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  1. Hyperuricemia is prevalent in patients with chronic kidney disease (CKD). We explored the hypothesis that asymptmatic hyperuricemia may be associated with new-onset CKD.

    Authors: Masatoshi Kawashima, Koji Wada, Hiroshi Ohta, Hiroyuki Terawaki and Yoshiharu Aizawa

    Citation: BMC Nephrology 2011 12:31

    Content type: Research article

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  2. Animal and human studies suggest that inflammation and malnutrition are common in acute kidney injury (AKI) patients. However, only a few studies reported CRP, a marker of inflammation, albumin, prealbumin and...

    Authors: Qionghong Xie, Ying Zhou, Zhongye Xu, Yanjiao Yang, Dingwei Kuang, Huaizhou You, Shuai Ma, Chuanming Hao, Yong Gu, Shanyan Lin and Feng Ding

    Citation: BMC Nephrology 2011 12:30

    Content type: Research article

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  3. Coping with the stresses of chronic disease is considered as a key factor in the perceived impairment of health related quality of life (HRQL). Little is known though about these associations in chronic kidney...

    Authors: Anna Kaltsouda, Petros Skapinakis, Dimitrios Damigos, Margarita Ikonomou, Rigas Kalaitzidis, Venetsanos Mavreas and Kostas C Siamopoulos

    Citation: BMC Nephrology 2011 12:28

    Content type: Research article

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  4. Renal kallikrein (KLK1) synthesis and urinary excretion are reportedly diminished during AKI (acute kidney injury) in animal models, and provision of kallikrein abrogates renal injury in this setting, but data...

    Authors: Sun Woo Kang, Pei-an Betty Shih, Roy O Mathew, Manjula Mahata, Nilima Biswas, Fangwen Rao, Liying Yan, Josee Bouchard, Rakesh Malhotra, Ashita Tolwani, Srikrishna Khandrika, Ravindra L Mehta and Daniel T O'Connor

    Citation: BMC Nephrology 2011 12:27

    Content type: Research article

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  5. Pulmonary-renal syndrome associated with anti-glomerular basement membrane (GBM) antibodies, also known as Goodpasture's syndrome, is a rare but acute and life-threatening condition. One third of patients pres...

    Authors: Christoph Etter, Ariana Gaspert, Stephan Regenass, Rudolf P Wüthrich, Thomas Kistler, Renate Kain and Clemens D Cohen

    Citation: BMC Nephrology 2011 12:26

    Content type: Case report

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  6. Primary hyperoxaluria type I (PH1) is a rare genetic disorder characterized by allelic and clinical heterogeneity. Four mutations (G170R, 33_34insC, I244T and F152I) account for more than 50% of PH1 alleles an...

    Authors: Ibtihel Benhaj Mbarek, Saoussen Abroug, Asma Omezzine, Dorsaf Zellama, Abdellatif Achour, Abdelaziz Harbi and Ali Bouslama

    Citation: BMC Nephrology 2011 12:25

    Content type: Research article

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  7. Circulating 25-hydroxyvitamin D [25(OH)D] concentration is inversely associated with peripheral arterial disease and hypertension. Vascular remodeling may play a role in this association, however, data relatin...

    Authors: Haimanot Wasse, Francesca Cardarelli, Christine De Staercke, Craig Hooper, Emir Veledar and Idris Guessous

    Citation: BMC Nephrology 2011 12:24

    Content type: Research article

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  8. Increased plasma levels of cellular adhesion molecules (CAMs) have been shown to be predictors of all cause mortality in individuals with chronic renal failure [1, 2] and patients with end-stage renal disease rec...

    Authors: Grainne M Connolly, Ronan Cunningham, Peter T McNamee, Ian S Young and Alexander P Maxwell

    Citation: BMC Nephrology 2011 12:23

    Content type: Research article

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  9. A key goal of anemia management in dialysis patients is to maintain patients' hemoglobin (Hb) levels consistently within a target range. Our aim in this study was to assess the association of facility-level pr...

