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Pre-dialysis care and dialysis

Section edited by Giorgina Piccoli 

The Pre-dialysis Care and Dialysis section considers clinical research relating to the care of patients both before and during dialysis and their post-dialysis outcomes. Articles may describe interventional and non-interventional studies as well as qualitative studies. Systematic reviews, meta-analyses and large epidemiological studies should be directed to the Epidemiology and Health Outcomes section. This section does not consider case reports and these should be directed to the dedicated Case Reports section.

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  1. Haemodialysis (HD) patients are burdened by frequent fluid shifts which amplify their comorbidities. Bioimpedance (bioZ) is a promising technique to monitor changes in fluid status. The aim of this study is to...

    Authors: Melanie K. Schoutteten, Julie Vranken, Seulki Lee, Christophe J. P. Smeets, Hélène De Cannière, Chris Van Hoof, Jacques Peeters, Willemijn Groenendaal and Pieter M. Vandervoort

    Citation: BMC Nephrology 2020 21:264

    Content type: Technical advance

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  2. Dialysis patients have a high pill burden, increasing their care complexity. A previous study in our institution’s dialysis unit found notable discrepancies between medication prescriptions, purchases and pati...

    Authors: Lee Gilad, Yosef S. Haviv, Inbal Cohen-Glickman, David Chinitz and Matan J. Cohen

    Citation: BMC Nephrology 2020 21:239

    Content type: Research article

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  3. This study aimed to ascertain whether the correlation of high serum ferritin with mortality is affected by systemic inflammation and to investigate the optimal serum ferritin level for predicting death when in...

    Authors: Sha Fu, Junzhe Chen, Bo Liu, Peifen Liang, Yuchun Zeng, Min Feng, Zhenjian Xu, Guiqiong Zheng, Suqiong Yang, Anping Xu and Ying Tang

    Citation: BMC Nephrology 2020 21:237

    Content type: Research article

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  4. Low levels of physical activity are implicated in low life expectancies of people receiving maintenance haemodialysis. Accelerometers are increasingly being used to quantify activity behaviours of this populat...

    Authors: Sean Prescott, Jamie P. Traynor, Ilona Shilliday, Tobia Zanotto, Robert Rush and Thomas H. Mercer

    Citation: BMC Nephrology 2020 21:230

    Content type: Research article

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  5. Acute kidney injury (AKI) occurs in 12–20% of multiple myeloma (MM) patients. Several studies have shown a reduction of free light chains (FLC) using hemodialysis with High-Cut-Off membranes. However, this tec...

    Authors: M. Victoria Pendón-Ruiz de Mier, Raquel Ojeda, M. Antonia Álvarez-Lara, Ana Navas, Corona Alonso, Javier Caballero-Villarraso, Pedro Aljama, Miguel A. Álvarez, Sagrario Soriano, Mariano Rodríguez and Alejandro Martín-Malo

    Citation: BMC Nephrology 2020 21:227

    Content type: Research article

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  6. Chronic kidney disease (CKD) affects drug elimination and patients with CKD require appropriate adjustment of renally cleared medications to ensure safe and effective pharmacotherapy. The main objective of thi...

    Authors: Ronald L. Castelino, Timothy Saunder, Alex Kitsos, Gregory M. Peterson, Matthew Jose, Barbara Wimmer, Masuma Khanam, Woldesellassie Bezabhe, Jim Stankovich and Jan Radford

    Citation: BMC Nephrology 2020 21:216

    Content type: Research article

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  7. Older patients with advanced chronic kidney disease often do not understand treatment options for renal replacement therapy, conservative kidney management, and advance care planning. It is unclear whether bot...

    Authors: Nwamaka D. Eneanya, Allison K. Labbe, Taylor L. Stallings, Shananssa Percy, Jennifer S. Temel, Tamar A. Klaiman and Elyse R. Park

    Citation: BMC Nephrology 2020 21:213

    Content type: Research article

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  8. Anaemia is common in haemodialysis (HD) patients and associated with significant morbidity and mortality. Intravenous (IV) iron combined with erythropoiesis-stimulating agents (ESA) is the mainstay treatment o...

