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Renal transplantation

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  1. Content type: Research article

    Cilastatin (CL) is an inhibitor of dehydropeptidase-I, which is safely used in clinical practice to prevent nephrotoxicity of antibiotics. Tacrolimus (TAC) is the most important immunosuppressant in renal tran...

    Authors: Kang Luo, Sun Woo Lim, Jian Jin, Long Jin, Hyo Wook Gil, Dai Sig Im, Hyeon Seok Hwang and Chul Woo Yang

    Citation: BMC Nephrology 2019 20:221

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  2. Content type: Research article

    Chronic-active antibody mediated rejection (c-aABMR) is a major contributor to long-term kidney allograft loss. We conducted a retrospective analysis to establish the efficacy of treatment with intravenous imm...

    Authors: Kasia A. Sablik, Marian C. Clahsen-van Groningen, Caspar W. N. Looman, Jeffrey Damman, Madelon van Agteren and Michiel G. H. Betjes

    Citation: BMC Nephrology 2019 20:218

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  3. Content type: Research article

    Pneumocystis jirovecii pneumonia (PCP) remains an important cause of morbidity and mortality in kidney transplant recipients. While the acute phase toxicity in patients with PCP is well-characterized, there is a ...

    Authors: Ji Eun Kim, Ahram Han, Hajeong Lee, Jongwon Ha, Yon Su Kim and Seung Seok Han

    Citation: BMC Nephrology 2019 20:212

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  4. Content type: Research article

    Kidney transplant (KT) patients presenting with cardiovascular (CVD) events are being managed increasingly in non-transplant facilities. We aimed to identify drivers of mortality and costs, including transplan...

    Authors: Amit K. Mathur, Yu-Hui Chang, D. Eric Steidley, Raymond L. Heilman, Nabil Wasif, David Etzioni, Kunam S. Reddy and Adyr A. Moss

    Citation: BMC Nephrology 2019 20:190

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  5. Content type: Research article

    Inflammation is more common among African Americans (AAs), and it is associated with frailty, poor physical performance, and mortality in community-dwelling older adults. Given the elevated inflammation levels...

    Authors: Prakriti Shrestha, Christine E. Haugen, Nadia M. Chu, Ashton Shaffer, Jacqueline Garonzik-Wang, Silas P. Norman, Jeremy D. Walston, Dorry L. Segev and Mara A. McAdams-DeMarco

    Citation: BMC Nephrology 2019 20:176

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  6. Content type: Research article

    The effect of a kidney transplant on a recipient extends beyond the restoration of kidney function. However, there is limited qualitative analysis of recipient perspectives on life following transplantation, p...

    Authors: Emily L. Tucker, Abigail R. Smith, Mark S. Daskin, Hannah Schapiro, Sabrina M. Cottrell, Evelyn S. Gendron, Peg Hill-Callahan, Alan B. Leichtman, Robert M. Merion, Stephen J. Gill and Kayse Lee Maass

    Citation: BMC Nephrology 2019 20:175

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  7. Content type: Technical advance

    Increased morbidity and mortality are well documented in Status 7(inactive list) patients. Delays in transplantation secondary to prolonged periods on inactive status also negatively impacts transplant outcome...

    Authors: Ashish Kataria, Madan Gowda, Brian Paul Lamphron, Kabir Jalal, Rocco C. Venuto and Aijaz A. Gundroo

    Citation: BMC Nephrology 2019 20:174

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  8. Content type: Research article

    Physicians are faced with a growing number of patients after renal transplantation undergoing graft-unrelated surgery. So far, little is known about the postoperative restitution of graft function and the risk...

    Authors: Ann-Kathrin Lederer, Dominic Haffa, Philipp Felgendreff, Frank Makowiec, Stefan Fichtner-Feigl, Roman Huber and Lampros Kousoulas

    Citation: BMC Nephrology 2019 20:170

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  9. Content type: Research article

    Despite the good prognosis in patients with transplant organs, limited evidence is available on how immunosuppressants affect pregnancy. The aim of this study was to determine whether immunosuppressant use aff...

    Authors: Bo Hyon Yun, Dong Jin Joo, Seok Kyo Seo, Si Hyun Cho, Young Sik Choi and Byung Seok Lee

    Citation: BMC Nephrology 2019 20:161

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  10. Content type: Research article

    Post transplantation diabetes mellitus (PTDM) is a common and serious complication after renal transplantation with significant morbidity and mortality. Metformin has proven benefits in the general population ...

