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Pre-dialysis care and dialysis

Section edited by Giorgina Piccoli 

The Pre-dialysis Care and Dialysis section considers clinical research relating to the care of patients both before and during dialysis and their post-dialysis outcomes. Articles may describe interventional and non-interventional studies as well as qualitative studies. Systematic reviews, meta-analyses and large epidemiological studies should be directed to the Epidemiology and Health Outcomes section. This section does not consider case reports and these should be directed to the dedicated Case Reports section.

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  1. Nonadherence to medications by patients requiring hemodialysis (HD) leads to unfavorable clinical outcomes. Limited data exist to demonstrate the effect of incorporating patient-centered interventions using co...

    Authors: Sherine Ismail, Abrar Al-Subhi, Eman Youssif, Medhat Ahmed, Abdullah Almalki, Diane L. Seger, Andrew C. Seger and Earl Cook

    Citation: BMC Nephrology 2019 20:408

    Content type: Research article

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  2. Patients with chronic kidney diseases (CKD) on haemodialysis (HD) have high morbidity and mortality rates, which are also due to the inherent risks associated with nephropathy. Non-adherence (NA) to the differ...

    Authors: Lianna G. G. Dantas, Mário de Seixas Rocha, José Andrade Moura Junior, Edson Luiz Paschoalin, Sandra R. K. P. Paschoalin and Constança M. Sampaio Cruz

    Citation: BMC Nephrology 2019 20:402

    Content type: Research article

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  3. Conservative management, an approach to treating end-stage kidney disease without dialysis, while generally associated with shorter life expectancy than treatment with dialysis, is associated with fewer hospit...

    Authors: Melissa W. Wachterman, Tarikwa Leveille, Nancy L. Keating, Steven R. Simon, Sushrut S. Waikar and Barbara Bokhour

    Citation: BMC Nephrology 2019 20:385

    Content type: Research article

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  5. More than 6200 End Stage Renal Disease patients in the Netherlands are dependent on dialysis, either performed at home or in a dialysis centre. Visiting a dialysis centre three times a week is considered a lar...

    Authors: A. van Eck van der Sluijs, A. A. Bonenkamp, F. W. Dekker, A. C. Abrahams and B. C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:361

    Content type: Study protocol

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  6. Pulsatility is an important property of hemodialysis arteriovenous fistulas (AVF) and can be perceived by the fingers as a gradual decrease in strength downstream from the anastomosis along the main trunk of t...

    Authors: Matt Chiung-Yu Chen, Mei-Jui Weng, Misoso Yi-Wen Wu, Yi-Chun Liu and Wen-Che Chi

    Citation: BMC Nephrology 2019 20:356

    Content type: Research article

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  7. Intradialytic blood pressure (BP) measurement is currently the main parameter used for monitoring hemodynamics during hemodialysis (HD). Since BP is dependent on cardiac output and total peripheral resistance,...

    Authors: Keren Doenyas-Barak, Marcia H. F. G. de Abreu, Lucas E. Borges, Helcio A. Tavares Filho, Feng Yunlin, Zou Yurong, Nathan W. Levin, Allen M. Kaufman, Shay Efrati, David Pereg, Ilya Litovchik, Shmuel Fuchs and Sa’ar Minha

    Citation: BMC Nephrology 2019 20:347

    Content type: Research article

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  8. Patient-reported outcome measures (PROMs) are becoming increasingly important in healthcare. In nephrology, there is no agreement on which chronic kidney disease (CKD) symptom questionnaire to use. Therefore, ...

    Authors: Esmee M. van der Willik, Yvette Meuleman, Karen Prantl, Giel van Rijn, Willem Jan W. Bos, Frans J. van Ittersum, Hans A. J. Bart, Marc H. Hemmelder and Friedo W. Dekker

    Citation: BMC Nephrology 2019 20:344

    Content type: Research article

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  9. Patients treated with conventional hemodialysis have poor physical performance, explained by insufficient metabolic clearance and shortage of time by time-consuming dialysis. Nocturnal hemodialysis improves me...

    Authors: Manouk Dam, Peter J. M. Weijs, Frans J. van Ittersum and Brigit C. van Jaarsveld

    Citation: BMC Nephrology 2019 20:317

    Content type: Research article

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  10. Chromium is an essential trace metal that reduces oxidative stress and inflammation. In patients undergoing maintenance hemodialysis (MHD), a correlation among chromium exposure, inflammation, and malnutrition...

    Authors: Ching-Wei Hsu, Cheng-Hao Weng, Cheng-Chia Lee, Tzung-Hai Yen and Wen-Hung Huang

    Citation: BMC Nephrology 2019 20:302

    Content type: Research article

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  11. Haemodialysis is capable of prolonging life in patients with end stage renal disease, however this therapy comes with significant negative impact on quality of life. For patients requiring haemodialysis, the n...

