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Pre-dialysis care and dialysis

Section edited by Giorgina Piccoli 

The Pre-dialysis Care and Dialysis section considers clinical research relating to the care of patients both before and during dialysis and their post-dialysis outcomes. Articles may describe interventional and non-interventional studies as well as qualitative studies. Systematic reviews, meta-analyses and large epidemiological studies should be directed to the Epidemiology and Health Outcomes section. This section does not consider case reports and these should be directed to the dedicated Case Reports section.

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  1. Although fatigue is common in dialysis patients, polypharmacy is seldom listed among its causes. In this report, we describe a dialysis patient who developed severe fatigue due to pharmacological interaction b...

    Authors: Emanuela Cataldo, Valeria Columbano, Louise Nielsen, Lurlynis Gendrot, Bianca Covella and Giorgina Barbara Piccoli

    Citation: BMC Nephrology 2018 19:155

    Content type: Case report

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  2. For patients with end-stage renal failure (ESFR), thrice-weekly hemodialysis is a standard care. Once-weekly hemodialysis combined with low-protein and low-salt dietary treatment (OWHD-DT) have been rarely stu...

    Authors: Toshiyuki Nakao, Yoshie Kanazawa and Toshimasa Takahashi

    Citation: BMC Nephrology 2018 19:151

    Content type: Research article

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  3. Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that meas...

    Authors: Meaghan Lunney, Bronwyn Tonelli, Rachel Lewis, Natasha Wiebe, Chandra Thomas, Jennifer MacRae and Marcello Tonelli

    Citation: BMC Nephrology 2018 19:137

    Content type: Research article

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  4. Patient activation is associated with better outcomes and lower costs. Although the concept is widely investigated, little attention was given to patient activation and its predictors in patients undergoing he...

    Authors: Liesbet Van Bulck, Kathleen Claes, Katrien Dierickx, Annelies Hellemans, Sofie Jamar, Sven Smets and Gijs Van Pottelbergh

    Citation: BMC Nephrology 2018 19:126

    Content type: Research article

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  5. Inadequate volume control may be a main contributor to poor survival and high mortality in hemodialysis patients. Bioimpedance measurement has the potential to improve fluid management, but several dialysis ce...

    Authors: Jenny Stenberg, Catrin Henriksson, Magnus Lindberg and Hans Furuland

    Citation: BMC Nephrology 2018 19:121

    Content type: Research article

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  6. The impact of the low-protein diet on nutrition in CKD diabetics is uncertain.

    Authors: Vincenzo Bellizzi, Patrizia Calella, Julia Nava Hernández, Verónica Figueroa González, Silvia Moran Lira, Serena Torraca, Rocio Urbina Arronte, Pietro Cirillo, Roberto Minutolo and Rafael A. Montúfar Cárdenas

    Citation: BMC Nephrology 2018 19:110

    Content type: Research article

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  7. Research on factors associated with dialysis withdrawal is scarce. This study examined the predictors that might influence rate of dialysis withdrawal. Existing literature is summarized, analyzed and synthesiz...

    Authors: Hammad Ali Qazi, Helen Chen and Meng Zhu

    Citation: BMC Nephrology 2018 19:96

    Content type: Research article

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  8. Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial E...

    Authors: R. Krishnasamy, C. M. Hawley, M. J. Jardine, M. A. Roberts, Y. J. Cho, M. G. Wong, A. Heath, C. L. Nelson, S. Sen, P. F. Mount, E. M. Pascoe, D. Darssan, L. A. Vergara, P. A. Paul-Brent, N. D. Toussaint, D. W. Johnson…

    Citation: BMC Nephrology 2018 19:89

    Content type: Study protocol

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  9. Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant i...

    Authors: Andrea Angioi, Gianfranca Cabiddu, Maura Conti, Gianfranco Pili, Alice Atzeni, Valeria Matta, Riccardo Cao, Matteo Floris, Marco Songini, Maria Franca Mulas, Mitchell Rosner and Antonello Pani

    Citation: BMC Nephrology 2018 19:77

    Content type: Research article

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  10. Insufficient vigilance for renal insufficiency is associated with late referral, increased morbidity and mortality. The present study examines whether increased vigilance for chronic kidney disease (CKD) leads...

