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Renal transplantation

The Renal Transplantation section considers manuscripts describing all aspects of renal transplantation, including pre-transplantation care and organization, and pre- and post-operative outcomes. Research describing large epidemiological studies should be directed to the dedicated Epidemiology and Health Outcomes section and case reports to the dedicated Case Reports section. 

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  1. Kidney allograft survival continuously improved with introduction of novel immunosuppressants. However, also immunologically challenging transplants (blood group incompatibility and sensitized recipients) incr...

    Authors: Miriam Good-Weber, Malgorzata Roos, Thomas F. Mueller, Barbara Rüsi and Thomas Fehr

    Citation: BMC Nephrology 2020 21:501

    Content type: Research article

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  2. Although young adulthood is associated with transplant loss, many studies do not examine eGFR decline. We aimed to establish clinical risk factors to identify where early intervention might prevent subsequent ...

    Authors: Alexander J. Hamilton, Lucy A. Plumb, Anna Casula and Manish D. Sinha

    Citation: BMC Nephrology 2020 21:492

    Content type: Research article

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  3. There is concern about the impact of immunosuppressive agents taken by male kidney transplant (KT) recipients on the risk of foetal malformations. The aim of our survey was to estimate the paternity rate and t...

    Authors: Annabel Boyer, Thierry Lobbedez, Mohamed Ouethrani, Angélique Thuillier Lecouf, Nicolas Bouvier, Valérie Châtelet and Bruno Hurault de Ligny

    Citation: BMC Nephrology 2020 21:483

    Content type: Research article

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  4. As organs infected with Hepatitis C virus (HCV) provide an opportunity to expand the donor pool, the primary aim of this study is to explore patient willingness to accept a kidney from HCV-infected donors comp...

    Authors: Gretchen C. Edwards, Maren E. Shipe, Lindsay Smith, Christianna Gamble, David Shaffer, Beatrice P. Concepcion and Rachel Forbes

    Citation: BMC Nephrology 2020 21:473

    Content type: Research article

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  5. Aging and mortality of patients on waiting lists for kidney transplantation have increased, as a result of the shortage of organs available all over the world. Living donor grafts represent a significant sourc...

    Authors: Rostand Emmanuel Nguefouet Momo, Paola Donato, Gabriele Ugolini, Francesco Nacchia, Luca Mezzetto, Gian Franco Veraldi, Stefano Marletta, Enrico Cavallo, Albino Eccher, Annamaria Giambanco, Daniela Cenzi and Luigino Boschiero

    Citation: BMC Nephrology 2020 21:451

    Content type: Case report

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  6. Early identification and treatment of kidney transplant rejection episodes is vital to limit loss of function and prolong the life of the transplanted kidney and recipient. Current practice depends on detectin...

    Authors: Amy Riddell, John Kirkwood, Miranda Smallwood, Paul Winyard, Beatrice Knight, Lidia Romanczuk, Angela Shore and Mark Gilchrist

    Citation: BMC Nephrology 2020 21:441

    Content type: Research article

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  7. New-onset diabetes after transplantation (NODAT) is associated with reduced patient and graft survival. This study examined the clinical and selected genetic factors associated with NODAT among renal-transplan...

    Authors: Rhanye Mac Guad, Andrew W. Taylor-Robinson, Yuan Seng Wu, Siew Hua Gan, Nur Lisa Zaharan, Roma Choudhury Basu, Constance Sat Lin Liew and Wan Ahmad Hafiz Wan Md Adnan

    Citation: BMC Nephrology 2020 21:388

    Content type: Research article

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  8. Despite its established association with chronic kidney disease (CKD) the role of myosin-9 (MYH9) gene variation on transplanted kidney function remains unknown. This study aimed at evaluating the effect of donor...

    Authors: Joanna Pazik, Monika Oldak, Dominika Oziębło, Dominika Dęborska Materkowska, Anna Sadowska, Jacek Malejczyk and Magdalena Durlik

    Citation: BMC Nephrology 2020 21:380

    Content type: Research article

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  9. After kidney transplantation non-adherence and inadequate self-management undermine clinical outcomes and quality of life. Both have been demonstrated to be substantial in all age groups. However, intervention...

