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  1. Acute kidney injury (AKI) is a common manifestation among patients critically ill with SARS-CoV-2 infection (Coronavirus 2019) and is associated with significant morbidity and mortality. The pathophysiology of...

    Authors: R. Lowe, M. Ferrari, M. Nasim-Mohi, A. Jackson, R. Beecham, K. Veighey, R. Cusack, D. Richardson, MPW Grocott, DZH Levett and A. Dushianthan

    Citation: BMC Nephrology 2021 22:92

    Content type: Research article

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  2. COVID-19 infection in kidney transplant recipients often lead to allograft dysfunction. The allograft injury has various histopathological manifestations. Our case illustrates the unusual combination of allogr...

    Authors: Urmila Anandh, Swarnalata Gowrishankar, Alok Sharma, Alan Salama and Indranil Dasgupta

    Citation: BMC Nephrology 2021 22:91

    Content type: Case report

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  3. Peritoneal dialysis (PD)-associated peritonitis caused by nontuberculous Mycobacterium is rare; however, the number of cases has increased over the past decades. Mycobacteroides massiliense is a subspecies of the...

    Authors: Shintaro Hamada, Tomoaki Takata, Tsuyoshi Kitaura, Chiori Teraoka, Akio Aono, Sosuke Taniguchi, Yukari Mae, Hajime Isomoto, Hiroki Chikumi and Satoshi Mitarai

    Citation: BMC Nephrology 2021 22:90

    Content type: Case report

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  4. Preoperative characteristics of living kidney donors are commonly considered during donor selection and postoperative follow-up. However, the impact of preoperative uric acid (UA) levels is poorly documented. ...

    Authors: Kosuke Tanaka, Shigeyoshi Yamanaga, Yuji Hidaka, Sho Nishida, Kohei Kinoshita, Akari Kaba, Toshinori Ishizuka, Satoshi Hamanoue, Kenji Okumura, Chiaki Kawabata, Mariko Toyoda, Akira Miyata, Masayuki Kashima and Hiroshi Yokomizo

    Citation: BMC Nephrology 2021 22:89

    Content type: Research article

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  5. To field test the Disadvantaged Populations eGFR Epidemiology (DEGREE) protocol, outdoor point-of-care (POC) testing for serum creatinine, and a new risk factor module on chronic kidney disease of undetermined...

    Authors: Erika Figueroa-Solis, David Gimeno Ruiz de Porras and George L. Delclos

    Citation: BMC Nephrology 2021 22:88

    Content type: Research article

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  6. Residual renal function is closely linked to quality of life, morbidity and mortality in dialysis patients. Beta-trace protein (BTP), a low molecular weight protein, has been suggested as marker of residual re...

    Authors: Sebastian Schwab, Carola Ellen Kleine, Dominik Bös, Sylvie Bohmann, Christian P. Strassburg, Philipp Lutz and Rainer Peter Woitas

    Citation: BMC Nephrology 2021 22:87

    Content type: Research article

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  7. Thrombotic microangiopathy (TMA), a rare but serious complication of systemic lupus erythematosus (SLE), is associated with poor outcomes to conventional immunosuppressive therapy. Recently, eculizumab, a huma...

    Authors: Mi Jung Kim, Haekyung Lee, Yon Hee Kim, So Young Jin, Hee-Jin Kim, Doyeun Oh and Jin Seok Jeon

    Citation: BMC Nephrology 2021 22:86

    Content type: Case report

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  8. Physical frailty has previously been associated with adverse clinical outcomes in patients with end-stage renal disease (ESRD). This study aimed to determine whether impaired physical performance at baseline i...

    Authors: Hee-won Jung, In Young Choi, Dong Wook Shin, Kyungdo Han, Jung Eun Yoo, Sohyun Chun and Yongjin Yi

    Citation: BMC Nephrology 2021 22:85

    Content type: Research article

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  9. As chronic kidney disease (CKD) is amongst the current global health challenges, this study is aiming to evaluate the long-term intake of total polyphenol and its subclasses in association with CKD incidence.

    Authors: Parvin Mirmiran, Emad Yuzbashian, Pegah Rahbarinejad, Golaleh Asghari and Fereidoun Azizi

    Citation: BMC Nephrology 2021 22:84

    Content type: Research article

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  10. Primary hyperoxaluria(PH)is a rare autosomal recessive genetic disease that contains three subtypes (PH1, PH2 and PH3). Approximately 80% of PH patients has been reported as subtype PH1, this subtype of PH has...

    Authors: Chang Bao Xu, Xu Dong Zhou, Hong En Xu, Yong Li Zhao, Xing Hua Zhao, Dan Hua Liu, Yong An Tian, Xin Xin Hu, Jing Yuan Guan, Jian Cheng Guo, Wen Xue Tang and Xia Xue

    Citation: BMC Nephrology 2021 22:83

    Content type: Case report

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  11. Patients with rapidly declining renal function face the dual threat of end-stage renal disease (ESRD) and mortality prior to ESRD. What is less well characterised is whether the pattern of the renal trajectory...