    Authors: M. De Wilde, M. Speeckaert and W. Van Biesen

    Citation: BMC Nephrology 2018 19:74

    Content type: Research article

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  11. Although aortic calcification has a significant negative impact on prognosis in patients on hemodialysis (HD), risk factors for aortic calcification progression remain unclear. The aim of this study was to inv...

    Authors: Teppei Okamoto, Shingo Hatakeyama, Hirotake Kodama, Hirotaka Horiguchi, Yuka Kubota, Koichi Kido, Masaki Momota, Shogo Hosogoe, Yoshimi Tanaka, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki and Chikara Ohyama

    Citation: BMC Nephrology 2018 19:71

    Content type: Research article

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  12. Decreased residual urine volume (RUV) is associated with higher mortality in hemodialysis (HD). However, few studies have examined RUV in patients on HD in Sub-Saharan Africa. The aim of this study was to iden...

    Authors: Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, François Bompeka Lepira, Fiston Ikwa Ndol Mbutiwi, Jean Robert Rissassy Makulo, Justine Busanga Bukabau, Patrick Parmba Izeidi, Jeannine Losa Luse, Stéphane Kalambay Mukendi, Désiré Kulimba Mashinda and Nazaire Mangani Nseka

    Citation: BMC Nephrology 2018 19:68

    Content type: Research article

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  13. Patients with late referral and positive history of volume overload may have a poor prognosis after initiating dialysis due to insufficient and/or inadequate management of complications of renal failure and th...

    Authors: Masaki Okazaki, Daijo Inaguma, Takahiro Imaizumi, Akiko Kada, Takaaki Yaomura, Naotake Tsuboi and Shoichi Maruyama

    Citation: BMC Nephrology 2018 19:65

    Content type: Research article

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  14. Accelerated muscle atrophy is associated with a three-fold increase in mortality in chronic kidney disease (CKD) patients. It is suggested that hyperphosphatemia might contribute to muscle wasting, but the und...

    Authors: Yue-yue Zhang, Man Yang, Jin-fang Bao, Li-jie Gu, Hong-lei Yu and Wei-jie Yuan

    Citation: BMC Nephrology 2018 19:45

    Content type: Research article

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  15. Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those...

    Authors: Hyoungnae Kim, Hyunwook Kim, Misol Lee, Min-Uk Cha, Ki Heon Nam, Seong Yeong An, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang…

    Citation: BMC Nephrology 2018 19:32

    Content type: Research article

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  16. Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies...

    Authors: Ann Bonner, Kerri Gillespie, Katrina L. Campbell, Katina Corones-Watkins, Bronwyn Hayes, Barbara Harvie, Jaimon T. Kelly and Kathryn Havas

    Citation: BMC Nephrology 2018 19:28

    Content type: Research article

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  17. There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR...

    Authors: Hamad Bahbahani, Ahmed AlTurki, Ahmed Dawas and Mark L. Lipman

    Citation: BMC Nephrology 2018 19:4

    Content type: Research article

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  18. Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of isc...

    Authors: Claire Delsuc, Alexandre Faure, Julien Berthiller, Didier Dorez, Xavier Matillon, Vannary Meas-Yedid, Bernard Floccard, Guillaume Marcotte, Vanessa Labeye, Maud Rabeyrin, Ricardo Codas, Cécile Chauvet, Philip Robinson, Emmanuel Morelon, Lionel Badet, William Hanf…

    Citation: BMC Nephrology 2018 19:3

    Content type: Research article

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  19. Despite pre-kidney-transplant cardiovascular (CV) assessment being routine care to minimise perioperative risk, the utility of such assessment is not well established. The study reviewed the evaluation and out...

    Authors: Robin Ramphul, Maria Fernandez, Sam Firoozi, Juan C. Kaski, Rajan Sharma and Debasish Banerjee

    Citation: BMC Nephrology 2018 19:2

    Content type: Research article

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  20. Membranes with increasing pore size are introduced to enhance removal of large uremic toxins with regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation pr...

    Authors: Eva Schepers, Griet Glorieux, Sunny Eloot, Michael Hulko, Adriana Boschetti-de-Fierro, Werner Beck, Bernd Krause and Wim Van Biesen

    Citation: BMC Nephrology 2018 19:1

    Content type: Research article

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  21. Chronic kidney disease patients have an increased prevalence of subclinical cerebrovascular diseases. Dialysis patients have severe vascular diseases burden. The cerebral small vessel diseases (CSVD) are diffi...

