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  1. Despite estimated glomerular filtration rate (eGFR) being the best marker for kidney function, there are no studies in sub-Saharan Africa comparing the performance of various equations used to determine eGFR. ...

    Authors: SSenabulya F. Ronny, Nankabirwa I. Joaniter, Kalyesubula Robert, Wandera Bonnie, Kirenga Bruce, Kayima James, Ocama Posiano and Bagasha Peace
    Citation: BMC Nephrology 2022 23:242
    Content type: Research Published on:

  2. COVID-19 infection is considered to cause high mortality in kidney transplant recipients (KTR). Old age, comorbidities and acute kidney injury are known risk factors for increased mortality in KTR. Nevertheles...

    Authors: Devprakash Choudhary, Deepesh Kenwar, Ajay Sharma, Ashish Bhalla, Sarbpreet Singh, Mini P Singh, Vivek Kumar and Ashish Sharma
    Citation: BMC Nephrology 2022 23:241
    Content type: Research Published on:

  3. The clinical trajectory for patients with primary membranous nephropathy ranges widely from spontaneous remission to a rapid decline in kidney function. Etiologies for rapid progression with membranous nephrop...

    Authors: Sumaiya Ahmed, David Massicotte-Azarniouch, Mark Canney, Clare Booth, Paula Blanco and Gregory L. Hundemer
    Citation: BMC Nephrology 2022 23:240
    Content type: Case report Published on:

  4. Mortality from chronic kidney disease of unknown etiology (CKDu) is extremely high along the Pacific coast of Central America, particularly among sugarcane workers. The Mesoamerican Nephropathy Occupational St...

    Authors: Sinead A. Keogh, Jessica H. Leibler, Caryn M. Sennett Decker, Juan Jose Amador Velázquez, Emmanuel R. Jarquin, Damaris Lopez-Pilarte, Ramon Garcia-Trabanino, Iris S. Delgado, Zoe E. Petropoulos, David J. Friedman, Magaly Rosario Amador Sánchez, Raul Guevara, Michael D. McClean, Daniel R. Brooks and Madeleine K. Scammell
    Citation: BMC Nephrology 2022 23:238
    Content type: Research Published on:

  5. Patients with chronic kidney disease undergoing hemodialysis (HD) have a high incidence of falls. Impairment of balance function is a risk factor for falls in the general elderly, and no report examining the a...

    Authors: Nobuyuki Shirai, Suguru Yamamoto, Yutaka Osawa, Atsuhiro Tsubaki, Shinichiro Morishita and Ichiei Narita
    Citation: BMC Nephrology 2022 23:237
    Content type: Research Published on:

  6. Patient decision aids (PtDAs) support patients and clinicians in shared decision-making (SDM). Real-world outcome information may improve patients’ risk perception, and help patients make decisions congruent w...

    Authors: Noel Engels, Paul B. van der Nat, Jet W. Ankersmid, Janine C. M. Prick, Ellen Parent, Regina The, Asako Takahashi, Hans A. J. Bart, Cornelia F. van Uden-Kraan, Anne M. Stiggelbout, Willem J. W. Bos and Marinus A. van den Dorpel
    Citation: BMC Nephrology 2022 23:236
    Content type: Research Published on:

  7. Lupus nephritis is a common manifestation of Systemic Lupus Erythematosus. Mycophenolate is recommended by guidelines for induction therapy in patients with proliferative lupus nephritis and nephrotic range pr...

    Authors: Chi Xu, Kim Ling Goh, Asanga Abeyaratne and Kelum Priyadarshana
    Citation: BMC Nephrology 2022 23:235
    Content type: Research Published on:

  8. The all-cause mortality of patients undergoing hemodialysis (HD) is higher than in the general population. The first 6 months after dialysis are important for new patients. The aim of this study was to develop...

    Authors: Guode Li, linsen Jiang, Jiangpeng Li, Huaying Shen, Shan Jiang, Han Ouyang and Kai Song
    Citation: BMC Nephrology 2022 23:234
    Content type: Research Published on:

  9. Investigating the effect of metabolic disorders on chronic kidney disease (CKD) in the presence or the absence of obesity is of great importance. This study aimed to examine the independent and joint relations...

    Authors: Samira Arbabi Jam, Behrooz Moloudpour, Farid Najafi, Mitra Darbandi and Yahya Pasdar
    Citation: BMC Nephrology 2022 23:233
    Content type: Research Published on:

  10. Patients on maintenance hemodialysis (HD) exhibit a high risk of death, cardiovascular and cerebrovascular diseases (CCDs). Previous studies indicated complement activation associated with the increased risk o...

