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  1. The kidneys ability to concentrate and dilute urine is deteriorated during progressive renal insufficiency. We wanted to test the hypothesis that these phenomena could be attributed to an abnormal function of ...

    Authors: Erling B Pedersen, Ingrid M Thomsen and Thomas G Lauridsen
    Citation: BMC Nephrology 2010 11:26
    Content type: Research article Published on:

  2. The main hypothesis of this study is that neutral pH, low glucose degradation product (GDP) peritoneal dialysis (PD) fluid better preserves residual renal function in PD patients over time compared with conven...

    Authors: David W Johnson, Margaret Clarke, Vanessa Wilson, Feidhlim Woods and Fiona G Brown
    Citation: BMC Nephrology 2010 11:25
    Content type: Study protocol Published on:

  3. Patients undergoing liver transplantation with preexisting renal dysfunction are prone to further renal impairment with the early postoperative use of Calcineurin-inhibitors. However, there is only little scie...

    Authors: Andreas A Schnitzbauer, Marcus N Scherer, Justine Rochon, Johannes Sothmann, Stefan A Farkas, Martin Loss, Edward K Geissler, Aiman Obed and Hans J Schlitt
    Citation: BMC Nephrology 2010 11:24
    Content type: Study protocol Published on:

  4. Polycystic Kidney Disease is characterized by the formation of large fluid-filled cysts that eventually destroy the renal parenchyma leading to end-stage renal failure. Although remarkable progress has been ma...

    Authors: Panayiota Koupepidou, Kyriacos N Felekkis, Bettina Kränzlin, Carsten Sticht, Norbert Gretz and Constantinos Deltas
    Citation: BMC Nephrology 2010 11:23
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Nephrology 2011 12:6

  5. The incidence of acute kidney injury (AKI) has been increasing over time and is associated with a high risk of short-term death. Previous studies on hospital-acquired AKI have important methodological limitati...

    Authors: Alan S Go, Chirag R Parikh, T Alp Ikizler, Steven Coca, Edward D Siew, Vernon M Chinchilli, Chi-yuan Hsu, Amit X Garg, Michael Zappitelli, Kathleen D Liu, W Brian Reeves, Nasrollah Ghahramani, Prasad Devarajan, Georgia Brown Faulkner, Thida C Tan, Paul L Kimmel…
    Citation: BMC Nephrology 2010 11:22
    Content type: Study protocol Published on:

  6. Performing clinical research among pediatric end-stage renal disease patients is challenging. Barriers to successful initiation and completion of clinical research projects include small sample sizes and resul...

    Authors: Susan M Samuel, Marcello A Tonelli, Bethany J Foster, Alberto Nettel-Aguirre, Yingbo Na, Robert Williams, Andrea Soo and Brenda R Hemmelgarn
    Citation: BMC Nephrology 2010 11:21
    Content type: Database Published on:

  7. Since men with chronic kidney disease (CKD) progress faster than women, an accurate assessment of CKD progression rates should be based on gender differences in age-related decline of glomerular filtration rat...

    Authors: Rong Xu, Lu-Xia Zhang, Pu-Hong Zhang, Fang Wang, Li Zuo and Hai-Yan Wang
    Citation: BMC Nephrology 2010 11:20
    Content type: Research article Published on:

  8. Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury. At least 70% of AIN is caused by various drugs, mainly penicillines and non-steroidal anti-inflammatory drugs. Quinol...

    Authors: Christos Chatzikyrkou, Iyas Hamwi, Christian Clajus, Jan Becker, Carsten Hafer and Jan T Kielstein
    Citation: BMC Nephrology 2010 11:19
    Content type: Case report Published on:

  9. The apoE-/-/LDL-/- double knockout mice are bearing considerable structural homology to human atherosclerosis. We hypothesized, that advanced lesion formation in the renal artery is associated with kidney alterat...

    Authors: Alexander C Langheinrich, Marian Kampschulte, Franziska Scheiter, Christian Dierkes, Philip Stieger, Rainer M Bohle and Wolfgang Weidner
    Citation: BMC Nephrology 2010 11:18
    Content type: Research article Published on:

  10. Chronic kidney disease (CKD) is associated with an increased risk of fracture. Decreased bone mass and disruption of microarchitecture occur early in the course of CKD and worsens with the progressive decline ...

    Authors: Sarah L West, Charmaine E Lok and Sophie A Jamal
    Citation: BMC Nephrology 2010 11:17
    Content type: Study protocol Published on:

  11. Infections in hemodialysis (HD) patients lead to high morbidity and mortality rates and are associated with early cardiovascular mortality, possibly related to chronic inflammation. Intravenous (IV) iron is wi...

