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  1. Survivors of acute kidney injury are at an increased risk of developing irreversible deterioration in kidney function and in some cases, the need for chronic dialysis. We aimed to determine predictors of chron...

    Authors: Ziv Harel, Chaim M Bell, Stephanie N Dixon, Eric McArthur, Matthew T James, Amit X Garg, Shai Harel, Samuel Silver and Ron Wald
    Citation: BMC Nephrology 2014 15:114
    Content type: Research article Published on:

  2. Hyponatremia is known to be a marker of poor prognosis in many clinical conditions. The association between hyponatremia and clinical outcomes in peritoneal dialysis-related peritonitis (PDRP) has not been stu...

    Authors: Min-Hua Tseng, Chih-Jen Cheng, Chih-Chien Sung, Yu-Ching Chou, Pauling Chu, Giien Shuen Chen and Shih-Hua Lin
    Citation: BMC Nephrology 2014 15:113
    Content type: Research article Published on:

  3. Chronic kidney disease has become a public health problem worldwide. Its terminal stage requires renal replacement therapy – dialysis or transplantation – for the maintenance of life, resulting in high economi...

    Authors: Lenildo de Moura, Isaías Valente Prestes, Bruce Bartholow Duncan, Fernando Saldanha Thome and Maria Inês Schmidt
    Citation: BMC Nephrology 2014 15:111
    Content type: Research article Published on:

  5. Patients with X-linked agammaglobulinemia (XLA) develop immune-complex induced diseases such as nephropathy only rarely, presumably because their immunoglobulin (Ig) G concentration is low. We encountered a pa...

    Authors: Keisuke Sugimoto, Hitomi Nishi, Tomoki Miyazawa, Norihisa Wada, Akane Izu, Takuji Enya, Mitsuru Okada and Tsukasa Takemura
    Citation: BMC Nephrology 2014 15:109
    Content type: Case report Published on:

  6. Obesity and physical inactivity are major public health problems. We studied the associations between measures of adiposity, lean body mass, leisure time physical activity (LTPA), and death in those with and w...

    Authors: Sankar D Navaneethan, John P Kirwan, Susana Arrigain and Jesse D Schold
    Citation: BMC Nephrology 2014 15:108
    Content type: Research article Published on:

  7. IgA nephropathy (IgAN) may progress to renal failure for some patients without any clinical risk factors and it is not unusual to find severe pathologic damage in clinically mild IgAN. We therefore investigate...

    Authors: Peng-cheng Xu, Li Wei, Wen-ya Shang, Shun-li Tian, Dong-mei Gu, Tie-kun Yan and Shan Lin
    Citation: BMC Nephrology 2014 15:107
    Content type: Research article Published on:

  8. Emerging evidence suggests modulating the microbiota in the large bowel of patients with chronic kidney disease (CKD) through pre- and/probiotic supplementation may inhibit the development of key nephrovascula...

    Authors: Megan Rossi, David W Johnson, Mark Morrison, Elaine Pascoe, Jeff S Coombes, Josephine M Forbes, Brett C McWhinney, Jacobus PJ Ungerer, Goce Dimeski and Katrina L Campbell
    Citation: BMC Nephrology 2014 15:106
    Content type: Study protocol Published on:

  9. Adjudication of patient outcomes is a common practice in medical research and clinical trials. However minimal data exists on the adjudication process in the setting of Acute Kidney Injury (AKI) as well as the...

    Authors: Jay L Koyner, Amit X Garg, Heather Thiessen-Philbrook, Steven G Coca, Lloyd G Cantley, Aldo Peixoto, Cary S Passik, Kwangik Hong and Chirag R Parikh
    Citation: BMC Nephrology 2014 15:105
    Content type: Research article Published on:

  10. Since October 2010, the combination of a heparin-grafted polyacrilonitrile (AN69ST) membrane with a 0.80 mmol/L citric acid-containing dialysate is routinely used in our centre for intermittent haemodialysis, ...

