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  1. In patients with end stage renal disease (ESRD), left ventricular (LV) hypertrophy with impaired LV function, which is called uremic cardiomyopathy (UC) is often observed. The UC historically has been consider...

    Authors: Tomasz Zapolski, Jacek Furmaga, Andrzej P. Wysokiński, Anna Wysocka, Sławomir Rudzki and Andrzej Jaroszyński
    Citation: BMC Nephrology 2019 20:152
  2. Health related quality of life (HRQOL) is an important predictor of clinical outcomes for End Stage Renal Disease (ESRD) patients and to establish quality adjusted life years (QALYs) for economic evaluation st...

    Authors: Naren Kumar Surendra, Mohd Rizal Abdul Manaf, Lai Seong Hooi, Sunita Bavanandan, Fariz Safhan Mohamad Nor, Shahnaz Shah Firdaus Khan, Loke Meng Ong and Abdul Halim Abdul Gafor
    Citation: BMC Nephrology 2019 20:151
  3. The serum immunoglobulin A (IgA)/C3 ratio is considered to be an effective predictor of IgA nephropathy (IgAN). This study sought to explore the diagnostic value of the IgA/C3 ratio in IgAN among primary glome...

    Authors: Wen-yu Gong, Man Liu, Dan Luo, Fan-na Liu, Liang-hong Yin, Yuan-qing Li, Jun Zhang and Hui Peng
    Citation: BMC Nephrology 2019 20:150
  4. Tunnelled dialysis catheter (TC) infections are a major health complication and are associated with increased antibiotic consumption, hospital stays, health costs and mortality. Experimental data provide evide...

    Authors: Julien Aniort, Aurélien Piraud, Mireille Adda, Bruno Perreira, Marc Bouiller, Jacques Fourcade, Abdallah Guerraoui, Emilie Kalbacher, Thierry Krumel, Hélène Leray Moragues, Damien Thibaudin, Carlos Gustavo Vela, Guillaume Vernin, Hugo Weclawiak, Lise Bernard, Anne Elisabeth Heng…
    Citation: BMC Nephrology 2019 20:149
  5. Autosomal Dominant Polycystic Kidney Disease (ADPKD) is thought to affect about 1 in 1000 people in the UK. ADPKD causes a progressive decline in kidney function, with kidney failure tending to occur in middle...

    Authors: Jan Dudley, Paul Winyard, Matko Marlais, Oliver Cuthell, Tess Harris, Jiehan Chong, John Sayer, Daniel P. Gale, Lucy Moore, Kay Turner, Sarah Burrows and Richard Sandford
    Citation: BMC Nephrology 2019 20:148
  6. Post transplantation diabetes mellitus (PTDM) is a common and serious complication after renal transplantation with significant morbidity and mortality. Metformin has proven benefits in the general population ...

    Authors: Basil Alnasrallah, Tze Liang Goh, Lai Wan Chan, Paul Manley and Helen Pilmore
    Citation: BMC Nephrology 2019 20:147
  7. Fewer trainees are choosing to pursue nephrology. Only 60.1% of positions filled in the 2018 fellowship Match, which is concerning given the rising prevalence of end-stage kidney disease. Identifying factors i...

    Authors: Devika Nair, Kurtis A. Pivert, Adrian Baudy IV and Charuhas V. Thakar
    Citation: BMC Nephrology 2019 20:146
  8. The invention of an effective kidney preservation solution capable of prolonging harvested kidney viability is the core of kidney transplantation procedure. Researchers have been working on upgrading the prese...

    Authors: Sherif Khedr, Oleg Palygin, Tengis S. Pavlov, Gregory Blass, Vladislav Levchenko, Ammar Alsheikh, Michael W. Brands, Ashraf El-Meanawy and Alexander Staruschenko
    Citation: BMC Nephrology 2019 20:145
  9. Health-related quality of life (HRQoL) is an important component of patient-centered outcomes and a useful parameter for monitoring quality of care. We assessed HRQoL, its determinants, and associations with m...

    Authors: Ming Pei, Rute Aguiar, Agneta A. Pagels, Olof Heimbürger, Peter Stenvinkel, Peter Bárány, Charlotte Medin, Stefan H. Jacobson, Britta Hylander, Bengt Lindholm and Abdul Rashid Qureshi
    Citation: BMC Nephrology 2019 20:144
  10. To support effective self-management after kidney transplantation, a holistic nurse-led self-management support intervention was developed using the Intervention Mapping approach. The primary aim was to evalua...

