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  1. Left ventricular hypertrophy (LVH) increases the risk of death in chronic kidney disease (CKD). The transcription factor Kruppel-like factor 15 (KLF15) is expressed in the heart and regulates cardiac remodelli...

    Authors: Sheila K. Patel, Elena Velkoska, Daniel Gayed, Jay Ramchand, Jessica Lesmana and Louise M. Burrell
    Citation: BMC Nephrology 2018 19:159
    Content type: Research article Published on:

  2. Although fatigue is common in dialysis patients, polypharmacy is seldom listed among its causes. In this report, we describe a dialysis patient who developed severe fatigue due to pharmacological interaction b...

    Authors: Emanuela Cataldo, Valeria Columbano, Louise Nielsen, Lurlynis Gendrot, Bianca Covella and Giorgina Barbara Piccoli
    Citation: BMC Nephrology 2018 19:155
    Content type: Case report Published on:

  3. Conversion from calcineurin inhibitor (CNI) therapy to everolimus within 6 months after kidney transplantation improves long-term graft function but can increase the risk of mild biopsy-proven acute cellular r...

    Authors: Ute Eisenberger, Klemens Budde, Frank Lehner, Claudia Sommerer, Petra Reinke, Oliver Witzke, Rudolf P. Wüthrich, Rolf Stahl, Katharina Heller, Barbara Suwelack, Anja Mühlfeld, Ingeborg A. Hauser, Silvio Nadalin, Martina Porstner and Wolfgang Arns
    Citation: BMC Nephrology 2018 19:154
    Content type: Research article Published on:

  4. Peritonitis secondary to bowel perforation is a rare and potentially fatal complication in peritoneal dialysis (PD) patients. However, the early diagnosis of bowel perforation is difficult in PD patients becau...

    Authors: Kentaro Fujii, Naoki Washida, Eri Arai, Masashi Tsuruta, Shu Wakino and Hiroshi Itoh
    Citation: BMC Nephrology 2018 19:153
    Content type: Case report Published on:

  6. For patients with end-stage renal failure (ESFR), thrice-weekly hemodialysis is a standard care. Once-weekly hemodialysis combined with low-protein and low-salt dietary treatment (OWHD-DT) have been rarely stu...

    Authors: Toshiyuki Nakao, Yoshie Kanazawa and Toshimasa Takahashi
    Citation: BMC Nephrology 2018 19:151
    Content type: Research article Published on:

  7. Hematuria is associated with chronic kidney disease (CKD), but has rarely been examined as a risk factor for CKD progression. We explored whether individuals with hematuria had worse outcomes compared to those...

    Authors: Paula F. Orlandi, Naohiko Fujii, Jason Roy, Hsiang-Yu Chen, L. Lee Hamm, James H. Sondheimer, Jiang He, Michael J. Fischer, Hernan Rincon-Choles, Geetha Krishnan, Raymond Townsend, Tariq Shafi, Chi-yuan Hsu, John W. Kusek, John T. Daugirdas and Harold I. Feldman
    Citation: BMC Nephrology 2018 19:150
    Content type: Research article Published on:

  8. The Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury (AKI) guidelines assign the same stage of AKI to patients whether they fulfil urine output criteria, serum creatinine criteria or both ...

    Authors: Samuel H. Howitt, Stuart W. Grant, Camila Caiado, Eric Carlson, Dowan Kwon, Ioannis Dimarakis, Ignacio Malagon and Charles McCollum
    Citation: BMC Nephrology 2018 19:149
    Content type: Research article Published on:

  9. It has been suggested that C3 glomerulonephritis (C3GN) and atypical hemolytic-uremic syndrome (a stereotypical phenotype of thrombotic microangiopathy), two rare entities caused by complement alternative path...

    Authors: Jiqiu Wen, Wei Wang, Feng Xu, Jun Sun, Jinsong Chen and Xuefeng Ni
    Citation: BMC Nephrology 2018 19:148
    Content type: Case report Published on:

  10. There are no guidelines for transitioning patients from chronic kidney disease stage 5 to hemodialysis. We conducted this study to determine if there are uniform patterns in how nephrologists transition patien...

