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Pre-dialysis care and dialysis

Section edited by Giorgina Piccoli 

The Pre-dialysis Care and Dialysis section considers clinical research relating to the care of patients both before and during dialysis and their post-dialysis outcomes. Articles may describe interventional and non-interventional studies as well as qualitative studies. Systematic reviews, meta-analyses and large epidemiological studies should be directed to the Epidemiology and Health Outcomes section. This section does not consider case reports and these should be directed to the dedicated Case Reports section.

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  1. Observational studies of hemodialysis patients treated thrice weekly have shown that serum and dialysate potassium and bicarbonate concentrations are associated with patient outcomes. The effect of more freque...

    Authors: John K. Leypoldt, Michael A. Kraus, Bertrand L. Jaber, Eric D. Weinhandl and Allan J. Collins

    Citation: BMC Nephrology 2019 20:252

    Content type: Research article

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  2. Globally 10% of the population worldwide are affected by chronic kidney disease (CKD), making it one of the most prevalent chronic diseases. Several studies have highlighted that the symptoms of CKD have a sig...

    Authors: Bushra Alshammari, Helen Noble, Helen McAneney and Peter O’Halloran

    Citation: BMC Nephrology 2019 20:250

    Content type: Study protocol

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  4. Many studies have evaluated the usefulness of creatinine- (eGFRcr) and cystatin C-based estimated glomerular filtration rate (eGFRcys) at specific time points in predicting renal outcome. This study compared t...

    Authors: Suhyun Kim, Subin Hwang, Hye Ryoun Jang, Insuk Sohn, Hyeon Seon Ahn, Hyung-Doo Park, Wooseong Huh, Dong-Chan Jin, Yoon-Goo Kim, Dae Joong Kim, Ha Young Oh and Jung Eun Lee

    Citation: BMC Nephrology 2019 20:214

    Content type: Research article

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  6. Due to rising vascular comorbidities of patients undergoing dialysis, the prevalence of permanent hemodialysis catheters as hemodialysis access is increasing. However, infection is a major complication of thes...

    Authors: Fani Delistefani, Manuel Wallbach, Gerhard A. Müller, Michael J. Koziolek and Clemens Grupp

    Citation: BMC Nephrology 2019 20:199

    Content type: Research article

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  7. Successful vascular access (VA) cannulation is integral to the delivery of adequate dialysis, highlighting the importance of ensuring the viability of arteriovenous access in hemodialysis (HD) patients. Missed...

    Authors: Linda L. Coventry, Jon M. Hosking, Doris T. Chan, Evelyn Coral, Wai H. Lim, Amanda Towell-Barnard, Diane E. Twigg and Claire M. Rickard

    Citation: BMC Nephrology 2019 20:197

    Content type: Research article

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  8. Thrombophilia due to protein C (PC) and protein S (PS) deficiencies is highly prevalent among patients with stage 5 chronic kidney disease and is reported to arise due to extracorporeal circulation during hemo...

    Authors: Mayuri Ichinose, Naru Sasagawa, Tetsuo Chiba, Katsuhide Toyama, Yuzo Kayamori and Dongchon Kang

    Citation: BMC Nephrology 2019 20:191

    Content type: Research article

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  9. Reduced muscle strength and physical performance are prevalent in patients of maintenance hemodialysis (MHD), and deleterious changes in these parameters are associated with increased mortality.

    Authors: Yoshifumi Moriyama, Masahiko Hara, Sae Aratani, Hideaki Ishikawa, Kenichi Kono and Masatake Tamaki

    Citation: BMC Nephrology 2019 20:172

    Content type: Research article

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  10. The putative benefits of cinacalcet therapy for management of secondary hyperparathyroidism (SHPT) are thought to be most manifested when patients are taking it consistently and as prescribed. Real-world descr...

    Authors: Douglas S. Fuller, David Hallett, Paul J. Dluzniewski, Bruno Fouqueray, Michel Jadoul, Hal Morgenstern, Friedrich K. Port, Francesca Tentori and Ronald L. Pisoni

    Citation: BMC Nephrology 2019 20:169

    Content type: Research article

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  11. Tunnelled dialysis catheter (TC) infections are a major health complication and are associated with increased antibiotic consumption, hospital stays, health costs and mortality. Experimental data provide evide...