    Authors: Karlien François, Karl Martin Wissing, Rita Jacobs, Dries Boone, Kristine Jacobs and Christian Tielemans
    Citation: BMC Nephrology 2014 15:104
    Content type: Research article Published on:

  11. Exact mechanism of causation of chronic kidney disease of unknown etiology (CKDu) in Sri Lanka is not described to date, despite the identification of possible multiple risk factors. Questions have been raised...

    Authors: EA Ranga IE Siriwardhana, Ponnumperuma AJ Perera, Ramiah Sivakanesan, Thilak Abeysekara, Danaseela B Nugegoda and Kosala GAD Weerakoon
    Citation: BMC Nephrology 2014 15:103
    Content type: Research article Published on:

  12. Adenine phosphoribosyltransferase deficiency (APRTD) is an under estimated genetic form of kidney stones and/or kidney failure, characterized by intratubular precipitation of 2,8-dihydroxyadenine crystals (2,8...

    Authors: Rea Valaperta, Vittoria Rizzo, Fortunata Lombardi, Chiara Verdelli, Marco Piccoli, Andrea Ghiroldi, Pasquale Creo, Alessio Colombo, Massimiliano Valisi, Elisabetta Margiotta, Rossella Panella and Elena Costa
    Citation: BMC Nephrology 2014 15:102
    Content type: Case report Published on:

  13. Renal handling of sodium and water is abnormal in chronic kidney disease (CKD). The aim of this study was to test the hypothesis that abnormal activity of the aquaporin-2 water channels (AQP2), the sodium-pota...

    Authors: Janni M Jensen, Frank H Mose, Anna-Ewa O Kulik, Jesper N Bech, Robert A Fenton and Erling B Pedersen
    Citation: BMC Nephrology 2014 15:101
    Content type: Research article Published on:

  14. Tolvaptan is a selective vasopressin receptor antagonist (V2R) that increases free water excretion. We wanted to test the hypotheses that tolvaptan changes both renal handling of water and sodium and systemic ...

    Authors: Safa Al Therwani, Frank Holden Mose, Janni Majgaard Jensen, Jesper Nørgaard Bech and Erling Bjerregaard Pedersen
    Citation: BMC Nephrology 2014 15:100
    Content type: Research article Published on:

  15. In developing countries, accessibility to specialists, and physician to patient contact time is limited. In Thailand, A unique community health service is provided by subdistrict health care officers and Villa...

    Authors: Teerayuth Jiamjariyaporn, Atiporn Ingsathit, Kriang Tungsanga, Chatri Banchuin, Kotcharat Vipattawat, Suphattra Kanchanakorn, Vinai Leesmidt, Watcharapong Watcharasaksilp, Akhathai Saetie, Chanida Pachotikarn, Sunard Taechangam, Tanyarat Teerapornlertratt, Teerachai Chantarojsiri and Visith Sitprija
    Citation: BMC Nephrology 2014 15:99
    Content type: Study protocol Published on:

  16. HS219 (40 mg chitosan-loaded chewing gum) is designed to bind salivary phosphorus as an add-on to available phosphorus binders. We performed a randomized, placebo-controlled, double-blind study to evaluate the...

    Authors: Tadao Akizawa, Yoshinari Tsuruta, Yoichi Okada, Yoshihiro Miyauchi, Akio Suda, Hiroshi Kasahara, Nobuhiro Sasaki, Yoshitaka Maeda, Takako Suzuki, Noriaki Matsui, Jun Niwayama, Toshiaki Suzuki, Hideaki Hara, Yasushi Asano, Sadao Komemushi and Masafumi Fukagawa
    Citation: BMC Nephrology 2014 15:98
    Content type: Research article Published on:

  17. Vitamin D deficiencies and increases in urinary albumin excretion (UAE) are both important and potentially related health problems; however, the nature of their relationship has not been established in normoal...