    Authors: Basil Alnasrallah, Tze Liang Goh, Lai Wan Chan, Paul Manley and Helen Pilmore

    Citation: BMC Nephrology 2019 20:147

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  11. Content type: Research article

    The invention of an effective kidney preservation solution capable of prolonging harvested kidney viability is the core of kidney transplantation procedure. Researchers have been working on upgrading the prese...

    Authors: Sherif Khedr, Oleg Palygin, Tengis S. Pavlov, Gregory Blass, Vladislav Levchenko, Ammar Alsheikh, Michael W. Brands, Ashraf El-Meanawy and Alexander Staruschenko

    Citation: BMC Nephrology 2019 20:145

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  12. Content type: Research article

    To support effective self-management after kidney transplantation, a holistic nurse-led self-management support intervention was developed using the Intervention Mapping approach. The primary aim was to evalua...

    Authors: Janet M. J. Been-Dahmen, Denise K. Beck, Mariëlle A. C. Peeters, Heleen van der Stege, Mirjam Tielen, Marleen C. van Buren, Erwin Ista, AnneLoes van Staa and Emma K. Massey

    Citation: BMC Nephrology 2019 20:143

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  13. Content type: Research article

    Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these paramet...

    Authors: Natascha J. H. Broers, Tsz Yeung Fung, Jeroen P. Kooman and Maarten H. L. Christiaans

    Citation: BMC Nephrology 2019 20:109

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  14. Content type: Research article

    Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed to compare the therapeutic efficacy and safety between ra...

    Authors: Jiang Qiu, Jun Li, Guodong Chen, Gang Huang, Qian Fu, Changxi Wang and Lizhong Chen

    Citation: BMC Nephrology 2019 20:101

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  15. Content type: Study protocol

    Five-year survival on dialysis is only 40%, compared to 74% with a deceased donor kidney transplant (DDKT) and 87% with a living donor kidney transplant (LDKT). An American Society of Transplantation (AST) Con...

    Authors: Amy D. Waterman, Crystal Anderson, Angelika Alem, John D. Peipert, Jennifer L. Beaumont, Shayna L. Henry, Bhanuja Dub, Lizeth Ambriz, Neha Bijjala, Amanda Faye Lipsey and Brian Mittman

    Citation: BMC Nephrology 2019 20:78

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  16. Content type: Research article

    Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of an...

    Authors: Amir Schechter, Anat Gafter-Gvili, Daniel Shepshelovich, Ruth Rahamimov, Uzi Gafter, Eytan Mor, Avry Chagnac and Benaya Rozen-Zvi

    Citation: BMC Nephrology 2019 20:51

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  17. Content type: Research article

    The magnitude of renal function recovery after kidney donation differs in donors with a heterogeneous background. Preoperative assessment of candidates with potentially unfavorable renal functional compensatio...

    Authors: Kazunobu Shinoda, Shinya Morita, Hirotaka Akita, Satoshi Tamaki, Ryohei Takahashi, Hidaka Kono, Hiroshi Asanuma, Eiji Kikuchi, Masahiro Jinzaki, Ken Nakagawa and Mototsugu Oya

    Citation: BMC Nephrology 2019 20:46

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  18. Content type: Research article

    The problem of organ shortage is an important issue in kidney transplantation, but the effect of kidney donation on AKI is unclear. The aim of this study was to investigate the impact of acute kidney injury (A...

    Authors: Woo Yeong Park, Min-Seok Choi, Young Soo Kim, Bum Soon Choi, Cheol Whee Park, Chul Woo Yang, Yong-Soo Kim, Kyubok Jin, Seungyeup Han and Byung Ha Chung

    Citation: BMC Nephrology 2019 20:39

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  19. Content type: Research article

    Only a few prospective trials exist regarding the use of novel direct-acting antiviral agents (DAAs) in kidney transplant recipients (KTR) with chronic hepatitis C virus (HCV) infection.

    Authors: Michael Duerr, Eva V. Schrezenmeier, Lukas J. Lehner, Léon Bergfeld, Petra Glander, Stephan R. Marticorena Garcia, Christian E. Althoff, Ingolf Sack, Susanne Brakemeier, Kai-Uwe Eckardt, Klemens Budde and Fabian Halleck

    Citation: BMC Nephrology 2019 20:36

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  20. Content type: Research article

    Only few studies of living kidney donors have included controls that were similarly healthy, including excellent kidney function.

