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  1. Content type: Research article

    Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated t...

    Authors: Leszek Domanski, Karolina Kłoda, Maciej Patrzyk, Magda Wisniewska, Krzysztof Safranow, Jerzy Sienko, Tadeusz Sulikowski, Marzena Staniszewska and Andrzej Pawlik

    Citation: BMC Nephrology 2019 20:124

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  2. Content type: Research article

    Little is known about salt taste dysfunction among hemodialysis (HD) patients. This study aimed to elucidate the prevalence of salt taste dysfunction and its relationship with interdialytic weight gain (IDWG) ...

    Authors: Mai Tanaka, Hiroki Nishiwaki, Hiroshi Kado, Yohei Doi, Chieko Ihoriya, Kenji Omae and Keiichi Tamagaki

    Citation: BMC Nephrology 2019 20:121

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  3. Content type: Case report

    Gastrointestinal stromal tumors (GISTs) in transplant recipients are very rare and only a handful of cases have been reported to date. Here we present the first known case of a huge GIST in a kidney transplant...

    Authors: Ryohei Takahashi, Kazunobu Shinoda, Takashi Ishida, Yasuo Hamamoto, Shinya Morita, Hirotaka Akita, Sotaro Kitaoka, Satoshi Tamaki, Hiroshi Asanuma, Tadashi Yoshida, Masahiro Jinzaki, Kaori Kameyama and Mototsugu Oya

    Citation: BMC Nephrology 2019 20:120

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  4. Content type: Research article

    Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. However, little is k...

    Authors: Hyo Jin Kim, Joongyub Lee, Dong-Wan Chae, Kyu-Beck Lee, Su Ah Sung, Tae-Hyun Yoo, Seung Hyeok Han, Curie Ahn and Kook-Hwan Oh

    Citation: BMC Nephrology 2019 20:119

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  5. Content type: Research article

    Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate es...

    Authors: Sachimi Kubo, Yoko Nishida, Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Takumi Hirata, Naomi Miyamatsu, Ayumi Tanabe, Aya Hirata, Yukako Tatsumi, Aya Kadota, Kazuyo Kuwabara, Tomofumi Nishikawa, Yoshihiro Miyamoto and Tomonori Okamura

    Citation: BMC Nephrology 2019 20:117

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  6. Content type: Research article

    Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the ...

    Authors: Nidhi Sukul, Junhui Zhao, Douglas S. Fuller, Angelo Karaboyas, Brian Bieber, James A. Sloand, Lalita Subramanian, David W. Johnson, Matthew J. Oliver, Kriang Tungsanga, Tadashi Tomo, Rachael L. Morton, Hal Morgenstern, Bruce M. Robinson and Jeffrey Perl

    Citation: BMC Nephrology 2019 20:116

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  7. Content type: Research article

    Blood urea nitrogen (BUN) is one of the substances that affects the calculated serum osmolality (cSosm). A previous study demonstrated that BUN and cSosm were independently associated with the development of c...

    Authors: Makiko Seki, Masaru Nakayama, Teppei Sakoh, Ryota Yoshitomi, Akiko Fukui, Eisuke Katafuchi, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya and Takanari Kitazono

    Citation: BMC Nephrology 2019 20:115

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  8. Content type: Research article

    Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evalu...

    Authors: Philipp Russ, Martin Russwurm, Birgit Kortus-Goetze, Joachim Hoyer and Sahana Kamalanabhaiah

    Citation: BMC Nephrology 2019 20:114

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  9. Content type: Research article

    Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the sel...

    Authors: Edward Zimbudzi, Clement Lo, Peter G. Kerr and Sophia Zoungas

    Citation: BMC Nephrology 2019 20:113

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  10. Content type: Research article

    Health-related quality of life (HRQOL) is a key outcome for dialysis patients, and its assessment is mandated by the Centers for Medicaid and Medicare Services. The Kidney Disease Quality of Life (KDQOL-36™) s...

    Authors: Dena E. Cohen, Andrew Lee, Scott Sibbel, Deborah Benner, Steven M. Brunelli and Francesca Tentori

    Citation: BMC Nephrology 2019 20:112

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  11. Content type: Editorial

    Natalina Tomilina, a pioneer of Russian nephrology, is a clinician, researcher, teacher, organizer, leader, and a real pioneer, who has worked in nephrology from the very beginning of its development in Russia...

    Authors: Elena Zakharova

    Citation: BMC Nephrology 2019 20:111

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  12. Content type: Research article

    The Kidney Failure Risk Equation (KFRE) predicts risk of progression to kidney failure and is used to guide clinical decisions for patients with chronic kidney disease (CKD).