    Authors: M. Field, A.Z Khawaja, J. Ellis, T. Nieto, J. Hodson and N. Inston

    Citation: BMC Nephrology 2019 20:299

    Content type: Research article

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  12. Short-term hemoglobin (Hb) variability related to volume status is observed in chronic kidney disease (CKD) patients receiving hemodialysis (HD). Given the lack of studies regarding outcomes according to the d...

    Authors: Soo Ya Bae, Jae Wan Jeon, Seong Hoon Kim, Chung Hee Baek, Jai Won Jang, Won Seok Yang, Soon Bae Kim, Su-Kil Park, Sang Koo Lee and Hyosang Kim

    Citation: BMC Nephrology 2019 20:295

    Content type: Research article

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  13. Although hemodialysis is a highly effective treatment for diffusive clearance of low molecular weight uremic toxins, its effect on circulating extracellular vesicles and submicron particles is less clear. The ...

    Authors: Marcel Ruzicka, Fengxia Xiao, Hussein Abujrad, Yasamin Al-Rewashdy, Vera A. Tang, Marc-André Langlois, Alexander Sorisky, Teik Chye Ooi and Dylan Burger

    Citation: BMC Nephrology 2019 20:294

    Content type: Research article

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  14. Readmission within 30 days of hospital discharge is common and costly among end-stage renal disease (ESRD) patients. Little is known about long-term outcomes after readmission. We estimated the association bet...

    Authors: Katherine H. Ross, Bernard G. Jaar, Janice P. Lea, Tahsin Masud, Rachel E. Patzer and Laura C. Plantinga

    Citation: BMC Nephrology 2019 20:285

    Content type: Research article

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  15. Despite well-publicized suggestions to utilize arteriovenous fistulae and grafts to initiate hemodialysis, too many patients in the United States start dialysis via central venous catheters despite their well-...

    Authors: Tanya T. Tang, Murray L. Levin, Shubhada N. Ahya, Khaled Boobes and Muhammad H. Hasan

    Citation: BMC Nephrology 2019 20:270

    Content type: Research article

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  16. Many older patients approaching end-stage kidney disease have to decide whether to go for dialysis or non-dialytic conservative care (CC). Shared decision-making is recommended to align the treatment plan with...

    Authors: Wouter R. Verberne, Wanda S. Konijn, Karen Prantl, Janneke Dijkers, Margriet T. Roskam, Johannes J. M. van Delden and Willem Jan W. Bos

    Citation: BMC Nephrology 2019 20:264

    Content type: Research article

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  17. Observational studies of hemodialysis patients treated thrice weekly have shown that serum and dialysate potassium and bicarbonate concentrations are associated with patient outcomes. The effect of more freque...

    Authors: John K. Leypoldt, Michael A. Kraus, Bertrand L. Jaber, Eric D. Weinhandl and Allan J. Collins

    Citation: BMC Nephrology 2019 20:252

    Content type: Research article

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  18. Globally 10% of the population worldwide are affected by chronic kidney disease (CKD), making it one of the most prevalent chronic diseases. Several studies have highlighted that the symptoms of CKD have a sig...

    Authors: Bushra Alshammari, Helen Noble, Helen McAneney and Peter O’Halloran

    Citation: BMC Nephrology 2019 20:250

    Content type: Study protocol

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  20. Many studies have evaluated the usefulness of creatinine- (eGFRcr) and cystatin C-based estimated glomerular filtration rate (eGFRcys) at specific time points in predicting renal outcome. This study compared t...

    Authors: Suhyun Kim, Subin Hwang, Hye Ryoun Jang, Insuk Sohn, Hyeon Seon Ahn, Hyung-Doo Park, Wooseong Huh, Dong-Chan Jin, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Jung Eun Lee

    Citation: BMC Nephrology 2019 20:214

    Content type: Research article

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  22. Due to rising vascular comorbidities of patients undergoing dialysis, the prevalence of permanent hemodialysis catheters as hemodialysis access is increasing. However, infection is a major complication of thes...

    Authors: Fani Delistefani, Manuel Wallbach, Gerhard A. Müller, Michael J. Koziolek and Clemens Grupp

    Citation: BMC Nephrology 2019 20:199

    Content type: Research article

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  23. Successful vascular access (VA) cannulation is integral to the delivery of adequate dialysis, highlighting the importance of ensuring the viability of arteriovenous access in hemodialysis (HD) patients. Missed...

    Authors: Linda L. Coventry, Jon M. Hosking, Doris T. Chan, Evelyn Coral, Wai H. Lim, Amanda Towell-Barnard, Diane E. Twigg and Claire M. Rickard

    Citation: BMC Nephrology 2019 20:197

    Content type: Research article

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  24. Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemo...