    Authors: Ayelet Grupper, Yoel Angel, Aharon Baruch, Idit F. Schwartz, Doron Schwartz, Richard Nakache, Yaacov Goykhman, Paulina Katz, Ido Nachmany, Nir Lubezky, Talia Weinstein, Moshe Shashar, Orit Kliuk Ben-Bassat, Shlomo Berliner, Ori Rogowski, David Zeltser…

    Citation: BMC Nephrology 2019 20:30

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  21. Content type: Research article

    Reproductive function in women with end stage renal disease generally improves after kidney transplant. However, pregnancy remains challenging due to the risk of adverse clinical outcomes.

    Authors: Silvi Shah, Renganathan Lalgudi Venkatesan, Ayank Gupta, Maitrik K. Sanghavi, Jeffrey Welge, Richard Johansen, Emily B. Kean, Taranpreet Kaur, Anu Gupta, Tiffany J. Grant and Prasoon Verma

    Citation: BMC Nephrology 2019 20:24

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  22. Content type: Research article

    The use of HbA1c ≥6.5% for diagnosis of diabetes has been challenged for post-transplantation diabetes mellitus (PTDM) also known as new onset diabetes after transplantation (NODAT) due to a low sensitivity ea...

    Authors: Amin M. Ussif, Anders Åsberg, Thea Anine Strøm Halden, Espen Nordheim, Anders Hartmann and Trond Jenssen

    Citation: BMC Nephrology 2019 20:12

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  23. Content type: Research article

    The clinical outcome and health-related quality of life (HRQoL) of living kidney donors is mostly not detrimental, but some donors experience impairment after donation. Gender-specific effects of living kidney...

    Authors: Claudia Sommerer, Sarah Estelmann, Nicole G. Metzendorf, Maren Leuschner and Martin Zeier

    Citation: BMC Nephrology 2018 19:377

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  24. Content type: Research article

    Therapeutic plasma exchange (TPE) is an important therapy for recurrent focal segmental glomerulosclerosis (rFSGS) post kidney transplant. suPAR has been causally implicated in rFSGS, and shown to be a unique ...

    Authors: Nada Alachkar, Jing Li, Dany Matar, Vikas Vujjini, Sami Alasfar, Melissa Tracy, Jochen Reiser and Changli Wei

    Citation: BMC Nephrology 2018 19:361

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  26. Content type: Research article

    There is a need for a large, contemporary, multi-centre series of measured glomerular filtration rates (mGFR) from healthy individuals to determine age- and gender-specific reference ranges for GFR. We aimed t...

    Authors: Anthony Fenton, Emma Montgomery, Peter Nightingale, A. Michael Peters, Neil Sheerin, A. Caroline Wroe and Graham W. Lipkin

    Citation: BMC Nephrology 2018 19:336

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  27. Content type: Research article

    The goal of this study was to identify predictors for development of Pneumocystis jirovecii pneumonia (PJP) in kidney and simultaneous kidney and pancreas transplant recipients in the present era of universal pri...

    Authors: Neetika Garg, Margaret Jorgenson, Jillian Descourouez, Christopher M. Saddler, Sandesh Parajuli, Brad C. Astor, Arjang Djamali and Didier Mandelbrot

    Citation: BMC Nephrology 2018 19:332

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  29. Content type: Research article

    Vitamin D, apart from being an important part of the “calcium-vitamin D-parathyroid hormone” endocrine axis, has diverse range of “non-calcemic” biological actions. A high prevalence of vitamin D deficiency has b...

    Authors: Santosh Timalsina, Mahesh Raj Sigdel, Santosh Baniya and Shantos Subedee

    Citation: BMC Nephrology 2018 19:290

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  30. Content type: Research article

    Chronic active antibody-mediated rejection (c-aABMR) is an important cause of allograft failure and graft loss in long-term kidney transplants.

    Authors: Gastón J Piñeiro, Erika De Sousa-Amorim, Manel Solé, José Ríos, Miguel Lozano, Frederic Cofán, Pedro Ventura-Aguiar, David Cucchiari, Ignacio Revuelta, Joan Cid, Eduard Palou, Josep M Campistol, Federico Oppenheimer, Jordi Rovira and Fritz Diekmann

    Citation: BMC Nephrology 2018 19:261

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  31. Content type: Case report

    ABO-incompatible living related kidney transplantation (ABO-iLKT) has increased the possibilities for kidney transplantation in patients with end stage renal disease. Due to advancements in immunosuppressive a...

    Authors: Hiroaki Nishimura, Yasutoshi Yamada, Satoshi Hisano, Akihiko Mitsuke, Syuichi Tatarano, Takenari Gotanda, Hiroshi Hayami, Masayuki Nakagawa and Hideki Enokida

    Citation: BMC Nephrology 2018 19:254

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  32. Content type: Research article

    Anaemia after kidney transplantation may reduce quality of life, graft or patient survival. We aimed to determine the prevalence and risk factors for anaemia in the initial 12 months after transplantation.