    Authors: Michelle D. Smekal, Helen Tam-Tham, Juli Finlay, Maoliosa Donald, Chandra Thomas, Robert G. Weaver, Robert R. Quinn, Kin Tam, Braden J. Manns, Marcello Tonelli, Aminu Bello, Navdeep Tangri and Brenda R. Hemmelgarn

    Citation: BMC Nephrology 2019 20:110

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  13. Content type: Research article

    Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these paramet...

    Authors: Natascha J. H. Broers, Tsz Yeung Fung, Jeroen P. Kooman and Maarten H. L. Christiaans

    Citation: BMC Nephrology 2019 20:109

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  14. Content type: Research article

    Maximal conservative management (MCM) may be an appropriate alternative option for dialysis in some elderly patients with end-stage kidney disease (ESKD). Evidence about the impact of dialysis or MCM on qualit...

    Authors: I. N. van Loon, N. A. Goto, F. T. J. Boereboom, M. C. Verhaar, M. L. Bots and M. E. Hamaker

    Citation: BMC Nephrology 2019 20:108

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  15. Content type: Research article

    In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo mal...

    Authors: Martina Taborelli, Federica Toffolutti, Stefania Del Zotto, Elena Clagnan, Lucrezia Furian, Pierluca Piselli, Franco Citterio, Loris Zanier, Giuliano Boscutti and Diego Serraino

    Citation: BMC Nephrology 2019 20:107

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  16. Content type: Research article

    To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims include...

    Authors: Yi Chen, Liyu Lin, Xuan Tao, Yankun Song, Jiong Cui and Jianxin Wan

    Citation: BMC Nephrology 2019 20:106

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  17. Content type: Research article

    Sarcopenia has become a serious disorder in modern society. Chronic kidney disease requiring dialysis and diabetes are some of the disorders that accelerate the onset and progression of sarcopenia. We, therefo...

    Authors: Katsuhito Mori, Kozo Nishide, Senji Okuno, Tetsuo Shoji, Masanori Emoto, Akihiro Tsuda, Shinya Nakatani, Yasuo Imanishi, Eiji Ishimura, Tomoyuki Yamakawa, Shigeichi Shoji and Masaaki Inaba

    Citation: BMC Nephrology 2019 20:105

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  18. Content type: Research article

    Guidelines for general hypertension treatment do not recommend the combined use of renin-angiotensin-aldosterone system (RAAS) inhibitors due to the risk of hyperkalemia. However, a recent clinical trial showe...

    Authors: Hyoungnae Kim, Seohyun Park, Jong Hyun Jhee, Hae-Ryong Yun, Jung Tak Park, Seung Hyeok Han, Joongyub Lee, Soo Wan Kim, Yeong Hoon Kim, Yun Kyu Oh, Shin-Wook Kang, Kyu Hun Choi and Tae-Hyun Yoo

    Citation: BMC Nephrology 2019 20:104

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  19. Content type: Research article

    As more patients at lower cardiovascular (CV) risk are treated with statins, the balance between cardiovascular benefits and the risk of adverse events becomes increasingly important.

    Authors: Marcello Tonelli, Anita M. Lloyd, Aminu K. Bello, Matthew T. James, Scott W. Klarenbach, Finlay A. McAlister, Braden J. Manns, Ross T. Tsuyuki and Brenda R. Hemmelgarn

    Citation: BMC Nephrology 2019 20:103

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  20. Content type: Research article

    Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a...

    Authors: Inayat Ur Rehman, Pauline Siew Mei Lai, Soo Kun Lim, Learn Han Lee and Tahir Mehmood Khan

    Citation: BMC Nephrology 2019 20:102

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  21. Content type: Research article

    Recipients of living donor renal transplantation are typically considered to have a relatively lower immunological risk. This retrospective study aimed to compare the therapeutic efficacy and safety between ra...

    Authors: Jiang Qiu, Jun Li, Guodong Chen, Gang Huang, Qian Fu, Changxi Wang and Lizhong Chen

    Citation: BMC Nephrology 2019 20:101

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  22. Content type: Case report

    The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substance...

    Authors: José Célio Costa Lima Filho, Maurício Yukio Ogawa, Tacilla Hanny de Souza Andrade, Sami de Andrade Cordeiro Gadelha, Paula Frassinetti Castelo Branco Camurça Fernandes, Anaiara Lucena Queiroz and Elizabeth De Francesco Daher

    Citation: BMC Nephrology 2019 20:99

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  23. Content type: Study protocol

    End stage renal disease (ESRD) patients require a renal replacement therapy (RRT) to filter accumulated toxins and remove excess water, which are associated with impaired physical function. Hemodialysis (HD) r...