    Authors: Yun Jung Oh, Rae Woong Park, Dukyong Yoon, Myounghee Kim, Seung Seok Han, Hye Ryoun Jang, Hyosang Kim, Nam Ju Heo, Su-Kil Park, Hajeong Lee, Kwon Wook Joo, Chun-Soo Lim, Yon Su Kim and Dong Ki Kim
    Citation: BMC Nephrology 2014 15:97
    Content type: Research article Published on:

  18. Although percutaneous renal biopsy remains an essential tool in the diagnosis and treatment of renal diseases, in recent times the traditional procedure of nephrologists has been performed by non-nephrologists...

    Authors: Sungjin Chung, Eun Sil Koh, Sung Jun Kim, Hye Eun Yoon, Cheol Whee Park, Yoon Sik Chang and Seok Joon Shin
    Citation: BMC Nephrology 2014 15:96
    Content type: Research article Published on:

  19. Acute kidney injury (AKI) is a common clinical problem. Studies have documented the incidence of AKI in a variety of populations but to date we do not believe the real incidence of AKI has been accurately docu...

    Authors: Michael Bedford, Paul E Stevens, Toby WK Wheeler and Christopher KT Farmer
    Citation: BMC Nephrology 2014 15:95
    Content type: Research article Published on:

  20. The long-term prognosis of clinically early IgA nephropathy (IgAN) patients remains to be clarified. We investigated the long-term outcomes of IgAN patients with an apparently benign presentation and evaluated...

    Authors: Hajeong Lee, Jin Ho Hwang, Jin Ho Paik, Hyun Jin Ryu, Dong Ki Kim, Ho Jun Chin, Yun Kyu Oh, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim and Jung Pyo Lee
    Citation: BMC Nephrology 2014 15:94
    Content type: Research article Published on:

  21. Proteinuria and hematuria are both important health issues; however, the nature of the association between these findings and acute kidney injury (AKI) or mortality remains unresolved in critically ill patients.

    Authors: Seung Seok Han, Shin Young Ahn, Jiwon Ryu, Seon Ha Baek, Ho Jun Chin, Ki Young Na, Dong-Wan Chae and Sejoong Kim
    Citation: BMC Nephrology 2014 15:93
    Content type: Research article Published on:

  22. Primary hyperoxaluria type 1 is a rare autosomal recessive disease of glyoxylate metabolism caused by a defect in the liver-specific peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT) that leads to h...

    Authors: Guo-min Li, Hong Xu, Qian Shen, Yi-nv Gong, Xiao-yan Fang, Li Sun, Hai-mei Liu and Yu An
    Citation: BMC Nephrology 2014 15:92
    Content type: Research article Published on:

  23. In patients with chronic kidney disease (CKD) hyperuricemia is common. Evidence that hyperuricemia might also play a causal role in vascular disease, hypertension and progression of CKD is accumulating. Theref...

    Authors: Hakan Nacak, Merel van Diepen, Moniek CM de Goeij, Joris I Rotmans and Friedo W Dekker
    Citation: BMC Nephrology 2014 15:91
    Content type: Research article Published on:

  24. Chronic kidney disease (CKD) is increasing being recognized as a global public health problem. However, there is dearth of information on the prevalence, determinants, and management of CKD from low- and middl...

    Authors: Saleem Jessani, Rasool Bux and Tazeen H Jafar
    Citation: BMC Nephrology 2014 15:90
    Content type: Research article Published on:

  25. Although serum under-O-glycosylated IgA1 in IgA nephropathy (IgAN) patients may deposit more preferentially in glomeruli than heavily-O-glycosylated IgA1, the relationship between the glomerular IgA deposition le...

    Authors: Kenji Satake, Yoshio Shimizu, Yohei Sasaki, Hiroyuki Yanagawa, Hitoshi Suzuki, Yusuke Suzuki, Satoshi Horikoshi, Shinichiro Honda, Kazuko Shibuya, Akira Shibuya and Yasuhiko Tomino
    Citation: BMC Nephrology 2014 15:89
    Content type: Research article Published on:

  26. After renal transplantation, many patients experience adverse effects from maintenance immunosuppressive drugs. When these adverse effects occur, patient adherence with immunosuppression may be reduced and imp...

