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Pre-dialysis care and dialysis

Section edited by Giorgina Piccoli 

The Pre-dialysis Care and Dialysis section considers clinical research relating to the care of patients both before and during dialysis and their post-dialysis outcomes. Articles may describe interventional and non-interventional studies as well as qualitative studies. Systematic reviews, meta-analyses and large epidemiological studies should be directed to the Epidemiology and Health Outcomes section. This section does not consider case reports and these should be directed to the dedicated Case Reports section.

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  1. Arteriovenous fistulae can restrict daily living behaviors involving the upper limbs in hemodialysis patients, but no studies have investigated the detailed effects of an arteriovenous fistula on routine life ...

    Authors: Yuuta Hara, Kosuke Sonoda, Koji Hashimoto, Kazuaki Fuji, Yosuke Yamada and Yuji Kamijo

    Citation: BMC Nephrology 2018 19:284

    Content type: Research article

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  2. Previous clinical studies found inconsistent relationship between circulating sclerostin levels and treatment outcome in patients undergoing maintenance hemodialysis (MHD). Therefore, this study aimed to asses...

    Authors: Aiqun Chen, Ying Sun, Ju Cui, Ban Zhao, Haitao Wang, Xianguang Chen and Yonghui Mao

    Citation: BMC Nephrology 2018 19:264

    Content type: Research article

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  3. Although the efficacy of iron sucrose (IS) and ferric carboxymaltose (FCM) in treating anemia in hemodialysis (HD) patients has been studied individually, a comparison of these two intravenous iron formulation...

    Authors: Jesse M. G. Hofman, Michele F. Eisenga, Adry Diepenbroek, Ilja M. Nolte, Bastiaan van Dam, Ralf Westerhuis, Stephan J. L. Bakker, Casper F. M. Franssen and Carlo A. J. M. Gaillard

    Citation: BMC Nephrology 2018 19:242

    Content type: Research article

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  4. Metabolic syndrome (MetS) has been established as a risk for cardiovascular diseases and mortality in hemodialysis patients. Energy intake (EI) is an important nutritional therapy for preventing MetS. We exami...

    Authors: Tuyen Van Duong, Te-Chih Wong, Hsi-Hsien Chen, Tzen-Wen Chen, Tso-Hsiao Chen, Yung-Ho Hsu, Sheng-Jeng Peng, Ko-Lin Kuo, Hsiang-Chung Liu, En-Tzu Lin, Chi-Sin Wang, I-Hsin Tseng, Yi-Wei Feng, Tai-Yue Chang, Chien-Tien Su and Shwu-Huey Yang

    Citation: BMC Nephrology 2018 19:236

    Content type: Research article

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  5. Emergency start (ES) of dialysis has been associated with worse outcome, but remains poorly documented. This study aims to compare the profile and outcome of a large cohort of patients starting dialysis as an ...

    Authors: Alain Michel, Adelaide Pladys, Sahar Bayat, Cécile Couchoud, Thierry Hannedouche and Cécile Vigneau

    Citation: BMC Nephrology 2018 19:233

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2018 19:266

  6. End-stage renal disease (ESRD) although rare among infants presents many management challenges. We sought to evaluate factors associated with PD catheter failure among infants initiated on chronic PD.

    Authors: Peace D. Imani, Jennifer L. Carpenter, Cynthia S. Bell, Mary L. Brandt, Michael C. Braun and Sarah J. Swartz

    Citation: BMC Nephrology 2018 19:231

    Content type: Research article

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  7. The risk of infective endocarditis (IE) is markedly increased in patients receiving chronic hemodialysis compared with the general population, but outcome data are sparse. The present study investigated causes...