    Authors: Andy K.H. Lim, Arushi Kansal and John Kanellis

    Citation: BMC Nephrology 2018 19:252

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  33. Content type: Research article

    Patients with Alport syndrome (AS) develop progressive kidney dysfunction due to a hereditary type IV collagen deficiency. Survival of the kidney allograft in patients with AS is reportedly excellent because A...

    Authors: Ai Katsuma, Yasuyuki Nakada, Izumi Yamamoto, Shigeru Horita, Miyuki Furusawa, Kohei Unagami, Haruki Katsumata, Masayoshi Okumi, Hideki Ishida, Takashi Yokoo and Kazunari Tanabe

    Citation: BMC Nephrology 2018 19:249

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  34. Content type: Research article

    Conversion from calcineurin inhibitor (CNI) therapy to a mammalian target of rapamycin (mTOR) inhibitor following kidney transplantation may help to preserve graft function. Data are sparse, however, concernin...

    Authors: Claudia Sommerer, Oliver Witzke, Frank Lehner, Wolfgang Arns, Petra Reinke, Ute Eisenberger, Bruno Vogt, Katharina Heller, Johannes Jacobi, Markus Guba, Rolf Stahl, Ingeborg A. Hauser, Volker Kliem, Rudolf P. Wüthrich, Anja Mühlfeld, Barbara Suwelack…

    Citation: BMC Nephrology 2018 19:237

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  35. Content type: Research article

    The effect of pretransplant peritoneal dialysis (PD) or hemodialysis (HD) modality on outcomes of kidney transplantation (KT) for end-stage renal disease (ESRD) is debatable. We evaluated the outcomes these mo...

    Authors: Xiajing Che, Xiaoqian Yang, Jiayi Yan, Yanhong Yuan, Qing Ma, Liang Ying, Minfang Zhang, Qin Wang, Ming Zhang, Zhaohui Ni and Shan Mou

    Citation: BMC Nephrology 2018 19:235

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  36. Content type: Research article

    In low-immunological risk kidney transplant recipients (KTRs), reduced exposure to calcineurin inhibitor (CNI) appears particularly attractive for avoiding adverse events, but may increase the risk of developi...

    Authors: S. Girerd, J. Schikowski, N. Girerd, K. Duarte, H. Busby, N. Gambier, M. Ladrière, M. Kessler, L. Frimat and A. Aarnink

    Citation: BMC Nephrology 2018 19:232

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  37. Content type: Study protocol

    Patients on dialysis are physically inactive, with most reporting activity levels below the fifth percentile of healthy age-matched groups. Several small studies have reported efficacy of diverse exercise inte...

    Authors: Ram Jagannathan, Susan Lynn Ziolkowski, Mary Beth Weber, Jason Cobb, Nhat Pham, Jin Long, Shuchi Anand and Felipe Lobelo

    Citation: BMC Nephrology 2018 19:230

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  38. Content type: Study protocol

    Long-term outcomes in kidney transplantation (KT) have not significantly improved during the past twenty years. Despite being a leading cause of graft failure, glomerular disease (GD) recurrence remains poorly...

    Authors: Audrey Uffing, Maria José Pérez-Sáez, Gaetano La Manna, Giorgia Comai, Clara Fischman, Samira Farouk, Roberto Ceratti Manfro, Andrea Carla Bauer, Bruno Lichtenfels, Juliana B. Mansur, Hélio Tedesco-Silva, Gianna M. Kirsztajn, Anna Manonelles, Oriol Bestard, Miguel Carlos Riella, Silvia Regina Hokazono…

    Citation: BMC Nephrology 2018 19:229

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  39. Content type: Technical advance

    Transcriptome analysis is emerging as emerging as a promising tool to enhance precision of diagnosis and monitoring in solid organ transplantation. Clinical progress has however been hampered by the current re...

    Authors: Øystein Eikrem, Tedd C. Walther, Arnar Flatberg, Vidar Beisvag, Philipp Strauss, Magnus Farstad, Christian Beisland, Even Koch, Thomas F. Mueller and Hans-Peter Marti

    Citation: BMC Nephrology 2018 19:221

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  40. Content type: Research article

    Previous studies have reported a wide range of prevalence of post-donation anxiety, depression, and regret in living kidney donors (LKDs). It is also unclear what risk factors are associated with these outcomes.