    Authors: Julien Aniort, Aurélien Piraud, Mireille Adda, Bruno Perreira, Marc Bouiller, Jacques Fourcade, Abdallah Guerraoui, Emilie Kalbacher, Thierry Krumel, Hélène Leray Moragues, Damien Thibaudin, Carlos Gustavo Vela, Guillaume Vernin, Hugo Weclawiak, Lise Bernard, Anne Elisabeth Heng…

    Citation: BMC Nephrology 2019 20:149

    Content type: Study protocol

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  12. Despite an increasing number of older people commencing dialysis the impact of dialysis on their quality of life and survival, remains unclear. The Dialysis Outcomes in those aged over 65 years or older study ...

    Authors: Bronwen McNoe, John B. W. Schollum, Sarah Derrett, Mark R. Marshall, Andrew Henderson, Ari Samaranayaka and Robert J. Walker

    Citation: BMC Nephrology 2019 20:137

    Content type: Research article

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  13. Prolonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concent...

    Authors: Esther D. Kim, Jacqueline Watt, Larisa G. Tereshchenko, Bernard G. Jaar, Stephen M. Sozio, W. H. Linda Kao, Michelle M. Estrella and Rulan S. Parekh

    Citation: BMC Nephrology 2019 20:133

    Content type: Research article

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  14. The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal dise...

    Authors: Elliot K. Tannor, Betty R. Norman, Kwame K. Adusei, Fred S. Sarfo, Mogamat R. Davids and George Bedu-Addo

    Citation: BMC Nephrology 2019 20:122

    Content type: Research article

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  15. Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the sel...

    Authors: Edward Zimbudzi, Clement Lo, Peter G. Kerr and Sophia Zoungas

    Citation: BMC Nephrology 2019 20:113

    Content type: Research article

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  18. Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietiti...

    Authors: Ali M. Omari, Leen S. Omari, Hazar H. Dagash, Waleed M. Sweileh, Nehal Natour and Sa’ed H. Zyoud

    Citation: BMC Nephrology 2019 20:92

    Content type: Research article

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  19. Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein which has half-life three-fold longer than that of Erythropoietin alfa (EPO). The objective of this study was to compare the eff...

    Authors: Shubhadeep D. Sinha, Vamsi Krishna Bandi, Bala Reddy Bheemareddy, Pankaj Thakur, Sreenivasa Chary, Kalpana Mehta, Vikranth Reddy Pinnamareddy, Rajendra Pandey, Subhramanyam Sreepada and Santosh Durugkar

    Citation: BMC Nephrology 2019 20:90

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2019 20:415

  20. Assessment of adequacy of intermittent hemodialysis (IHD) is conventionally based upon urea kinetic models for calculation of single pool Kt/Vurea (Kt/V), with 1.2 accepted as minimum adequate clearance for thric...

    Authors: Kelly V. Liang, Jane H. Zhang and Paul M. Palevsky

    Citation: BMC Nephrology 2019 20:82

    Content type: Research article

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  22. Hemodialysis patients suffer from a serious threat of cerebrovascular disease. Klotho, as an aging-suppressor gene, contributes to protect on vascular calcification and oxidative stress, which are the risk fac...

    Authors: Honglan Wei, Hua Li, Xiaohong Song, Xingguo Du, Yuan Cai, Chengxu Li, Liping Dong and Junwu Dong

    Citation: BMC Nephrology 2019 20:63

    Content type: Research article

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  23. Sarcopenia, defined as low muscle mass and strength, is highly prevalent in patients undergoing chronic hemodialysis (HD). However, muscle function and muscle mass do not share the same clinical relevance. In ...

    Authors: Yu-Li Lin, Shu-Yuan Chen, Yu-Hsien Lai, Chih-Hsien Wang, Chiu-Huang Kuo, Hung-Hsiang Liou and Bang-Gee Hsu

    Citation: BMC Nephrology 2019 20:54

    Content type: Research article

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  24. The survival rate for dialysis patients is poor. Previous studies have shown improved survival with home hemodialysis (HHD), but this could be due to patient selection, since HHD patients tend to be younger an...