    Authors: Zheyu Xing, Yaqin Wang, Kunjing Gong and Yuqing Chen
    Citation: BMC Nephrology 2022 23:232
    Content type: Research Published on:

  11. The association between serum total indoxyl sulfate (tIS), and cardiovascular disease (CVD) and all-cause mortality is a matter of debate. In the current study we sought to determine the association, if any, b...

    Authors: Qian Li, Shuang Zhang, Qi-Jun Wu, Jia Xiao, Zhi-Hong Wang, Xiang-Wei Mu, Yu Zhang, Xue-Na Wang, Lian-Lian You, Sheng-Nan Wang, Jia-Ni Song, Xiu-Nan Zhao, Zhen-Zhen Wang, Xin-Yi Yan, Yu-Xin Jin, Bo-Wen Jiang…
    Citation: BMC Nephrology 2022 23:231
    Content type: Research Published on:

  12. Engagement in exercise by haemodialysis (HD) patients has been shown to generate benefits both in terms of improved functional capacity and in the health-related quality of life. The use of non-immersive virtu...

    Authors: Alicia García-Testal, Francisco José Martínez-Olmos, Jose Antonio Gil-Gómez, Javier Villalón-Coca, Rafael Ortiz-Ramón, Alicia Cana-Poyatos, Rafael García-Maset and Eva Segura-Ortí
    Citation: BMC Nephrology 2022 23:230
    Content type: Research Published on:

  13. Controversy surrounds which factors are important for predicting early mortality after dialysis initiation (DI). We investigated associations of predialysis course and circumstances affecting planning and exec...

    Authors: James Heaf, Maija Heiro, Aivars Petersons, Baiba Vernere, Johan V. Povlsen, Anette Bagger Sørensen, Naomi Clyne, Inga Bumblyte, Alanta Zilinskiene, Else Randers, Niels Løkkegaard, Mai Rosenberg, Stig Kjellevold, Jan Dominik Kampmann, Björn Rogland, Inger Lagreid…
    Citation: BMC Nephrology 2022 23:229
    Content type: Research Published on:

  14. Arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome is a rare disease with a high mortality rate caused by VPS33B or VIPAS39 mutations. ARC syndrome typically presents with arthrogryposis, renal tubula...

    Authors: Lianhu Yu, Dan Li, Ting Zhang, Yongmei Xiao, Yizhong Wang and Ting Ge
    Citation: BMC Nephrology 2022 23:228
    Content type: Case report Published on:

  15. Nephrolithiasis is not common in children, but the incidence is gradually increased in these years. Urinary tract malformations, urinary infection, dietary habits, geographic region and genetic factor are invo...

    Authors: Saisai Yang, Guanghui Yao, Xin Chen, Huirong Shi, Chihhong Lou, Shumin Ren, Zhihui Jiao, Cong Wang, Xiangdong Kong and Qinghua Wu
    Citation: BMC Nephrology 2022 23:227
    Content type: Research Published on:

  16. Kidney biopsy is the most vital tool guiding a nephrologist in diagnosis and treatment of kidney disease. Over the last few years, we have seen an increasing number of kidney biopsies being performed by interv...

    Authors: Daria Emelianova, Marios Prikis, Christopher S. Morris, Pamela C. Gibson, Richard Solomon, Geoffrey Scriver, Zachary T. Smith, Anant Bhave, Joseph Shields, Michael DeSarno and Abhishek Kumar
    Citation: BMC Nephrology 2022 23:226
    Content type: Research Published on:

  17. Clinical practice guidelines recommend specialist referral according to different criteria. The aim was to assess recommended and observed referral rate and health care expenditure according to recommendations...

    Authors: Simone Kiel, Gesine Weckmann, Jean-François Chenot, Sylvia Stracke, Jacob Spallek and Aniela Angelow
    Citation: BMC Nephrology 2022 23:225
    Content type: Research Published on:

  19. Asymptomatic hyperuricemia was found to be associated with increased cardiovascular disease risk but the potential benefits of urate-lowering therapy (ULT) remain controversial. We conducted a systematic revie...

    Authors: Tunlanut Sapankaew, Kunlawat Thadanipon, Narisa Ruenroengbun, Kamolpat Chaiyakittisopon, Atiporn Ingsathit, Pawin Numthavaj, Nathorn Chaiyakunapruk, Gareth McKay, John Attia and Ammarin Thakkinstian
    Citation: BMC Nephrology 2022 23:223
    Content type: Research Published on:

  20. Chronic renal failure can lead to dialysis and/or a kidney transplant in the final stage. The number of patients under dialysis has increased considerably in the world and particularly in sub-Saharan Africa. Dial...