    Authors: Irfan Khan, Mahesh Krishnan, Anupam Kothawala and Akhtar Ashfaq

    Citation: BMC Nephrology 2011 12:22

    Content type: Research article

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  10. Human leukocyte antigen (HLA) alleles are associated with many autoimmune diseases, including anti-glomerular basement membrane (GBM) disease. In our previous study, it was demonstrated that HLA-DRB1*1501 was ...

    Authors: Huan Luo, Min Chen, Zhao Cui, Rui Yang, Peng-Cheng Xu, Xu-Jie Zhou and Ming-Hui Zhao

    Citation: BMC Nephrology 2011 12:21

    Content type: Research article

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  11. Aluminium-containing phosphate binders have long been used for treatment of hyperphosphatemia in dialysis patients. Their safety became controversial in the early 1980's after reports of aluminium related neur...

    Authors: David W Mudge, David W Johnson, Carmel M Hawley, Scott B Campbell, Nicole M Isbel, Carolyn L van Eps and James JB Petrie

    Citation: BMC Nephrology 2011 12:20

    Content type: Debate

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  12. Macrocytosis occurs in chronic hemodialysis (CHD) patients; however, its significance is unknown. The purpose of this study was to establish the prevalence and distribution of macrocytosis, to identify its cli...

    Authors: Karthik K Tennankore, Steven D Soroka, Kenneth A West and Bryce A Kiberd

    Citation: BMC Nephrology 2011 12:19

    Content type: Research article

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  13. Subclinical inflammation is a common phenomenon in patients on either continuous ambulatory peritoneal dialysis (CAPD) or maintenance hemodialysis (MHD). We hypothesized that vitamin C had anti-inflammation ef...

    Authors: Kunying Zhang, Li Liu, Xuyang Cheng, Jie Dong, Qiuming Geng and Li Zuo

    Citation: BMC Nephrology 2011 12:18

    Content type: Research article

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  14. Previous studies of predictors of end-stage renal disease (ESRD) have limitations: (1) some focused on patients with clinically recognized chronic kidney disease (CKD); (2) others identified population-based p...

    Authors: Eric S Johnson, David H Smith, Micah L Thorp, Xiuhai Yang and Juhaeri Juhaeri

    Citation: BMC Nephrology 2011 12:17

    Content type: Research article

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  15. Extracorporeal lung assist devices are increasingly used in the intensive care unit setting to improve extracorporeal gas exchange mainly in patients with acute respiratory distress syndrome. ARDS is frequentl...

    Authors: Jan T Kielstein, Soeren Tolk, Carsten Hafer, Anna Heiden, Olaf Wiesner, Christian Kühn, Johannes Hadem, Marius M Hoeper and Stefan Fischer

    Citation: BMC Nephrology 2011 12:15

    Content type: Research article

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  16. A rapid decrease of serum potassium concentrations during haemodialysis produces a significant increase in blood pressure parameters at the end of the session, even if effects on intra-dialysis pressure are no...

    Authors: Luca Gabutti, Igor Salvadé, Barbara Lucchini, Davide Soldini and Michel Burnier

    Citation: BMC Nephrology 2011 12:14

    Content type: Research article

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  17. Anemia is common among peritoneal dialysis (PD) patients, and most patients require erythropoiesis-stimulating agents (ESA) to maintain their hemoglobin concentrations within current guideline recommendations....

    Authors: Mariano Feriani, Johan MJ De Meester, Lawrence P McMahon, Jacques B Rottembourg, Ian Bridges, Mourad Farouk and Wolfgang Pronai

    Citation: BMC Nephrology 2011 12:13

    Content type: Research article

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  18. Chronic kidney disease (CKD) is a common disorder associated with increased morbidity and mortality. Primary care physicians (PCPs) care for the majority of pre-dialysis CKD patients; however, PCPs often do no...

    Authors: Khaled Abdel-Kader, Gary S Fischer, James R Johnston, Chen Gu, Charity G Moore and Mark L Unruh

    Citation: BMC Nephrology 2011 12:12

    Content type: Research article

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  19. The increasing use of erythropoietins with long half-lives and the tendency to lengthen the administration interval to monthly injections call for raising awareness on the pharmacokinetics and risks of new ery...

