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  1. Evidence increasingly points to the importance of chronic hypoxia in the tubulointerstitium as a final common pathway to end-stage renal disease (ESRD). Beraprost sodium (BPS) is an orally active prostacyclin ...

    Authors: Akio Koyama, Toshiro Fujita, Fumitake Gejyo, Hideki Origasa, Masanao Isono, Hajimu Kurumatani, Kiyonobu Okada, Hiroyuki Kanoh, Takashi Kiriyama and Shunsuke Yamada
    Citation: BMC Nephrology 2015 16:165
    Content type: Research article Published on:

  2. Guidelines exist for chronic kidney disease (CKD) but are not well implemented in clinical practice. We evaluated the impact of a guideline-based clinical decision support system (CDSS) on laboratory monitorin...

    Authors: Jennifer Ennis, Daniel Gillen, Arthur Rubenstein, Elaine Worcester, Mark E. Brecher, John Asplin and Fredric Coe
    Citation: BMC Nephrology 2015 16:163
    Content type: Research article Published on:

  3. Primary care physicians (PCPs) typically manage early chronic kidney disease (CKD), but recent guidelines recommend nephrology co-management for some patients with stage 3 CKD and all patients with stage 4 CKD...

    Authors: Lipika Samal, Adam Wright, Sushrut S. Waikar and Jeffrey A. Linder
    Citation: BMC Nephrology 2015 16:162
    Content type: Research article Published on:

  4. The burden of chronic kidney disease (CKD) is substantial, and is associated with high hospitalization rates, premature deaths, and considerable health care costs. These factors provide strong rationale for qu...

    Authors: Tanya S. Johns, Jerry Yee, Terrian Smith-Jules, Ruth C. Campbell and Carolyn Bauer
    Citation: BMC Nephrology 2015 16:161
    Content type: Review Published on:

  5. Live donor kidney transplantation (LDKT), an optimal therapy for many patients with end-stage kidney disease, is underutilized, particularly by African Americans. Potential recipient difficulties initiating an...

    Authors: Tara S. Strigo, Patti L. Ephraim, Iris Pounds, Felicia Hill-Briggs, Linda Darrell, Matthew Ellis, Debra Sudan, Hamid Rabb, Dorry Segev, Nae-Yuh Wang, Mary Kaiser, Margaret Falkovic, Jill F. Lebov and L. Ebony Boulware
    Citation: BMC Nephrology 2015 16:160
    Content type: Study protocol Published on:

  6. Diabetic nephropathy is one of the major microvascular complications of diabetes. We investigated the association between urinary Smad3 (usmad3) levels, glomerular hyperfiltration, and the development of nephr...

    Authors: Kaifeng Guo, Junxi Lu, Jingxin Kou, Mian Wu, Lei Zhang, Haoyong Yu, Mingliang Zhang, Yuqian Bao, Haibing Chen and Weiping Jia
    Citation: BMC Nephrology 2015 16:159
    Content type: Research article Published on:

  7. Dose adjustment for certain drugs is required in patients with reduced renal function to avoid toxicity as many drugs are eliminated by the kidneys. The aim of this study was to assess whether appropriate dosa...

    Authors: Henok Getachew, Yewondwossen Tadesse and Workineh Shibeshi
    Citation: BMC Nephrology 2015 16:158
    Content type: Research article Published on:

  8. Frailty is a state of physiological vulnerability common in the elderly. It is more predominant in patients with Chronic Kidney Disease in comparison to healthy subjects, which can also be diagnosed in non-eld...

    Authors: Henrique Novais Mansur, Júlio César Moraes Lovisi, Fernando Antonio Basile Colugnati, Nadia Rezende Barbosa Raposo, Natália Maria da Silva Fernandes and Marcus Gomes Bastos
    Citation: BMC Nephrology 2015 16:157
    Content type: Research article Published on:

  9. Nephrotic syndrome is a relatively rare but serious condition in children. Infantile nephrotic syndrome often has a genetic origin; the treatment is then symptomatic, with a poor prognosis, and a rapid evoluti...