    Authors: Ajay Gupta, Jiaying Zhuo, Junli Zha, Srinivasa Reddy, Jonathan Olp and Amy Pai
    Citation: BMC Nephrology 2010 11:16
    Content type: Research article Published on:

  13. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). Cardiovascular risk assessment in this population is hampered by the failure of tradi...

    Authors: Mireia Junyent, Montserrat Martínez, Mercè Borràs, Blai Coll, Jose Manuel Valdivielso, Teresa Vidal, Felipe Sarró, Jordi Roig, Lourdes Craver and Elvira Fernández
    Citation: BMC Nephrology 2010 11:14
    Content type: Study protocol Published on:

  14. Left ventricular (LV) hypertrophy is common among patients on hemodialysis. While a relationship between blood pressure (BP) and LV hypertrophy has been established, it is unclear which BP measurement method i...

    Authors: Jaspreet Khangura, Bruce F Culleton, Braden J Manns, Jianguo Zhang, Lianne Barnieh, Michael Walsh, Scott W Klarenbach, Marcello Tonelli,, Magdalena Sarna and Brenda R Hemmelgarn
    Citation: BMC Nephrology 2010 11:13
    Content type: Research article Published on:

  15. Renal vasculitis presents as rapidly progressive glomerulonephritis and comprises of a group of conditions characterised by acute kidney failure, haematuria and proteinuria. Treatment of these conditions invol...

    Authors: Giles D Walters, Narelle S Willis and Jonathan C Craig
    Citation: BMC Nephrology 2010 11:12
    Content type: Research article Published on:

  16. The most appropriate time to initiate dialysis after surgical insertion of Tenckhoff catheters is not clear in the literature. There is the possibility of peritoneal dialysis (PD) complications such as leakage...

    Authors: Dwarakanathan Ranganathan, Richard Baer, Robert G Fassett, Nicola Williams, Thin Han, Melanie Watson and Helen Healy
    Citation: BMC Nephrology 2010 11:11
    Content type: Study protocol Published on:

  17. Heart and coronary calcifications in hemodialysis patients are of very common occurrence and linked to cardiovascular events and mortality. Several studies have been published with similar results. Most of the...

    Authors: Giorgio Coen, Andrea Pierantozzi, Daniele Spizzichino, Daniela Sardella, Daniela Mantella, Micaela Manni, Luigi Pellegrino, Andrea Romagnoli, Roberta Pacifici, Piergiorgio Zuccaro and Salvatore DiGiulio
    Citation: BMC Nephrology 2010 11:10
    Content type: Research article Published on:

  18. Acute kidney injury (AKI) is associated with increased short-term mortality of septic patients; however, the exact influence of AKI on long-term mortality in such patients has not yet been determined.

    Authors: José António Lopes, Paulo Fernandes, Sofia Jorge, Cristina Resina, Carla Santos, Álvaro Pereira, José Neves, Francisco Antunes and António Gomes da Costa
    Citation: BMC Nephrology 2010 11:9
    Content type: Research article Published on:

  19. Prevalence of stage 3 chronic kidney disease (CKD) is increasing according to the NHANES study. Prevalence has been calculated using the MDRD study equation for estimating glomerular filtration rate (GFR). Rec...

    Authors: Pierre Delanaye, Etienne Cavalier, Christophe Mariat, Nicolas Maillard and Jean-Marie Krzesinski
    Citation: BMC Nephrology 2010 11:8
    Content type: Research article Published on:

  20. Chronic kidney disease (CKD) is a newly recognized high-risk condition for cardiovascular disease (CVD), and previous studies reported the changes in inflammation and oxidative stress in advanced stages of CKD...

    Authors: Shoko Tsuchikura, Tetsuo Shoji, Naoko Shimomura, Ryusuke Kakiya, Masanori Emoto, Hidenori Koyama, Eiji Ishimura, Masaaki Inaba and Yoshiki Nishizawa
    Citation: BMC Nephrology 2010 11:7
    Content type: Research article Published on:

  21. Diarrhea is common in patients with Crohn's disease and may be accompanied by acid base disorders, most commonly metabolic acidosis due to intestinal loss of bicarbonate.

    Authors: Johannes Jacobi, Susanne Schnellhardt, Mirian Opgenoorth, Kerstin U Amann, Axel Küttner, Axel Schmid, Kai-Uwe Eckardt and Karl F Hilgers
    Citation: BMC Nephrology 2010 11:6
    Content type: Case report Published on:

  22. The beneficial effects of early statin use in kidney transplant recipients, especially those on tacrolimus-based immunosuppression, are not well established. We evaluated the predictors of statin use following...