    Authors: Jorge A. Jesus-Silva, Archie Lamplugh, Sameera Dhada, James O. Burton and Sunil Bhandari

    Citation: BMC Nephrology 2020 21:212

    Content type: Research article

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  9. A large body mass index (BMI) has been considered as a relative contraindication for percutaneous catheter insertion, although this technique has many advantages. Up to now, there are few studies on peritoneal...

    Authors: Dayang Xie, Jianhui Zhou, Xueying Cao, Qingtao Zhang, Yanli Sun, Li Tang, Jing Huang, Juanli Zheng, Li Lin, Zhenzhen Li, Guangyan Cai and Xiangmei Chen

    Citation: BMC Nephrology 2020 21:199

    Content type: Research article

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  10. Physical activity (PA) is typically lower on hemodialysis (HD) days. Albeit intradialytic inactivity is expected, it is unknown whether recovery after HD contributes to low PA. We investigated the impact of HD...

    Authors: John W. Larkin, Maggie Han, Hao Han, Murilo H. Guedes, Priscila Bezerra Gonçalves, Carlos Eduardo Poli-de-Figueiredo, Américo Lourenço Cuvello-Neto, Ana Beatriz L. Barra, Thyago Proença de Moraes, Len A. Usvyat, Peter Kotanko, Maria Eugenia F. Canziani, Jochen G. Raimann and Roberto Pecoits-Filho

    Citation: BMC Nephrology 2020 21:197

    Content type: Research article

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  11. Accurate assessment of volume status to direct dialysis remains a clinical challenge. Despite current attempts at volume-directed dialysis, inadequate dialysis and intradialytic hypotension (IDH) are common oc...

    Authors: Bret D. Alvis, Monica Polcz, Merrick Miles, Donald Wright, Mohammad Shwetar, Phil Leisy, Rachel Forbes, Rachel Fissell, Jon Whitfield, Susan Eagle, Colleen Brophy and Kyle Hocking

    Citation: BMC Nephrology 2020 21:194

    Content type: Technical advance

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  12. Quality of life (QOL) is important to patients with end stage renal disease and their partners. Despite the first 12 weeks being a critical time in the treatment pathway, limited research exists which examines...

    Authors: Currie Moore, Lesley-Anne Carter, Sandip Mitra, Suzanne Skevington and Alison Wearden

    Citation: BMC Nephrology 2020 21:185

    Content type: Research article

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  13. Rehabilitation effects of exercise training on adults with chronic kidney disease (CKD) have been generally recognised; however, the effects of exercise training on proteinuria have been underexplored. Our aim...

    Authors: Lei Yang, Xiaoxia Wu, Ying Wang, Chunfeng Wang, Rong Hu and Yong Wu

    Citation: BMC Nephrology 2020 21:172

    Content type: Research article

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  14. Low physical performance in patients undergoing maintenance hemodialysis is associated with a high mortality rate. We investigated the clinical relevance of gait speed and handgrip strength, the two most commo...

    Authors: Yu Ho Lee, Jin Sug Kim, Su-Woong Jung, Hyeon Seok Hwang, Ju-Young Moon, Kyung-Hwan Jeong, Sang-Ho Lee, So-Young Lee, Gang Jee Ko, Dong-Young Lee, Hong joo Lee and Yang Gyun Kim

    Citation: BMC Nephrology 2020 21:166

    Content type: Research article

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  15. Twice-weekly maintenance hemodialysis sessions in patients with end stage renal disease are commonly practiced due to economic constraints in developing countries including Eritrea. To ameliorate the paucity o...