    Authors: Mayuri Ichinose, Naru Sasagawa, Tetsuo Chiba, Katsuhide Toyama, Yuzo Kayamori and Dongchon Kang

    Citation: BMC Nephrology 2019 20:191

    Content type: Research article

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  25. Reduced muscle strength and physical performance are prevalent in patients of maintenance hemodialysis (MHD), and deleterious changes in these parameters are associated with increased mortality.

    Authors: Yoshifumi Moriyama, Masahiko Hara, Sae Aratani, Hideaki Ishikawa, Kenichi Kono and Masatake Tamaki

    Citation: BMC Nephrology 2019 20:172

    Content type: Research article

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  26. The putative benefits of cinacalcet therapy for management of secondary hyperparathyroidism (SHPT) are thought to be most manifested when patients are taking it consistently and as prescribed. Real-world descr...

    Authors: Douglas S. Fuller, David Hallett, Paul J. Dluzniewski, Bruno Fouqueray, Michel Jadoul, Hal Morgenstern, Friedrich K. Port, Francesca Tentori and Ronald L. Pisoni

    Citation: BMC Nephrology 2019 20:169

    Content type: Research article

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  27. Tunnelled dialysis catheter (TC) infections are a major health complication and are associated with increased antibiotic consumption, hospital stays, health costs and mortality. Experimental data provide evide...

    Authors: Julien Aniort, Aurélien Piraud, Mireille Adda, Bruno Perreira, Marc Bouiller, Jacques Fourcade, Abdallah Guerraoui, Emilie Kalbacher, Thierry Krumel, Hélène Leray Moragues, Damien Thibaudin, Carlos Gustavo Vela, Guillaume Vernin, Hugo Weclawiak, Lise Bernard, Anne Elisabeth Heng…

    Citation: BMC Nephrology 2019 20:149

    Content type: Study protocol

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  28. Despite an increasing number of older people commencing dialysis the impact of dialysis on their quality of life and survival, remains unclear. The Dialysis Outcomes in those aged over 65 years or older study ...

    Authors: Bronwen McNoe, John B. W. Schollum, Sarah Derrett, Mark R. Marshall, Andrew Henderson, Ari Samaranayaka and Robert J. Walker

    Citation: BMC Nephrology 2019 20:137

    Content type: Research article

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  29. Prolonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concent...

    Authors: Esther D. Kim, Jacqueline Watt, Larisa G. Tereshchenko, Bernard G. Jaar, Stephen M. Sozio, W. H. Linda Kao, Michelle M. Estrella and Rulan S. Parekh

    Citation: BMC Nephrology 2019 20:133

    Content type: Research article

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  30. The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal dise...

    Authors: Elliot K. Tannor, Betty R. Norman, Kwame K. Adusei, Fred S. Sarfo, Mogamat R. Davids and George Bedu-Addo

    Citation: BMC Nephrology 2019 20:122

    Content type: Research article

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  31. Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the sel...

    Authors: Edward Zimbudzi, Clement Lo, Peter G. Kerr and Sophia Zoungas

    Citation: BMC Nephrology 2019 20:113

    Content type: Research article

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  34. Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietiti...

    Authors: Ali M. Omari, Leen S. Omari, Hazar H. Dagash, Waleed M. Sweileh, Nehal Natour and Sa’ed H. Zyoud

    Citation: BMC Nephrology 2019 20:92

    Content type: Research article

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  35. Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein which has half-life three-fold longer than that of Erythropoietin alfa (EPO). The objective of this study was to compare the eff...

    Authors: Shubhadeep D. Sinha, Vamsi Krishna Bandi, Bala Reddy Bheemareddy, Pankaj Thakur, Sreenivasa Chary, Kalpana Mehta, Vikranth Reddy Pinnamareddy, Rajendra Pandey, Subhramanyam Sreepada and Santosh Durugkar

    Citation: BMC Nephrology 2019 20:90

    Content type: Research article

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  36. Assessment of adequacy of intermittent hemodialysis (IHD) is conventionally based upon urea kinetic models for calculation of single pool Kt/Vurea (Kt/V), with 1.2 accepted as minimum adequate clearance for thric...

    Authors: Kelly V. Liang, Jane H. Zhang and Paul M. Palevsky

    Citation: BMC Nephrology 2019 20:82

    Content type: Research article

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  38. Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk fac...

    Authors: Honglan Wei, Hua Li, Xiaohong Song, Xingguo Du, Yuan Cai, Chengxu Li, Liping Dong and Junwu Dong

    Citation: BMC Nephrology 2019 20:63

    Content type: Research article

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  39. Sarcopenia, defined as low muscle mass and strength, is highly prevalent in patients undergoing chronic hemodialysis (HD). However, muscle function and muscle mass do not share the same clinical relevance. In ...