    Authors: Nizar Younas, Christine M Wu, Ron Shapiro, Jerry McCauley, James Johnston, Henkie Tan, Amit Basu, Heidi Schaefer, Cynthia Smetanka, Wolfgang C Winkelmayer and Mark Unruh
    Citation: BMC Nephrology 2010 11:5
    Content type: Research article Published on:

  23. Malnutrition and inflammation are common and serious complications in patients with acute kidney injury (AKI). However, the profile of these complications in patients with AKI caused by crush syndrome (CS) rem...

    Authors: Gui-Sen Li, Xiu-Ling Chen, Yuan Zhang, Qiang He, Fang Wang, Da-Qing Hong, Ping Zhang, Lei Pu, Yue Zhang, Xiu-Chuan Yang and Li Wang
    Citation: BMC Nephrology 2010 11:4
    Content type: Research article Published on:

  24. Renal hypertrophy occurs early in diabetic nephropathy, its later value is unknown. Do large kidneys still predict poor outcome in patients with diabetes and Chronic Kidney Disease (CKD)?

    Authors: Vincent Rigalleau, Magalie Garcia, Catherine Lasseur, François Laurent, Michel Montaudon, Christelle Raffaitin, Nicole Barthe, Marie-Christine Beauvieux, Benoit Vendrely, Philippe Chauveau, Christian Combe and Henri Gin
    Citation: BMC Nephrology 2010 11:3
    Content type: Research article Published on:

  25. Patients with resistant primary focal segmental glomerulosclerosis (FSGS) are at high risk of progression to chronic kidney disease stage V. Antifibrotic agents may slow or halt this process. We present outcom...

    Authors: Alexandra Peyser, Nathaniel MacHardy, Freya Tarapore, Jacqueline MacHardy, Leslie Powell, Debbie S Gipson, Virginia Savin, Cynthia Pan, Theresa Kump, Suzanne Vento and Howard Trachtman
    Citation: BMC Nephrology 2010 11:2
    Content type: Research article Published on:

  26. African Americans have an increased incidence and worse prognosis with chronic kidney disease (CKD - estimated glomerular filtration rate [eGFR] <60 ml/min/1.73 m2) than their counterparts of European-descent. In...

    Authors: Ervin R Fox, Emelia J Benjamin, Daniel F Sarpong, Harsha Nagarajarao, Jason K Taylor, Michael W Steffes, Abdullah K Salahudeen, Michael F Flessner, Ermeg L Akylbekova, Caroline S Fox, Robert J Garrison and Herman A Taylor Jr
    Citation: BMC Nephrology 2010 11:1
    Content type: Research article Published on:

  27. Antibiotics are preferentially delivered via the peritoneal route to treat peritonitis, a major complication of peritoneal dialysis (PD), so that maximal concentrations are delivered at the site of infection. ...

    Authors: Dwarakanathan Ranganathan, Julie M Varghese, Robert G Fassett, Jeffrey Lipman, Vincent D'Intini, Helen Healy and Jason A Roberts
    Citation: BMC Nephrology 2009 10:42
    Content type: Study protocol Published on:

  28. Approximately 50% of patients with stage 3 Chronic Kidney Disease are 25-hydroxyvitamin D insufficient, and this prevalence increases with falling glomerular filtration rate. Vitamin D is now recognised as hav...

    Authors: William G Petchey, Ingrid J Hickman, Emma Duncan, Johannes B Prins, Carmel M Hawley, David W Johnson, Katherine Barraclough and Nicole M Isbel
    Citation: BMC Nephrology 2009 10:41
    Content type: Study protocol Published on:

  29. Risk factors in childhood create a life-long burden important in the development of cardiovascular (CV) disease in adulthood. Many risk factors for CV disease (e.g., hypertension) also increase the risk of ren...

    Authors: Paul Muntner, Asghar Arshad, Stephen A Morse, Dharmendrakumar A Patel, Pronabesh D Manapatra, Efrain Reisin, Erwin A Aguilar, Wei Chen, Sathanur Srinivasan and Gerald S Berenson
    Citation: BMC Nephrology 2009 10:40
    Content type: Research article Published on:

  30. Although health-related quality of life (HRQOL) is a potential independent predictor of mortality, nephrologists have shown little interest in HRQOL with respect to mortality in chronic kidney disease (CKD). T...

