citation: BMC Nephrology 2020 21:461

    Content type: Study protocol

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  11. Patients on continuous ambulatory peritoneal dialysis (PD) are encouraged to warm dialysate to 37 °C before peritoneal infusion; main international PD guidelines do not provide specific recommendation, and pat...

    Authors: Francesco Fontana, Chiara Torelli, Silvia Giovanella, Giulia Ligabue, Gaetano Alfano, Karin Gerritsen, Rafael Selgas and Gianni Cappelli

    Citation: BMC Nephrology 2020 21:448

    Content type: Research article

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  12. Phase angle (PA), measured by bioelectrical impedance analysis (BIA) has been studied as indicator of nutritional status or muscle function in hemodialysis (HD) patients. It remains unclear if the phase angle ...

    Authors: Masakazu Saitoh, Masumi Ogawa, Hisae Kondo, Kiichi Suga, Tetsuya Takahashi, Haruki Itoh and Yoichiro Tabata

    Citation: BMC Nephrology 2020 21:438

    Content type: Research article

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  13. Early kidney transplantation (KT) is the best option for patients with end-stage kidney disease, but little is known about dialysis access strategy in this context. We studied practice patterns of dialysis acc...

    Authors: Raphaëlle Sylvestre, Natalia Alencar de Pinho, Ziad A. Massy, Christian Jacquelinet, Mathilde Prezelin-Reydit, Roula Galland, Bénédicte Stengel and Raphael Coscas

    Citation: BMC Nephrology 2020 21:422

    Content type: Research article

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  14. Patients with end-stage kidney disease, receiving haemodialysis rely increasingly on informal carers to help manage their debilitating chronic disease. Informal carers may experience a negative impact on their...

    Authors: Michael Matthews, Joanne Reid, Clare McKeaveney, Robert Mullan, Stephanie Bolton, Christopher Hill and Helen Noble

    Citation: BMC Nephrology 2020 21:421

    Content type: Study protocol

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  15. The causes of anaemia in patients with end-stage renal disease include a relative deficiency in erythropoietin production and complex clinical conditions. We aimed to investigate the underlying mechanisms of a...

    Authors: Koichiro Matsumura, Toshika Okumiya, Tetsuro Sugiura, Nobuyuki Takahashi, Yoshihiro Yamamoto, Sanae Kikuchi, Kenichi Fujii, Munemitsu Otagaki and Ichiro Shiojima

    Citation: BMC Nephrology 2020 21:418

    Content type: Research article

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  16. Chronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investiga...

    Authors: Xiaobo Duan, Xiaolei Chen, Megha Gupta, Dutmanee Seriwatanachai, Hanxiao Xue, Qiuchan Xiong, Tong Xu, Dan Li, Anchun Mo, Xi Tang, Xuedong Zhou, Yuqing Li and Quan Yuan

    Citation: BMC Nephrology 2020 21:414

    Content type: Research article

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  17. The optimal choice of treatment, with hemodialysis (HD) or peritoneal dialysis (PD), for end-stage renal disease (ESRD) patients, is still controversial. Only a few studies comparing HD and PD have been conduc...

    Authors: Zhiren He, Haijing Hou, Difei Zhang, Yenan Mo, La Zhang, Guobin Su, Junjie Lin, Liming Lu, Jingyao Huang, Yewen Gu, Ying Zhang, Jingxia Lin, Fengling Yuan, Yu Peng, Hui Liang, Daixin Zhao…

    Citation: BMC Nephrology 2020 21:412

    Content type: Research article

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  18. Platelet activation is an important side effect of dialysis, resulted in a subsequent release of arachidonic acid (AA) from activated platelets. AA is involved in many pathologic conditions, such as inflammati...

    Authors: Elżbieta Cecerska-Heryć, Rafał Heryć, Magda Wiśniewska, Natalia Serwin, Bartłomiej Grygorcewicz and Barbara Dołęgowska

    Citation: BMC Nephrology 2020 21:394

    Content type: Research article

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  19. Uricemia dramatically rises with the stage of chronic kidney disease (CKD) and correlates with its mortality. Hemodialysis (HD) being the most used treatment at the end stage in sub-Saharan Africa, we sought t...

    Authors: Marie Doualla, Jan René Nkeck, Marie Patrice Halle, Félicité Kamdem, Aude Ingrid Agouak, Mickael Essouma, Yonathan Batchama Lobe and Gloria Ashuntantang

    Citation: BMC Nephrology 2020 21:378

    Content type: Research article

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  20. Older haemodialysis patients accompany a high burden of functional impairment, limited life expectancy, and healthcare utilization. This meta-analysis aimed to evaluate how various risk factors influenced the ...