    Authors: Helena Rydell, Kerstin Ivarsson, Martin Almquist, Mårten Segelmark and Naomi Clyne

    Citation: BMC Nephrology 2019 20:52

    Content type: Research article

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  25. Globally, there is increased clinical interest and uptake of hemodiafiltration (HDF) for increased removal of uremic toxins. To date, there has been no epidemiological analysis of HDF in China. We present HDF ...

    Authors: Weiming Zhang, Changlin Mei, Nan Chen, Xiaoqiang Ding, Zhaohui Ni, Chuanming Hao, Jinghong Zhang, Jinyuan Zhang, Niansong Wang, Gengru Jiang, Zhiyong Guo, Chen Yu, Yueyi Deng, Haiming Li, Qiang Yao, Mark R. Marshall…

    Citation: BMC Nephrology 2019 20:34

    Content type: Research article

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  26. Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers...

    Authors: Javier Deira, Miguel A. Suárez, Francisca López, Emilio García-Cabrera, Antonio Gascón, Eduardo Torregrosa, Giannina E. García, Jorge Huertas, Jose C. de la Flor, Suleya Puello, Jonathan Gómez-Raja, Jesús Grande, José L. Lerma, Carlos Corradino, Carlos Musso, Manuel Ramos…

    Citation: BMC Nephrology 2019 20:8

    Content type: Study protocol

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  27. Health-related quality of life (HrQoL) varies among dialysis patients. However, little is known about the association of dialysis modality with HrQoL over time. We describe longitudinal patterns of HrQoL among...

    Authors: Nwamaka D. Eneanya, Dugan W. Maddux, Marta M. Reviriego-Mendoza, John W. Larkin, Len A. Usvyat, Frank M. van der Sande, Jeroen P. Kooman and Franklin W. Maddux

    Citation: BMC Nephrology 2019 20:7

    Content type: Research article

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  28. Electronic health record (EHR) data is increasingly used to identify patients with chronic kidney disease (CKD). EHR queries used to capture CKD status, identify comorbid conditions, measure awareness by provi...

    Authors: Martin Frigaard, Anna Rubinsky, Lo Lowell, Anna Malkina, Leah Karliner, Michael Kohn and Carmen A Peralta

    Citation: BMC Nephrology 2019 20:3

    Content type: Research article

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  29. This is the first qualitative study to explore patient decision-making regarding end-stage kidney disease (ESKD) treatment in sub-Saharan Africa. The study addresses an important gap in the literature concerni...

    Authors: Edward Appiah Boateng, Linda East and Catrin Evans

    Citation: BMC Nephrology 2018 19:371

    Content type: Research article

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  30. Evidence regarding the effect of psychosocial factors on hospital readmission in the setting of hemodialysis is limited. We examined whether social worker-assessed factors were associated with 30-day readmissi...

    Authors: Olufunmilola Adisa, Bernard G. Jaar, Tahsin Masud, Abyalew Sahlie, Catherine Obadina, Joshua Ang, Janice P. Lea and Laura C. Plantinga

    Citation: BMC Nephrology 2018 19:360

    Content type: Research article

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  31. Decreased heat shock protein 27 (HSP27) participates in many processes that are involved in cardiovascular (CV) disease. The objective of the study was to evaluate if HSP27 level was predictive of mortality as...

    Authors: Andrzej Jaroszyński, Anna Jaroszyńska, Tomasz Zaborowski, Anna Drelich-Zbroja, Tomasz Zapolski and Wojciech Dąbrowski

    Citation: BMC Nephrology 2018 19:359

    Content type: Research article

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  32. The hepatic circulation is involved in adaptive systemic responses to circulatory stress. However, it is vulnerable to both chronic hypervolemia and cardiac dysfunction. The influence of hemodialysis (HD) and ...

    Authors: Claire J. Grant, Trevor P. Wade, Charles A. McKenzie, Guido Filler, Christopher W. McIntyre and Shih-Han S. Huang

    Citation: BMC Nephrology 2018 19:356

    Content type: Research article

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  33. To date, limited research has been dedicated to exploring the experience of decision-making for chronic kidney disease (CKD) patients who have initiated dialysis and have to make decisions in the context of ma...