    Authors: Ibrahim Ali, Rajkumar Chinnadurai, Sara T. Ibrahim and Philip A. Kalra

    Citation: BMC Nephrology 2021 22:82

    Content type: Research article

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  12. Emory Dialysis serves an urban and predominantly African American population at its four outpatient dialysis facilities. We describe COVID-19 infection control measures implemented and clinical characteristics...

    Authors: Ibironke W. Apata, Jason Cobb, Jose Navarrete, John Burkart, Laura Plantinga and Janice P. Lea

    Citation: BMC Nephrology 2021 22:81

    Content type: Research article

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  14. Whilst there are a number of publications comparing the relationship between body mass index (BMI) of kidney transplant recipients and graft/patient survival, no study has assessed this for a French patient co...

    Authors: Y. Foucher, M. Lorent, L. Albano, S. Roux, V. Pernin, M. Le Quintrec, C. Legendre, F. Buron, E. Morelon, S. Girerd, M. Ladrière, D. Glotz, C. Lefaucher, C. Kerleau, J. Dantal, J. Branchereau…

    Citation: BMC Nephrology 2021 22:79

    Content type: Research article

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  16. Chronic kidney disease as well as acute kidney injury are associated with adverse outcomes after transcatheter aortic valve replacement (TAVR). However, little is known about the prognostic implications of an ...

    Authors: Dominik Kylies, Sandra Freitag-Wolf, Florian Fulisch, Hatim Seoudy, Christian Kuhn, Lars Philipp Kihm, Thomas Pühler, Georg Lutter, Astrid Dempfle, Norbert Frey, Thorsten Feldkamp and Derk Frank

    Citation: BMC Nephrology 2021 22:77

    Content type: Research article

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  17. A growing body of evidence supports the potential role of social determinants of health on health outcomes. However, few studies have examined the cumulative effect of social determinants of health on health o...

    Authors: Mukoso N. Ozieh, Emma Garacci, Rebekah J. Walker, Anna Palatnik and Leonard E. Egede

    Citation: BMC Nephrology 2021 22:76

    Content type: Research article

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  18. Anti-glomerular basement membrane disease (GBM) disease is a rare autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary haemorrhage. Recently, an association between COVID-19 and anti...

    Authors: Alexander Winkler, Emanuel Zitt, Hannelore Sprenger-Mähr, Afschin Soleiman, Manfred Cejna and Karl Lhotta

    Citation: BMC Nephrology 2021 22:75

    Content type: Case report

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  19. Lately, monoclonal gammopathy of renal significance (MGRS) has been defined as a group of renal disorders that are strongly associated with monoclonal protein, including amyloid immunoglobulin light chain (AL)...

    Authors: Erina Ono, Akira Ishii, Yoshiaki Higashi, Natsuko Koita, Takashi Ayaki, Katsuya Tanigaki, Shunsuke Takayanagi, Naoya Kondo, Kaoru Sakai, Shuichiro Endo, Hideki Yokoi, Takeshi Matsubara, Sachiko Minamiguchi, Ichizo Nishino, Ryosuke Takahashi and Motoko Yanagita

    Citation: BMC Nephrology 2021 22:74

    Content type: Case report

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  20. Hemodialysis patients with COVID-19 have been reported to be at higher risk for death than the general population. Several prognostic factors have been identified in the studies from Asian, European or America...

    Authors: Mabel Aoun, Rabab Khalil, Walid Mahfoud, Haytham Fatfat, Line Bou Khalil, Rashad Alameddine, Nabil Afiouni, Issam Ibrahim, Mohamad Hassan, Haytham Zarzour, Ali Jebai, Nina Mourad Khalil, Luay Tawil, Zeina Mechref, Zuhair El Imad, Fadia Chamma…

    Citation: BMC Nephrology 2021 22:73

    Content type: Research article

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  21. Associations between microvascular variation and chronic kidney disease (CKD) have been reported previously. Non-invasive retinal fundus imaging enables evaluation of the microvascular network and may offer in...

    Authors: Euan N. Paterson, Chris Cardwell, Thomas J. MacGillivray, Emanuele Trucco, Alexander S. Doney, Paul Foster, Alexander P. Maxwell and Gareth J. McKay

    Citation: BMC Nephrology 2021 22:72

    Content type: Research article

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  22. Higher plasma magnesium concentrations are associated with reduced cardiovascular disease risk in chronic kidney disease (CKD) patients. The importance of plasma magnesium concentration for vascular calcificat...

    Authors: Anique D. ter Braake, Larissa P. Govers, Mieke J. Peeters, Arjan D. van Zuilen, Jack F. M. Wetzels, Peter J. Blankenstijn, Joost G. J. Hoenderop, Jeroen H. F. de Baaij and Jan A. J. G. van den Brand

    Citation: BMC Nephrology 2021 22:71

    Content type: Research article

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  23. Due to a critical shortage of available kidney grafts, most patients with Stage 5 Chronic Kidney Disease (CKD5) require bridging dialysis support. It remains unclear whether treatment by different dialysis mod...