    Authors: Julien Hogan, Marc Fila, Véronique Baudouin, Michel Peuchmaur, Georges Deschênes and Olivier Niel
    Citation: BMC Nephrology 2015 16:156
    Content type: Case report Published on:

  10. Depressive symptoms have been reported to be associated with adverse clinical outcome in patients with chronic kidney disease (CKD) not on dialysis. This association has not been examined in Europe. Anxiety an...

    Authors: Wim L. Loosman, Marcus A. Rottier, Adriaan Honig and Carl E.H. Siegert
    Citation: BMC Nephrology 2015 16:155
    Content type: Research article Published on:

  11. We aimed to evaluate the association between hearing impairment and the prevalence of chronic kidney disease (CKD) in the largest population-based cross-sectional study to date.

    Authors: Young Joon Seo, Sang Baek Ko, Tae Hyung Ha, Tae Hoon Gong, Jeong Pyo Bong, Dong-Joon Park and Sang Yoo Park
    Citation: BMC Nephrology 2015 16:154
    Content type: Research article Published on:

  12. Reliable and timely detection of acute rejection in renal transplant patients is important to preserve the allograft function and to prevent premature allograft failure. The current gold standard for the rejec...

    Authors: Antonia Zapf, Wilfried Gwinner, Annika Karch, Jochen Metzger, Hermann Haller and Armin Koch
    Citation: BMC Nephrology 2015 16:153
    Content type: Study protocol Published on:

  13. Genetic renal diseases (GRD) are a heterogeneous and incompletely understood group of disorders accounting for approximately 10 % of those diagnosed with kidney disease. The advent of Next Generation sequencin...

    Authors: Andrew Mallett, Chirag Patel, Barbara Maier, Julie McGaughran, Michael Gabbett, Minoru Takasato, Anne Cameron, Peter Trnka, Stephen I. Alexander, Gopala Rangan, Michel C. Tchan, Georgina Caruana, George John, Cathy Quinlan, Hugh J. McCarthy, Valentine Hyland…
    Citation: BMC Nephrology 2015 16:152
    Content type: Study protocol Published on:

  14. It is sometimes challenging to diagnose unsusual cases of fibrillary glomerulonephritis (FGN) and immunotactoid glomerulopathy (ITG), the rare causes of nephrotic syndrome.

    Authors: Ikuyo Narita, Michiko Shimada, Takeshi Fujita, Reiichi Murakami, Masayuki Nakamura, Norio Nakamura, Hideaki Yamabe and Ken Okumura
    Citation: BMC Nephrology 2015 16:151
    Content type: Case report Published on:

  15. Compared to others, dialysis patients who are socioeconomically disadvantaged or Black are less likely to receive education about deceased donor kidney transplant (DDKT) and living donor kidney transplant (LDK...

    Authors: Amy D. Waterman, Anna-Michelle M. McSorley, John D. Peipert, Christina J. Goalby, Leanne J. Peace, Patricia A. Lutz and Jessica L. Thein
    Citation: BMC Nephrology 2015 16:150
    Content type: Study protocol Published on:

  16. Kidney stone disease has been associated with reduced kidney function and chronic kidney disease (CKD). The objective of the study was to examine kidney function, body mass index (BMI) and the prevalence of ca...

    Authors: Vaka K. Sigurjonsdottir, Hrafnhildur L. Runolfsdottir, Olafur S. Indridason, Runolfur Palsson and Vidar O. Edvardsson
    Citation: BMC Nephrology 2015 16:149
    Content type: Research article Published on:

  17. Fractalkine (FKN) is involved in the occurrence and development of human lupus nephritis. It is known to be upregulated by lipopolysaccharide (LPS) as a stimulus in vivo. MRL/lpr mice have been used as an in vivo

    Authors: Yanwu You, Yueqiu Qin, Xu Lin, Fafen Yang, Jun Li, Suren R. Sooranna and Liao Pinhu
    Citation: BMC Nephrology 2015 16:148
    Content type: Research article Published on:

  18. Unfractionated heparin is the most common anticoagulant used in haemodialysis (HD), although it has many potential adverse effects. Citrate dialysate (CD) has an anticoagulant effect which may allow reduction ...