    Authors: Mary C. Mallappallil, Steven Fishbane, Rimda Wanchoo, Edgar Lerma, Andrea Roche-Recinos and Moro Salifu
    Citation: BMC Nephrology 2018 19:147
    Content type: Research article Published on:

  11. Chronic kidney disease (CKD) is highly prevalent but identification of patients at high risk for fast CKD progression before reaching end-stage renal disease in the short-term has been challenging. Whether fac...

    Authors: Alan S. Go, Jingrong Yang, Thida C. Tan, Claudia S. Cabrera, Bergur V. Stefansson, Peter J. Greasley and Juan D. Ordonez
    Citation: BMC Nephrology 2018 19:146
    Content type: Research article Published on:

  12. Neutrophil extracellular traps (NETs) are web-like DNA decorated with antimicrobial proteins, such as myeloperoxidase (MPO), which are extruded from activated neutrophils. Although NETs are essential in innate...

    Authors: Haruki Shida, Nobuhiro Hashimoto, Yoshihiro Kusunoki, Fumihiko Hattanda, Yayoi Ogawa, Terumasa Hayashi, Daigo Nakazawa, Sakiko Masuda, Utano Tomaru and Akihiro Ishizu
    Citation: BMC Nephrology 2018 19:145
    Content type: Case report Published on:

  13. Arthrogryposis-Renal dysfunction-Cholestasis syndrome (ARC, MIM#208085) is a rare multisystem disease due to mutations in the VPS33B and VIPAR genes, both involved in maintaining apical-basolateral cell polarity....

    Authors: Alejandra Rosales, Maissa Mhibik, Paul Gissen, Oscar Segarra, Susana Redecillas and Gema Ariceta
    Citation: BMC Nephrology 2018 19:144
    Content type: Case report Published on:

  14. Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseas...

    Authors: Shuma Hirashio, Takahiro Arima, Ayaka Satoh, Kouichi Mandai, Shigeo Hara and Takao Masaki
    Citation: BMC Nephrology 2018 19:143
    Content type: Case report Published on:

  15. The patients with secondary hyperparathyroidism (SHPT) usually had reduced bone mineral density, which might lead to a substantial increase in osteoporosis, fracture and mortality. Although surgical interventi...

    Authors: Li Fang, Jining Wu, Jing Luo, Ping Wen, Mingxia Xiong, Jinlong Cao, Xiaolan Chen and Junwei Yang
    Citation: BMC Nephrology 2018 19:142
    Content type: Research article Published on:

  16. This study describes the time trend of renal replacement therapy for end-stage renal disease (ESRD) in the Provence-Alpes Côte d’Azur region (PACA) between 2004 and 2015, and forecasts up to 2030.

    Authors: Anne-Claire Durand, Elisabeth Jouve, Jean-Christophe Delarozière, Mohamed Boucekine, Ghizlane Izaaryene, Adeline Crémades, Franck Mazoué, Bénédicte Devictor, Asmatullah Kakar, Roland Sambuc, Philippe Brunet and Stéphanie Gentile
    Citation: BMC Nephrology 2018 19:141
    Content type: Research article Published on:

  17. The mechanism of podocyte apoptosis is not fully understood. In addition, the role of the inositol 1,4,5-triphosphate receptor (IP3R)/glucose-regulated protein 75 (Grp75)/voltage-dependent anion channel 1 (VDAC1)...

    Authors: Han Xu, Na Guan, Ya-Li Ren, Qi-Jiao Wei, Ying-Hong Tao, Guo-Sheng Yang, Xiao-Ya Liu, Ding-Fang Bu, Ying Zhang and Sai-Nan Zhu
    Citation: BMC Nephrology 2018 19:140
    Content type: Research article Published on:

  18. Chronic kidney disease (CKD) is global health concern and priority. It is the 12th leading cause of death worldwide. Protein Energy Wasting occurs in 20–25% of patients with chronic kidney disease and can lead...

    Authors: Lydia Namuyimbwa, Collins Atuheire, Joel Okullo and Robert Kalyesubula
    Citation: BMC Nephrology 2018 19:139
    Content type: Research article Published on:

  19. Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical charact...

    Authors: Liu Yang, Honglang Xie, Zhengzhao Liu, Yinghua Chen, Jinquan Wang, Haitao Zhang, Yongchun Ge and Weixin Hu
    Citation: BMC Nephrology 2018 19:138
    Content type: Research article Published on:

  20. Thermometers that measure core (internal) body temperature are the gold standard for monitoring temperature. Despite that most modern hemodialysis machines are equipped with an internal blood monitor that meas...