    Authors: Amadou Oury Toure, Mamadou Dioulde Balde, Aissatou Diallo, Sadan Camara, Anne Marie Soumah, Alpha Oumar Sall, Karifa Kourouma, Bienvenu Salim Camara, Fadima Yaya Bocoum and Seni Kouanda
    Citation: BMC Nephrology 2022 23:222
    Content type: Research Published on:

  21. The purpose of this study is to present the prevalence and effects of direct arterial puncture (DAP) for hemodialysis patients, and to introduce optimal option for the vascular access (VA) in certain hemodialy...

    Authors: Chun-Yan Sun, Mi Zhong, Li Song, Ying-Gui Chen, Zi-lin Quan, Li-Yan Zhao, Dong-Mei Cui and Xia Fu
    Citation: BMC Nephrology 2022 23:221
    Content type: Research Published on:

  22. In end-stage kidney disease, patients may undergo parathyroidectomy if secondary hyperparathyroidism cannot be managed medically. This study was designed to estimate the parathyroidectomy rate in the United St...

    Authors: Mark D Danese, Kathleen M Fox, Jennifer L. Duryea, Pooja Desai and Robert J Rubin
    Citation: BMC Nephrology 2022 23:220
    Content type: Research Published on:

  23. Prediction of graft survival for Kidney Transplantation (KT) is considered a risky task due to the scarcity of donating organs and the use of health care resources. The present study aimed to design and evalua...

    Authors: Leila Shahmoradi, Alireza Borhani, Mostafa Langarizadeh, Gholamreza Pourmand, Ziba Aghsaei fard and Sorayya Rezayi
    Citation: BMC Nephrology 2022 23:219
    Content type: Software Published on:

  24. The vascular access preservation and the maintenance of a complication-free fistula remains an Achilles’ heel of hemodialysis in chronic kidney patients due to its substantial contribution to the morbidity and...

    Authors: Ricardo Peralta, Anna Wammi, Manuela Stauss-Gabo, Óscar Dias, Helena Carvalho and António Cristóvão
    Citation: BMC Nephrology 2022 23:218
    Content type: Study protocol Published on:

  25. Most patients on peritoneal dialysis (PD) in the United States choose automated PD via cyclers. Cyclers have evolved considerably over time with older versions (e.g. HomeChoice Pro) replaced by more sophistica...

    Authors: Osama El Shamy, Sara Atallah, Shuchita Sharma and Jaime Uribarri
    Citation: BMC Nephrology 2022 23:217
    Content type: Research Published on:

  26. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination has become a major part of the strategy to reduce Coronavirus disease 2019 (COVID-19) numbers worldwide. To date, vaccinations based on ...

    Authors: Yuri Uchiyama, Hirotaka Fukasawa, Yuri Ishino, Daisuke Nakagami, Mai Kaneko, Hideo Yasuda and Ryuichi Furuya
    Citation: BMC Nephrology 2022 23:216
    Content type: Case report Published on:

  27. Chemokine (C–C motif) receptor 2 (CCR2) is involved in important physiological and pathological processes, such as inflammation and autoimmune diseases. Abnormal immune and inflammatory responses play a critic...

    Authors: Yanjie Shen, Zhiqing Zhu, Rui Wang, Lili Yan, Shuaichen Sun, Ling Lu, Zhenhua Ren and Qin Zhang
    Citation: BMC Nephrology 2022 23:215
    Content type: Research Published on:

  28. Lupus nephritis (LN) is the most common severe complication of systemic lupus erythematosus (SLE) which results in high morbidity and mortality. Up to 60% of adult patients with SLE develop the renal disease w...

    Authors: Gebre-Mariam Tsegay Hailu, Shemsu Umer Hussen, Seifemichael Getachew and Alemseged Beyene Berha
    Citation: BMC Nephrology 2022 23:214
    Content type: Research Published on:

  29. CKD-associated pruritus (chronic kidney disease-associated pruritus) is one of the common symptoms in hemodialysis patients, with a major effect on sleep quality because it occurs at night. The main objective ...