    Authors: Denise Karin Beck, Mirjam Tielen, Marloes Rechards, Reinier Timman, Charlotte Boonstra, Josette Versteegh, Jacqueline van de Wetering, Robert Zietse, Teun van Gelder, Willem Weimar, Jan van Saase, Jan van Busschbach and Emma Kay Massey

    Citation: BMC Nephrology 2020 21:374

    Content type: Study protocol

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  10. Reliable estimates of the absolute and relative risks of postoperative complications in kidney transplant recipients undergoing elective surgery are needed to inform clinical practice. This systematic review a...

    Authors: Dharmenaan Palamuthusingam, Kuhan Kunarajah, Elaine M. Pascoe, David W. Johnson, Camel M. Hawley and Magid Fahim

    Citation: BMC Nephrology 2020 21:365

    Content type: Research article

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  11. Although recipients and donors in living kidney transplantation experience psychological distress—including depression and anxiety—during the pre-operative period, very few studies have evaluated the related p...

    Authors: Yujin Lee, Hyewon Park, Hee-Jung Jee, Heon-Jeong Lee, Jun Gyo Gwon, Hyeonjin Min, Cheol Woong Jung, Myung-Gyu Kim and Chul-Hyun Cho

    Citation: BMC Nephrology 2020 21:355

    Content type: Research article

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  12. In de novo kidney transplant recipients (KTR) treatment with belatacept has been established as a comparable option as maintenance immunosuppression, preferably as a strategy to convert from calcineurin inhibi...

    Authors: Mira Choi, Friederike Bachmann, Kaiyin Wu, Nils Lachmann, Danilo Schmidt, Susanne Brakemeier, Michael Duerr, Andreas Kahl, Kai-Uwe Eckardt, Klemens Budde and Peter Nickel

    Citation: BMC Nephrology 2020 21:354

    Content type: Research article

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  13. A potential pitfall of policies intended to promote referral for kidney transplant is that greater numbers of patients may be evaluated for transplant without experiencing the intended benefit of receiving a k...

    Authors: Catherine R. Butler, Janelle S. Taylor, Peter P. Reese and Ann M. O’Hare

    Citation: BMC Nephrology 2020 21:300

    Content type: Research article

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  14. Angiotensin II type 1 receptors (AT1Rs) are expressed on podocytes, endothelial and other cells, and play an essential role in the maintenance of podocyte function and vascular homeostasis. The presence of AT1...

    Authors: Mohammad Abuzeineh, Amtul Aala, Sami Alasfar and Nada Alachkar

    Citation: BMC Nephrology 2020 21:253

    Content type: Research article

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  15. Access to kidney transplantation by uremic children is very limited due to the lack of donors in many countries. We sought to explore small pediatric kidney donors as a strategy to provide transplant opportuni...

    Authors: Xiaojun Su, Wenjun Shang, Longshan Liu, Jun Li, Qian Fu, Yonghua Feng, Huanxi Zhang, Ronghai Deng, Chenglin Wu, Zhigang Wang, Xinlu Pang, Björn Nashan, Guiwen Feng and Changxi Wang

    Citation: BMC Nephrology 2020 21:250

    Content type: Research article

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  16. Currently very little is known about the perceptions and experiences of kidney transplant recipients from a qualitative perspective. As highlighted by the European Kidney Health Alliance recommendations, provi...

    Authors: C. McKeaveney, H. Noble, A. E. Courtney, P. Gill, S. Griffin, W. Johnston, A. P. Maxwell, F. Teasdale and J. Reid

    Citation: BMC Nephrology 2020 21:222

    Content type: Study protocol

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  17. Atypical hemolytic uremic syndrome (aHUS) can result in severe kidney dysfunction, secondary to thrombotic microangiopathy. Eculizumab has been used to treat this disorder, and has resulted in favourable outco...