    Authors: Meaghan Lunney, Bronwyn Tonelli, Rachel Lewis, Natasha Wiebe, Chandra Thomas, Jennifer MacRae and Marcello Tonelli
    Citation: BMC Nephrology 2018 19:137
    Content type: Research article Published on:

  21. Renal replacement therapy (RRT) with regional citrate anticoagulation (RCA) is an important therapeutic approach for refractory hypercalcemia complicated with renal failure. However, RCA has the potential to i...

    Authors: Buyun Wu, Jing Wang, Guang Yang, Changying Xing and Huijuan Mao
    Citation: BMC Nephrology 2018 19:136
    Content type: Case report Published on:

  22. A combination of safety concerns and labeling changes impacted use of erythropoiesis-stimulating agents (ESAs) in renal anemia. Data regarding contemporary utilization in pre-dialysis chronic kidney disease (C...

    Authors: Heide A. Stirnadel-Farrant, Jiacong Luo, Lata Kler, Borut Cizman, Delyth Jones, Steven M. Brunelli and Alexander R. Cobitz
    Citation: BMC Nephrology 2018 19:135
    Content type: Research article Published on:

  23. The high mortality and cardiovascular disease (CVD) burden in patients with end-stage renal disease (ESRD) is well-documented. Recent literature suggests that acute kidney injury is also associated with CVD. I...

    Authors: Benjamin J. Lee, Chi-yuan Hsu, Rishi V. Parikh, Thomas K. Leong, Thida C. Tan, Sophia Walia, Kathleen D. Liu, Raymond K. Hsu and Alan S. Go
    Citation: BMC Nephrology 2018 19:134
    Content type: Research article Published on:

  24. Sickle cell trait is not completely benign, and some renal complications can occur. The baseline rate of admission for gross hematuria in normal males carrying the sickle cell trait is 2%.

    Authors: Alexandre Le Joncour, Laurent Mesnard, Alexandre Hertig and Thomas Robert
    Citation: BMC Nephrology 2018 19:133
    Content type: Case report Published on:

  25. Catastrophic antiphospholipid syndrome (CAPS) is a rare, life-threatening form of antiphospholipid syndrome (APS) involving many organs and leading to their insufficiency. The pathogenesis of CAPS is associate...

    Authors: Aleksandra Rymarz and Stanisław Niemczyk
    Citation: BMC Nephrology 2018 19:132
    Content type: Case report Published on:

  26. Female sex has been included as a risk factor in models developed to predict the risk of acute kidney injury (AKI) associated with cardiac surgery, aminoglycoside nephrotoxicity and contrast-induced nephropath...

    Authors: Joel Neugarten, Ladan Golestaneh and Nitin V. Kolhe
    Citation: BMC Nephrology 2018 19:131
    Content type: Research article Published on:

  27. Efforts are underway to improve living kidney donor (LKD) education, but current LKD concerns and information-gathering preferences have not been ascertained to inform evidence-based resource development. As a...

    Authors: Jessica M. Ruck, Sarah E. Van Pilsum Rasmussen, Macey L. Henderson, Allan B. Massie and Dorry L. Segev
    Citation: BMC Nephrology 2018 19:130
    Content type: Research article Published on:

  28. Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stoppin...

    Authors: Juana Alonso-Titos, Lara Perea-Ortega, Eugenia Sola, Alvaro Torres-Rueda, Myriam León, Remedios Toledo, Ana D. Duarte, Teresa Vazquez, Maria Dolores Martinez-Esteban, Alicia Bailen, Pedro Ruiz-Esteban and Domingo Hernandez
    Citation: BMC Nephrology 2018 19:129
    Content type: Case report Published on:

  29. The 2014 Consensus Conference on Best Practices in Living Kidney Donations recognized live donor kidney transplantation as the best treatment for late-stage kidney disease, yielding superior graft and patient ...

    Authors: Walter G. Wasser, Geoffrey Boner, Meni Koslowsky and Adi Lazar
    Citation: BMC Nephrology 2018 19:128
    Content type: Research article Published on:

  30. Diabetic nephropathy requires periodic monitoring, dietary modification, and early intervention to prevent the disease severity within limited resource settings. To emphasize the importance of continuous care ...