    Authors: Calvin J Meaney, Ziad Arabi, Rocco C Venuto, Joseph D Consiglio, Gregory E Wilding and Kathleen M Tornatore
    Citation: BMC Nephrology 2014 15:88
    Content type: Research article Published on:

  27. Serum p-cresyl sulfate (PCS) associates with cardiovascular disease in patients with chronic kidney disease. PCS concentrations are determined by intestinal uptake of p-cresol, human metabolism to PCS and renal c...

    Authors: Ruben Poesen, Liesbeth Viaene, Kristin Verbeke, Patrick Augustijns, Bert Bammens, Kathleen Claes, Dirk Kuypers, Pieter Evenepoel and Björn Meijers
    Citation: BMC Nephrology 2014 15:87
    Content type: Research article Published on:

  28. Medication safety in patients with chronic kidney disease (CKD) is a growing concern. This is particularly relevant in older adults due to underlying CKD. Metformin use is contraindicated in patients with abno...

    Authors: Deborah L Huang, Itamar B Abrass and Bessie A Young
    Citation: BMC Nephrology 2014 15:86
    Content type: Research article Published on:

  29. After the publication of our paper Lin et al. “Determinants of the creatinine clearance to glomerular filtration rate ratio in patients with chronic kidney disease: a cross-sectional study” BMC Nephrology 2013...

    Authors: Yen-chung Lin, Nisha Bansal, Eric Vittinghoff, Alan S Go and Chi-yuan Hsu
    Citation: BMC Nephrology 2014 15:85
    Content type: Erratum Published on:

    The original article was published in BMC Nephrology 2013 14:268

  30. AKI is common among hospital in-patients and places a huge financial burden on the UK National Health Service, causing increased length of hospital stay and use of critical care services, with increased requir...

    Authors: Rachael Challiner, James P Ritchie, Catherine Fullwood, Paul Loughnan and Alastair J Hutchison
    Citation: BMC Nephrology 2014 15:84
    Content type: Research article Published on:

  31. There is no national policy for allocation of kidneys from Donation after circulatory death (DCD) donors in the UK. Allocation is geographical and based on individual/regional centre policies. We have evaluate...

    Authors: Shanka K Benaragama, Teressa Tymkewycz, Biku J John, Andrew Davenport, Ben Lindsey, David Nicol, Jonathon Olsburgh, Martin Drage, Nizam Mamode, Francis Calder, John Taylor, Geoff Koffman, Nicos Kessaris, Mohamed Morsy, Roberto Cacciola, Carmelo Puliatti…
    Citation: BMC Nephrology 2014 15:83
    Content type: Research article Published on:

  32. Urinary (U)-complement components have been detected in patients with proteinuric renal diseases, and complement activation via the alternative pathway (AP) is believed to play a role in renal tubular damage. ...

    Authors: Seiji Nagamachi, Isao Ohsawa, Hiyori Suzuki, Nobuyuki Sato, Hiroyuki Inoshita, Atsuko Hisada, Daisuke Honda, Mamiko Shimamoto, Yoshio Shimizu, Satoshi Horikoshi and Yasuhiko Tomino
    Citation: BMC Nephrology 2014 15:82
    Content type: Research article Published on:

  33. AMG 416 is a novel peptide agonist of the calcium-sensing receptor (CaSR). This report describes the activity of AMG 416 in two different rodent models of uremia, compared in each case to cinacalcet, an approv...