    Authors: Mefleh Daraghmeh, Montaser Badran, Ahmad Janajreh, Mohanad Hassan, Adham Abu Taha, Amer A. Koni and Sa’ed H. Zyoud
    Citation: BMC Nephrology 2022 23:213
    Content type: Research Published on:

  30. Hypercalcemic hyperparathyroidism has been associated with poor outcomes after kidney transplantation (KTx). However, the clinical implications of normocalcemic hyperparathyroidism after KTx are unclear. This ...

    Authors: Manabu Okada, Yoshihiro Tominaga, Tetsuhiko Sato, Toshihide Tomosugi, Kenta Futamura, Takahisa Hiramitsu, Toshihiro Ichimori, Norihiko Goto, Shunji Narumi, Takaaki Kobayashi, Kazuharu Uchida and Yoshihiko Watarai
    Citation: BMC Nephrology 2022 23:212
    Content type: Research Published on:

  31. T-type calcium channels (TTCC) are low voltage activated channels that are widely expressed in the heart, smooth muscle and neurons. They are known to impact on cell cycle progression in cancer and smooth musc...

    Authors: Sudha Priya Soundara Pandi, Michael J. Shattock, Bruce M. Hendry and Claire C. Sharpe
    Citation: BMC Nephrology 2022 23:211
    Content type: Research Published on:

  32. Atherosclerotic renovascular disease (ARVD) often follows an asymptomatic chronic course which may be undetected for many years. However, there are certain critical acute presentations associated with ARVD and...

    Authors: Áine de Bhailis, Saif Al-Chalabi, Rodrigo Hagemann, Sara Ibrahim, Amy Hudson, Edward Lake, Constantina Chysochou, Darren Green and Philip A. Kalra
    Citation: BMC Nephrology 2022 23:210
    Content type: Case report Published on:

  33. Stage 5 chronic kidney disease (CKD) patients often experience decisional conflict when faced with the selection between the initiation of dialysis and conservative care. The study examined the effects of a br...

    Authors: Kitty Chan, Frances Kam Yuet Wong, Suet Lai Tam, Ching Ping Kwok, Yuen Ping Fung and Ping Nam Wong
    Citation: BMC Nephrology 2022 23:209
    Content type: Research article Published on:

  34. Diabetic kidney disease (DKD) is the leading cause of kidney failure worldwide. Mortality and morbidity associated with DKD are increasing with the global prevalence of type 2 diabetes. Chronic, sub-clinical, ...

    Authors: Alexis Hofherr, Julie Williams, Li-Ming Gan, Magnus Söderberg, Pernille B. L. Hansen and Kevin J. Woollard
    Citation: BMC Nephrology 2022 23:208
    Content type: Review Published on:

  35. Technique failure is more likely to occur during the first 12 months after peritoneal dialysis (PD) initiation, which is a great challenge encountered in PD patients. The aim of this study was to investigate t...

    Authors: Xiao Dong, Haishan Wu, Hongjian Ye, Chunyan Yi, Xiangwen Diao, Ruihua Liu, Haiping Mao, Fengxian Huang, Xueqing Yu and Xiao Yang
    Citation: BMC Nephrology 2022 23:207
    Content type: Research Published on:

  37. Progression of chronic kidney disease (CKD) may be delayed if patients engage in healthy lifestyle behaviors. However, lifestyle adherence is very difficult and may be influenced by problems in psychosocial fu...

    Authors: Cinderella K. Cardol, Karin Boslooper-Meulenbelt, Henriët van Middendorp, Yvette Meuleman, Andrea W. M. Evers and Sandra van Dijk
    Citation: BMC Nephrology 2022 23:205
    Content type: Research Published on:

  38. For the optimal management of patients with both allograft kidneys and native kidney diseases, the recognition of the histological features associated with older age is important. This is because most patholog...

    Authors: Satoshi Hara, Yutaka Yamaguchi, Takeshi Zoshima, Ichiro Mizushima, Kazunori Yamada, Ryo Inoue, Hisao Muto, Kazuaki Mizutomi, Masayoshi Hirata, Hideo Araki, Ryoichi Miyazaki and Mitsuhiro Kawano
    Citation: BMC Nephrology 2022 23:204
    Content type: Research Published on:

  39. Chronic kidney disease (CKD) is one of the major global causes of mortality, described as the most neglected chronic disease. This study aimed to determine the prevalence and determinants of CKD in the setting...

    Authors: Ali Dehghani, Sadegh Alishavandi, Nader Nourimajalan, Hossein Fallahzadeh and Vahid Rahmanian
    Citation: BMC Nephrology 2022 23:203
    Content type: Research Published on:

  40. In critically ill patients, acute pain occurs frequently, causes sympathetic activation, release of inflammatory mediators, and potential organ dysfunction, with the kidneys potentially sensitive to inflammati...