    Authors: Yu-Huan Song, Guang-Yan Cai, Yue-Fei Xiao and Xiang-Mei Chen

    Citation: BMC Nephrology 2020 21:377

    Content type: Research article

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  21. Plasma fibrinogen is significantly associated with cardiovascular (CV) events and mortality in the general population. However, the association between plasma fibrinogen and mortality in patients undergoing pe...

    Authors: Jing Yu, Tong Lin, Naya Huang, Xi Xia, Jianbo Li, Yagui Qiu, Xiao Yang, Haiping Mao and Fengxian Huang

    Citation: BMC Nephrology 2020 21:349

    Content type: Research article

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  22. Elevated levels of serum indoxyl sulfate (IS) have been linked to cardiovascular complications in patients with chronic kidney disease (CKD). Oral sorbent therapy using spherical carbons selectively attenuates...

    Authors: Seok-hyung Kim, Jong Hyun Jhee, Hoon Young Choi, Sang-Ho Lee, Sug Kyun Shin, So-Young Lee, Dong Ho Yang, Joo-Hark Yi, Sang-Woong Han, Young-Il Jo and Hyeong Cheon Park

    Citation: BMC Nephrology 2020 21:317

    Content type: Research article

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  23. Patients with chronic kidney disease make day-to-day decisions about how to self-manage their disease. Chronic kidney disease (CKD) includes a risk for progression towards end-stage renal disease and the devel...

    Authors: Une Elisabeth Stømer, Astrid Klopstad Wahl, Lasse Gunnar Gøransson and Kristin Hjorthaug Urstad

    Citation: BMC Nephrology 2020 21:314

    Content type: Research article

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  24. There are conflicting research results about the survival differences between hemodialysis(HD) and peritoneal dialysis (PD). The present study estimated the survival and the relative mortality hazard for incid...

    Authors: Xi Yao, Wenhua Lei, Nan Shi, Weiqiang Lin, Xiaoying Du, Ping Zhang and Jianghua Chen

    Citation: BMC Nephrology 2020 21:310

    Content type: Research article

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  25. The editorial comments on a recently published study in which 242 patients, with “stable” chronic kidney disease, recruited during a hospital stay, were randomised either to receiving support from nephrologist...

    Authors: Giorgina Barbara Piccoli

    Citation: BMC Nephrology 2020 21:309

    Content type: Correspondence

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  26. Hemodialysis (HD) tend to have more hemodynamic changes than peritoneal dialysis (PD), which aggravates inflammation and oxidative stress. Whether HD and PD have different effects on the progression of vascula...

    Authors: Qingyu Niu, Huiping Zhao, Li Zuo, Mei Wang and Liangying Gan

    Citation: BMC Nephrology 2020 21:302

    Content type: Research article

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  27. Most end-stage renal disease (ESRD) patients undergo open surgical techniques for peritoneal dialysis (PD) catheter placement. An alternative method to PD catheter implantation is the half-percutaneous (“Half-...

    Authors: Difei Zhang, Yu Peng, Tingting Zheng, Hui Liu, Jianfeng Wu, Zewen Li, Jingxu Su, Yuan Xu, Xiaoxuan Hu, Guowei Chen, Haijing Hou, La Zhang, Liwen Wu, Xusheng Liu and Fuhua Lu

    Citation: BMC Nephrology 2020 21:288

    Content type: Research article

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  28. Haemodialysis (HD) patients are burdened by frequent fluid shifts which amplify their comorbidities. Bioimpedance (bioZ) is a promising technique to monitor changes in fluid status. The aim of this study is to...

    Authors: Melanie K. Schoutteten, Julie Vranken, Seulki Lee, Christophe J. P. Smeets, Hélène De Cannière, Chris Van Hoof, Jacques Peeters, Willemijn Groenendaal and Pieter M. Vandervoort

    Citation: BMC Nephrology 2020 21:264

    Content type: Technical advance

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  29. Dialysis patients have a high pill burden, increasing their care complexity. A previous study in our institution’s dialysis unit found notable discrepancies between medication prescriptions, purchases and pati...

    Authors: Lee Gilad, Yosef S. Haviv, Inbal Cohen-Glickman, David Chinitz and Matan J. Cohen

    Citation: BMC Nephrology 2020 21:239

    Content type: Research article

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  30. This study aimed to ascertain whether the correlation of high serum ferritin with mortality is affected by systemic inflammation and to investigate the optimal serum ferritin level for predicting death when in...

    Authors: Sha Fu, Junzhe Chen, Bo Liu, Peifen Liang, Yuchun Zeng, Min Feng, Zhenjian Xu, Guiqiong Zheng, Suqiong Yang, Anping Xu and Ying Tang

    Citation: BMC Nephrology 2020 21:237

    Content type: Research article

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  31. Low levels of physical activity are implicated in low life expectancies of people receiving maintenance haemodialysis. Accelerometers are increasingly being used to quantify activity behaviours of this populat...