    Authors: Saud Mohammed Raja and Yemane Seyoum

    Citation: BMC Nephrology 2020 21:163

    Content type: Research article

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  16. The inflammatory mediator calprotectin (CPT, myeloid-related protein 8/14) is known as an endogenous ligand contributing to pathophysiology in inflammatory diseases. Serum CPT reportedly became a potential bio...

    Authors: Tomoko Kanki, Takashige Kuwabara, Jun Morinaga, Hirotaka Fukami, Shuro Umemoto, Daisuke Fujimoto, Teruhiko Mizumoto, Manabu Hayata, Yutaka Kakizoe, Yuichiro Izumi, Saeko Tajiri, Tetsuya Tajiri, Kenichiro Kitamura and Masashi Mukoyama

    Citation: BMC Nephrology 2020 21:158

    Content type: Research article

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  17. Regarding lupus disease activity, morbidity and survival, limited literature concluded conflicting results when comparing hemodialysis versus peritoneal dialysis as initial renal replacement therapies (RRT) pr...

    Authors: Joel Swai, Xiexiong Zhao, Julie-Raisa Noube and Gui Ming

    Citation: BMC Nephrology 2020 21:156

    Content type: Research article

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  18. Fluid overload (FO) assessed by bioimpedance spectroscopy (BIS) is associated with higher mortality risk in maintenance haemodialysis (HD). The aim was to assess if a better management of FO through short dail...

    Authors: Ana Beatriz Lesqueves Barra, Ana Paula Roque-da-Silva, Marcos S. Vasconcellos, Jocemir R. Lugon and Jorge Paulo Strogoff-de-Matos

    Citation: BMC Nephrology 2020 21:153

    Content type: Research article

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  19. Dialysis patients are at high risk of developing glucose metabolism disturbances (GMDs), such as diabetes mellitus (DM), impaired fast glucose (IFG), and impaired glucose tolerance (IGT). However, it is unclea...

    Authors: Yanan Shi, Jiajie Cai, Chunxia Shi, Conghui Liu and Zhongxin Li

    Citation: BMC Nephrology 2020 21:152

    Content type: Research article

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  20. Contrast-induced nephropathy (CIN) following a percutaneous coronary intervention (PCI) is the third most common cause of acute kidney injury (AKI) worldwide. Patients who require hemodialysis secondary to CIN...

    Authors: Luis F. Reyes, Diego F. Severiche-Bueno, Carlos A. Bustamante, Sixta Murillo, Nilam J. Soni, Marcela Poveda, Efraín Gomez, Ricardo Buitrago and Alejandro Rodriguez

    Citation: BMC Nephrology 2020 21:143

    Content type: Research article

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  21. Adults with end-stage renal disease (ESRD) requiring chronic dialysis continue to suffer from poor health outcomes and represent a population rightfully targeted for quality improvement. Electronic dashboards ...

    Authors: Michael J. Fischer, Wissam M. Kourany, Karen Sovern, Kurt Forrester, Cassandra Griffin, Nancy Lightner, Shawn Loftus, Katherine Murphy, Greg Roth, Paul M. Palevsky and Susan T. Crowley

    Citation: BMC Nephrology 2020 21:136

    Content type: Research article

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  22. Optimal clinical care of patients with chronic kidney disease (CKD) requires collaboration between primary care physicians (PCPs) and nephrologists. We undertook a randomised trial to determine the impact of s...

    Authors: Patrick Saudan, Belen Ponte, Nicola Marangon, Chantal Martinez, Lena Berchtold, David Jaques, Thomas Ernandez, Sophie de Seigneux, Sebastian Carballo, Thomas Perneger and Pierre-Yves Martin

    Citation: BMC Nephrology 2020 21:128

    Content type: Research article

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  23. The purse-string suture has been widely used for bleeding control after percutaneous interventions through arteriovenous fistula (AVF) and graft (AVG), and it requires suture removal the next day. This study a...