    Authors: Janet M. J. Been-Dahmen, Denise K. Beck, Mariëlle A. C. Peeters, Heleen van der Stege, Mirjam Tielen, Marleen C. van Buren, Erwin Ista, AnneLoes van Staa and Emma K. Massey
    Citation: BMC Nephrology 2019 20:143
  11. Self-management intervention aims to facilitate an individual’s ability to make lifestyle changes. The effectiveness of this intervention in non-dialysis patients with chronic kidney disease (CKD) is limited. ...

    Authors: Suyuan Peng, Jiawei He, Jiasheng Huang, Longwei Lun, Jiahao Zeng, Shan Zeng, La Zhang, Xusheng Liu and Yifan Wu
    Citation: BMC Nephrology 2019 20:142
  12. Meprin metalloproteases are abundantly expressed in the brush border membranes of kidney proximal tubules and small intestines. Meprins are also expressed in podocytes and leukocytes (monocytes and macrophages...

    Authors: Jessica Gooding, Lei Cao, Courtney Whitaker, Jean-Marie Mwiza, Mizpha Fernander, Faihaa Ahmed, Zach Acuff, Susan McRitchie, Susan Sumner and Elimelda Moige Ongeri
    Citation: BMC Nephrology 2019 20:141
  13. Chronic kidney disease (CKD) is a public health problem worldwide, and proteinuria is a well-established marker of disease progression in CKD patients. Propolis, a natural resin produced by bees from plant mat...

    Authors: Marcelo Augusto Duarte Silveira, Flávio Teles, Andressa A. Berretta, Talita R. Sanches, Camila Eleutério Rodrigues, Antonio Carlos Seguro and Lúcia Andrade
    Citation: BMC Nephrology 2019 20:140
  14. An increased incidence of thromboembolic events (TE) are reported in nephrotic syndrome (NS) leading to recommendations for prophylactic anticoagulation (PAC). However, as no randomized clinical trial has esta...

    Authors: Sarah Kelddal, Karen Marie Nykjær, Jon Waarst Gregersen and Henrik Birn
    Citation: BMC Nephrology 2019 20:139
  15. Apparent treatment-resistant hypertension (aTRH) is a common condition associated with risk of cardiovascular events. However, the risk of cardiovascular mortality associated with aTRH in the US population is ...

    Authors: Katerina R. Kaczmarski, Stephen M. Sozio, Jingsha Chen, Yingying Sang and Tariq Shafi
    Citation: BMC Nephrology 2019 20:138
  16. Despite an increasing number of older people commencing dialysis the impact of dialysis on their quality of life and survival, remains unclear. The Dialysis Outcomes in those aged over 65 years or older study ...

    Authors: Bronwen McNoe, John B. W. Schollum, Sarah Derrett, Mark R. Marshall, Andrew Henderson, Ari Samaranayaka and Robert J. Walker
    Citation: BMC Nephrology 2019 20:137
  17. The short-term efficacy of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) has been demonstrated across several phase 3 trials, while the ADPKD Outcomes Model (ADPKD-OM) represe...

    Authors: Hayley Bennett, Phil McEwan, Karina Hamilton and Karl O’Reilly
    Citation: BMC Nephrology 2019 20:136
  18. Sphingosine-1-phosphate receptor 2 (S1PR2) is a G-protein-coupled receptor that regulates sphingosine-1-phosphate-triggered cellular response. However, the role of S1PR2 in diabetes-induced glomerular endothel...

    Authors: Wei Chen, Hong Xiang, Ruifang Chen, Jie Yang, Xiaoping Yang, Jianda Zhou, Hengdao Liu, Shaoli Zhao, Jie Xiao, Pan Chen, Alex F. Chen, Shuhua Chen and Hongwei Lu
    Citation: BMC Nephrology 2019 20:135
  19. Chronic kidney disease (CKD) is a devastating illness associated with increased mortality, reduced quality of life, impaired growth, neurocognitive impairment and psychosocial maladjustment in children. There ...

    Authors: Anita van Zwieten, Patrina Caldwell, Kirsten Howard, Allison Tong, Jonathan C. Craig, Stephen Alexander, Martin Howell, Teixeira-Pinto Armando, Carmel Hawley, Shilpa Jesudason, Amanda Walker, Fiona Mackie, Sean Kennedy, Steve McTaggart, Hugh McCarthy, Simon Carter…
    Citation: BMC Nephrology 2019 20:134

    The Update to this article has been published in Trials 2022 23:824

  20. Prolonged QT interval in hemodialysis patients may be associated with sudden cardiac death, however, few studies examined the longitudinal associations of modifiable factors such as serum and dialysate concent...