    Authors: Danielle Marie Muscat, Roshana Kanagaratnam, Heather L. Shepherd, Kamal Sud, Kirsten McCaffery and Angela Webster

    Citation: BMC Nephrology 2018 19:339

    Content type: Research article

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  34. Caregivers of hemodialysis patients endure a significant caring pressure as a result of caring for patients with chronic illness, which can affect their quality of life. Disruptions in the quality of life of t...

    Authors: Haleh Jafari, Azita Ebrahimi, Abbas Aghaei and Alireza Khatony

    Citation: BMC Nephrology 2018 19:321

    Content type: Research article

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  35. Blood pressure (BP) is currently the main hemodynamic parameter used to assess the influence of fluid removal during hemodialysis session. Since BP is dependent on cardiac output (CO) and total peripheral resi...

    Authors: Yunlin Feng, Yurong Zou, Yifei Zheng, Nathan W. Levin and Li Wang

    Citation: BMC Nephrology 2018 19:310

    Content type: Research article

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  36. The number of elderly patients with end-stage renal disease is increasing rapidly. The higher prevalence of comorbidities and shorter life expectancy in these patients make it difficult to decide on the type o...

    Authors: Eunjin Bae, Hajeong Lee, Dong Ki Kim, Kook-Hwan Oh, Yon Su Kim, Curie Ahn, Jin Suk Han, Sang-Il Min, Seung-Kee Min, Hyo-Cheol Kim and Kwon Wook Joo

    Citation: BMC Nephrology 2018 19:306

    Content type: Research article

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  37. It is debated whether transperitoneal membrane transport of larger (charged) molecules in peritoneal dialysis can be partially governed by the electrokinetic model. In this model, it is postulated that streami...

    Authors: Anneleen Pletinck, Wim Van Biesen, Clement Dequidt and Sunny Eloot

    Citation: BMC Nephrology 2018 19:299

    Content type: Research article

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  38. Patients reaching end-stage renal disease must make a difficult decision regarding renal replacement therapy (RRT) options. Because the choice between dialysis modalities should include patient preferences, it...

    Authors: Jarcy Zee, Junhui Zhao, Lalita Subramanian, Erica Perry, Nicole Bryant, Margie McCall, Yanko Restovic, Delma Torres, Bruce M. Robinson, Ronald L. Pisoni and Francesca Tentori

    Citation: BMC Nephrology 2018 19:298

    Content type: Research article

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  39. Inflammation-based prognostic scores have been used as outcome predictors in patients with cancer or on hemodialysis. However, their role in patients on continuous ambulatory peritoneal dialysis (CAPD) remains...

    Authors: Lu Cai, Jianwen Yu, Jing Yu, Yuan Peng, Habib Ullah, Chunyan Yi, Jianxiong Lin, Xiao Yang and Xueqing Yu

    Citation: BMC Nephrology 2018 19:297

    Content type: Research article

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  40. Arteriovenous fistulae can restrict daily living behaviors involving the upper limbs in hemodialysis patients, but no studies have investigated the detailed effects of an arteriovenous fistula on routine life ...

    Authors: Yuuta Hara, Kosuke Sonoda, Koji Hashimoto, Kazuaki Fuji, Yosuke Yamada and Yuji Kamijo

    Citation: BMC Nephrology 2018 19:284

    Content type: Research article

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  41. Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD). Therefore, this study aimed to asses...

    Authors: Aiqun Chen, Ying Sun, Ju Cui, Ban Zhao, Haitao Wang, Xianguang Chen and Yonghui Mao

    Citation: BMC Nephrology 2018 19:264

    Content type: Research article

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  42. Although the efficacy of iron sucrose (IS) and ferric carboxymaltose (FCM) in treating anemia in hemodialysis (HD) patients has been studied individually, a comparison of these two intravenous iron formulation...

    Authors: Jesse M. G. Hofman, Michele F. Eisenga, Adry Diepenbroek, Ilja M. Nolte, Bastiaan van Dam, Ralf Westerhuis, Stephan J. L. Bakker, Casper F. M. Franssen and Carlo A. J. M. Gaillard

    Citation: BMC Nephrology 2018 19:242

    Content type: Research article

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  43. Metabolic syndrome (MetS) has been established as a risk for cardiovascular diseases and mortality in hemodialysis patients. Energy intake (EI) is an important nutritional therapy for preventing MetS. We exami...