    Authors: Sarah Walter, Amos Baruch, Shawn T Alexander, Julie Janes, Eiketsu Sho, Jin Dong, Qun Yin, Derek Maclean, Dirk B Mendel, Felix Karim and Randolph M Johnson
    Citation: BMC Nephrology 2014 15:81
    Content type: Research article Published on:

  34. The progression and complications of chronic kidney disease should differ depending on the cause (C), glomerular filtration rate category (G), and albuminuria (A). The KNOW-CKD (KoreaN Cohort Study for Outcome...

    Authors: Kook-Hwan Oh, Sue Kyung Park, Hayne Cho Park, Ho Jun Chin, Dong Wan Chae, Kyu Hun Choi, Seung Hyeok Han, Tae Hyun Yoo, Kyubeck Lee, Yong-Soo Kim, Wookyung Chung, Young-Hwan Hwang, Soo Wan Kim, Yeong Hoon Kim, Sun Woo Kang, Byung-Joo Park…
    Citation: BMC Nephrology 2014 15:80
    Content type: Study protocol Published on:

  35. Many older patients have chronic kidney disease (CKD), and a lower dose of anti-depressants paroxetine, mirtazapine and venlafaxine is recommended in patients with CKD to prevent drug accumulation from reduced...

    Authors: Varun Dev, Stephanie N Dixon, Jamie L Fleet, Sonja Gandhi, Tara Gomes, Ziv Harel, Arsh K Jain, Salimah Z Shariff, Davy Tawadrous, Matthew A Weir and Amit X Garg
    Citation: BMC Nephrology 2014 15:79
    Content type: Research article Published on:

  36. This study investigated the impact of renal dysfunction (RD) on long-term outcomes in elderly patients with acute coronary syndrome (ACS), and evaluated prognostic factors in elderly patients with ACS and RD.

    Authors: Yuqi Liu, Lei Gao, Qiao Xue, Muyang Yan, Pu Chen, Yu Wang and Yang Li
    Citation: BMC Nephrology 2014 15:78
    Content type: Research article Published on:

  37. Asian patients undergoing kidney transplantation (KT) generally have better renal allograft survival and a lower burden of cardiovascular disease than those of other racial groups. The KNOW-KT aims to explore ...

    Authors: Jaeseok Yang, Joongyup Lee, Kyu Ha Huh, Jae Berm Park, Jang-Hee Cho, Sik Lee, Han Ro, Seung-Yeup Han, Young Hoon Kim, Jong Cheol Jeong, Byung-Joo Park, Duck Jong Han, Sung-Bae Park, Wookyung Chung, Sung Kwang Park, Chan-Duck Kim…
    Citation: BMC Nephrology 2014 15:77
    Content type: Study protocol Published on:

  38. Familial juvenile hyperuricaemic nephropathy is a rare inherited nephropathy with genetic heterogeneity. Categorised by genetic defect, mutations in uromodulin (UMOD), renin (REN) and hepatocyte nuclear factor-1β...

    Authors: Lucy A Plumb, Matko Marlais, Agnieszka Bierzynska, Howard Martin, Kim Brugger, Stephen Abbs and Moin A Saleem
    Citation: BMC Nephrology 2014 15:76
    Content type: Case report Published on:

  39. Many patients on renal replacement therapy (RRT) require parathyroidectomy (PTX). Trends and current rates of PTX on a national level are not known. Furthermore, it is not completely clear which factors influe...

    Authors: Shahriar Akaberi, Naomi Clyne, Gunnar Sterner, Bengt Rippe, Eva Reihnér, Philippe Wagner, Rebecca Rylance, Karl Göran Prütz and Martin Almquist
    Citation: BMC Nephrology 2014 15:75
    Content type: Research article Published on:

  40. Treatment of idiopathic membranous nephropathy with nephrotic syndrome is still controversial. There is currently little known about the clinical use of renal biomarkers which may explain contradictory results...

    Authors: Claudio Bazzi, Virginia Rizza, Daniela Casellato, Rafid Tofik, Anna-Lena Berg, Maurizio Gallieni, Giuseppe D’Amico and Omran Bakoush
    Citation: BMC Nephrology 2014 15:74
    Content type: Research article Published on:

  41. In the UK, chronic disease, including chronic kidney disease (CKD) is largely managed in primary care. We developed a tool to assess practitioner confidence and knowledge in managing CKD compared to other chro...