    Authors: Sam Kant, Anshul Bhalla, Sami Alasfar and Nada Alachkar

    Citation: BMC Nephrology 2020 21:189

    Content type: Research article

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  18. Induction therapy is crucial in kidney transplantation and constitutes an important cornerstone for long-term allograft survival. Alemtuzumab is a depleting CD52-specific antibody with T- and B-cell activity, ...

    Authors: Martina Guthoff, Kilian Berger, Karina Althaus, Thomas Mühlbacher, Tamam Bakchoul, Wolfgang Steurer, Silvio Nadalin, Alfred Königsrainer and Nils Heyne

    Citation: BMC Nephrology 2020 21:178

    Content type: Research article

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  19. In the past urine was considered sterile. Through the introduction of next generation sequencing, it has become clear that a urinary microbiome exists. Acute kidney injury (AKI) represents a major threat to ki...

    Authors: Daniela Gerges-Knafl, Peter Pichler, Alexander Zimprich, Christoph Hotzy, Wolfgang Barousch, Rita M. Lang, Elisabeth Lobmeyr, Sabina Baumgartner-Parzer, Ludwig Wagner and Wolfgang Winnicki

    Citation: BMC Nephrology 2020 21:117

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2020 21:168

  20. Non-adherence (NA) to immunosuppressants (IS) among renal transplant recipients (RTRs) is associated with higher risk of allograft rejection, graft loss, and mortality. A precise measurement of NA is indispens...

    Authors: Marietta Lieb, Tobias Hepp, Mario Schiffer, Mirian Opgenoorth and Yesim Erim

    Citation: BMC Nephrology 2020 21:114

    Content type: Research article

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  21. Human leukocyte antigen (HLA)-G is a non-classical HLA molecule with immunomodulant and immunosuppressive functions, involved in transplantation tolerance. HLA-G14bp ins/del polymorphism in exon 8 has been ass...

    Authors: Daniela Piancatelli, Daniela Maccarone, Alessia Colanardi, Pierluigi Sebastiani, Katia Clemente, Samuele Iesari, Quirino Lai and Francesco Pisani

    Citation: BMC Nephrology 2020 21:109

    Content type: Research article

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  22. The efficacy and safety of minimisation of immunosuppression including early steroid withdrawal in kidney transplant recipients treated with Basiliximab induction remains unclear.

    Authors: Mysore K. Phanish, Richard P. Hull, Peter A. Andrews, Joyce Popoola, Edward J. Kingdon and Iain A. M. MacPhee

    Citation: BMC Nephrology 2020 21:92

    Content type: Research article

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  23. Surgical correction of hyperparathyroidism after kidney transplantation has been associated with significant graft function decline. We examined the effects of parathyroidectomy on short- and long-term graft f...

    Authors: Margret Patecki, Irina Scheffner, Hermann Haller and Wilfried Gwinner

    Citation: BMC Nephrology 2020 21:53

    Content type: Research article

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  24. Soluble ST2 is a novel biomarker of myocardial fibrosis with an established role in prognostication of patients with heart failure. Its role in cardiovascular risk prediction for renal transplant recipients ha...

    Authors: Paul A. Devine, Christopher Cardwell and Alexander P. Maxwell

    Citation: BMC Nephrology 2020 21:22

    Content type: Research article

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  25. Chronic active antibody-mediated rejection is a major etiology of graft loss in renal transplant recipients. However, there is no consensus on the optimal treatment strategies.

    Authors: Hsien-Fu Chiu, Mei-Chin Wen, Ming-Ju Wu, Cheng-Hsu Chen, Tung-Min Yu, Ya-Wen Chuang, Shih-Ting Huang, Shang-Feng Tsai, Ying-Chih Lo, Hao-Chung Ho and Kuo-Hsiung Shu

    Citation: BMC Nephrology 2020 21:6

    Content type: Research article

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  26. Several factors such as recipient age, BMI, serum cratinine, and positive history of dialysis are important in predicting graft survival among kidney transplant recipients. One factor affecting the transplant ...