    Authors: Luca Gabutti, Filippo Nobile, Valentina Forni, Fabio Rigamonti, Nadir Weibel and Michel Burnier

    Citation: BMC Nephrology 2011 12:11

    Content type: Research article

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  20. Many nephrology observational studies use renal registries, which have well known limitations. The Canadian Kidney Disease Cohort Study (CKDCS) is a large prospective observational study of patients commencing...

    Authors: Aminu K Bello, Ravi Thadhani, Brenda Hemmelgarn, Scott Klarenbach, John Gill, Christopher Chan, Deborah Zimmerman, Daniel Holmes, George Cembrowski, Dawn Opgenorth, Rafael Sibrian, Mohammad Karkhaneh, Sophanny Tiv, Natasha Wiebe and Marcello Tonelli

    Citation: BMC Nephrology 2011 12:10

    Content type: Study protocol

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  21. Hyperphosphatemia in patients with chronic kidney disease (CKD) contributes to secondary hyperparathyroidism, soft tissue calcification, and increased mortality risk. This trial was conducted to examine the ef...

    Authors: Wajeh Qunibi, Wolfgang C Winkelmayer, Richard Solomon, Moustafa Moustafa, Paul Kessler, Chiang-Hong Ho, Jonathan Greenberg and Jose A Diaz-Buxo

    Citation: BMC Nephrology 2011 12:9

    Content type: Research article

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  22. The lack of adequate randomized clinical trials (RCT) has hindered identification of new therapies that are safe and effective for patients with primary focal segmental glomerulosclerosis (FSGS), especially in...

    Authors: Howard Trachtman, Suzanne Vento, Debbie Gipson, Larysa Wickman, Jennifer Gassman, Melanie Joy, Virginia Savin, Michael Somers, Maury Pinsk and Tom Greene

    Citation: BMC Nephrology 2011 12:8

    Content type: Study protocol

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  23. In patients with Stage 5 Chronic Kidney Disease who require renal replacement therapy a major decision concerns modality choice. However, many patients defer the decision about modality choice or they have an ...

    Authors: Mary Ann Murray, Alison Thomas, Ron Wald, Rosa Marticorena, Sandra Donnelly and Lianne Jeffs

    Citation: BMC Nephrology 2011 12:7

    Content type: Study protocol

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  24. Poor adherence to treatment is common in patients on hemodialysis which may increase risk for poor clinical outcomes and mortality. Self management interventions have been shown to be effective in improving co...

    Authors: Konstadina Griva, Nandakumar Mooppil, Penny Seet, Deby Sarojiuy Pala Krishnan, Hayley James and Stanton P Newman

    Citation: BMC Nephrology 2011 12:4

    Content type: Study protocol

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  25. Defined as estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that...

    Authors: Ruth Dubin, Mary Cushman, Aaron R Folsom, Linda F Fried, Walter Palmas, Carmen A Peralta, Christina Wassel and Michael G Shlipak

    Citation: BMC Nephrology 2011 12:3

    Content type: Research article

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  26. A common variant of the UMOD gene was linked with prevalent chronic kidney disease (CKD) in large, genomics consortia. One community-based study found that urine concentrations of the uromodulin protein foreca...

    Authors: Michael G Shlipak, Yongmei Li, Caroline Fox, Josef Coresh, Carl Grunfeld and Mary Whooley

    Citation: BMC Nephrology 2011 12:2

    Content type: Research article

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  27. Primary care providers' suboptimal recognition of the severity of chronic kidney disease (CKD) may contribute to untimely referrals of patients with CKD to subspecialty care. It is unknown whether U.S. primary...

    Authors: Raquel C Greer, Neil R Powe, Bernard G Jaar, Misty U Troll and L Ebony Boulware

    Citation: BMC Nephrology 2011 12:1

    Content type: Research article

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  28. In Singapore, the prevalence of end-stage renal disease (ESRD) and the number of people on dialysis is increasing. The impact of ESRD on patient quality of life has been recognized as an important outcome meas...