    Authors: Esther D. Kim, Jacqueline Watt, Larisa G. Tereshchenko, Bernard G. Jaar, Stephen M. Sozio, W. H. Linda Kao, Michelle M. Estrella and Rulan S. Parekh
    Citation: BMC Nephrology 2019 20:133
  21. Proteinuria screening is recommended for patients with hypertension to screen for kidney disease and identify those at elevated risk for cardiovascular disease. However, screening rates among hypertensive pati...

    Authors: Julia Leddy, Jamie A. Green, Christina Yule, Juliann Molecavage, Josef Coresh and Alex R. Chang
    Citation: BMC Nephrology 2019 20:132
  22. The aim of the present study was to investigate the clinical impact of prediabetes on the development of incident chronic kidney disease (CKD) in a Korean adult population, using data from the Korea Genome and...

    Authors: Gwang Sil Kim, Hyun Ho Oh, Sang Hyun Kim, Byung Ok Kim and Young Sup Byun
    Citation: BMC Nephrology 2019 20:130
  23. Prediction of successful discontinuation of continuous renal replacement therapy (CRRT) might reduce complications of over- and under-treatment. The aim of this study was to identify renal and non-renal predic...

    Authors: Susanne Stads, K. Merijn Kant, Margriet F. C. de Jong, Wouter de Ruijter, Christa M. Cobbaert, Michiel G. H. Betjes, Diederik Gommers and Heleen M. Oudemans-van Straaten
    Citation: BMC Nephrology 2019 20:129
  24. Mitochondrial DNA (mtDNA) released into extracellular subsequent to cell injury and death can promote inflammation in patients and animal models. However, the effects of peritoneal dialysate cell-free mtDNA on...

    Authors: Xishao Xie, Junni Wang, Shilong Xiang, Zhimin Chen, Xiaohui Zhang and Jianghua Chen
    Citation: BMC Nephrology 2019 20:128
  25. MicroRNAs have been related to tumor progression in diverse human cancers including clear-cell renal cell carcinoma (ccRCC). Previous study has suggested the important regulation function of miR-10b in ccRCC. ...

    Authors: Cheng He, Zhi-Yong Chen, Yang Li, Zhong-Qing Yang, Feng Zeng, Yu Cui, Yao He, Jin-Bo Chen and He-Qun Chen
    Citation: BMC Nephrology 2019 20:127
  26. Galloway-Mowat syndrome (GAMOS) is a rare autosomal recessive disorder characterized by early-onset nephrotic syndrome and microcephaly with brain anomalies. WDR73 pathogenic variants were described as the first ...

    Authors: Andrea Domingo-Gallego, Mónica Furlano, Marc Pybus, Daniel Barraca, Ana Belén Martínez, Emiliano Mora Muñoz, Roser Torra and Elisabet Ars
    Citation: BMC Nephrology 2019 20:126
  27. There are limited long-term outcome data in eculizumab-treated patients with atypical hemolytic uremic syndrome (aHUS). We report final results from the largest prospective, observational, multicenter study of...

    Authors: Jan Menne, Yahsou Delmas, Fadi Fakhouri, Christoph Licht, Åsa Lommelé, Enrico E. Minetti, François Provôt, Eric Rondeau, Neil S. Sheerin, Jimmy Wang, Laurent E. Weekers and Larry A. Greenbaum
    Citation: BMC Nephrology 2019 20:125
  28. Interleukin 17 is a proinflammatory cytokine involved in immune response after allograft transplantation. IL-17 family of proinflammatory cytokines includes IL-17A and IL-17F. Previous studies have demonstrated t...

    Authors: Leszek Domanski, Karolina Kłoda, Maciej Patrzyk, Magda Wisniewska, Krzysztof Safranow, Jerzy Sienko, Tadeusz Sulikowski, Marzena Staniszewska and Andrzej Pawlik
    Citation: BMC Nephrology 2019 20:124
  29. Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and mem...

    Authors: Yasunori Miyamoto, Kouichi Hirayama, Hiroshi Maruyama, Kentaro Ohgi, Mamiko Takayasu, Homare Shimohata and Masaki Kobayashi
    Citation: BMC Nephrology 2019 20:123
  30. The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal dise...