    Authors: Mohammad Tahir, Simon Hassan, Simon de Lusignan, Lazza Shaheen, Tom Chan and Olga Dmitrieva
    Citation: BMC Nephrology 2014 15:73
    Content type: Research article Published on:

  43. High levels of circulating fibroblast growth factor 23 (FGF23) are associated with chronic kidney disease (CKD) progression and high mortality. In the Phosphate Reduction Evaluation of FGF23 in Early CKD Treat...

    Authors: Pablo Ureña-Torres, Dominique Prié, Karim Keddad, Peter Preston, Paul Wilde, Hong Wan and J Brian Copley
    Citation: BMC Nephrology 2014 15:71
    Content type: Research article Published on:

  45. Experimental models are important to the understanding of the pathophysiology of, as well as the effects of therapy on, certain diseases. In the case of chronic kidney disease-mineral bone disorder, there are ...

    Authors: Guaraciaba O Ferrari, Juliana C Ferreira, Raquel T Cavallari, Katia R Neves, Luciene M dos Reis, Wagner V Dominguez, Elizabeth C Oliveira, Fabiana G Graciolli, Jutta Passlick-Deetjen, Vanda Jorgetti and Rosa MA Moysés
    Citation: BMC Nephrology 2014 15:69
    Content type: Research article Published on:

  46. This is the first study that has examined non-cardiac incidental findings in research cardiac computed tomography (CT) of hemodialysis patients and their relationship with patient characteristics.

    Authors: Bernard G Jaar, Lili Zhang, Svetlana V Chembrovich, Stephen M Sozio, Tariq Shafi, Julia J Scialla, Gordon F Tomaselli, Joao A C Lima, Wen Hong Linda Kao, Rulan S Parekh and Lucy A Meoni
    Citation: BMC Nephrology 2014 15:68
    Content type: Research article Published on:

  47. Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-prove...

    Authors: Qingjun Pan, Yaning Li, Ling Ye, Zhenzhen Deng, Lu Li, Yongmin Feng, Weijing Liu and Huafeng Liu
    Citation: BMC Nephrology 2014 15:67
    Content type: Research article Published on:

  48. The optimal revascularization strategy for patients with impaired glomerular filtration rate (IGFR) has not been established in acute coronary syndrome (ACS). We investigated the prognosis and impact of IGFR a...

    Authors: Tsung-Hsien Lin, Ho-Tsung Hsin, Chun-Li Wang, Wen-Ter Lai, Ai-Hsien Li, Chi-Tai Kuo, Juey-Jen Hwang, Fu-Tien Chiang, Shu-Chen Chang and Chee-Jen Chang
    Citation: BMC Nephrology 2014 15:66
    Content type: Research article Published on:

  49. Left ventricular hypertrophy (LVH) is common in kidney transplant (KT) recipients. LVH is associated with a worse outcome, though m-TOR therapy may help to revert this complication. We therefore conducted a lo...

    Authors: Domingo Hernández, Pedro Ruiz-Esteban, Daniel Gaitán, Dolores Burgos, Auxiliadora Mazuecos, Rocío Collantes, Eva Briceño, Eulalia Palma, Mercedes Cabello, Miguel González-Molina and Manuel De Mora
    Citation: BMC Nephrology 2014 15:65
    Content type: Research article Published on:

  50. Most non-dialysis dependent chronic kidney disease (CKD) patients are cared for by their primary care physicians (PCPs). Studies suggest many CKD patients receive suboptimal care. Recently, CKD clinical practi...

    Authors: Khaled Abdel-Kader, Raquel C Greer, L Ebony Boulware and Mark L Unruh
    Citation: BMC Nephrology 2014 15:64
    Content type: Research article Published on:
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BMC Nephrology

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