    Authors: Mavish S. Chaudry, Gunnar H. Gislason, Anne-Lise Kamper, Marianne Rix, Anders Dahl, Lauge Østergaard, Emil L. Fosbøl, Trine K. Lauridsen, Louise B. Oestergaard, Christian Hassager, Christian Torp-Pedersen and Niels E. Bruun

    Citation: BMC Nephrology 2018 19:216

    Content type: Research article

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  8. Intradialytic hypotension is a common complication of hemodialysis. The Hemocontrol biofeedback system, improving intradialytic hemodynamic stability, is associated with an initial transient increase in plasma...

    Authors: Esmée M. Ettema, Johanna Kuipers, Martijn van Faassen, Henk Groen, Arie M. van Roon, Joop D. Lefrandt, Ralf Westerhuis, Ido P. Kema, Harry van Goor, Ron T. Gansevoort, Carlo A. J. M. Gaillard and Casper F. M. Franssen

    Citation: BMC Nephrology 2018 19:214

    Content type: Research article

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  9. Obesity is a well-established risk factor for atherosclerosis. However, it is unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We a...

    Authors: Chaomin Zhou, Hongying Peng, Jing Yuan, Xin Lin, Yan Zha and Hui Chen

    Citation: BMC Nephrology 2018 19:206

    Content type: Research article

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  10. Conservative care is argued to be a reasonable treatment alternative for dialysis in older patients with advanced chronic kidney disease (CKD). However, comparisons are scarce and generally focus on survival o...

    Authors: Wouter R. Verberne, Janneke Dijkers, Johannes C. Kelder, Anthonius B. M. Geers, Wilbert T. Jellema, Hieronymus H. Vincent, Johannes J. M. van Delden and Willem Jan W. Bos

    Citation: BMC Nephrology 2018 19:205

    Content type: Research article

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    The Research note to this article has been published in BMC Research Notes 2019 12:722

  11. Exercise improves functional outcomes and quality of life of older patients with end-stage renal disease undergoing hemodialysis. Yet exercise is not promoted as part of routine care. Health care providers and...

    Authors: Pia Kontos, Alisa Grigorovich, Romeo Colobong, Karen-Lee Miller, Gihad E. Nesrallah, Malcolm A. Binns, Shabbir M. H. Alibhai, Trisha Parsons, Sarbjit Vanita Jassal, Alison Thomas and Gary Naglie

    Citation: BMC Nephrology 2018 19:195

    Content type: Research article

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  12. Choice of dialysis is context sensitive, explored for PD and extracorporeal dialysis, but less studied for haemodialysis (HD) and hemodiafiltration (HDF), both widely employed in Italy and France; reasons of c...

    Authors: Giorgina Barbara Piccoli, Gianfranca Cabiddu, Maria Rita Moio, Antioco Fois, Riccardo Cao, Ida Molfino, Ana Kaniassi, Francoise Lippi, Ludivine Froger, Antonello Pani and Marilisa Biolcati

    Citation: BMC Nephrology 2018 19:171

    Content type: Research article

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  13. Although fatigue is common in dialysis patients, polypharmacy is seldom listed among its causes. In this report, we describe a dialysis patient who developed severe fatigue due to pharmacological interaction b...

    Authors: Emanuela Cataldo, Valeria Columbano, Louise Nielsen, Lurlynis Gendrot, Bianca Covella and Giorgina Barbara Piccoli

    Citation: BMC Nephrology 2018 19:155

    Content type: Case report

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  14. For patients with end-stage renal failure (ESFR), thrice-weekly hemodialysis is a standard care. Once-weekly hemodialysis combined with low-protein and low-salt dietary treatment (OWHD-DT) have been rarely stu...

    Authors: Toshiyuki Nakao, Yoshie Kanazawa and Toshimasa Takahashi

    Citation: BMC Nephrology 2018 19:151

    Content type: Research article

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  15. Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that meas...

    Authors: Meaghan Lunney, Bronwyn Tonelli, Rachel Lewis, Natasha Wiebe, Chandra Thomas, Jennifer MacRae and Marcello Tonelli

    Citation: BMC Nephrology 2018 19:137

    Content type: Research article

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  16. Patient activation is associated with better outcomes and lower costs. Although the concept is widely investigated, little attention was given to patient activation and its predictors in patients undergoing he...