    Authors: Gholamhossein Naderi, Amin Azadfar, Seyed Reza Yahyazadeh, Fatemeh Khatami and Seyed Mohammad Kazem Aghamir

    Citation: BMC Nephrology 2020 21:5

    Content type: Research article

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    The Correction to this article has been published in BMC Nephrology 2020 21:487

  27. Dual kidney transplantation (DKT) offers a way to extend the use of kidneys from expanded criteria donors (ECDs). Here, we compared the outcomes of DKT with those of single kidney transplantation from standard...

    Authors: Kyo Won Lee, Jae Berm Park, So Ra Cha, Seo Hee Lee, Young Jae Chung, Heejin Yoo, Kyunga Kim and Sung Joo Kim

    Citation: BMC Nephrology 2020 21:3

    Content type: Research article

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  28. Urinary tract infections (UTI) are the most common of infections after renal transplantation. The consequences of UTIs in this population are serious, with increased morbidity and hospitalisation rates as well...

    Authors: Simon OLENSKI, Carla SCUDERI, Alex CHOO, Aneesha Kaur BHAGAT SINGH, Mandy WAY, Lakshmanan JEYASEELAN and George JOHN

    Citation: BMC Nephrology 2019 20:479

    Content type: Research article

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  29. Despite the obvious survival benefit compared to that among waitlist patients, outcomes of positive crossmatch kidney transplantation (KT) are generally inferior to those of human leukocyte antigen (HLA)-compa...

    Authors: Deok Gie Kim, Juhan Lee, Younhee Park, Myoung Soo Kim, Hyeon Joo Jeong, Soon Il Kim, Yu Seun Kim, Beom Seok Kim and Kyu Ha Huh

    Citation: BMC Nephrology 2019 20:456

    Content type: Research article

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  30. The effects of Simultaneous Pancreas Kidney Transplantation (SPKT) on Peripheral Vascular Disease (PVD) warrants additional study and more target focus, since little is known about the mid- and long-term effec...

    Authors: Robert Sucher, Sebastian Rademacher, Nora Jahn, Max Brunotte, Tristan Wagner, Athanasios Alvanos, Elisabeth Sucher, Daniel Seehofer, Uwe Scheuermann and Hans-Michael Hau

    Citation: BMC Nephrology 2019 20:453

    Content type: Research article

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  31. To investigate predictive factors related to graft failure of IgA nephropathy(IgAN) in renal allografts following living donor transplantation.

    Authors: Jin Zhang, Guo-dong Chen, Jiang Qiu, Guo-chang Liu, Li-zhong Chen, Kai Fu and Zi-xuan Wu

    Citation: BMC Nephrology 2019 20:446

    Content type: Research article

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  32. Proteinuria after kidney transplantation portends a worse graft survival. However the magnitude of proteinuria related to patient and graft survival and its correlation with donor and recipient characteristics...

    Authors: Davide Diena, Maria Messina, Consuelo De Biase, Fabrizio Fop, Edoardo Scardino, Maura M. Rossetti, Antonella Barreca, Aldo Verri and Luigi Biancone

    Citation: BMC Nephrology 2019 20:443

    Content type: Research article

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  33. Successful renal transplantation (RT) reverses some of the cardiac changes and reduces cardiac mortality in hemodialysis (HD) patients. Widened QRS-T angle reflects both ventricular repolarization and depolari...

    Authors: Andrzej Jaroszyński, Jacek Furmaga, Tomasz Zapolski, Tomasz Zaborowski, Sławomir Rudzki and Wojciech Dąbrowski

    Citation: BMC Nephrology 2019 20:441

    Content type: Research article

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  34. Despite improvement in short-term outcome of kidney transplants, the long-term survival of kidney transplants has not changed over past decades. Kidney biopsy is the gold standard of transplant pathology but i...