    Authors: Qiquan Lai, Hui Zhang, Bo Chen, Xuejing Gao, Ling Chen, Bo Tu, Baifei Li, Bo Hu, Fan He, Yong Xu and Ziming Wan

    Citation: BMC Nephrology 2020 21:112

    Content type: Research article

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  24. A randomized trial of a pedometer-based intervention with weekly activity goals led to a modest increase in step count among dialysis patients. In a secondary analysis, we investigated the effect of this inter...

    Authors: Anoop Sheshadri, Piyawan Kittiskulnam, Jennifer C. Lai and Kirsten L. Johansen

    Citation: BMC Nephrology 2020 21:100

    Content type: Research article

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  25. Acute kidney injury (AKI) is a common complication among human immunodeficiency virus (HIV)-infected patients resulting in increased morbidity and mortality. Continuous renal replacement therapy (CRRT) is a us...

    Authors: Hebing Guo, Jingyuan Liu, Lin Pu, Jingjing Hao, Ningning Yin, Yufeng Liu, Haofeng Xiong and Ang Li

    Citation: BMC Nephrology 2020 21:95

    Content type: Research article

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  26. Nutritional factors are associated with high mortality and morbidity in dialysis patients, and protein-energy wasting is regarded as an important one. The modality of dialysis may affect patients’ dietary beha...

    Authors: Seon-Mi Kim, Byung Chin Kang, Hyun-Jung Kim, Min-Sook Kyung, Hyung Jung Oh, Jung-Hyun Kim, Oran Kwon and Dong-Ryeol Ryu

    Citation: BMC Nephrology 2020 21:91

    Content type: Research article

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  27. Vascular calcification (VC) is a risk factor for cardiovascular disease in end-stage renal disease (ESRD) patients undergoing maintenance haemodialysis (MHD). However, evidence is still insufficient about the ...

    Authors: Sung Keun Park, Won Joong Kim, Hyun Jin Kim, Hae Won Kim, Beom Kim, Hong Joo Lee, So-Young Lee, Yu Ho Lee, Dong-Jin Kim, Kyung-Hwan Jeong, Ju-Young Moon, Sang-Ho Lee, Shin Young Ahn, Gang Jee Ko, Jae-Hong Ryoo and Dong-Young Lee

    Citation: BMC Nephrology 2020 21:86

    Content type: Research article

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  28. Chronic kidney disease (CKD) is increasing worldwide, and the majority of the CKD burden is in low- and middle-income countries (LMICs). However, there is wide variability in global access to kidney care thera...

    Authors: David Flood, Katharine Wilcox, Andrea Aguilar Ferro, Carlos Mendoza Montano, Joaquin Barnoya, Pablo Garcia, Randall Lou-Meda, Peter Rohloff and Anita Chary

    Citation: BMC Nephrology 2020 21:71

    Content type: Research article

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  29. Calcific Uremic Arteriolopathy (CUA) is a rare disease, causing painful skin ulcers in patients with end stage renal disease. Recommendations for CUA management and treatment are lacking.

    Authors: Raphaël Gaisne, Morgane Péré, Victorio Menoyo, Maryvonne Hourmant and David Larmet-Burgeot

    Citation: BMC Nephrology 2020 21:63

    Content type: Research article

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  30. This study aimed to determine the lifetime cost-effectiveness of first-line dialysis modalities for end-stage renal disease (ESRD) patients under the “Peritoneal Dialysis First” policy.

    Authors: Carlos K. H. Wong, Julie Chen, Samuel K. S. Fung, Maggie Mok, Yuk lun Cheng, Irene Kong, Wai Kei Lo, Sing Leung Lui, T. M. Chan and Cindy L. K. Lam

    Citation: BMC Nephrology 2020 21:42

    Content type: Research article

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  31. Older patients on dialysis may not have optimal outcomes, particularly with regards to quality of life. Existing research is focused mainly on survival, with limited information about other outcomes. Such info...