    Authors: Liesbet Van Bulck, Kathleen Claes, Katrien Dierickx, Annelies Hellemans, Sofie Jamar, Sven Smets and Gijs Van Pottelbergh

    Citation: BMC Nephrology 2018 19:126

    Content type: Research article

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  17. Inadequate volume control may be a main contributor to poor survival and high mortality in hemodialysis patients. Bioimpedance measurement has the potential to improve fluid management, but several dialysis ce...

    Authors: Jenny Stenberg, Catrin Henriksson, Magnus Lindberg and Hans Furuland

    Citation: BMC Nephrology 2018 19:121

    Content type: Research article

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  18. The impact of the low-protein diet on nutrition in CKD diabetics is uncertain.

    Authors: Vincenzo Bellizzi, Patrizia Calella, Julia Nava Hernández, Verónica Figueroa González, Silvia Moran Lira, Serena Torraca, Rocio Urbina Arronte, Pietro Cirillo, Roberto Minutolo and Rafael A. Montúfar Cárdenas

    Citation: BMC Nephrology 2018 19:110

    Content type: Research article

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  19. Research on factors associated with dialysis withdrawal is scarce. This study examined the predictors that might influence rate of dialysis withdrawal. Existing literature is summarized, analyzed and synthesiz...

    Authors: Hammad Ali Qazi, Helen Chen and Meng Zhu

    Citation: BMC Nephrology 2018 19:96

    Content type: Research article

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  20. Removal of uraemic toxins is inadequate using current dialysis strategies. A new class of dialysis membranes have been developed that allow clearance of larger middle molecules. The REMOVAL-HD study (a tRial E...

    Authors: R. Krishnasamy, C. M. Hawley, M. J. Jardine, M. A. Roberts, Y. J. Cho, M. G. Wong, A. Heath, C. L. Nelson, S. Sen, P. F. Mount, E. M. Pascoe, D. Darssan, L. A. Vergara, P. A. Paul-Brent, N. D. Toussaint, D. W. Johnson…

    Citation: BMC Nephrology 2018 19:89

    Content type: Study protocol

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  21. Metformin associated lactic acidosis (MALA) is a well-known serious side effect of biguanides. However, the best treatment strategy remains a matter of debate. In the last 14 years, we observed a significant i...

    Authors: Andrea Angioi, Gianfranca Cabiddu, Maura Conti, Gianfranco Pili, Alice Atzeni, Valeria Matta, Riccardo Cao, Matteo Floris, Marco Songini, Maria Franca Mulas, Mitchell Rosner and Antonello Pani

    Citation: BMC Nephrology 2018 19:77

    Content type: Research article

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  22. Insufficient vigilance for renal insufficiency is associated with late referral, increased morbidity and mortality. The present study examines whether increased vigilance for chronic kidney disease (CKD) leads...

    Authors: M. De Wilde, M. Speeckaert and W. Van Biesen

    Citation: BMC Nephrology 2018 19:74

    Content type: Research article

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  23. Although aortic calcification has a significant negative impact on prognosis in patients on hemodialysis (HD), risk factors for aortic calcification progression remain unclear. The aim of this study was to inv...

    Authors: Teppei Okamoto, Shingo Hatakeyama, Hirotake Kodama, Hirotaka Horiguchi, Yuka Kubota, Koichi Kido, Masaki Momota, Shogo Hosogoe, Yoshimi Tanaka, Tooru Takashima, Fumitada Saitoh, Tadashi Suzuki and Chikara Ohyama

    Citation: BMC Nephrology 2018 19:71

    Content type: Research article

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  24. Decreased residual urine volume (RUV) is associated with higher mortality in hemodialysis (HD). However, few studies have examined RUV in patients on HD in Sub-Saharan Africa. The aim of this study was to iden...