    Authors: Roberto Pecoits-Filho, John W. Larkin, Carlos Eduardo Poli-de-Figueiredo, Américo Lourenço Cuvello Neto, Ana Beatriz Barra, Sinaia Canhada, Ludimila Guedim de Campos, Juliane Woehl, Priscila Bezerra Gonçalves, Hao Han, Thyago Proença de Moraes, Jochen G. Raimann and Maria Eugenia F. Canziani

    Citation: BMC Nephrology 2019 20:98

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  24. Content type: Research article

    Hyperuricemia (HUA) is very common in chronic kidney disease (CKD). HUA is associated with an increased risk of cardiovascular events and accelerates the progression of CKD. Our study aimed to explore the rela...

    Authors: Shulei Fan, Ping Zhang, Amanda Ying Wang, Xia Wang, Li Wang, Guisen Li and Daqing Hong

    Citation: BMC Nephrology 2019 20:95

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  25. Content type: Research article

    Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout its...

    Authors: Jasvinder A. Singh and John D. Cleveland

    Citation: BMC Nephrology 2019 20:93

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  26. Content type: Research article

    Protein-energy wasting (PEW) is a relatively prevalent problem among adult haemodialysis patients (HDP). PEW is an important determinant of morbidity and mortality in HDP, therefore it is essential for dietiti...

    Authors: Ali M. Omari, Leen S. Omari, Hazar H. Dagash, Waleed M. Sweileh, Nehal Natour and Sa’ed H. Zyoud

    Citation: BMC Nephrology 2019 20:92

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  27. Content type: Case report

    Microangiopathic hemolytic anemias and thrombocytopenias in pregnant or postpartum women constitute an interdisciplinary diagnostic and therapeutic challenge in the evaluation of thrombotic microangiopathies (...

    Authors: Katharina Artinger, Gerald Hackl, Gernot Schilcher, Florian Eisner, Marion J. Pollheimer, Christoph Mache, Eva-Christine Weiss, Kathrin Eller and Philipp Eller

    Citation: BMC Nephrology 2019 20:91

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  28. Content type: Research article

    Darbepoetin alfa (DA-α) is a long-acting erythropoiesis-stimulating glycoprotein which has half-life three-fold longer than that of Erythropoietin alfa (EPO). The objective of this study was to compare the eff...

    Authors: Shubhadeep D. Sinha, Vamsi Krishna Bandi, Bala Reddy Bheemareddy, Pankaj Thakur, Sreenivasa Chary, Kalpana Mehta, Vikranth Reddy Pinnamareddy, Rajendra Pandey, Subhramanyam Sreepada and Santosh Durugkar

    Citation: BMC Nephrology 2019 20:90

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  29. Content type: Research article

    Acute kidney injury (AKI) in critically ill children is associated with increased mortality and morbidity. In this study we evaluated the effect of AKI severity on the incidence of short-term mortality and mor...

    Authors: Osama Y. Safder, Khalid A. Alhasan, Mohamed A. Shalaby, Norah Khathlan, Suleman A. Al Rezgan, Amr S. Albanna and Jameela A. Kari

    Citation: BMC Nephrology 2019 20:89

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  30. Content type: Research article

    Acute tubulointerstitial nephritis (ATIN) is an important cause of acute kidney injury and often a potentially reversible disease. However, the role of steroids in ATIN remains controversial and the underlying...

    Authors: Donghwan Yun, Myoung-jin Jang, Jung Nam An, Jung Pyo Lee, Dong Ki Kim, Ho Jun Chin, Yon Su Kim, Dong-Sup Lee and Seung Seok Han

    Citation: BMC Nephrology 2019 20:88

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  31. Content type: Case report

    Dasatinib is a second-generation tyrosine kinase inhibitor that is indicated for the treatment of patients with chronic myeloid leukemia. Here, we report the case of a man with nephrotic syndrome that was caus...

    Authors: Shoko Ochiai, Yuji Sato, Akihiro Minakawa, Akihiro Fukuda and Shouichi Fujimoto

    Citation: BMC Nephrology 2019 20:87

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  32. Content type: Correction

    Following publication

    Authors: Jan Ebbing, Felix Menzel, Paolo Frumento, Kurt Miller, Bernhard Ralla, Tom Florian Fuller, Jonas Busch, Justin William Collins, Christofer Adding, Hans Helge Seifert, Peter Ardelt, Christian Wetterauer, Timm Westhoff and Carsten Kempkensteffen

    Citation: BMC Nephrology 2019 20:86

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    The original article was published in BMC Nephrology 2019 20:40

  33. Content type: Research article

    Real-world incidence, clinical consequences, and healthcare resource utilization (HRU) of hyperkalemia (HK) remain poorly characterized, particularly in patients with specific comorbidities.