    Authors: Davina J. Tai, Kelvin Leung, Pietro Ravani, Robert R. Quinn, Nairne Scott-Douglas and Jennifer M. MacRae
    Citation: BMC Nephrology 2015 16:147
    Content type: Study protocol Published on:

  21. Some patients with chronic kidney disease do not respond adequately to erythropoiesis-stimulating agent (ESA) treatment; these patients are referred to as ESA hyporesponders. There is no widely accepted contem...

    Authors: Scott P. Sibbel, Carol E. Koro, Steven M. Brunelli and Alexander R. Cobitz
    Citation: BMC Nephrology 2015 16:144
    Content type: Research article Published on:

  22. Cardiovascular complications are the leading cause of mortality in patients with end-stage kidney disease. Research indicates that the Mediterranean diet is protective of cardiovascular disease in the general ...

    Authors: Erica Bessell, Matthew D. Jose and Charlotte McKercher
    Citation: BMC Nephrology 2015 16:143
    Content type: Research article Published on:

  23. Burn patients with AKI have a higher mortality, rapid diagnosis and early treatment of AKI are necessary. Recent studies have demonstrated that urinary KIM-1 and IL-18 are potential biomarkers of early-stage A...

    Authors: Hongqi Ren, Xuan Zhou, Deshu Dai, Xiang Liu, Liangxi Wang, Yifang Zhou, Xiaomei Luo and Qing Cai
    Citation: BMC Nephrology 2015 16:142
    Content type: Research article Published on:

  25. Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterised by progressive renal cyst formation leading to renal failure in the majority of patients. The likelihood and rate of ADP...

    Authors: Claire Woon, Ashleigh Bielinski-Bradbury, Karl O’Reilly and Paul Robinson
    Citation: BMC Nephrology 2015 16:140
    Content type: Research article Published on:

  26. Seasonal mortality differences have been reported in US hemodialysis (HD) patients. Here we examine the effect of seasons on mortality, clinical and laboratory parameters on a global scale.

    Authors: Adrian M. Guinsburg, Len A. Usvyat, Michael Etter, Xiaoqi Xu, Stephan Thijssen, Daniele Marcelli, Bernard Canaud, Cristina Marelli, Claudia Barth, Yuedong Wang, Paola Carioni, Frank M. van der Sande, Peter Kotanko and Jeroen P. Kooman
    Citation: BMC Nephrology 2015 16:139
    Content type: Research article Published on:

  27. A noninvasive system for determining left ventricular (LV) filling pressure may help to improve personalized fluid removal goals in hemodialysis patients. We previously showed that the change in photoplethysmo...

    Authors: Panagis Galiatsatos, Kapil Parakh, Jennifer Monti, Sumeska Thavarajah, Harriet Aneke-Ogbu, Amaris Watson, Daniel Kim, Nae-Yuh Wang, Tariq Shafi and Harry A. Silber
    Citation: BMC Nephrology 2015 16:138
    Content type: Research article Published on:

  28. Low mean arterial pressure (MAP) can cause low renal blood flow and damage the kidneys. However, in the general population, it remains unclear whether or not decline in renal function is related to MAP. The pr...

    Authors: Hongmei Yang, Xiaofan Guo, Xingang Zhang, Zhao Li, Shasha Yu, Liqiang Zheng, Wenna Li, Ying Zhou and Yingxian Sun
    Citation: BMC Nephrology 2015 16:137
    Content type: Research article Published on:

  29. Observational data suggest that serum magnesium (Mg) concentration is inversely related to vascular calcification and hyperparathyroidism among patients with end-stage renal disease (ESRD). In recent years, th...

    Authors: Paraish S. Misra, Ahsan Alam, Mark L. Lipman and Sharon J. Nessim
    Citation: BMC Nephrology 2015 16:136
    Content type: Research article Published on:

  30. Anemia is a common disorder in CKD patients. It is largely attributed to decreased erythropoietin (EPO) production and iron deficiency. Therefore, besides EPO, therapy includes iron replenishment. However, the...