    Authors: Sean Prescott, Jamie P. Traynor, Ilona Shilliday, Tobia Zanotto, Robert Rush and Thomas H. Mercer

    Citation: BMC Nephrology 2020 21:230

    Content type: Research article

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  32. Acute kidney injury (AKI) occurs in 12–20% of multiple myeloma (MM) patients. Several studies have shown a reduction of free light chains (FLC) using hemodialysis with High-Cut-Off membranes. However, this tec...

    Authors: M. Victoria Pendón-Ruiz de Mier, Raquel Ojeda, M. Antonia Álvarez-Lara, Ana Navas, Corona Alonso, Javier Caballero-Villarraso, Pedro Aljama, Miguel A. Álvarez, Sagrario Soriano, Mariano Rodríguez and Alejandro Martín-Malo

    Citation: BMC Nephrology 2020 21:227

    Content type: Research article

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  33. Chronic kidney disease (CKD) affects drug elimination and patients with CKD require appropriate adjustment of renally cleared medications to ensure safe and effective pharmacotherapy. The main objective of thi...

    Authors: Ronald L. Castelino, Timothy Saunder, Alex Kitsos, Gregory M. Peterson, Matthew Jose, Barbara Wimmer, Masuma Khanam, Woldesellassie Bezabhe, Jim Stankovich and Jan Radford

    Citation: BMC Nephrology 2020 21:216

    Content type: Research article

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  34. Older patients with advanced chronic kidney disease often do not understand treatment options for renal replacement therapy, conservative kidney management, and advance care planning. It is unclear whether bot...

    Authors: Nwamaka D. Eneanya, Allison K. Labbe, Taylor L. Stallings, Shananssa Percy, Jennifer S. Temel, Tamar A. Klaiman and Elyse R. Park

    Citation: BMC Nephrology 2020 21:213

    Content type: Research article

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  35. Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment o...

    Authors: Jorge A. Jesus-Silva, Archie Lamplugh, Sameera Dhada, James O. Burton and Sunil Bhandari

    Citation: BMC Nephrology 2020 21:212

    Content type: Research article

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  36. A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal...

    Authors: Dayang Xie, Jianhui Zhou, Xueying Cao, Qingtao Zhang, Yanli Sun, Li Tang, Jing Huang, Juanli Zheng, Li Lin, Zhenzhen Li, Guangyan Cai and Xiangmei Chen

    Citation: BMC Nephrology 2020 21:199

    Content type: Research article

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  37. Physical activity (PA) is typically lower on hemodialysis (HD) days. Albeit intradialytic inactivity is expected, it is unknown whether recovery after HD contributes to low PA. We investigated the impact of HD...

    Authors: John W. Larkin, Maggie Han, Hao Han, Murilo H. Guedes, Priscila Bezerra Gonçalves, Carlos Eduardo Poli-de-Figueiredo, Américo Lourenço Cuvello-Neto, Ana Beatriz L. Barra, Thyago Proença de Moraes, Len A. Usvyat, Peter Kotanko, Maria Eugenia F. Canziani, Jochen G. Raimann and Roberto Pecoits-Filho

    Citation: BMC Nephrology 2020 21:197

    Content type: Research article

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  38. Accurate assessment of volume status to direct dialysis remains a clinical challenge. Despite current attempts at volume-directed dialysis, inadequate dialysis and intradialytic hypotension (IDH) are common oc...

    Authors: Bret D. Alvis, Monica Polcz, Merrick Miles, Donald Wright, Mohammad Shwetar, Phil Leisy, Rachel Forbes, Rachel Fissell, Jon Whitfield, Susan Eagle, Colleen Brophy and Kyle Hocking

    Citation: BMC Nephrology 2020 21:194

    Content type: Technical advance

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  39. Quality of life (QOL) is important to patients with end stage renal disease and their partners. Despite the first 12 weeks being a critical time in the treatment pathway, limited research exists which examines...

    Authors: Currie Moore, Lesley-Anne Carter, Sandip Mitra, Suzanne Skevington and Alison Wearden

    Citation: BMC Nephrology 2020 21:185

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2020 21:254

  40. Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim...

    Authors: Lei Yang, Xiaoxia Wu, Ying Wang, Chunfeng Wang, Rong Hu and Yong Wu

    Citation: BMC Nephrology 2020 21:172

    Content type: Research article

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  41. Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commo...