    Authors: Yu-Li Lin, Shu-Yuan Chen, Yu-Hsien Lai, Chih-Hsien Wang, Chiu-Huang Kuo, Hung-Hsiang Liou and Bang-Gee Hsu

    Citation: BMC Nephrology 2019 20:54

    Content type: Research article

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  40. The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger an...

    Authors: Helena Rydell, Kerstin Ivarsson, Martin Almquist, Mårten Segelmark and Naomi Clyne

    Citation: BMC Nephrology 2019 20:52

    Content type: Research article

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  41. Globally, there is increased clinical interest and uptake of hemodiafiltration (HDF) for increased removal of uremic toxins. To date, there has been no epidemiological analysis of HDF in China. We present HDF ...

    Authors: Weiming Zhang, Changlin Mei, Nan Chen, Xiaoqiang Ding, Zhaohui Ni, Chuanming Hao, Jinghong Zhang, Jinyuan Zhang, Niansong Wang, Gengru Jiang, Zhiyong Guo, Chen Yu, Yueyi Deng, Haiming Li, Qiang Yao, Mark R. Marshall…

    Citation: BMC Nephrology 2019 20:34

    Content type: Research article

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  42. Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers...

    Authors: Javier Deira, Miguel A. Suárez, Francisca López, Emilio García-Cabrera, Antonio Gascón, Eduardo Torregrosa, Giannina E. García, Jorge Huertas, Jose C. de la Flor, Suleya Puello, Jonathan Gómez-Raja, Jesús Grande, José L. Lerma, Carlos Corradino, Carlos Musso, Manuel Ramos…

    Citation: BMC Nephrology 2019 20:8

    Content type: Study protocol

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  43. Health-related quality of life (HrQoL) varies among dialysis patients. However, little is known about the association of dialysis modality with HrQoL over time. We describe longitudinal patterns of HrQoL among...

    Authors: Nwamaka D. Eneanya, Dugan W. Maddux, Marta M. Reviriego-Mendoza, John W. Larkin, Len A. Usvyat, Frank M. van der Sande, Jeroen P. Kooman and Franklin W. Maddux

    Citation: BMC Nephrology 2019 20:7

    Content type: Research article

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  44. Electronic health record (EHR) data is increasingly used to identify patients with chronic kidney disease (CKD). EHR queries used to capture CKD status, identify comorbid conditions, measure awareness by provi...

    Authors: Martin Frigaard, Anna Rubinsky, Lo Lowell, Anna Malkina, Leah Karliner, Michael Kohn and Carmen A Peralta

    Citation: BMC Nephrology 2019 20:3

    Content type: Research article

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  45. This is the first qualitative study to explore patient decision-making regarding end-stage kidney disease (ESKD) treatment in sub-Saharan Africa. The study addresses an important gap in the literature concerni...

    Authors: Edward Appiah Boateng, Linda East and Catrin Evans

    Citation: BMC Nephrology 2018 19:371

    Content type: Research article

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  46. Evidence regarding the effect of psychosocial factors on hospital readmission in the setting of hemodialysis is limited. We examined whether social worker-assessed factors were associated with 30-day readmissi...

    Authors: Olufunmilola Adisa, Bernard G. Jaar, Tahsin Masud, Abyalew Sahlie, Catherine Obadina, Joshua Ang, Janice P. Lea and Laura C. Plantinga

    Citation: BMC Nephrology 2018 19:360

    Content type: Research article

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  47. Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as...

    Authors: Andrzej Jaroszyński, Anna Jaroszyńska, Tomasz Zaborowski, Anna Drelich-Zbroja, Tomasz Zapolski and Wojciech Dąbrowski

    Citation: BMC Nephrology 2018 19:359

    Content type: Research article

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  48. The hepatic circulation is involved in adaptive systemic responses to circulatory stress. However, it is vulnerable to both chronic hypervolemia and cardiac dysfunction. The influence of hemodialysis (HD) and ...

    Authors: Claire J. Grant, Trevor P. Wade, Charles A. McKenzie, Guido Filler, Christopher W. McIntyre and Shih-Han S. Huang

    Citation: BMC Nephrology 2018 19:356

    Content type: Research article

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  49. To date, limited research has been dedicated to exploring the experience of decision-making for chronic kidney disease (CKD) patients who have initiated dialysis and have to make decisions in the context of ma...

    Authors: Danielle Marie Muscat, Roshana Kanagaratnam, Heather L. Shepherd, Kamal Sud, Kirsten McCaffery and Angela Webster

    Citation: BMC Nephrology 2018 19:339

    Content type: Research article

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  50. Caregivers of hemodialysis patients endure a significant caring pressure as a result of caring for patients with chronic illness, which can affect their quality of life. Disruptions in the quality of life of t...

    Authors: Haleh Jafari, Azita Ebrahimi, Abbas Aghaei and Alireza Khatony

    Citation: BMC Nephrology 2018 19:321

    Content type: Research article

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