    Authors: Veena D Joshi, Nandakumar Mooppil and Jeremy FY Lim

    Citation: BMC Nephrology 2010 11:36

    Content type: Research article

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  29. Compared to healthy people, patients with chronic kidney disease (CKD) participate less in paid jobs and social activities. The aim of the study was to examine a) the perceived autonomy, self-esteem and labor ...

    Authors: Daphne L Jansen, Diana C Grootendorst, Mieke Rijken, Monique Heijmans, Ad A Kaptein, Elisabeth W Boeschoten and Friedo W Dekker

    Citation: BMC Nephrology 2010 11:35

    Content type: Research article

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  30. The complement system is vital for innate immunity and is implicated in the pathogenesis of inflammatory diseases and the mechanism of host defense. Complement deficiencies occasionally cause life-threatening ...

    Authors: Hiroyuki Inoshita, Isao Ohsawa, Gaku Kusaba, Masaya Ishii, Kisara Onda, Satoshi Horikoshi, Hiroyuki Ohi and Yasuhiko Tomino

    Citation: BMC Nephrology 2010 11:34

    Content type: Research article

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  31. Low molecular weight (LMW) heparins are used for anticoagulation during hemodialysis (HD). Studies in animals have shown that LMW-heparins release lipoprotein lipase (LPL) as efficiently as unfractionated (UF)...

    Authors: Dana Mahmood, Maria Grubbström, Lennart DI Lundberg, Gunilla Olivecrona, Thomas Olivecrona and Bernd G Stegmayr

    Citation: BMC Nephrology 2010 11:33

    Content type: Research article

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  32. Minimization of hemodynamic instability during renal replacement therapy (RRT) in patients with acute kidney injury (AKI) is often challenging. We examined the relative hemodynamic tolerability of sustained lo...

    Authors: Heather E Fieghen, Jan O Friedrich, Karen E Burns, Rosane Nisenbaum, Neill K Adhikari, Michelle A Hladunewich, Stephen E Lapinsky, Robert M Richardson and Ron Wald

    Citation: BMC Nephrology 2010 11:32

    Content type: Research article

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  33. Bone Morphogenetic Protein (BMP)-7 is protective in different animal models of acute and chronic kidney disease. Its role in human kidneys, and in particular hypertensive nephrosclerosis, has thus far not been...

    Authors: Carsten P Bramlage, Björn Tampe, Michael Koziolek, Imad Maatouk, Jelena Bevanda, Peter Bramlage, Katharina Ahrens, Katharina Lange, Holger Schmid, Clemens D Cohen, Matthias Kretzler and Gerhard A Müller

    Citation: BMC Nephrology 2010 11:31

    Content type: Research article

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  34. Acute kidney injury (AKI) occurs commonly in the setting of orthotopic liver transplantation (OLT). To date, the correlation between AKI post-OLT and pre-operative changes in renal function has not been rigoro...

    Authors: Jose I Iglesias, John A DePalma and Jerrold S Levine

    Citation: BMC Nephrology 2010 11:30

    Content type: Research article

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  35. Previously the angiotensin II receptor blocker Irbesartan has been demonstrated to reduce the risk for progression from microalbuminuria to macroalbuminuria in type 2 diabetic patients. The purpose of this stu...

    Authors: Sten Andersen, Harald Mischak, Petra Zürbig, Hans-Henrik Parving and Peter Rossing

    Citation: BMC Nephrology 2010 11:29

    Content type: Research article

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  36. Treatment with prostaglandin inhibitors can reduce renal function and impair renal water and sodium excretion. We tested the hypotheses that a reduction in prostaglandin synthesis by ibuprofen treatment during...

    Authors: Thomas G Lauridsen, Henrik Vase, Jørn Starklint, Carolina C Graffe, Jesper N Bech, Søren Nielsen and Erling B Pedersen

    Citation: BMC Nephrology 2010 11:28

    Content type: Research article

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  37. Chronic kidney disease (CKD) is associated to a higher stroke risk. Anemia is a common consequence of CKD, and is also a possible risk factor for cerebrovascular diseases. The purpose of this study was to exam...