    Authors: Yu Ho Lee, Jin Sug Kim, Su-Woong Jung, Hyeon Seok Hwang, Ju-Young Moon, Kyung-Hwan Jeong, Sang-Ho Lee, So-Young Lee, Gang Jee Ko, Dong-Young Lee, Hong joo Lee and Yang Gyun Kim

    Citation: BMC Nephrology 2020 21:166

    Content type: Research article

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  42. Twice-weekly maintenance hemodialysis sessions in patients with end stage renal disease are commonly practiced due to economic constraints in developing countries including Eritrea. To ameliorate the paucity o...

    Authors: Saud Mohammed Raja and Yemane Seyoum

    Citation: BMC Nephrology 2020 21:163

    Content type: Research article

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  43. The inflammatory mediator calprotectin (CPT, myeloid-related protein 8/14) is known as an endogenous ligand contributing to pathophysiology in inflammatory diseases. Serum CPT reportedly became a potential bio...

    Authors: Tomoko Kanki, Takashige Kuwabara, Jun Morinaga, Hirotaka Fukami, Shuro Umemoto, Daisuke Fujimoto, Teruhiko Mizumoto, Manabu Hayata, Yutaka Kakizoe, Yuichiro Izumi, Saeko Tajiri, Tetsuya Tajiri, Kenichiro Kitamura and Masashi Mukoyama

    Citation: BMC Nephrology 2020 21:158

    Content type: Research article

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  44. Regarding lupus disease activity, morbidity and survival, limited literature concluded conflicting results when comparing hemodialysis versus peritoneal dialysis as initial renal replacement therapies (RRT) pr...

    Authors: Joel Swai, Xiexiong Zhao, Julie-Raisa Noube and Gui Ming

    Citation: BMC Nephrology 2020 21:156

    Content type: Research article

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  45. Fluid overload (FO) assessed by bioimpedance spectroscopy (BIS) is associated with higher mortality risk in maintenance haemodialysis (HD). The aim was to assess if a better management of FO through short dail...

    Authors: Ana Beatriz Lesqueves Barra, Ana Paula Roque-da-Silva, Marcos S. Vasconcellos, Jocemir R. Lugon and Jorge Paulo Strogoff-de-Matos

    Citation: BMC Nephrology 2020 21:153

    Content type: Research article

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  46. Dialysis patients are at high risk of developing glucose metabolism disturbances (GMDs), such as diabetes mellitus (DM), impaired fast glucose (IFG), and impaired glucose tolerance (IGT). However, it is unclea...

    Authors: Yanan Shi, Jiajie Cai, Chunxia Shi, Conghui Liu and Zhongxin Li

    Citation: BMC Nephrology 2020 21:152

    Content type: Research article

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  47. Contrast-induced nephropathy (CIN) following a percutaneous coronary intervention (PCI) is the third most common cause of acute kidney injury (AKI) worldwide. Patients who require hemodialysis secondary to CIN...

    Authors: Luis F. Reyes, Diego F. Severiche-Bueno, Carlos A. Bustamante, Sixta Murillo, Nilam J. Soni, Marcela Poveda, Efraín Gomez, Ricardo Buitrago and Alejandro Rodriguez

    Citation: BMC Nephrology 2020 21:143

    Content type: Research article

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  48. Adults with end-stage renal disease (ESRD) requiring chronic dialysis continue to suffer from poor health outcomes and represent a population rightfully targeted for quality improvement. Electronic dashboards ...

    Authors: Michael J. Fischer, Wissam M. Kourany, Karen Sovern, Kurt Forrester, Cassandra Griffin, Nancy Lightner, Shawn Loftus, Katherine Murphy, Greg Roth, Paul M. Palevsky and Susan T. Crowley

    Citation: BMC Nephrology 2020 21:136

    Content type: Research article

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  49. Optimal clinical care of patients with chronic kidney disease (CKD) requires collaboration between primary care physicians (PCPs) and nephrologists. We undertook a randomised trial to determine the impact of s...

    Authors: Patrick Saudan, Belen Ponte, Nicola Marangon, Chantal Martinez, Lena Berchtold, David Jaques, Thomas Ernandez, Sophie de Seigneux, Sebastian Carballo, Thomas Perneger and Pierre-Yves Martin

    Citation: BMC Nephrology 2020 21:128

    Content type: Research article

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  50. The purse-string suture has been widely used for bleeding control after percutaneous interventions through arteriovenous fistula (AVF) and graft (AVG), and it requires suture removal the next day. This study a...

    Authors: Qiquan Lai, Hui Zhang, Bo Chen, Xuejing Gao, Ling Chen, Bo Tu, Baifei Li, Bo Hu, Fan He, Yong Xu and Ziming Wan

    Citation: BMC Nephrology 2020 21:112

    Content type: Research article

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