    Authors: Rajesh Raj, Bridget Brown, Kiran Ahuja, Mai Frandsen and Matthew Jose

    Citation: BMC Nephrology 2020 21:28

    Content type: Research article

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  32. Chronic kidney disease (CKD) disease affects gut flora by causing dysbiosis and lead to systemic inflammatory conditions. Here, we provide intestinal flora changes of CKD patients undertook different hemodialy...

    Authors: Jianguang Hu, Xiaoshi Zhong, Jing Yan, Daoyuan Zhou, Danping Qin, Xiao Xiao, Yuanyuan Zheng and Yan Liu

    Citation: BMC Nephrology 2020 21:12

    Content type: Research article

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  33. The impact of length of hospital stay on activities of daily living (ADLs) has not specifically been investigated among dialysis patients. Therefore, we attempt to verify the association between the length of ...

    Authors: Tsukasa Kamitani, Shingo Fukuma, Sayaka Shimizu, Tadao Akizawa and Shunichi Fukuhara

    Citation: BMC Nephrology 2020 21:9

    Content type: Research article

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  34. Impaired physical function due to muscle weakness and exercise intolerance reduces the ability to perform activities of daily living in patients with end-stage kidney disease, and by consequence, Health-Relate...

    Authors: Karsten Vanden Wyngaert, Amaryllis H. Van Craenenbroeck, Sunny Eloot, Patrick Calders, Bert Celie, Els Holvoet and Wim Van Biesen

    Citation: BMC Nephrology 2020 21:7

    Content type: Research article

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  35. Online haemodiafiltration (OL-HDF) may improve middle molecular clearance in contrast to conventional haemodialysis (HD). However, OL-HDF requires higher convective flows and cannot sufficiently remove large m...

    Authors: Tae Hoon Kim, Seok-hyung Kim, Tae Yeon Kim, Hae Yeul Park, Kwon Soo Jung, Moon Hyoung Lee, Jong Hyun Jhee, Jung Eun Lee, Hoon Young Choi and Hyeong Cheon Park

    Citation: BMC Nephrology 2019 21:2

    Content type: Research article

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  36. Patients on home hemodialysis (HHD) exhibit superior survival compared with patients on institutional hemodialysis (IHD) and peritoneal dialysis (PD). There is a sparsity of reports comparing morbidity between...

    Authors: Helena Rydell, Kerstin Ivarsson, Martin Almquist, Naomi Clyne and Mårten Segelmark

    Citation: BMC Nephrology 2019 20:480

    Content type: Research article

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  37. Physical activity (PA) is exceptionally low amongst the haemodialysis (HD) population, and physical inactivity is a powerful predictor of mortality, making it a prime focus for intervention. Objective measurem...

    Authors: Hannah M. L. Young, Mark W. Orme, Yan Song, Maurice Dungey, James O. Burton, Alice C. Smith and Sally J. Singh

    Citation: BMC Nephrology 2019 20:450

    Content type: Research article

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  38. Arteriovenous fistula (AVF) is the vascular access of choice for patients on hemodialysis. Recent evidence suggests that AVF creation may slow estimated glomerular filtration rate (eGFR) decline. The study obj...

    Authors: Valérie Bénard, Maude Pichette, Jean-Philippe Lafrance, Naoual Elftouh, Vincent Pichette, Louis-Philippe Laurin and Annie-Claire Nadeau-Fredette

    Citation: BMC Nephrology 2019 20:420

    Content type: Research article

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  39. Nonadherence to medications by patients requiring hemodialysis (HD) leads to unfavorable clinical outcomes. Limited data exist to demonstrate the effect of incorporating patient-centered interventions using co...

    Authors: Sherine Ismail, Abrar Al-Subhi, Eman Youssif, Medhat Ahmed, Abdullah Almalki, Diane L. Seger, Andrew C. Seger and Earl Cook

    Citation: BMC Nephrology 2019 20:408

    Content type: Research article

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  40. Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the differ...

