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  1. Glycemic variability (GV) creates challenges to glycemic control and may be an independent marker for unfavorable outcome in management of patients with diabetes. This study was designed to investigate the eff...

    Authors: Fang Wei, Xiaolin Sun, Yingxin Zhao, Hua Zhang, Yutao Diao and Zhendong Liu
    Citation: BMC Nephrology 2016 17:67
  2. Podocyte apoptosis is a major mechanism that leads to proteinuria in many kidney diseases. However, the concert mechanisms that cause podocyte apoptosis in these kidney diseases are not fully understood. RhoA ...

    Authors: Zongshun Huang, Li Zhang, Yuanhan Chen, Hong Zhang, Chunping Yu, Fangjian Zhou, Zhiling Zhang, Lijuan Jiang, Ruizhao Li, Jianchao Ma, Zhuo Li, Yuxiong Lai, Ting Lin, Xinchen Zhao, Qianmei Zhang, Bin Zhang…
    Citation: BMC Nephrology 2016 17:66
  3. Malignant hypertension is a condition characterized by severe hypertension and multi-organ ischemic complications. Albeit mortality and renal survival have improved with antihypertensive therapy, progression t...

    Authors: Andrea Michelli, Stella Bernardi, Andrea Grillo, Emiliano Panizon, Matteo Rovina, Moreno Bardelli, Renzo Carretta and Bruno Fabris
    Citation: BMC Nephrology 2016 17:65
  4. U.S. hemodialysis patients with systemic lupus erythematosus (SLE) and end-stage renal disease (ESRD) are less likely than other ESRD patients to have a permanent vascular access (fistula or graft) in place at...

    Authors: Laura C. Plantinga, S. Sam Lim, Rachel E. Patzer, Stephen O. Pastan and Cristina Drenkard
    Citation: BMC Nephrology 2016 17:64
  5. Renal replacement therapy (RRT) is growing by 10 % per year in Russia, but pre-dialysis care which can retard CKD progression and delay the start of RRT remains limited. We evaluate the effect of Essential Ami...

    Authors: Alexander Zemchenkov and Irina N. Konakova
    Citation: BMC Nephrology 2016 17:62
  6. There are limited data on the trends of incidence or prevalence of end stage renal disease (ESRD) in China. To assist in future planning for the ESRD program, the trends of incidence, prevalence and health car...

    Authors: Ling Sun, Lu-Xi Zou, Yu-Chen Han, Han-Ming Huang, Zhao-Ming Tan, Min Gao, Kun-Ling Ma, Hong Liu and Bi-Cheng Liu
    Citation: BMC Nephrology 2016 17:60
  7. Diabetes mellitus (DM) is the leading cause of end-stage renal disease. Little is known about practice patterns of anti-diabetic therapy in the presence of chronic kidney disease (CKD) and correlates with glyc...

    Authors: Martin Busch, Jennifer Nadal, Matthias Schmid, Katharina Paul, Stephanie Titze, Silvia Hübner, Anna Köttgen, Ulla T. Schultheiss, Seema Baid-Agrawal, Johan Lorenzen, Georg Schlieper, Claudia Sommerer, Vera Krane, Robert Hilge, Jan T. Kielstein, Florian Kronenberg…
    Citation: BMC Nephrology 2016 17:59
  8. Cardiovascular complications represent a major cause of morbidity and mortality for patients who received kidney transplantation (KT). However, the impact of KT and chronic immunosuppression on platelet respon...

    Authors: Clotilde Muller, Nathan Messas, Peggy Perrin, Jerome Olagne, Gabriela Gautier-Vargas, Noelle Cognard, Sophie Caillard, Bruno Moulin and Olivier Morel
    Citation: BMC Nephrology 2016 17:58
  9. The capacity of electronic health record (EHR) data to guide targeted surveillance in chronic kidney disease (CKD) is unclear. We sought to leverage EHR data for predicting risk of progressing from CKD to end-...