    Authors: Laura Horne, Akhtar Ashfaq, Sharon MacLachlan, Marvin Sinsakul, Lei Qin, Robert LoCasale and James B. Wetmore

    Citation: BMC Nephrology 2019 20:85

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  34. Content type: Research article

    People with Chronic Kidney Disease (CKD) often present with prevalent gait impairment and high fall rates, particularly in advanced CKD stages. Gait impairment and its consequences is associated with increased...

    Authors: Damiano D. Zemp, Olivier Giannini, Pierluigi Quadri and Eling D. de Bruin

    Citation: BMC Nephrology 2019 20:83

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  35. Content type: Research article

    Assessment of adequacy of intermittent hemodialysis (IHD) is conventionally based upon urea kinetic models for calculation of single pool Kt/Vurea (Kt/V), with 1.2 accepted as minimum adequate clearance for thric...

    Authors: Kelly V. Liang, Jane H. Zhang and Paul M. Palevsky

    Citation: BMC Nephrology 2019 20:82

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  36. Content type: Research article

    DOPPS reported that thousands of life-years could be gained in the US and Europe over 5 years by correcting six modifiable haemodialysis practices. We estimated potential life-years gained across 10 European c...

    Authors: Christian Combe, Johannes Mann, David Goldsmith, Frank Dellanna, Philippe Zaoui, Gérard London, Kris Denhaerynck, Andriy Krendyukov, Ivo Abraham and Karen MacDonald

    Citation: BMC Nephrology 2019 20:81

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  37. Content type: Research article

    Hemodialysis patients have high rates of sudden death, but relationships between serum electrolytes, the dialysis prescription, and intra-dialytic shifts in fluid and electrolyte with arrhythmia are uncertain.

    Authors: James A. Tumlin, Prabir Roy-Chaudhury, Bruce A. Koplan, Alexandru I. Costea, Vijay Kher, Don Williamson, Saurabh Pokhariyal and David M. Charytan

    Citation: BMC Nephrology 2019 20:80

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  38. Content type: Research article

    It is evident that renal dysfunction (RD) is associated with unique infectious and non-infectious causes in African children. However, little data exists about the prevalence and factors associated with RD in ...

    Authors: Neema Chami, Rogatus Kabyemera, Tulla Masoza, Emmanuela Ambrose, Franscisca Kimaro, Neema Kayange, Adolfine Hokororo, Francis F. Furia and Rob Peck

    Citation: BMC Nephrology 2019 20:79

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  39. Content type: Study protocol

    Five-year survival on dialysis is only 40%, compared to 74% with a deceased donor kidney transplant (DDKT) and 87% with a living donor kidney transplant (LDKT). An American Society of Transplantation (AST) Con...

    Authors: Amy D. Waterman, Crystal Anderson, Angelika Alem, John D. Peipert, Jennifer L. Beaumont, Shayna L. Henry, Bhanuja Dub, Lizeth Ambriz, Neha Bijjala, Amanda Faye Lipsey and Brian Mittman

    Citation: BMC Nephrology 2019 20:78

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  40. Content type: Research article

    IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Urinary micro-RNA (miRNA) level is increasingly reported to as non-invasive markers of various kidney diseases. We aim to identif...

    Authors: Cheuk-Chun Szeto, Gang Wang, Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Fernand Mac-Moune Lai, Kai-Ming Chow, Cathy Choi-Wan Luk, Ka-Bik Lai and Philip Kam-Tao Li

    Citation: BMC Nephrology 2019 20:77

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  41. Content type: Research article

    Chronic kidney disease (CKD) is strongly associated with cardiovascular disease and is a significant risk factor for increased morbidity and mortality. In contrast, GLP-1 receptor (GLP-1R) activation has been ...

    Authors: Seung Jung Kim, Soon Kil Kwon, Hye-Young Kim, Sun Moon Kim, Jang-Whan Bae and Joong-Kook Choi

    Citation: BMC Nephrology 2019 20:75

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  42. Content type: Research article

    Exacerbated inflammatory response is considered one of the key elements of acute kidney injury (AKI). Interleukin-6 (IL-6) is an inflammatory cytokine that plays important roles in the inflammatory response an...

    Authors: Takashi Shimazui, Taka-aki Nakada, Yoshihisa Tateishi, Taku Oshima, Tuerxun Aizimu and Shigeto Oda

    Citation: BMC Nephrology 2019 20:74

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  43. Content type: Research article

    Patients with chronic kidney disease (CKD) have a high risk of recurring thrombotic events following acute myocardial infarction (AMI). Microparticles (MPs) are circulating small vesicles shed from various cel...

    Authors: Josefin Mörtberg, Kristina Lundwall, Fariborz Mobarrez, Håkan Wallén, Stefan H. Jacobson and Jonas Spaak

    Citation: BMC Nephrology 2019 20:71

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