    Authors: Elliot K. Tannor, Betty R. Norman, Kwame K. Adusei, Fred S. Sarfo, Mogamat R. Davids and George Bedu-Addo
    Citation: BMC Nephrology 2019 20:122
  31. Little is known about salt taste dysfunction among hemodialysis (HD) patients. This study aimed to elucidate the prevalence of salt taste dysfunction and its relationship with interdialytic weight gain (IDWG) ...

    Authors: Mai Tanaka, Hiroki Nishiwaki, Hiroshi Kado, Yohei Doi, Chieko Ihoriya, Kenji Omae and Keiichi Tamagaki
    Citation: BMC Nephrology 2019 20:121
  32. Gastrointestinal stromal tumors (GISTs) in transplant recipients are very rare and only a handful of cases have been reported to date. Here we present the first known case of a huge GIST in a kidney transplant...

    Authors: Ryohei Takahashi, Kazunobu Shinoda, Takashi Ishida, Yasuo Hamamoto, Shinya Morita, Hirotaka Akita, Sotaro Kitaoka, Satoshi Tamaki, Hiroshi Asanuma, Tadashi Yoshida, Masahiro Jinzaki, Kaori Kameyama and Mototsugu Oya
    Citation: BMC Nephrology 2019 20:120
  33. Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. However, little is k...

    Authors: Hyo Jin Kim, Joongyub Lee, Dong-Wan Chae, Kyu-Beck Lee, Su Ah Sung, Tae-Hyun Yoo, Seung Hyeok Han, Curie Ahn and Kook-Hwan Oh
    Citation: BMC Nephrology 2019 20:119
  34. Although several epidemiological studies have suggested that high serum uric acid (SUA) levels are related to a decline in kidney function, only a few studies have investigated using cystatin C to calculate es...

    Authors: Sachimi Kubo, Yoko Nishida, Yoshimi Kubota, Aya Higashiyama, Daisuke Sugiyama, Takumi Hirata, Naomi Miyamatsu, Ayumi Tanabe, Aya Hirata, Yukako Tatsumi, Aya Kadota, Kazuyo Kuwabara, Tomofumi Nishikawa, Yoshihiro Miyamoto and Tomonori Okamura
    Citation: BMC Nephrology 2019 20:117
  35. Patient-reported measures are increasingly recognized as important predictors of clinical outcomes in peritoneal dialysis (PD). We sought to understand associations between patient-reported perceptions of the ...

    Authors: Nidhi Sukul, Junhui Zhao, Douglas S. Fuller, Angelo Karaboyas, Brian Bieber, James A. Sloand, Lalita Subramanian, David W. Johnson, Matthew J. Oliver, Kriang Tungsanga, Tadashi Tomo, Rachael L. Morton, Hal Morgenstern, Bruce M. Robinson and Jeffrey Perl
    Citation: BMC Nephrology 2019 20:116
  36. Blood urea nitrogen (BUN) is one of the substances that affects the calculated serum osmolality (cSosm). A previous study demonstrated that BUN and cSosm were independently associated with the development of c...

    Authors: Makiko Seki, Masaru Nakayama, Teppei Sakoh, Ryota Yoshitomi, Akiko Fukui, Eisuke Katafuchi, Susumu Tsuda, Toshiaki Nakano, Kazuhiko Tsuruya and Takanari Kitazono
    Citation: BMC Nephrology 2019 20:115
  37. Calciphylaxis is a life threatening complication in renal patients. Of great importance is the identification of concomitant factors for calciphylaxis. Due to the variability of clinical presentation the evalu...

    Authors: Philipp Russ, Martin Russwurm, Birgit Kortus-Goetze, Joachim Hoyer and Sahana Kamalanabhaiah
    Citation: BMC Nephrology 2019 20:114
  38. Self-management education needs have not been assessed in patients with complex co-morbid conditions such as diabetes and chronic kidney disease (CKD). The objectives of this study were to 1) determine the sel...

    Authors: Edward Zimbudzi, Clement Lo, Peter G. Kerr and Sophia Zoungas
    Citation: BMC Nephrology 2019 20:113
  39. Health-related quality of life (HRQOL) is a key outcome for dialysis patients, and its assessment is mandated by the Centers for Medicaid and Medicare Services. The Kidney Disease Quality of Life (KDQOL-36™) s...