    Authors: Yuxiang Xie, Marlena Maziarz, Delphine S. Tuot, Glenn M. Chertow, Jonathan Himmelfarb and Yoshio N. Hall
    Citation: BMC Nephrology 2016 17:57
  10. Illicit drug use is common and known to cause and exacerbate a wide spectrum of kidney disease, often leading to end-stage renal disease (ESRD), but little is known about its prevalence or associated mortality...

    Authors: Vanessa Grubbs, Eric Vittighoff, Barbara Grimes and Kirsten L. Johansen
    Citation: BMC Nephrology 2016 17:56
  11. Exertional heat stroke (EHS) is a life-threatening illness and leads to multi-organ dysfunction including acute kidney injury (AKI). The clinical significance of abnormal electrolytes and renal outcomes in ESH...

    Authors: Bancha Satirapoj, Suramanat Kongthaworn, Panbubpa Choovichian and Ouppatham Supasyndh
    Citation: BMC Nephrology 2016 17:55
  12. The 2011 expanded Prospective Payment System (PPS) and contemporaneous Food and Drug Administration label revision for erythropoiesis-stimulating agents (ESAs) were associated with changes in ESA use and mean ...

    Authors: James B. Wetmore, Spiros Tzivelekis, Allan J. Collins and Craig A. Solid
    Citation: BMC Nephrology 2016 17:53
  13. Cardiovascular calcifications can be prevented by vitamin K and are accelerated by vitamin K antagonists. These effects are believed to be mainly mediated by the vitamin K-dependent matrix Gla protein. Another...

    Authors: Nadine Kaesler, Svenja Immendorf, Chun Ouyang, Marjolein Herfs, Nadja Drummen, Peter Carmeliet, Cees Vermeer, Jürgen Floege, Thilo Krüger and Georg Schlieper
    Citation: BMC Nephrology 2016 17:52
  14. The influence of donor and recipient factors on outcomes following kidney transplantation is commonly analysed using Cox regression models, but this approach is not useful for predicting long-term survival bey...

    Authors: Bernadette Li, John A. Cairns, Matthew L. Robb, Rachel J. Johnson, Christopher J. E. Watson, John L. Forsythe, Gabriel C. Oniscu, Rommel Ravanan, Christopher Dudley, Paul Roderick, Wendy Metcalfe, Charles R. Tomson and J. Andrew Bradley
    Citation: BMC Nephrology 2016 17:51
  15. Health-care for co-morbid diabetes and chronic kidney disease (CKD) is often sub-optimal. To improve health-care, we explored the perspectives of general practitioners (GPs) and tertiary health-care profession...

    Authors: Clement Lo, Dragan Ilic, Helena Teede, Greg Fulcher, Martin Gallagher, Peter G Kerr, Kerry Murphy, Kevan Polkinghorne, Grant Russell, Timothy Usherwood, Rowan Walker and Sophia Zoungas
    Citation: BMC Nephrology 2016 17:50
  16. Silver is a transition metal, toxic when ingested in significant amounts, causing argyria (skin deposition) and argyrosis (eye deposition). It is excreted mainly via the gastrointestinal tract with only small ...

    Authors: Tamer Rezk, James Penton, Anna Stevenson, Mared Owen-Casey, Mark Little, John Cunningham and Alan D. Salama
    Citation: BMC Nephrology 2016 17:49
  17. Endothelial-to-mesenchymal transition (EndoMT) is a crucial event during kidney interstitial fibrosis and it is believed to be inhibited by netrin-1. Our aim was to determine the influence of netrin-1 on renal...

    Authors: Jiuxu Bai, Junfeng Hao, Xiaoling Zhang, Hanmin Cui, Jingming Han and Ning Cao
    Citation: BMC Nephrology 2016 17:47
  18. This study compared the combination of estimated glomerular filtration rate (eGFR) and urine albumin-to-creatinine ratio (UACR) vs. eGFR and urine protein reagent strip testing to determine chronic kidney dise...