    Authors: Seung Seok Han, Ki Woong Kim, Ki Young Na, Dong-Wan Chae, Yon Su Kim, Suhnggwon Kim and Ho Jun Chin
    Citation: BMC Nephrology 2009 10:39
    Content type: Research article Published on:

  31. Alport syndrome (AS) is a progressive renal disease with cochlear and ocular involvement. The majority of AS cases are X-linked (XLAS) and due to mutations in the COL4A5 gene. Although the disease may appear e...

    Authors: Genevieve Pont-Kingdon, Kelli Sumner, Friederike Gedge, Chris Miller, Joyce Denison, Martin Gregory and Elaine Lyon
    Citation: BMC Nephrology 2009 10:38
    Content type: Technical advance Published on:

  32. Autosomal dominant pseudohypoaldosteronism type 1 (PHA1) is a rare inherited condition that is characterized by renal resistance to aldosterone as well as salt wasting, hyperkalemia, and metabolic acidosis. Re...

    Authors: Kyoko Kanda, Kandai Nozu, Naoki Yokoyama, Ichiro Morioka, Akihiro Miwa, Yuya Hashimura, Hiroshi Kaito, Kazumoto Iijima and Masafumi Matsuo
    Citation: BMC Nephrology 2009 10:37
    Content type: Research article Published on:

  33. Profound alterations in immune responses associated with uraemia and exacerbated by dialysis increase the risk of developing active tuberculosis (TB) in chronic haemodialysis patients (HDPs). In the current st...

    Authors: Antonios I Christopoulos, Athanasios A Diamantopoulos, Panagiotis A Dimopoulos, Demetrios S Goumenos and George A Barbalias
    Citation: BMC Nephrology 2009 10:36
    Content type: Research article Published on:

  34. The prevalence of patients with end stage renal disease (ESRD) who need dialysis and/or transplantation has more than doubled in Thailand during the past two decades. It has been suggested that therapeutic str...

    Authors: Leena Ong-ajyooth, Kriengsak Vareesangthip, Panrasri Khonputsa and Wichai Aekplakorn
    Citation: BMC Nephrology 2009 10:35
    Content type: Research article Published on:

  35. Chronic kidney disease (CKD) is increasingly being recognized as a predictor for both end-stage renal disease and cardiovascular disease. The present study, conducted on individuals from a community in Arita, ...

    Authors: Norimichi Takamatsu, Hideharu Abe, Tatsuya Tominaga, Kunihiko Nakahara, Yumi Ito, Yoko Okumoto, Jiyoong Kim, Masafumi Kitakaze and Toshio Doi
    Citation: BMC Nephrology 2009 10:34
    Content type: Research article Published on:

  36. The Italian and European Best Practice Guidelines (EBPG) recommend a target haemoglobin value greater than 11 g/dl in most patients with Chronic Kidney Diseases. However, it is still difficult to maintain thes...

    Authors: Silvia Soffritti, Giorgia Russo, Stefano Cantelli, Giuseppe Gilli and Luigi Catizone
    Citation: BMC Nephrology 2009 10:33
    Content type: Research article Published on:

  37. Oxidative stress is associated with increased cardiovascular morbidity and mortality particularly in patients with end stage kidney disease. Although observational data from the general population has shown di...

    Authors: Ashleigh Reed, Yeoung Jee Cho, Jeff S Coombes and Robert G Fassett
    Citation: BMC Nephrology 2009 10:32
    Content type: Study protocol Published on:

  38. Chronic heart failure (CHF) has a high morbidity and mortality. Chronic kidney disease (CKD) has consistently been found to be an independent risk factor for unfavorable cardiovascular (CV) outcomes. Early int...

    Authors: Arise GS Galil, Hélady S Pinheiro, Alfredo Chaoubah, Darcília MN Costa and Marcus G Bastos
    Citation: BMC Nephrology 2009 10:31
    Content type: Research article Published on:

  39. The Alberta Kidney Disease Network is a collaborative nephrology research organization based on a central repository of laboratory and administrative data from the Canadian province of Alberta.

    Authors: Brenda R Hemmelgarn, Fiona Clement, Braden J Manns, Scott Klarenbach, Matthew T James, Pietro Ravani, Neesh Pannu, Sofia B Ahmed, Jennifer MacRae, Nairne Scott-Douglas, Kailash Jindal, Robert Quinn, Bruce F Culleton, Natasha Wiebe, Richard Krause, Laurel Thorlacius…
    Citation: BMC Nephrology 2009 10:30
    Content type: Database Published on:

  40. Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin levels correlate inversely with renal function and higher levels are pr...