    Authors: Johanna Päivärinta, Vesa Oikonen, Anne Räisänen-Sokolowski, Tuula Tolvanen, Eliisa Löyttyniemi, Hidehiro Iida, Pirjo Nuutila, Kaj Metsärinne and Niina Koivuviita

    Citation: BMC Nephrology 2019 20:437

    Content type: Research article

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  35. Delayed graft function (DGF) is an important complication of kidney transplantation and can be diagnosed according to different definitions. DGF has been suggested to be associated with the long-term outcome o...

    Authors: Xiao-jun Hu, Jin Zheng, Yang Li, Xiao-hui Tian, Pu-xun Tian, He-li Xiang, Xiao-ming Pan, Chen-guang Ding, Xiao-ming Ding and Wu-jun Xue

    Citation: BMC Nephrology 2019 20:409

    Content type: Research article

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  36. The renal function of the remaining kidney in living donors recovers up to 60~70% of pre-donation estimated-glomerular filtration rate (eGFR) by compensatory hypertrophy. However, the degree of this hypertroph...

    Authors: Sho Nishida, Yuji Hidaka, Mariko Toyoda, Kohei Kinoshita, Kosuke Tanaka, Chiaki Kawabata, Satoshi Hamanoue, Akito Inadome, Hiroshi Yokomizo, Asami Takeda, Soichi Uekihara and Shigeyoshi Yamanaga

    Citation: BMC Nephrology 2019 20:403

    Content type: Research article

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  37. Medication non-adherence is a risk factor for acute kidney transplant rejection. The association of non-adherence with short-term allograft loss in patients who develop acute rejection and are subsequently tre...

    Authors: Ahmed Al-Sheyyab, Laura Binari, Mohammed Shwetar, Everly Ramos, Meghan E. Kapp, Stefanie Bala, Nikita Wilson, Rachel C. Forbes, J. Harold Helderman, Khaled Abdel-Kader and Beatrice P. Concepcion

    Citation: BMC Nephrology 2019 20:373

    Content type: Research article

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  38. Kidney transplantation is considered to be the treatment of choice for people with end-stage renal disease (ESRD). However, due to the shortage of available organs and the increase in the ESRD prevalence in Eu...

    Authors: M. Lorent, Y. Foucher, K. Kerleau, S. Brouard, C. Baayen, S. Lebouter, M. Naesens, O. Bestard Matamoros, A. Åsberg and M. Giral

    Citation: BMC Nephrology 2019 20:365

    Content type: Database

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  39. Chronic allograft damage (CAD) is the leading cause of long-term graft dysfunction. A noninvasive method that can diagnose CAD early and monitor its development is needed.

    Authors: Qiang Zhang, Zexing Yu, Song Zeng, Lu Liang, Yue Xu, Zijian Zhang, Hao Tang, Wenjiao Jiao, Wenrui Xue, Wei Wang, Xiaodong Zhang, Tao Jiang and Xiaopeng Hu

    Citation: BMC Nephrology 2019 20:364

    Content type: Research article

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  40. Although immunoglobulin A nephropathy (IgAN) is associated with an increased risk of renal allograft failure, evidences for its treatment, including renin-angiotensin-aldosterone system blockade (RAASB) usage,...

    Authors: Sehoon Park, Chung Hee Baek, Heounjeong Go, Young Hoon Kim, Sang–il Min, Jongwon Ha, Yong Chul Kim, Jung Pyo Lee, Yon Su Kim, Kyung Chul Moon, Su-Kil Park and Hajeong Lee

    Citation: BMC Nephrology 2019 20:354

    Content type: Research article

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  41. Kidney transplantation is the optimal treatment in end stage renal disease but the allograft survival is still hampered by immune reactions against the allograft. This process is driven by the recognition of a...