    Authors: Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, François Bompeka Lepira, Fiston Ikwa Ndol Mbutiwi, Jean Robert Rissassy Makulo, Justine Busanga Bukabau, Patrick Parmba Izeidi, Jeannine Losa Luse, Stéphane Kalambay Mukendi, Désiré Kulimba Mashinda and Nazaire Mangani Nseka

    Citation: BMC Nephrology 2018 19:68

    Content type: Research article

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  25. Patients with late referral and positive history of volume overload may have a poor prognosis after initiating dialysis due to insufficient and/or inadequate management of complications of renal failure and th...

    Authors: Masaki Okazaki, Daijo Inaguma, Takahiro Imaizumi, Akiko Kada, Takaaki Yaomura, Naotake Tsuboi and Shoichi Maruyama

    Citation: BMC Nephrology 2018 19:65

    Content type: Research article

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  26. Accelerated muscle atrophy is associated with a three-fold increase in mortality in chronic kidney disease (CKD) patients. It is suggested that hyperphosphatemia might contribute to muscle wasting, but the und...

    Authors: Yue-yue Zhang, Man Yang, Jin-fang Bao, Li-jie Gu, Hong-lei Yu and Wei-jie Yuan

    Citation: BMC Nephrology 2018 19:45

    Content type: Research article

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  27. Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those...

    Authors: Hyoungnae Kim, Hyunwook Kim, Misol Lee, Min-Uk Cha, Ki Heon Nam, Seong Yeong An, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang…

    Citation: BMC Nephrology 2018 19:32

    Content type: Research article

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  28. Chronic kidney disease (CKD) is increasing worldwide and early education to improve adherence to self-management is a key strategy to slow CKD progression. The use of the internet and mobile phone technologies...

    Authors: Ann Bonner, Kerri Gillespie, Katrina L. Campbell, Katina Corones-Watkins, Bronwyn Hayes, Barbara Harvie, Jaimon T. Kelly and Kathryn Havas

    Citation: BMC Nephrology 2018 19:28

    Content type: Research article

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  29. There is conflicting evidence of benefit versus harm for warfarin anticoagulation in hemodialysis patients with atrial fibrillation. This equipoise may be explained by suboptimal Time in Therapeutic Range (TTR...

    Authors: Hamad Bahbahani, Ahmed AlTurki, Ahmed Dawas and Mark L. Lipman

    Citation: BMC Nephrology 2018 19:4

    Content type: Research article

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  30. Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of isc...

    Authors: Claire Delsuc, Alexandre Faure, Julien Berthiller, Didier Dorez, Xavier Matillon, Vannary Meas-Yedid, Bernard Floccard, Guillaume Marcotte, Vanessa Labeye, Maud Rabeyrin, Ricardo Codas, Cécile Chauvet, Philip Robinson, Emmanuel Morelon, Lionel Badet, William Hanf…

    Citation: BMC Nephrology 2018 19:3

    Content type: Research article

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  31. Despite pre-kidney-transplant cardiovascular (CV) assessment being routine care to minimise perioperative risk, the utility of such assessment is not well established. The study reviewed the evaluation and out...

    Authors: Robin Ramphul, Maria Fernandez, Sam Firoozi, Juan C. Kaski, Rajan Sharma and Debasish Banerjee

    Citation: BMC Nephrology 2018 19:2

    Content type: Research article

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  32. Membranes with increasing pore size are introduced to enhance removal of large uremic toxins with regular hemodialysis. These membranes might theoretically have higher permeability for bacterial degradation pr...

    Authors: Eva Schepers, Griet Glorieux, Sunny Eloot, Michael Hulko, Adriana Boschetti-de-Fierro, Werner Beck, Bernd Krause and Wim Van Biesen

    Citation: BMC Nephrology 2018 19:1

    Content type: Research article

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  33. Chronic kidney disease patients have an increased prevalence of subclinical cerebrovascular diseases. Dialysis patients have severe vascular diseases burden. The cerebral small vessel diseases (CSVD) are diffi...