    Authors: Ke Zheng, Haiyun Wang, Bo Hou, Hui You, Jing Yuan, Kai Luo, Limeng Chen, Mingxi Li, Qun Xu, Yicheng Zhu, Liying Cui, Sagar Uday Nigwekar, Feng Feng and Xuemei Li

    Citation: BMC Nephrology 2017 18:366

    Content type: Research article

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  22. Increasing numbers of elderly patients are undergoing long-term dialysis. However, the role of dialysis in survival and quality of life is unclear, and poor outcomes may be associated with comorbidities rather...

    Authors: Debajyoti Roy, Anupama Roy Chowdhury, Shrikant Pande and Jia Wen Kam

    Citation: BMC Nephrology 2017 18:364

    Content type: Research article

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  23. The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage r...

    Authors: Wen-Yi Li, Yi-Cheng Wang, Shang-Jyh Hwang, Shih-Hua Lin, Kwan-Dun Wu and Yung-Ming Chen

    Citation: BMC Nephrology 2017 18:359

    Content type: Research article

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  24. End stage renal disease (ESRD) patients on maintenance hemodialysis, are high utilizers of inpatient services. Because of data showing improved outcomes in medical patients admitted to hospitalist-run, non-tea...

    Authors: Ladan Golestaneh, Eran Bellin, William Southern and Michal L. Melamed

    Citation: BMC Nephrology 2017 18:352

    Content type: Research article

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  25. Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is assoc...

    Authors: Elizabeth Helene Louw and Mogamat-Yazied Chothia

    Citation: BMC Nephrology 2017 18:336

    Content type: Research article

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  26. The study objective is to assess the effectiveness and economic impact of a structured programme to support patient involvement in centre-based haemodialysis and to understand what works for whom in what circu...

    Authors: James Fotheringham, Tania Barnes, Louese Dunn, Sonia Lee, Steven Ariss, Tracey Young, Stephen J. Walters, Paul Laboi, Andy Henwood, Rachel Gair and Martin Wilkie

    Citation: BMC Nephrology 2017 18:335

    Content type: Study protocol

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  27. Anemia management protocols in hemodialysis (HD) units differ conspicuously regarding optimal intravenous (IV) iron dosing; consequently, patients receive markedly different cumulative exposures to IV iron and...

    Authors: Bruce M. Robinson, Maria Larkina, Brian Bieber, Werner Kleophas, Yun Li, Francesco Locatelli, Keith P. McCullough, Jackie G. Nolen, Friedrich K. Port and Ronald L. Pisoni

    Citation: BMC Nephrology 2017 18:330

    Content type: Research article

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  28. Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD disconti...

    Authors: Masaaki Nakayama, Wan-Jun Zhu, Kimio Watanabe, Ayano Gibo, Ali M. Sherif, Shigeru Kabayama and Sadayoshi Ito

    Citation: BMC Nephrology 2017 18:327

    Content type: Research article

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  29. Latinos in the U.S. are almost twice as likely to progress to End Stage Renal disease (ESRD) compared to non-Latino whites. Patients with ESRD on dialysis experience high morbidity, pre-mature mortality and re...

    Authors: Karla Gonzalez, Jesus G. Ulloa, Gerardo Moreno, Oscar Echeverría, Keith Norris and Efrain Talamantes

    Citation: BMC Nephrology 2017 18:319

    Content type: Research article

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  30. Dietary modification is an important component of the management of end stage kidney disease (ESKD). The diet for ESKD involves modifying energy and protein intake, and altering sodium, phosphate, potassium an...

    Authors: Kelly Lambert, Judy Mullan and Kylie Mansfield

    Citation: BMC Nephrology 2017 18:318

    Content type: Research article

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  31. Regional anticoagulation with citrate is the recommended first line treatment for patients receiving continuous renal replacement therapy (CRRT). There is wide variability in filter patency which may be due to...

    Authors: Richard Fisher, Katie Lei, Mike J. Mitchell, Gary W. Moore, Helen Dickie, Linda Tovey, Siobhan Crichton and Marlies Ostermann

    Citation: BMC Nephrology 2017 18:304

    Content type: Study protocol

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  32. Exercise during haemodialysis improves strength and physical function. However, both patients and clinicians are time poor, and current exercise recommendations add an excessive time burden making exercise a r...