    Authors: Mohd O Kaisar, Kirsty Armstrong, Carmel Hawley, Scott Campbell, David Mudge, David W Johnson, John B Prins and Nicole M Isbel
    Citation: BMC Nephrology 2009 10:29
    Content type: Research article Published on:

  41. Secondary hyperparathyroidism is a common feature in patients with chronic kidney disease. Its serious clinical consequences include renal osteodystrophy, calcific uremic arteriolopathy, and vascular calcifica...

    Authors: Ditte Hansen, Lisbet Brandi and Knud Rasmussen
    Citation: BMC Nephrology 2009 10:28
    Content type: Study protocol Published on:

  42. Acute kidney injury is among the most serious complications after cardiac surgery and is associated with an impaired outcome. Multiple factors may concur in the development of this disease. Moreover, severe re...

    Authors: Jose Ramon Perez-Valdivieso, Pablo Monedero, Marc Vives, Nuria Garcia-Fernandez and Maira Bes-Rastrollo
    Citation: BMC Nephrology 2009 10:27
    Content type: Research article Published on:

  43. It is unknown whether defining chronic kidney disease (CKD) based on one versus two estimated glomerular filtration rate (eGFR) assessments changes the prognostic importance of reduced eGFR in a community-base...

    Authors: Daniel E Weiner, Maria Krassilnikova, Hocine Tighiouart, Deeb N Salem, Andrew S Levey and Mark J Sarnak
    Citation: BMC Nephrology 2009 10:26
    Content type: Research article Published on:

  44. Early detection of chronic kidney disease (CKD) is sub-optimal among the general population and among high risk patients. The prevalence and impact of major CKD risk factors, diabetes (DM) and hypertension (HT...

    Authors: Idris Guessous, William McClellan, Suma Vupputuri and Haimanot Wasse
    Citation: BMC Nephrology 2009 10:25
    Content type: Research article Published on:

  45. Chronic kidney disease (CKD) is an emerging worldwide problem. The lack of attention paid to kidney disease is well known and has been described in previous publications. However, little is known about the mag...

    Authors: Giorgio Gentile, Maurizio Postorino, Raymond D Mooring, Luigi De Angelis, Valeria Maria Manfreda, Fabrizio Ruffini, Manuela Pioppo and Giuseppe Quintaliani
    Citation: BMC Nephrology 2009 10:24
    Content type: Research article Published on:

  46. Catheter-related bacteraemias (CRBs) contribute significantly to morbidity, mortality and health care costs in dialysis populations. Despite international guidelines recommending avoidance of catheters for hae...

    Authors: Jennifer K Broom, Stacey O'Shea, Sridevi Govindarajulu, E Geoffrey Playford, Carmel M Hawley, Nicole M Isbel, Scott B Campbell, David W Mudge, Sally Carpenter, Barbara C Johnson, Neil P Underwood and David W Johnson
    Citation: BMC Nephrology 2009 10:23
    Content type: Study protocol Published on:

  47. Ideally, care prior to the initiation of dialysis should increase the likelihood that patients start electively outside of the hospital setting with a mature arteriovenous fistula (AVF) or peritoneal dialysis ...

    Authors: David C Mendelssohn, Christine Malmberg and Bassem Hamandi
    Citation: BMC Nephrology 2009 10:22
    Content type: Review Published on:

  48. The most common cause of idiopathic nephrotic syndrome in children and younger adults is the minimal change nephrotic syndrome (MCNS). In the elderly MCNS is relatively uncommon. Over the last decade some repo...

    Authors: Christian Clajus, Janine Spiegel, Verena Bröcker, Christos Chatzikyrkou and Jan T Kielstein
    Citation: BMC Nephrology 2009 10:21
    Content type: Case report Published on:

  49. The main hypothesis of this study is that oral heme iron polypeptide (HIP; Proferrin® ES) administration will more effectively augment iron stores in erythropoietic stimulatory agent (ESA)-treated peritoneal dial...

    Authors: Katherine A Barraclough, Euan Noble, Diana Leary, Fiona Brown, Carmel M Hawley, Scott B Campbell, Nicole M Isbel, David W Mudge, Carolyn L van Eps, Joanna M Sturtevant and David W Johnson
    Citation: BMC Nephrology 2009 10:20
    Content type: Study protocol Published on:

  50. There has not been a comprehensive, multi-centre study of streptococcal peritonitis in patients on peritoneal dialysis (PD) to date.

    Authors: Stacey O'Shea, Carmel M Hawley, Stephen P McDonald, Fiona G Brown, Johan B Rosman, Kathryn J Wiggins, Kym M Bannister and David W Johnson
    Citation: BMC Nephrology 2009 10:19
    Content type: Research article Published on:
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