    Authors: Ke Zheng, Haiyun Wang, Bo Hou, Hui You, Jing Yuan, Kai Luo, Limeng Chen, Mingxi Li, Qun Xu, Yicheng Zhu, Liying Cui, Sagar Uday Nigwekar, Feng Feng and Xuemei Li

    Citation: BMC Nephrology 2017 18:366

    Content type: Research article

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  34. Increasing numbers of elderly patients are undergoing long-term dialysis. However, the role of dialysis in survival and quality of life is unclear, and poor outcomes may be associated with comorbidities rather...

    Authors: Debajyoti Roy, Anupama Roy Chowdhury, Shrikant Pande and Jia Wen Kam

    Citation: BMC Nephrology 2017 18:364

    Content type: Research article

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  35. The clinical consequences of starting chronic peritoneal dialysis (PD) after emergent dialysis via a temporary hemodialysis (HD) catheter has rarely been evaluated within a full spectrum of treated end-stage r...

    Authors: Wen-Yi Li, Yi-Cheng Wang, Shang-Jyh Hwang, Shih-Hua Lin, Kwan-Dun Wu and Yung-Ming Chen

    Citation: BMC Nephrology 2017 18:359

    Content type: Research article

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  36. End stage renal disease (ESRD) patients on maintenance hemodialysis, are high utilizers of inpatient services. Because of data showing improved outcomes in medical patients admitted to hospitalist-run, non-tea...

    Authors: Ladan Golestaneh, Eran Bellin, William Southern and Michal L. Melamed

    Citation: BMC Nephrology 2017 18:352

    Content type: Research article

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  37. Anaemia is a very common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment. Residual renal function (RRF) is assoc...

    Authors: Elizabeth Helene Louw and Mogamat-Yazied Chothia

    Citation: BMC Nephrology 2017 18:336

    Content type: Research article

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  38. The study objective is to assess the effectiveness and economic impact of a structured programme to support patient involvement in centre-based haemodialysis and to understand what works for whom in what circu...

    Authors: James Fotheringham, Tania Barnes, Louese Dunn, Sonia Lee, Steven Ariss, Tracey Young, Stephen J. Walters, Paul Laboi, Andy Henwood, Rachel Gair and Martin Wilkie

    Citation: BMC Nephrology 2017 18:335

    Content type: Study protocol

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  39. Anemia management protocols in hemodialysis (HD) units differ conspicuously regarding optimal intravenous (IV) iron dosing; consequently, patients receive markedly different cumulative exposures to IV iron and...

    Authors: Bruce M. Robinson, Maria Larkina, Brian Bieber, Werner Kleophas, Yun Li, Francesco Locatelli, Keith P. McCullough, Jackie G. Nolen, Friedrich K. Port and Ronald L. Pisoni

    Citation: BMC Nephrology 2017 18:330

    Content type: Research article

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  40. Peritoneal dialysis (PD) is used as renal replacement therapy in patients with end-stage kidney disease. However, peritoneal membrane failure remains problematic and constitutes a critical cause of PD disconti...

    Authors: Masaaki Nakayama, Wan-Jun Zhu, Kimio Watanabe, Ayano Gibo, Ali M. Sherif, Shigeru Kabayama and Sadayoshi Ito

    Citation: BMC Nephrology 2017 18:327

    Content type: Research article

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  41. Latinos in the U.S. are almost twice as likely to progress to End Stage Renal disease (ESRD) compared to non-Latino whites. Patients with ESRD on dialysis experience high morbidity, pre-mature mortality and re...

    Authors: Karla Gonzalez, Jesus G. Ulloa, Gerardo Moreno, Oscar Echeverría, Keith Norris and Efrain Talamantes

    Citation: BMC Nephrology 2017 18:319

    Content type: Research article

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  42. Dietary modification is an important component of the management of end stage kidney disease (ESKD). The diet for ESKD involves modifying energy and protein intake, and altering sodium, phosphate, potassium an...