    Authors: Tuyen Van Duong, Te-Chih Wong, Hsi-Hsien Chen, Tzen-Wen Chen, Tso-Hsiao Chen, Yung-Ho Hsu, Sheng-Jeng Peng, Ko-Lin Kuo, Hsiang-Chung Liu, En-Tzu Lin, Chi-Sin Wang, I-Hsin Tseng, Yi-Wei Feng, Tai-Yue Chang, Chien-Tien Su and Shwu-Huey Yang

    Citation: BMC Nephrology 2018 19:236

    Content type: Research article

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  44. Emergency start (ES) of dialysis has been associated with worse outcome, but remains poorly documented. This study aims to compare the profile and outcome of a large cohort of patients starting dialysis as an ...

    Authors: Alain Michel, Adelaide Pladys, Sahar Bayat, Cécile Couchoud, Thierry Hannedouche and Cécile Vigneau

    Citation: BMC Nephrology 2018 19:233

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2018 19:266

  45. End-stage renal disease (ESRD) although rare among infants presents many management challenges. We sought to evaluate factors associated with PD catheter failure among infants initiated on chronic PD.

    Authors: Peace D. Imani, Jennifer L. Carpenter, Cynthia S. Bell, Mary L. Brandt, Michael C. Braun and Sarah J. Swartz

    Citation: BMC Nephrology 2018 19:231

    Content type: Research article

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  46. The risk of infective endocarditis (IE) is markedly increased in patients receiving chronic hemodialysis compared with the general population, but outcome data are sparse. The present study investigated causes...

    Authors: Mavish S. Chaudry, Gunnar H. Gislason, Anne-Lise Kamper, Marianne Rix, Anders Dahl, Lauge Østergaard, Emil L. Fosbøl, Trine K. Lauridsen, Louise B. Oestergaard, Christian Hassager, Christian Torp-Pedersen and Niels E. Bruun

    Citation: BMC Nephrology 2018 19:216

    Content type: Research article

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  47. Intradialytic hypotension is a common complication of hemodialysis. The Hemocontrol biofeedback system, improving intradialytic hemodynamic stability, is associated with an initial transient increase in plasma...

    Authors: Esmée M. Ettema, Johanna Kuipers, Martijn van Faassen, Henk Groen, Arie M. van Roon, Joop D. Lefrandt, Ralf Westerhuis, Ido P. Kema, Harry van Goor, Ron T. Gansevoort, Carlo A. J. M. Gaillard and Casper F. M. Franssen

    Citation: BMC Nephrology 2018 19:214

    Content type: Research article

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  48. Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We a...

    Authors: Chaomin Zhou, Hongying Peng, Jing Yuan, Xin Lin, Yan Zha and Hui Chen

    Citation: BMC Nephrology 2018 19:206

    Content type: Research article

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  49. Conservative care is argued to be a reasonable treatment alternative for dialysis in older patients with advanced chronic kidney disease (CKD). However, comparisons are scarce and generally focus on survival o...

    Authors: Wouter R. Verberne, Janneke Dijkers, Johannes C. Kelder, Anthonius B. M. Geers, Wilbert T. Jellema, Hieronymus H. Vincent, Johannes J. M. van Delden and Willem Jan W. Bos

    Citation: BMC Nephrology 2018 19:205

    Content type: Research article

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    The Research note to this article has been published in BMC Research Notes 2019 12:722

  50. Exercise improves functional outcomes and quality of life of older patients with end-stage renal disease undergoing hemodialysis. Yet exercise is not promoted as part of routine care. Health care providers and...

    Authors: Pia Kontos, Alisa Grigorovich, Romeo Colobong, Karen-Lee Miller, Gihad E. Nesrallah, Malcolm A. Binns, Shabbir M. H. Alibhai, Trisha Parsons, Sarbjit Vanita Jassal, Alison Thomas and Gary Naglie

    Citation: BMC Nephrology 2018 19:195

    Content type: Research article

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