    Authors: Zaher Armaly, Amir Abd El Qader, Adel Jabbour, Kamal Hassan, Rawi Ramadan, Abdalla Bowirrat and Bishara Bisharat
    Citation: BMC Nephrology 2015 16:135
    Content type: Research article Published on:

  31. Uremic neuropathy is a common complication in patients with end stage kidney disease. Its pathogenesis has been attributed to accumulation of uremic toxins. Kidney transplantation has been the best therapeutic...

    Authors: Sassan Ghazan-Shahi, Timothy Jee Kam Koh and Christopher T. Chan
    Citation: BMC Nephrology 2015 16:134
    Content type: Case report Published on:

  33. Despite its long-standing status as the diagnostic “gold standard”, the renal transplant biopsy is limited by a fundamental dependence on descriptive, empirically-derived consensus classification. The recent s...

    Authors: Benjamin Adam and Michael Mengel
    Citation: BMC Nephrology 2015 16:132
    Content type: Review Published on:

  34. Higher left ventricular mass (LV) strongly predicts cardiovascular mortality in hemodialysis patients. Although several parameters of preload and afterload have been associated with higher LV mass, whether the...

    Authors: Esther D. Kim, Stephen M. Sozio, Michelle M. Estrella, Bernard G. Jaar, Tariq Shafi, Lucy A. Meoni, Wen Hong Linda Kao, Joao A. C. Lima and Rulan S. Parekh
    Citation: BMC Nephrology 2015 16:131
    Content type: Research article Published on:

  35. Chronic kidney disease (CKD) is associated with dyslipidemia, but the role of atherogenic lipid fractions in CKD progression remains unclear. Here we assess whether baseline plasma levels of lipoprotein(a) [Lp...

    Authors: Jennie Lin, Sumeet A. Khetarpal, Karen Terembula, Muredach P. Reilly and F. Perry Wilson
    Citation: BMC Nephrology 2015 16:130
    Content type: Research article Published on:

  37. Vitamin D deficiency is highly prevalent in dialysis patients. Whether substitution of native vitamin D in these patients is beneficial is a matter of ongoing discussion, as is the optimal dosing schedule. The...

    Authors: Emanuel Zitt, Hannelore Sprenger-Mähr, Michael Mündle and Karl Lhotta
    Citation: BMC Nephrology 2015 16:128
    Content type: Research article Published on:

  38. Sustained low efficiency dialysis (SLED) is increasingly used as a renal replacement modality in critically ill patients with acute kidney injury (AKI) and hemodynamic instability. SLED may reduce the hemodyna...

    Authors: Abhijat Kitchlu, Neill Adhikari, Karen E. A. Burns, Jan O. Friedrich, Amit X. Garg, David Klein, Robert M. Richardson and Ron Wald
    Citation: BMC Nephrology 2015 16:127
    Content type: Research article Published on:

  39. Chronic kidney disease is a risk factor for development of cardiovascular diseases. Cardiovascular diseases are the primary cause of morbidity and mortality in patients with chronic kidney disease. There is li...

    Authors: Christopher Babua, Robert Kalyesubula, Emmy Okello, Barbara Kakande, Erias Sebatta, Michael Mungoma and Charles Mondo
    Citation: BMC Nephrology 2015 16:126
    Content type: Research article Published on:

  40. Telemedicine has emerged as an alternative mode of health care delivery over the last decade. To date, there is very limited published information in the field of telehealth and paediatric nephrology. The aim ...

    Authors: Peter Trnka, Megan M. White, William D. Renton, Steven J. McTaggart, John R. Burke and Anthony C. Smith
    Citation: BMC Nephrology 2015 16:125
    Content type: Research article Published on:

  42. Although adiponectin levels have been reported to be correlated with albuminuria, this issue remains unresolved in non-diabetic hypertensive subjects, particularly when urinary adiponectin is considered.

    Authors: Seung Seok Han, Eunjin Bae, Shin Young Ahn, Sejoong Kim, Jung Hwan Park, Sung Joon Shin, Sang Ho Lee, Bum Soon Choi, Ho Jun Chin, Chun Soo Lim, Suhnggwon Kim and Dong Ki Kim
    Citation: BMC Nephrology 2015 16:123
    Content type: Research article Published on:

  43. Hemodialysis is an increasingly common treatment in Vietnam as the diagnosis of end stage renal disease continues to rise. To provide appropriate hemodialysis treatment for end-stage renal disease patients, we...