    Authors: Patrizia Del Fabbro, Jean-Christophe Luthi, Emmanuel Carrera, Patrik Michel, Michel Burnier and Bernard Burnand

    Citation: BMC Nephrology 2010 11:27

    Content type: Research article

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  38. The kidneys ability to concentrate and dilute urine is deteriorated during progressive renal insufficiency. We wanted to test the hypothesis that these phenomena could be attributed to an abnormal function of ...

    Authors: Erling B Pedersen, Ingrid M Thomsen and Thomas G Lauridsen

    Citation: BMC Nephrology 2010 11:26

    Content type: Research article

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  39. The main hypothesis of this study is that neutral pH, low glucose degradation product (GDP) peritoneal dialysis (PD) fluid better preserves residual renal function in PD patients over time compared with conven...

    Authors: David W Johnson, Margaret Clarke, Vanessa Wilson, Feidhlim Woods and Fiona G Brown

    Citation: BMC Nephrology 2010 11:25

    Content type: Study protocol

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  40. Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors. However, there is only little scie...

    Authors: Andreas A Schnitzbauer, Marcus N Scherer, Justine Rochon, Johannes Sothmann, Stefan A Farkas, Martin Loss, Edward K Geissler, Aiman Obed and Hans J Schlitt

    Citation: BMC Nephrology 2010 11:24

    Content type: Study protocol

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  41. Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ma...

    Authors: Panayiota Koupepidou, Kyriacos N Felekkis, Bettina Kränzlin, Carsten Sticht, Norbert Gretz and Constantinos Deltas

    Citation: BMC Nephrology 2010 11:23

    Content type: Research article

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    The Erratum to this article has been published in BMC Nephrology 2011 12:6

  42. The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitati...

    Authors: Alan S Go, Chirag R Parikh, T Alp Ikizler, Steven Coca, Edward D Siew, Vernon M Chinchilli, Chi-yuan Hsu, Amit X Garg, Michael Zappitelli, Kathleen D Liu, W Brian Reeves, Nasrollah Ghahramani, Prasad Devarajan, Georgia Brown Faulkner, Thida C Tan, Paul L Kimmel…

    Citation: BMC Nephrology 2010 11:22

    Content type: Study protocol

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  43. Performing clinical research among pediatric end-stage renal disease patients is challenging. Barriers to successful initiation and completion of clinical research projects include small sample sizes and resul...

    Authors: Susan M Samuel, Marcello A Tonelli, Bethany J Foster, Alberto Nettel-Aguirre, Yingbo Na, Robert Williams, Andrea Soo and Brenda R Hemmelgarn

    Citation: BMC Nephrology 2010 11:21

    Content type: Database

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  44. Since men with chronic kidney disease (CKD) progress faster than women, an accurate assessment of CKD progression rates should be based on gender differences in age-related decline of glomerular filtration rat...

    Authors: Rong Xu, Lu-Xia Zhang, Pu-Hong Zhang, Fang Wang, Li Zuo and Hai-Yan Wang

    Citation: BMC Nephrology 2010 11:20

    Content type: Research article

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  45. Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury. At least 70% of AIN is caused by various drugs, mainly penicillines and non-steroidal anti-inflammatory drugs. Quinol...

    Authors: Christos Chatzikyrkou, Iyas Hamwi, Christian Clajus, Jan Becker, Carsten Hafer and Jan T Kielstein

    Citation: BMC Nephrology 2010 11:19

    Content type: Case report

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  46. Chronic kidney disease (CKD) is associated with an increased risk of fracture. Decreased bone mass and disruption of microarchitecture occur early in the course of CKD and worsens with the progressive decline ...

    Authors: Sarah L West, Charmaine E Lok and Sophie A Jamal

    Citation: BMC Nephrology 2010 11:17

    Content type: Study protocol

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