    Authors: Yun Jung Jang, Yoon Soo Choy, Chung Mo Nam, Ki Tae Moon and Eun-Cheol Park
    Citation: BMC Nephrology 2018 19:127
    Content type: Research article Published on:

  31. Patient activation is associated with better outcomes and lower costs. Although the concept is widely investigated, little attention was given to patient activation and its predictors in patients undergoing he...

    Authors: Liesbet Van Bulck, Kathleen Claes, Katrien Dierickx, Annelies Hellemans, Sofie Jamar, Sven Smets and Gijs Van Pottelbergh
    Citation: BMC Nephrology 2018 19:126
    Content type: Research article Published on:

  32. Accurate contemporary data on the burden of Chronic Kidney Disease (CKD) on the African continent are lacking. We determined the prevalence of CKD in adult populations living in Africa, and variations by stage...

    Authors: Arnaud D. Kaze, Titilayo Ilori, Bernard G. Jaar and Justin B. Echouffo-Tcheugui
    Citation: BMC Nephrology 2018 19:125
    Content type: Research article Published on:

  33. People with chronic renal disease are insulin resistant. We hypothesized that in a healthy population, baseline renal function is associated with insulin sensitivity three years later.

    Authors: Soline Siméon, Ziad Massy, Kurt Højlund, Katarina Lalic, Francesca Porcellati, Jacqueline Dekker, John Petrie, Gemma Currie and Beverley Balkau
    Citation: BMC Nephrology 2018 19:124
    Content type: Research article Published on:

  34. Epithelioid angiomyolipoma is defined as potentially malignant mesenchymal neoplasm, characterized by proliferating epithelioid cells, whereas classic angiomyolipoma, composed of fat, smooth muscle cells and d...

    Authors: Jan Tuma, Holger Moch, Gerd Stuckmann, Walter Gysel and Andreas L. Serra
    Citation: BMC Nephrology 2018 19:123
    Content type: Case report Published on:

  35. Liddle’s syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome prese...

    Authors: Eriko Yamaguchi, Kazuhiro Yoshikawa, Izaya Nakaya, Karen Kato, Yoshikazu Miyasato, Terumasa Nakagawa, Yutaka Kakizoe, Masashi Mukoyama and Jun Soma
    Citation: BMC Nephrology 2018 19:122
    Content type: Case report Published on:

  36. Inadequate volume control may be a main contributor to poor survival and high mortality in hemodialysis patients. Bioimpedance measurement has the potential to improve fluid management, but several dialysis ce...

    Authors: Jenny Stenberg, Catrin Henriksson, Magnus Lindberg and Hans Furuland
    Citation: BMC Nephrology 2018 19:121
    Content type: Research article Published on:

  37. Podocyte phospholipase A2 receptor (PLA2R) is a major target antigen in idiopathic adult membranous nephropathy (MN). Histological PLA2R staining in the renal tissue has proven to be useful for the detection of i...

    Authors: Kenta Tominaga, Takahiro Uchida, Toshihiko Imakiire, Kenji Itoh, Hideyuki Shimazaki, Kuniaki Nakanishi, Hiroo Kumagai and Naoki Oshima
    Citation: BMC Nephrology 2018 19:120
    Content type: Case report Published on:

  38. Both peritoneal small solute transport and peritoneal protein clearance are closely linked to outcomes in peritoneal dialysis (PD) patients. However, the associated factors of these two components are not full...

    Authors: Yuanyuan Shi, Hao Yan, Jiangzi Yuan, He Zhang, Jiaying Huang, Zhaohui Ni, Jiaqi Qian and Wei Fang
    Citation: BMC Nephrology 2018 19:119
    Content type: Research article Published on:

  40. There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angio...

    Authors: Christopher E. Anderson, L. Lee Hamm, Gem Batuman, Damodar R. Kumbala, Chung-Shiuan Chen, Swapna G. Kallu, Ravi Siriki, Shilpa Gadde, Myra A. Kleinpeter, N. Kevin Krane, Eric E. Simon, Jiang He and Jing Chen
    Citation: BMC Nephrology 2018 19:117
    Content type: Research article Published on:

  41. The magnitude effects of human leukocyte antigen (HLA) mismatching on post-transplant outcomes of kidney transplantation remain controversial. We aim to quantitatively assess the associations of HLA mismatchin...