    Authors: Kelly Lambert, Judy Mullan and Kylie Mansfield

    Citation: BMC Nephrology 2017 18:318

    Content type: Research article

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  43. Regional anticoagulation with citrate is the recommended first line treatment for patients receiving continuous renal replacement therapy (CRRT). There is wide variability in filter patency which may be due to...

    Authors: Richard Fisher, Katie Lei, Mike J. Mitchell, Gary W. Moore, Helen Dickie, Linda Tovey, Siobhan Crichton and Marlies Ostermann

    Citation: BMC Nephrology 2017 18:304

    Content type: Study protocol

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  44. Exercise during haemodialysis improves strength and physical function. However, both patients and clinicians are time poor, and current exercise recommendations add an excessive time burden making exercise a r...

    Authors: Matthew J. Clarkson, Steve F. Fraser, Paul N. Bennett, Lawrence P. McMahon, Catherine Brumby and Stuart A. Warmington

    Citation: BMC Nephrology 2017 18:294

    Content type: Study protocol

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  45. Adults on dialysis are at increased risk of foot ulceration, which commonly precedes more serious lower limb complications, including amputation. Limited data exist regarding the prevalence and factors associa...

    Authors: Michelle R. Kaminski, Anita Raspovic, Lawrence P. McMahon, Katrina A. Lambert, Bircan Erbas, Peter F. Mount, Peter G. Kerr and Karl B. Landorf

    Citation: BMC Nephrology 2017 18:293

    Content type: Research article

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  46. Despite improved health outcomes associated with arteriovenous fistulas, 80% of Americans initiate hemodialysis using a catheter, influenced by low socioeconomic status among other factors. Risk factors for in...

    Authors: Nicole C. Rich, Shant M. Vartanian, Shimi Sharief, Daniel J. Freitas and Delphine S. Tuot

    Citation: BMC Nephrology 2017 18:279

    Content type: Research article

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  47. Glucose is widely used as an osmotic agent in peritoneal dialysis (PD), but exerts untoward effects on the peritoneum. The potential protective effect of a reduced exposure to hypertonic glucose has never been...

    Authors: Dominique Pagniez, Alain Duhamel, Eric Boulanger, Celia Lessore de Sainte Foy and Jean-Baptiste Beuscart

    Citation: BMC Nephrology 2017 18:278

    Content type: Research article

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  48. Stroke is the third leading cause of cardiovascular mortality in dialysis patients. The objective of this study was to assess the extent of stroke in chronic hemodialysis patients.

    Authors: Yannick Nlandu, François Lepira, Jean-Robert Makulo, Yannick Engole, Ernest Sumaili, Marie-Noelle Wameso, Vieux Mokoli, Jeannine Luse, Augustin Longo, Chantal Zinga, Pierre Akilimali, Aliocha Nkodila, Mélanie Bavassa, François Kajingulu, Justine Bukabau and Nazaire Nseka

    Citation: BMC Nephrology 2017 18:277

    Content type: Research article

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  49. Secondary hyperparathyroidism (SHPT) is a severe complication for dialysis patients. Vitamin D receptor activators (VDRAs) are used to treat SHPT, but the comparative efficacy and safety between paricalcitol a...

    Authors: Yifeng Xie, Peiling Su, Yifan Sun, Hongsheng Zhang, Rong Zhao, Liang Li and Lanfen Meng

    Citation: BMC Nephrology 2017 18:272

    Content type: Research article

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  50. Endophthalmitis is a severe eye infection leading to disabling outcome. Because there were only a few case report illustrating endophthalmitis in chronic dialysis patient, we would like to investigate the epid...

    Authors: George Kuo, Yueh-An Lu, Wei-Chiao Sun, Chao-Yu Chen, Huang-Kai Kao, YuJr Lin, Chia-Hui Lee, Cheng-Chieh Hung, Ya-Chung Tian and Hsiang-Hao Hsu

    Citation: BMC Nephrology 2017 18:270

    Content type: Research article

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