    Authors: Yorihiko Koeda, Fumitaka Tanaka, Toshie Segawa, Mutsuko Ohta, Masaki Ohsawa, Kozo Tanno, Shinji Makita, Yasuhiro Ishibashi, Kazuyoshi Itai, Shin-ichi Omama, Toshiyuki Onoda, Kiyomi Sakata, Kuniaki Ogasawara, Akira Okayama and Motoyuki Nakamura
    Citation: BMC Nephrology 2016 17:46
  19. Sevelamer is an alternative to calcium carbonate for the treatment of hyperphosphatemia among non-dialysis dependent patients with chronic kidney disease (CKD). Although some studies show that it may reduce mo...

    Authors: Hai V. Nguyen, Saideep Bose and Eric Finkelstein
    Citation: BMC Nephrology 2016 17:45
  20. Haemodialysis (HD) is a life-sustaining treatment for patients with end-stage renal disease (ESRD). HD can bring about significant impairment in health-related quality of life (HRQOL) and outcomes. Therefore, ...

    Authors: Sa’ed H. Zyoud, Dala N. Daraghmeh, Diana O. Mezyed, Razan L. Khdeir, Mayas N. Sawafta, Nora A. Ayaseh, Ghada H. Tabeeb, Waleed M. Sweileh, Rahmat Awang and Samah W. Al-Jabi
    Citation: BMC Nephrology 2016 17:44
  21. This study aimed to investigate renal outcomes and their predictors in biopsy-proven hypertensive nephrosclerosis (HN) patients and to compare clinico-pathological characteristics and prognoses between benign ...

    Authors: Shaoshan Liang, Weibo Le, Dandan Liang, Hao Chen, Feng Xu, Huiping Chen, Zhihong Liu and Caihong Zeng
    Citation: BMC Nephrology 2016 17:42
  22. Shared decision making is nowadays acknowledged as an essential step when deciding on starting renal replacement therapy. Valid risk stratification of prognosis is, besides discussing quality of life, crucial ...

    Authors: Patrick Peeters, Wim Van Biesen, Nic Veys, Wim Lemahieu, Bart De Moor and Johan De Meester
    Citation: BMC Nephrology 2016 17:41
  23. IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, affecting close to a million people. Circulating galactose-deficient IgA (gd-IgA), present in patients with IgAN, form immune complex ...

    Authors: Kerstin Ebefors, Peidi Liu, Emelie Lassén, Johannes Elvin, Emma Candemark, Kristina Levan, Börje Haraldsson and Jenny Nyström
    Citation: BMC Nephrology 2016 17:40
  24. Dysfunction of renal tubule epithelial cells is associated with renal tubulointerstitial fibrosis. Exploration of the proteomic profiles of senesced tubule epithelial cells is essential to elucidate the mechan...

    Authors: Yang Lu, Jingchao Wang, Chen Dapeng, Di Wu, Guangyan Cai and Xiangmei Chen
    Citation: BMC Nephrology 2016 17:39
  25. Increased urinary albumin excretion rate is the earliest clinical manifestation of diabetic nephropathy. The development of microalbuminuria in patients with type 1 diabetes mellitus (T1D) usually begins 5 to ...

    Authors: Dovilė Ražanskaitė-Virbickienė, Evalda Danytė and Rimantas Žalinkevičius
    Citation: BMC Nephrology 2016 17:38
  26. Current first-line anti-proteinuric treatments for nephrotic syndrome (NS) do not produce an effective response in all patients and are not tolerated by some patients. Additional effective and tolerable treatm...

    Authors: Arvind Madan, Snezana Mijovic-Das, Ana Stankovic, Geoffrey Teehan, Amber S. Milward and Anupa Khastgir
    Citation: BMC Nephrology 2016 17:37
  27. To investigate the predictive value of decreased urine output based on the Risk of renal dysfunction, Injury to the kidney, Failure of kidney function, Loss of kidney function and End-stage renal disease (RIFL...

    Authors: Aldjia Hocine, Pierre Defrance, Jacques Lalmand, Christian Delcour, Patrick Biston and Michaël Piagnerelli
    Citation: BMC Nephrology 2016 17:36
  28. The global prevalence of chronic kidney disease (CKD) is increasing. In children, CKD exhibits unique etiologies and can have serious impacts on children’s growth and development. Therefore, an aggressive appr...