    Authors: Dena E. Cohen, Andrew Lee, Scott Sibbel, Deborah Benner, Steven M. Brunelli and Francesca Tentori
    Citation: BMC Nephrology 2019 20:112

    The Correction to this article has been published in BMC Nephrology 2019 20:461

    The Correspondence to this article has been published in BMC Nephrology 2019 20:447

  40. Natalina Tomilina, a pioneer of Russian nephrology, is a clinician, researcher, teacher, organizer, leader, and a real pioneer, who has worked in nephrology from the very beginning of its development in Russia...

    Authors: Elena Zakharova
    Citation: BMC Nephrology 2019 20:111
  41. The Kidney Failure Risk Equation (KFRE) predicts risk of progression to kidney failure and is used to guide clinical decisions for patients with chronic kidney disease (CKD).

    Authors: Michelle D. Smekal, Helen Tam-Tham, Juli Finlay, Maoliosa Donald, Chandra Thomas, Robert G. Weaver, Robert R. Quinn, Kin Tam, Braden J. Manns, Marcello Tonelli, Aminu Bello, Navdeep Tangri and Brenda R. Hemmelgarn
    Citation: BMC Nephrology 2019 20:110
  42. Prospective studies combining physical functioning (PF), physical activity (PA), and body composition (BC) after living donor transplantation/donation are scarce. We aimed to study differences in these paramet...

    Authors: Natascha J. H. Broers, Tsz Yeung Fung, Jeroen P. Kooman and Maarten H. L. Christiaans
    Citation: BMC Nephrology 2019 20:109
  43. Maximal conservative management (MCM) may be an appropriate alternative option for dialysis in some elderly patients with end-stage kidney disease (ESKD). Evidence about the impact of dialysis or MCM on qualit...

    Authors: I. N. van Loon, N. A. Goto, F. T. J. Boereboom, M. C. Verhaar, M. L. Bots and M. E. Hamaker
    Citation: BMC Nephrology 2019 20:108
  44. In southern Europe, the risk of cancer in patients with end-stage kidney disease receiving dialysis has not been well quantified. The aim of this study was to assess the overall pattern of risk for de novo mal...

    Authors: Martina Taborelli, Federica Toffolutti, Stefania Del Zotto, Elena Clagnan, Lucrezia Furian, Pierluca Piselli, Franco Citterio, Loris Zanier, Giuliano Boscutti and Diego Serraino
    Citation: BMC Nephrology 2019 20:107
  45. To establish a model of chronic renal fibrosis following acute kidney injury (AKI) in BALB/c mice and to observe the effect of AKI on podocyte injury and chronic fibrosis of the kidney. Additional aims include...

    Authors: Yi Chen, Liyu Lin, Xuan Tao, Yankun Song, Jiong Cui and Jianxin Wan
    Citation: BMC Nephrology 2019 20:106
  46. Sarcopenia has become a serious disorder in modern society. Chronic kidney disease requiring dialysis and diabetes are some of the disorders that accelerate the onset and progression of sarcopenia. We, therefo...

    Authors: Katsuhito Mori, Kozo Nishide, Senji Okuno, Tetsuo Shoji, Masanori Emoto, Akihiro Tsuda, Shinya Nakatani, Yasuo Imanishi, Eiji Ishimura, Tomoyuki Yamakawa, Shigeichi Shoji and Masaaki Inaba
    Citation: BMC Nephrology 2019 20:105
  47. Guidelines for general hypertension treatment do not recommend the combined use of renin-angiotensin-aldosterone system (RAAS) inhibitors due to the risk of hyperkalemia. However, a recent clinical trial showe...

    Authors: Hyoungnae Kim, Seohyun Park, Jong Hyun Jhee, Hae-Ryong Yun, Jung Tak Park, Seung Hyeok Han, Joongyub Lee, Soo Wan Kim, Yeong Hoon Kim, Yun Kyu Oh, Shin-Wook Kang, Kyu Hun Choi and Tae-Hyun Yoo
    Citation: BMC Nephrology 2019 20:104
  48. Chronic kidney disease-associated pruritus (CKD-aP) is a well-recognized, frequent and compromising complication among patients on hemodialysis. Despite advancement in basic medical sciences, CKD-aP is still a...

    Authors: Inayat Ur Rehman, Pauline Siew Mei Lai, Soo Kun Lim, Learn Han Lee and Tahir Mehmood Khan
    Citation: BMC Nephrology 2019 20:102

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