    Authors: Matthew J. Clarkson, Steve F. Fraser, Paul N. Bennett, Lawrence P. McMahon, Catherine Brumby and Stuart A. Warmington

    Citation: BMC Nephrology 2017 18:294

    Content type: Study protocol

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  33. Adults on dialysis are at increased risk of foot ulceration, which commonly precedes more serious lower limb complications, including amputation. Limited data exist regarding the prevalence and factors associa...

    Authors: Michelle R. Kaminski, Anita Raspovic, Lawrence P. McMahon, Katrina A. Lambert, Bircan Erbas, Peter F. Mount, Peter G. Kerr and Karl B. Landorf

    Citation: BMC Nephrology 2017 18:293

    Content type: Research article

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  34. Despite improved health outcomes associated with arteriovenous fistulas, 80% of Americans initiate hemodialysis using a catheter, influenced by low socioeconomic status among other factors. Risk factors for in...

    Authors: Nicole C. Rich, Shant M. Vartanian, Shimi Sharief, Daniel J. Freitas and Delphine S. Tuot

    Citation: BMC Nephrology 2017 18:279

    Content type: Research article

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  35. Glucose is widely used as an osmotic agent in peritoneal dialysis (PD), but exerts untoward effects on the peritoneum. The potential protective effect of a reduced exposure to hypertonic glucose has never been...

    Authors: Dominique Pagniez, Alain Duhamel, Eric Boulanger, Celia Lessore de Sainte Foy and Jean-Baptiste Beuscart

    Citation: BMC Nephrology 2017 18:278

    Content type: Research article

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  36. Stroke is the third leading cause of cardiovascular mortality in dialysis patients. The objective of this study was to assess the extent of stroke in chronic hemodialysis patients.

    Authors: Yannick Nlandu, François Lepira, Jean-Robert Makulo, Yannick Engole, Ernest Sumaili, Marie-Noelle Wameso, Vieux Mokoli, Jeannine Luse, Augustin Longo, Chantal Zinga, Pierre Akilimali, Aliocha Nkodila, Mélanie Bavassa, François Kajingulu, Justine Bukabau and Nazaire Nseka

    Citation: BMC Nephrology 2017 18:277

    Content type: Research article

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  37. Secondary hyperparathyroidism (SHPT) is a severe complication for dialysis patients. Vitamin D receptor activators (VDRAs) are used to treat SHPT, but the comparative efficacy and safety between paricalcitol a...

    Authors: Yifeng Xie, Peiling Su, Yifan Sun, Hongsheng Zhang, Rong Zhao, Liang Li and Lanfen Meng

    Citation: BMC Nephrology 2017 18:272

    Content type: Research article

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  38. Endophthalmitis is a severe eye infection leading to disabling outcome. Because there were only a few case report illustrating endophthalmitis in chronic dialysis patient, we would like to investigate the epid...

    Authors: George Kuo, Yueh-An Lu, Wei-Chiao Sun, Chao-Yu Chen, Huang-Kai Kao, YuJr Lin, Chia-Hui Lee, Cheng-Chieh Hung, Ya-Chung Tian and Hsiang-Hao Hsu

    Citation: BMC Nephrology 2017 18:270

    Content type: Research article

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  39. The main reason for anemia in renal failure patients is the insufficient erythropoietin production by the kidneys. Beside erythropoietin deficiency, in vitro studies have incriminated uremic toxins in the path...

    Authors: Stanislas Bataille, Marion Pelletier, Marion Sallée, Yvon Berland, Nathalie McKay, Ariane Duval, Stéphanie Gentile, Yosra Mouelhi, Philippe Brunet and Stéphane Burtey

    Citation: BMC Nephrology 2017 18:251

    Content type: Research article

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    The Publisher Correction to this article has been published in BMC Nephrology 2017 18:306

  40. Because chronic fluid volume overload is associated with higher mortality, we tested whether blood-volume monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafilt...

    Authors: Marlies Antlanger, Peter Josten, Michael Kammer, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Gere Sunder-Plassmann, Marcus D. Säemann and Manfred Hecking

    Citation: BMC Nephrology 2017 18:238

    Content type: Research article

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  41. Patients treated with dialysis have high rates of brain infarcts, brain atrophy, and white matter disease. There are limited data regarding the presence of more subtle damage to brain white matter.