    Authors: Xinmiao Shi, Jicheng Lv, Wenke Han, Xuhui Zhong, Xinfang Xie, Baige Su and Jie Ding
    Citation: BMC Nephrology 2018 19:116
    Content type: Research article Published on:

  42. Chronic kidney disease of unknown origin (CKDu) in Sri Lanka is grouped with several other epidemics of similar nature across the world as Chronic Interstitial Nephritis in Agricultural Communities (CINAC). In...

    Authors: S. B. Agampodi, G. S. Amarasinghe, P. G. C. R. Naotunna, C. S. Jayasumana and S. H. Siribaddana
    Citation: BMC Nephrology 2018 19:115
    Content type: Research article Published on:

  43. About 40–50% of patients with familial microscopic hematuria (FMH) caused by thin basement membrane nephropathy (TBMN) inherit heterozygous mutations in collagen IV genes (COL4A3, COL4A4). On long follow-up, the ...

    Authors: Konstantinos Voskarides, Gregory Papagregoriou, Despina Hadjipanagi, Ioanelli Petrou, Isavella Savva, Avraam Elia, Yiannis Athanasiou, Androulla Pastelli, Maria Kkolou, Michalis Hadjigavriel, Christoforos Stavrou, Alkis Pierides and Constantinos Deltas
    Citation: BMC Nephrology 2018 19:114
    Content type: Research article Published on:

  44. The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to as...

    Authors: Irene Ruderman, Edward R. Smith, Nigel D. Toussaint, Tim D. Hewitson and Stephen G. Holt
    Citation: BMC Nephrology 2018 19:113
    Content type: Research article Published on:

  45. Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a seve...

    Authors: Andreea Corina Sofronie, Isabelle Kooij, Claude Bursot, Giulia Santagati, Jean-Philippe Coindre and Giorgina Barbara Piccoli
    Citation: BMC Nephrology 2018 19:112
    Content type: Case report Published on:

  46. Lipodystrophy syndromes are rare disorders of variable body fat loss associated with potentially serious metabolic complications. Familial partial lipodystrophy (FPLD) is mostly inherited as an autosomal domin...

    Authors: Ru-Xuan Chen, Lei Zhang, Wei Ye, Yu-Bing Wen, Nuo Si, Hang Li, Ming-Xi Li, Xue-Mei Li and Ke Zheng
    Citation: BMC Nephrology 2018 19:111
    Content type: Case report Published on:

  47. The impact of the low-protein diet on nutrition in CKD diabetics is uncertain.

    Authors: Vincenzo Bellizzi, Patrizia Calella, Julia Nava Hernández, Verónica Figueroa González, Silvia Moran Lira, Serena Torraca, Rocio Urbina Arronte, Pietro Cirillo, Roberto Minutolo and Rafael A. Montúfar Cárdenas
    Citation: BMC Nephrology 2018 19:110
    Content type: Research article Published on:

  48. This study aimed to evaluate the longitudinal changes in cardiac structure and function in incident-automated peritoneal dialysis (APD) patients.

    Authors: Jin-Bor Chen, Ben-Chung Cheng, Wen-Hao Liu, Shang-Chih Liao, Mao-Young Morgan Fu, Sin-Hua Moi and Cheng-Hong Yang
    Citation: BMC Nephrology 2018 19:109
    Content type: Research article Published on:

  49. Monoclonal gammopathy causes several kinds of renal pathology. A rare and special form is monoclonal gammopathy-induced C3 glomerulopathy (MG-C3G). Like idiopathic C3G, MG-C3G frequently leads to end-stage ren...

    Authors: Philipp Moog, Philipp J. Jost and Maike Büttner-Herold
    Citation: BMC Nephrology 2018 19:106
    Content type: Case report Published on:

  50. Calcineurin inhibitor induced nephrotoxicity contributes to late allograft failure in kidney transplant patients. Evidence points towards aldosterone to play a role in the development of fibrosis in multiple o...

    Authors: Line Aas Mortensen, Helle C. Thiesson, Birgitte Tougaard, Martin Egfjord, Anne Sophie Lind Fischer and Claus Bistrup
    Citation: BMC Nephrology 2018 19:105
    Content type: Study protocol Published on:
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