    Authors: Lianna G. G. Dantas, Mário de Seixas Rocha, José Andrade Moura Junior, Edson Luiz Paschoalin, Sandra R. K. P. Paschoalin and Constança M. Sampaio Cruz

    Citation: BMC Nephrology 2019 20:402

    Content type: Research article

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  41. Conservative management, an approach to treating end-stage kidney disease without dialysis, while generally associated with shorter life expectancy than treatment with dialysis, is associated with fewer hospit...

    Authors: Melissa W. Wachterman, Tarikwa Leveille, Nancy L. Keating, Steven R. Simon, Sushrut S. Waikar and Barbara Bokhour

    Citation: BMC Nephrology 2019 20:385

    Content type: Research article

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  42. More than 6200 End Stage Renal Disease patients in the Netherlands are dependent on dialysis, either performed at home or in a dialysis centre. Visiting a dialysis centre three times a week is considered a lar...

    Authors: A. van Eck van der Sluijs, A. A. Bonenkamp, F. W. Dekker, A. C. Abrahams and B. C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:361

    Content type: Study protocol

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  43. Pulsatility is an important property of hemodialysis arteriovenous fistulas (AVF) and can be perceived by the fingers as a gradual decrease in strength downstream from the anastomosis along the main trunk of t...

    Authors: Matt Chiung-Yu Chen, Mei-Jui Weng, Misoso Yi-Wen Wu, Yi-Chun Liu and Wen-Che Chi

    Citation: BMC Nephrology 2019 20:356

    Content type: Research article

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  44. Intradialytic blood pressure (BP) measurement is currently the main parameter used for monitoring hemodynamics during hemodialysis (HD). Since BP is dependent on cardiac output and total peripheral resistance,...

    Authors: Keren Doenyas-Barak, Marcia H. F. G. de Abreu, Lucas E. Borges, Helcio A. Tavares Filho, Feng Yunlin, Zou Yurong, Nathan W. Levin, Allen M. Kaufman, Shay Efrati, David Pereg, Ilya Litovchik, Shmuel Fuchs and Sa’ar Minha

    Citation: BMC Nephrology 2019 20:347

    Content type: Research article

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  45. Patient-reported outcome measures (PROMs) are becoming increasingly important in healthcare. In nephrology, there is no agreement on which chronic kidney disease (CKD) symptom questionnaire to use. Therefore, ...

    Authors: Esmee M. van der Willik, Yvette Meuleman, Karen Prantl, Giel van Rijn, Willem Jan W. Bos, Frans J. van Ittersum, Hans A. J. Bart, Marc H. Hemmelder and Friedo W. Dekker

    Citation: BMC Nephrology 2019 20:344

    Content type: Research article

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  46. Patients treated with conventional hemodialysis have poor physical performance, explained by insufficient metabolic clearance and shortage of time by time-consuming dialysis. Nocturnal hemodialysis improves me...

    Authors: Manouk Dam, Peter J. M. Weijs, Frans J. van Ittersum and Brigit C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:317

    Content type: Research article

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  47. Chromium is an essential trace metal that reduces oxidative stress and inflammation. In patients undergoing maintenance hemodialysis (MHD), a correlation among chromium exposure, inflammation, and malnutrition...

    Authors: Ching-Wei Hsu, Cheng-Hao Weng, Cheng-Chia Lee, Tzung-Hai Yen and Wen-Hung Huang

    Citation: BMC Nephrology 2019 20:302

    Content type: Research article

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  48. Haemodialysis is capable of prolonging life in patients with end stage renal disease, however this therapy comes with significant negative impact on quality of life. For patients requiring haemodialysis, the n...

    Authors: M. Field, A.Z Khawaja, J. Ellis, T. Nieto, J. Hodson and N. Inston

    Citation: BMC Nephrology 2019 20:299

    Content type: Research article

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