    Authors: Courtenay M. Holscher, Joseph Leanza, Alvin G. Thomas, Madeleine M. Waldram, Christine E. Haugen, Kyle R. Jackson, Sunjae Bae, Allan B. Massie and Dorry L. Segev

    Citation: BMC Nephrology 2018 19:218

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  41. Content type: Research article

    Cardiovascular complications are common in kidney transplant patients and calcification propensity of blood, measured as T50, is associated with cardiovascular outcomes. Paricalcitol supplementation affects calci...

    Authors: Amin Ussif, Hege Pihlstrøm, Andreas Pasch, Hallvard Holdaas, Anders Hartmann, Knut Smerud and Anders Åsberg

    Citation: BMC Nephrology 2018 19:212

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  42. Content type: Research article

    Few post-marketing surveillance studies have examined the safety and efficacy of Rapamune® (Sirolimus) in Asian countries. This study aimed to better understand safety and efficacy of Rapamune for kidney trans...

    Authors: Hee Jung Jeon, Hahn-Ey Lee and Jaeseok Yang

    Citation: BMC Nephrology 2018 19:201

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  43. Content type: Research article

    Kidney transplantation (KTx) is the best therapeutic approach for chronic kidney diseases leading to irreversible kidney failure. Considering the origin of the graft, several studies have reported differences ...

    Authors: S. Inés Lozano-Ramos, Ioana Bancu, Laura Carreras-Planella, Marta Monguió-Tortajada, Laura Cañas, Javier Juega, Josep Bonet, M. Pilar Armengol, Ricardo Lauzurica and Francesc E. Borràs

    Citation: BMC Nephrology 2018 19:189

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  44. Content type: Study protocol

    Graft survival after kidney transplantation has significantly improved within the last decades but there is a substantial number of patients with declining transplant function and graft loss. Over the past yea...

    Authors: Anna Wiegand, Alexander Ritter, Nicole Graf, Spyridon Arampatzis, Daniel Sidler, Karine Hadaya, Thomas F. Müller, Carsten A. Wagner, Rudolf P. Wüthrich and Nilufar Mohebbi

    Citation: BMC Nephrology 2018 19:177

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  45. Content type: Research article

    We present a case series of 5 patients with proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) of renal allografts to better define its natural history, presenting characteristics, patholog...

    Authors: Jiqiu Wen, Wei Wang, Feng Xu, Jinsong Chen, Mingchao Zhang, Dongrui Cheng, Xuefeng Ni, Xue Li and Zhihong Liu

    Citation: BMC Nephrology 2018 19:173

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  46. Content type: Research article

    Conversion from calcineurin inhibitor (CNI) therapy to everolimus within 6 months after kidney transplantation improves long-term graft function but can increase the risk of mild biopsy-proven acute cellular r...

    Authors: Ute Eisenberger, Klemens Budde, Frank Lehner, Claudia Sommerer, Petra Reinke, Oliver Witzke, Rudolf P. Wüthrich, Rolf Stahl, Katharina Heller, Barbara Suwelack, Anja Mühlfeld, Ingeborg A. Hauser, Silvio Nadalin, Martina Porstner and Wolfgang Arns

    Citation: BMC Nephrology 2018 19:154

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  47. Content type: Research article

    Efforts are underway to improve living kidney donor (LKD) education, but current LKD concerns and information-gathering preferences have not been ascertained to inform evidence-based resource development. As a...

    Authors: Jessica M. Ruck, Sarah E. Van Pilsum Rasmussen, Macey L. Henderson, Allan B. Massie and Dorry L. Segev

    Citation: BMC Nephrology 2018 19:130

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  48. Content type: Research article

    The 2014 Consensus Conference on Best Practices in Living Kidney Donations recognized live donor kidney transplantation as the best treatment for late-stage kidney disease, yielding superior graft and patient ...

    Authors: Walter G. Wasser, Geoffrey Boner, Meni Koslowsky and Adi Lazar

    Citation: BMC Nephrology 2018 19:128

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  49. Content type: Research article

    The magnitude effects of human leukocyte antigen (HLA) mismatching on post-transplant outcomes of kidney transplantation remain controversial. We aim to quantitatively assess the associations of HLA mismatchin...

    Authors: Xinmiao Shi, Jicheng Lv, Wenke Han, Xuhui Zhong, Xinfang Xie, Baige Su and Jie Ding

    Citation: BMC Nephrology 2018 19:116

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  50. Content type: Study protocol

    Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple o...

    Authors: Line Aas Mortensen, Helle C. Thiesson, Birgitte Tougaard, Martin Egfjord, Anne Sophie Lind Fischer and Claus Bistrup

    Citation: BMC Nephrology 2018 19:105

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