    Authors: Cuong Minh Duong, Dariusz Piotr Olszyna, Phong Duy Nguyen and Mary-Louise McLaws
    Citation: BMC Nephrology 2015 16:122
    Content type: Research article Published on:

  44. Primary myelofibrosis (PMF) is a type of myeloproliferative neoplasm (MPN) characterized by the predominant proliferation of megakaryocytes and granulocytes in the bone marrow, leading to the deposition of fib...

    Authors: Arun Rajasekaran, Thuy-Trang Ngo, Maen Abdelrahim, William Glass, Amber Podoll, Srdan Verstovsek and Ala Abudayyeh
    Citation: BMC Nephrology 2015 16:121
    Content type: Case report Published on:

  45. After the publication of our paper Dunlop et al. “Rationale and design of the Sodium Lowering In Dialysate (SoLID) trial: a randomised controlled trial of low versus standard dialysate sodium concentration dur...

    Authors: Joanna Leigh Dunlop, Alain Charles Vandal, Janak Rashme de Zoysa, Ruvin Sampath Gabriel, Imad Adbi Haloob, Christopher John Hood, Philip James Matheson, David Owen Ross McGregor, Kannaiyan Samuel Rabindranath, David John Semple and Mark Roger Marshall
    Citation: BMC Nephrology 2015 16:120
    Content type: Study Protocol Published on:

  46. There currently is a need for a non-invasive measure of renal fibrosis. We aim to explore whether shear wave elastography (SWE)-derived estimates of tissue stiffness may serve as a non-invasive biomarker that ...

    Authors: Anthony E. Samir, Andrew S. Allegretti, Qingli Zhu, Manish Dhyani, Arash Anvari, Dorothy A. Sullivan, Caitlin A. Trottier, Sarah Dougherty, Winfred W. Williams, Jodie L. Babitt, Julia Wenger, Ravi I. Thadhani and Herbert Y. Lin
    Citation: BMC Nephrology 2015 16:119
    Content type: Research article Published on:

  47. Denosumab and abiraterone were approved by the United States Food and Drug Administration in 2011 for the treatment of metastatic castration-resistant prostate cancer. Neither denosumab nor abiraterone is know...

    Authors: Javier A. Neyra, Natalia A. Rocha, Rhea Bhargava, Omkar U. Vaidya, Allen R. Hendricks and Aylin R. Rodan
    Citation: BMC Nephrology 2015 16:118
    Content type: Case report Published on:

  48. Chronic kidney disease (CKD) is a global public health problem that disproportionally affects people of African ethnicity. We assessed the prevalence and determinants of CKD and albuminuria in urban and rural ...

    Authors: Francois Folefack Kaze, Diane Taghin Meto, Marie-Patrice Halle, Jeanne Ngogang and Andre-Pascal Kengne
    Citation: BMC Nephrology 2015 16:117
    Content type: Research article Published on:

  49. Whether phosphate itself has nephrotoxicity in patients with chronic kidney disease (CKD) is controversial, although phosphate excretion into urine may cause tubular damage in rat models. To evaluate actual ph...

    Authors: Tomoki Kawasaki, Yoshitaka Maeda, Hisazumi Matsuki, Yuko Matsumoto, Masanobu Akazawa and Tamaki Kuyama
    Citation: BMC Nephrology 2015 16:116
    Content type: Research article Published on:

  50. Vascular access-related infections and septicemia are the main causes of infections among hemodialysis patients, the majority of them caused by Staphylococcus species. Acetylsalicylic acid (ASA) has recently b...

    Authors: Hind Harrak, Isabelle Normand, Rachel Grinker, Naoual Elftouh, Louis-Philippe Laurin and Jean-Philippe Lafrance
    Citation: BMC Nephrology 2015 16:115
    Content type: Research article Published on:
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BMC Nephrology

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