    Authors: David A. Drew, Bang-Bon Koo, Rafeeque Bhadelia, Daniel E. Weiner, Sarah Duncan, Maria Mendoza-De la Garza, Aditi Gupta, Hocine Tighiouart, Tammy Scott and Mark J. Sarnak

    Citation: BMC Nephrology 2017 18:213

    Content type: Research article

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  42. Kidney Diseases contribute a significant proportion to the global burden of non-communicable diseases. Haemodialysis services as the main modality of renal replacement therapy in most resource limited countrie...

    Authors: Alfred J. Meremo, David P. Ngilangwa, Masumbuko Y. Mwashambwa, Matobogolo B. Masalu, Janet Kapinga, Rehema Tagalile and Issa Sabi

    Citation: BMC Nephrology 2017 18:212

    Content type: Research article

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  43. The prognostic values of baseline, longitudinal high-sensitivity C-reactive protein (hs-CRP) and its change over time on mortality in patients undergoing continuous ambulatory peritoneal dialysis (CAPD) remain...

    Authors: Wei Li, Liping Xiong, Li Fan, Yating Wang, Xuan Peng, Rong Rong, Yagui Qiu, Jiani Shen, Jianxiong Lin, Xueqing Yu and Haiping Mao

    Citation: BMC Nephrology 2017 18:211

    Content type: Research article

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  44. The role of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) reducing risk of cardiovascular events (CVEs) and preserving kidney function in patients with chronic kidne...

    Authors: Youxia Liu, Xinxin Ma, Jie Zheng, Junya Jia and Tiekun Yan

    Citation: BMC Nephrology 2017 18:206

    Content type: Research article

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  45. Dialysis initiation rates among older adults, aged 75 years or greater, are increasing at a faster rate than for younger age groups. Older adults with advanced CKD (eGFR < 30 ml/min/1.73 m2) typically lose renal ...

    Authors: Steven J. Rosansky, Jane Schell, Joseph Shega, Jennifer Scherer, Laurie Jacobs, Cecile Couchoud, Deidra Crews and Matthew McNabney

    Citation: BMC Nephrology 2017 18:200

    Content type: Review

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  46. Poor quality of life (QOL) and a high prevalence of depression have been identified among end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). We aimed to evaluate the associations between rel...

    Authors: Paulo Roberto Santos, José Roberto Frota Gomes Capote Júnior, José Renan Miranda Cavalcante Filho, Ticianne Pinto Ferreira, José Nilson Gadelha dos Santos Filho and Stênio da Silva Oliveira

    Citation: BMC Nephrology 2017 18:197

    Content type: Research article

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  47. Although angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-II receptor blockers (ARB) have been shown to preserve residual kidney function in a select group of Asian patients undergoing continuou...

    Authors: Jenny I. Shen, Anjali B. Saxena, Sitaram Vangala, Satvinder K. Dhaliwal and Wolfgang C. Winkelmayer

    Citation: BMC Nephrology 2017 18:196

    Content type: Research article

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  48. Primary hyperoxaluria type 1 (PH1), is a rare and heterogeneous disease and one of major causes of renal insufficiency in Tunisia, caused by mutations in the AGXT gene. 33-34InsC mutation, was mainly described in...

    Authors: Ibtihel Benhaj Mbarek, Saoussen Mdimeg, Amira Moussa, Dorsaf Zellama, Hayat Kaarout, Jaouida Abdelmoula, Abdellatif Achour, Saoussen Abroug, Asma Omezzine and Ali Bouslama

    Citation: BMC Nephrology 2017 18:195

    Content type: Research article

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  49. Vascular calcifications are highly prevalent in hemodialysis patients. Dephosphorylated-uncarboxylated MGP (dp-ucMGP) was found to increase in vitamin K-deficient patients and may be associated with vascular c...

    Authors: Mabel Aoun, Maha Makki, Hiba Azar, Hiam Matta and Dania Nehme Chelala

    Citation: BMC Nephrology 2017 18:191

    Content type: Research article

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  50. Results concerning the association between peritoneal dialysis-related peritonitis and mortality in peritoneal dialysis patients are inconclusive, with one potential reason being that the time-dependent effect...

    Authors: Hongjian Ye, Qian Zhou, Li Fan, Qunying Guo, Haiping Mao, Fengxian Huang, Xueqing Yu and Xiao Yang

    Citation: BMC Nephrology 2017 18:186

    Content type: Research article

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