    Authors: Laura Herranz Prinz, Isac de Castro, Luciano de Cesar Pontes Azevedo and Jose Mauro Vieira Jr
    Citation: BMC Nephrology 2022 23:202
    Content type: Research article Published on:

  41. Qualitative patient interviews and patient-reported outcome instruments are important tools to understand the patient experience of disease. The aim of this study was to use patient interviews to identify conc...

    Authors: Anna Rydén, Stephen Nolan, Joshua Maher, Oren Meyers, Anna Kündig and Magnus Bjursell
    Citation: BMC Nephrology 2022 23:201
    Content type: Research Published on:

  42. Left ventricular hypertrophy (LVH) is common among patients undergoing dialysis. However, the dynamic structural changes of LV are rarely discussed. The study aimed to investigate the prognostic significance o...

    Authors: Yun Chen, Shuqi Dai, Xiaolin Ge, Da Shang, Qionghong Xie, Chuanming Hao and Tongying Zhu
    Citation: BMC Nephrology 2022 23:200
    Content type: Research Published on:

  43. Dialysis patients and immunosuppressed renal patients are at increased risk of COVID-19 and were excluded from vaccine trials. We conducted a prospective multicentre study to assess SARS-CoV-2 vaccine antibody...

    Authors: Rona M. Smith, Daniel J. Cooper, Rainer Doffinger, Hannah Stacey, Abdulrahman Al-Mohammad, Ian Goodfellow, Stephen Baker, Sara Lear, Myra Hosmilo, Nicholas Pritchard, Nicholas Torpey, David Jayne, Vivien Yiu, Anil Chalisey, Jacinta Lee, Enric Vilnar…
    Citation: BMC Nephrology 2022 23:199
    Content type: Research Published on:

  45. Chronic kidney disease(CKD) is a major public health issue and is highly prevalent in the general population. Leptin is an adipose tissue-derived endocrine factor that has been associated with several metaboli...

    Authors: Yon Chul Park, Solam Lee, Young-Sang Kim, Jae-Min Park, Kunhee Han, Hunju Lee, Kyung-Won Hong, Jong-Koo Kim, Eun Suk Cho, Tae-Ha Chung, Bom-Taeck Kim and Sang Baek Koh
    Citation: BMC Nephrology 2022 23:197
    Content type: Research article Published on:

  47. To explore the biological variation (BV) of kidney injury markers in serum and urine of healthy subjects within 24 hours to assist with interpretation of future studies using these biomarkers in the context of...

    Authors: Li-Rui Kong, Fei Wei, Da-Hai He, Chao-Qiong Zhou, Hong-chuan Li, Feng Wu, Yu Luo, Jian-wei Luo, Qian-rong Xie, Hai Peng and Yan Zhang
    Citation: BMC Nephrology 2022 23:195
    Content type: Research Published on:

  48. Genus Desulfovibrio species is a sulphate-reducing anaerobic gram-negative rod that resides in the human oral cavity and intestinal tract. It was reported as the causative pathogen of bacteraemia and abdominal in...

    Authors: Yoshiki Okamoto, Yoei Miyabe, Momoko Seki, Yusuke Ushio, Keisuke Sato, Eri Kasama, Kenichi Akiyama, Kazunori Karasawa, Keiko Uchida, Ken Kikuchi, Kosaku Nitta, Takahito Moriyama and Junichi Hoshino
    Citation: BMC Nephrology 2022 23:194
    Content type: Case report Published on:

  49. Despite the high economic and mortality burden of chronic kidney disease, studies on survival and predictors of mortality among patients on hemodialysis in Ethiopia especially in the Amhara region are scarce c...

    Authors: Sewnet Getaye Workie, Taye Abuhay Zewale, Gizachew Tadesse Wassie, Makda Abate Belew and Eleni Dagnaw Abeje
    Citation: BMC Nephrology 2022 23:193
    Content type: Research Published on:

  50. Hyperphosphatemia (HP) is associated with vascular calcification (VC) in chronic kidney disease (CKD). However, relationship between HP-induced-endothelial extracellular vesicles (HP-EC-EVs) and VC is unclear,...

    Authors: Zhong Peng, Yingjie Duan, Shuzhu Zhong, Juan Chen, Jianlong Li and Zhangxiu He
    Citation: BMC Nephrology 2022 23:192
    Content type: Research Published on:
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