    Authors: Hee Gyung Kang, Hyun Jin Choi, Kyung Hee Han, Seong Heon Kim, Hee Yeon Cho, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Joongyub Lee, Kook Hwan Oh, Young Seo Park, Hae Il Cheong, Curie Ahn and Il-Soo Ha
    Citation: BMC Nephrology 2016 17:35
  29. Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable...

    Authors: Luciana Mazzei, Mercedes García, Juan Pablo Calvo, Mariana Casarotto, Miguel Fornés, María Angélica Abud, Darío Cuello-carrión, León Ferder and Walter Manucha
    Citation: BMC Nephrology 2016 17:34
  30. Fetuin-A is known as a circulating inhibitor of vascular calcification. Factors associated with serum fetuin-A concentrations after long-term use of different phosphate binders in hemodialysis patients is stil...

    Authors: Hsin-Hung Lin, Hung-Hsiang Liou, Ming-Shiou Wu and Chiu-Ching Huang
    Citation: BMC Nephrology 2016 17:33
  31. Duplication of the distal part of chromosome 6p is a rare genetic syndrome. Renal involvement has been reported in the majority of patients, including a wide range of congenital abnormalities of kidney and uri...

    Authors: Augustina Jankauskienė, Magdalena Koczkowska, Anna Bjerre, Joanna Bernaciak, Franz Schaefer and Beata S. Lipska-Ziętkiewicz
    Citation: BMC Nephrology 2016 17:32

    The Erratum to this article has been published in BMC Nephrology 2016 17:43

  32. Human Immunodeficiency Virus infection is a multisystem disease that contributes to significant morbidity. Renal involvement is reported to be common among patients with HIV. This study was carried out to dete...

    Authors: Francis Fredrick, Joel M. Francis, Paschal J. Ruggajo and Eden E. Maro
    Citation: BMC Nephrology 2016 17:30
  33. Anemia is common in diabetic patients and increases morbidity and mortality, but its burden has been less well characterized in sub-Saharan Africans. We determined the prevalence of anemia and investigated the...

    Authors: Vitalis F. Feteh, Simeon-Pierre Choukem, Andre-Pascal Kengne, Daniel N. Nebongo and Marcelin Ngowe-Ngowe
    Citation: BMC Nephrology 2016 17:29
  34. Acute interstitial nephritis (AIN) represents a frequent cause of acute kidney injury. While many etiologies of AIN have been recognized, the majority (60–70 %) are due to allergic reactions or drug exposure. ...

    Authors: Julius J. Schmidt, Leyla Ramazan, Clemens Bockemeyer, Hans-Heinrich Günter, Jens Martens-Lobenhoffer, Tina Ganzenmüller, Stefanie M. Bode-Böger and Jan T. Kielstein
    Citation: BMC Nephrology 2016 17:28
  35. In the general population, the association between uninsurance and mortality is well established. We sought to evaluate the association of health insurance status with mortality among working-age participants ...

    Authors: Milda R. Saunders, Ana Catherine Ricardo, Jinsong Chen, Marshall H. Chin and James P. Lash
    Citation: BMC Nephrology 2016 17:27
  36. Neck of femur fractures are associated with high mortality and have increased prevalence in dialysis patients. Delays in operating on dialysis patients can occur as a result of logistical or medical issues; it...

    Authors: Oscar Swift, Anouska Ayub, Suresh Mathavakkannan and Nick de Roeck
    Citation: BMC Nephrology 2016 17:26
  37. Cluster analysis (CA) is a frequently used applied statistical technique that helps to reveal hidden structures and “clusters” found in large data sets. However, this method has not been widely used in large h...

    Authors: Minlei Liao, Yunfeng Li, Farid Kianifard, Engels Obi and Stephen Arcona
    Citation: BMC Nephrology 2016 17:25
  38. Two-dimensional measures of vascular architecture provide incomplete information about vascular structure. This study applied a novel rigorous method for 3D microCT-based analysis of total and cortical renal v...