    Authors: Constantin Aschauer, Kira Jelencsics, Karin Hu, Andreas Heinzel, Julia Vetter, Thomas Fraunhofer, Susanne Schaller, Stephan Winkler, Lisabeth Pimenov, Guido A. Gualdoni, Michael Eder, Alexander Kainz, Heinz Regele, Roman Reindl-Schwaighofer and Rainer Oberbauer

    Citation: BMC Nephrology 2019 20:346

    Content type: Study protocol

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  42. In kidney transplantation, immunotherapy with thymoglobulin (rATG) has been used to down-regulate the patient immune system. rATG is a powerful immunobiologic drug used to deplete lymphocytes to prevent early ...

    Authors: Marcus Faria Lasmar, Rodrigo Santana Dutra, José Augusto Nogueira-Machado, Raquel A. Fabreti-Oliveira, Raquel Gomes Siqueira and Evaldo Nascimento

    Citation: BMC Nephrology 2019 20:314

    Content type: Research article

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  43. Neutrophil gelatinase-assoicated lipocalin (NGAL) appears to be a promising proximal tubular injury biomarker for early prediction of delayed graft function (DGF) in kidney transplant recipients. However, its ...

    Authors: Ya Mei Li, Yi Li, Lin Yan, Han Wang, Xiao Juan Wu, Jiang Tao Tang, Lan Lan Wang and Yun Ying Shi

    Citation: BMC Nephrology 2019 20:291

    Content type: Research article

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  44. Despite significant advances in surgical techniques, immunosuppression protocols, follow up periods and antimicrobial stewardship in modern medicine; post-renal transplantation urinary tract infection remained...

    Authors: Teklehaimanot Kiros, Daniel Asrat, Zeleke Ayenew and Estifanos Tsige

    Citation: BMC Nephrology 2019 20:289

    Content type: Research article

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  45. Disagreements between clinic and ambulatory blood pressure (BP) measurements are well-described in the general population. Though hypertension is frequent in renal transplant recipients, only a few studies add...

    Authors: Eitan Gluskin, Keren Tzukert, Irit Mor-Yosef Levi, Olga Gotsman, Itamar Sagiv, Roy Abel, Aharon Bloch, Dvorah Rubinger, Michal Aharon, Michal Dranitzki Elhalel and Iddo Z. Ben-Dov

    Citation: BMC Nephrology 2019 20:284

    Content type: Research article

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  46. Compensation of contralateral kidney function after living-donor kidney donation is well known, and many predictive factors have been proposed. However, no prediction model has been proposed. This study was pe...

    Authors: Kenji Okumura, Shigeyoshi Yamanaga, Kosuke Tanaka, Kohei Kinoshita, Akari Kaba, Mika Fujii, Masatomo Ogata, Yuji Hidaka, Mariko Toyoda, Soichi Uekihara, Akira Miyata, Akito Inadome and Hiroshi Yokomizo

    Citation: BMC Nephrology 2019 20:283

    Content type: Research article

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  47. In recent years we have witnessed an increase in infections due to multidrug-resistant organisms in kidney transplant recipients (KTR). In our setting, we have observed a dramatic increase in infections caused...

    Authors: Gemma Sanclemente, Marta Bodro, Carlos Cervera, Laura Linares, Frederic Cofán, Francesc Marco, Jordi Bosch, Federico Oppenheimer, Fritz Dieckmann and Asunción Moreno

    Citation: BMC Nephrology 2019 20:274

    Content type: Research article

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  48. Acute kidney injury represents a major threat to the transplanted kidney. Nevertheless, these kidneys have the potential to fully recover. Tubular regeneration following acute kidney injury is driven by the re...

    Authors: Daniela Knafl, Wolfgang Winnicki, Peter Mazal and Ludwig Wagner

    Citation: BMC Nephrology 2019 20:251

    Content type: Research article

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  49. “Acute kidney dysfunction with no rejection” (ADNR) corresponds to acute kidney injury without histological evidence of acute rejection (AR) in kidney transplant recipients (KTR). The prognosis of ADNR is unkn...

    Authors: François Paquot, Laurent Weekers, Catherine Bonvoisin, Hans Pottel and François Jouret

    Citation: BMC Nephrology 2019 20:249

    Content type: Research article

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