    Authors: Daniel S. Perrien, Mohamed A. Saleh, Keiko Takahashi, Meena S. Madhur, David G. Harrison, Raymond C. Harris and Takamune Takahashi
    Citation: BMC Nephrology 2016 17:24
  39. Emphysematous cholecystitis is a rare variant of acute cholecystitis with a high mortality rate. The combination of emphysematous cholecystitis, liver abscess and pneumoperitoneum are even rarer. Herein we pre...

    Authors: Chen-Yi Liao, Chi-chang Tsai, Wu-Hsien Kuo, Ren-Jy Ben, Ho-Cheng Lin, Ching-Chang Lee, Kuan-Jen Su, Han-En Wang, Chih-Chiang Wang, I-Hung Chen, Shang-Tao Chien and Ming-Kai Tsai
    Citation: BMC Nephrology 2016 17:23
  40. The pathogenesis of progressive renal insufficiency in autosomal dominant polycystic kidney disease (ADPKD) is unclear. Evidence from experimental models of ADPKD suggests that elevated endothelin-1 (ET-1) dri...

    Authors: Rupesh Raina, Linda Lou, Bruce Berger, Beth Vogt, Angelique Sao-Mai Do, Robert Cunningham, Pauravi Vasavada, Karin Herrmann, Katherine Dell and Michael Simonson
    Citation: BMC Nephrology 2016 17:22
  41. Intradialytic hypotension (IDH) is considered one of the most frequent complications of haemodialysis with an estimated prevalence of 20–50 %, but studies investigating its exact prevalence are scarce. A compl...

    Authors: Johanna Kuipers, Jurjen K. Oosterhuis, Wim P. Krijnen, Judith J. Dasselaar, Carlo A. J. M. Gaillard, Ralf Westerhuis and Casper F. M. Franssen
    Citation: BMC Nephrology 2016 17:21
  42. Non-tunneled (temporary) hemodialysis catheters (NTHCs) are the least-optimal initial vascular access for incident maintenance hemodialysis patients yet little is known about factors associated with NTHC use i...

    Authors: Edward G. Clark, Ayub Akbari, Brett Hiebert, Swapnil Hiremath, Paul Komenda, Charmaine E. Lok, Louise M. Moist, Michael E. Schachter, Navdeep Tangri and Manish M. Sood
    Citation: BMC Nephrology 2016 17:20
  43. Signal transducers and activators of transcription (STAT) proteins are critical transcription factor that are aberrantly activated in various types of malignancies, including renal cell carcinoma (RCC).

    Authors: Chulwon Kim, Sang Hyun Baek, Jae-Young Um, Bum Sang Shim and Kwang Seok Ahn
    Citation: BMC Nephrology 2016 17:19
  44. Sudden cardiac death (SCD) is the most common etiology of death in hemodialysis patients but not much is known about its risk factors. The goal of our study was to determine the association and risk prediction...

    Authors: Rachel M. Kruzan, Charles A. Herzog, Aozhou Wu, Yingying Sang, Rulan S. Parekh, Kunihiro Matsushita, Seungyoung Hwang, Alan Cheng, Josef Coresh, Neil R. Powe and Tariq Shafi
    Citation: BMC Nephrology 2016 17:18
  45. Fibrillary glomerulonephritis (FGN) is a rare primary glomerular disease that seldom coexists with other diseases. Membranoproliferative glomerulonephritis is a pathologic finding of renal lesions associated w...

    Authors: Chung-Kuan Wu, Jyh-Gang Leu, An-Hang Yang, Der-Cherng Tarng, Hsiang-Yuen Tung and Shou-Shan Chiang
    Citation: BMC Nephrology 2016 17:17
  46. Sleep disordered breathing (SDB) such as sleep apnea is associated with cardiovascular disease in the general population. However, little is known about the cardiovascular risks of SDB in patients with end-sta...

    Authors: C. Vaughan Tuohy, Maria E. Montez-Rath, Mintu Turakhia, Tara I. Chang, John W. Winkelman and Wolfgang C. Winkelmayer
    Citation: BMC Nephrology 2016 17:16

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