    Authors: Robin W. M. Vernooij, Way Law, Sanne A. E. Peters, Bernard Canaud, Andrew Davenport, Muriel P. C. Grooteman, Fatih Kircelli, Francesco Locatelli, Francisco Maduell, Marion Morena, Menso J. Nubé, Ercan Ok, Ferran Torres, Mark Woodward, Peter J. Blankestijn and Michiel L. Bots

    Citation: BMC Nephrology 2021 22:70

    Content type: Research article

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  24. It is unclear whether faster progression of atherosclerosis explains the higher risk of cardiovascular events in CKD. The objectives of this study were to 1. Characterize the associations of CKD with presence ...

    Authors: Srinivasan Beddhu, Robert E. Boucher, Jie Sun, Niranjan Balu, Michel Chonchol, Sankar Navaneethan, Glenn M. Chertow, Raymond Townsend, William Haley, Alfred K. Cheung, Molly B. Conroy, Dominic S. Raj, Dongxiang Xu, Thomas George, Reem Yunis, Guo Wei…

    Citation: BMC Nephrology 2021 22:69

    Content type: Research article

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  25. Diabetic nephropathy, a major complication of diabetes, is the primary risk factor for dialysis, cardiovascular diseases, and mortality. Dietary fatty acids (FAs) have been revealed to be related with cardiova...

    Authors: Takuro Okamura, Hanako Nakajima, Yoshitaka Hashimoto, Saori Majima, Takafumi Senmaru, Emi Ushigome, Naoko Nakanishi, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Hiroshi Takakuwa and Michiaki Fukui

    Citation: BMC Nephrology 2021 22:68

    Content type: Research article

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  26. Shared decision making (SDM) is recognized as the gold standard for patient-centered care. This study aimed to assess and compare the SDM among patients undergoing hemodialysis and peritoneal dialysis for choo...

    Authors: Sepide Ghodsian, Mansour Ghafourifard and Akram Ghahramanian

    Citation: BMC Nephrology 2021 22:67

    Content type: Research article

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  27. Sulfation of tyrosine, yielding O-sulfotyrosine, is a common but fixed post-translational modification in eukaryotes. Patients with increased circulating O-sulfotyrosine levels experience a faster decline in r...

    Authors: Shuai Chen, Yong-Hua Liu, Dao-Peng Dai, Zheng-Bin Zhu, Yang Dai, Zhi-Ming Wu, Li-Ping Zhang, Zhi-Feng Duan, Lin Lu, Feng-Hua Ding, Jin-Zhou Zhu and Rui-Yan Zhang

    Citation: BMC Nephrology 2021 22:66

    Content type: Research article

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  28. Individuals undergoing hemodialysis in the United States frequently report pain and receive three-fold more opioid prescriptions than the general population. While opioid use is appropriate for select patients...

    Authors: Matthew Daubresse, G. Caleb Alexander, Deidra C. Crews, Dorry L. Segev, Krista L. Lentine and Mara A. McAdams-DeMarco

    Citation: BMC Nephrology 2021 22:65

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:133

  29. Anemia is one of the common complications in patients with chronic kidney disease (CKD). However, there is no systematic investigation on the prevalence of anemia in CKD patients and its relationship with the ...

    Authors: Yan Shen, Jinwei Wang, Jing Yuan, Li Yang, Fangfang Yu, Xiaolei Wang, Ming-Hui Zhao, Luxia Zhang and Yan Zha

    Citation: BMC Nephrology 2021 22:64

    Content type: Research article

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  30. Acute kidney injury is common in the surgical intensive care unit (ICU). It is associated with poor patient outcomes and high healthcare resource usage. This study’s primary objective is to help identify which...

    Authors: Wen En Joseph Wong, Siew Pang Chan, Juin Keith Yong, Yen Yu Sherlyn Tham, Jie Rui Gerald Lim, Ming Ann Sim, Chai Rick Soh, Lian Kah Ti and Tsong Huey Sophia Chew

    Citation: BMC Nephrology 2021 22:63

    Content type: Research article

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  31. Renal resistive index (RI) predicts mortality in renal transplant recipients (RTR). However, its predictive value may be different according to the time of measurement. We analysed RI changes between 1 month a...

    Authors: Jean-Baptiste de Freminville, Louis-Marie Vernier, Jérome Roumy, Frédéric Patat, Philippe Gatault, Bénédicte Sautenet, Christelle Barbet, Hélène Longuet, Elodie Merieau, Matthias Buchler and Jean-Michel Halimi

    Citation: BMC Nephrology 2021 22:62

    Content type: Research article

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  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karine Moreau, Aurélie Desseix, Christine Germain, Pierre Merville, Lionel Couzi, Rodolphe Thiébaut and Philippe Chauveau

    Citation: BMC Nephrology 2021 22:61

    Content type: Correction

    Published on:

    The original article was published in BMC Nephrology 2021 22:31

  33. While catheters are often thought the result of emergency hemodialysis (HD) initiation among patients with little or no pre-dialysis nephrology care, the role of patient level of engagement in care and modalit...

    Authors: Vanessa Grubbs, Bernard G. Jaar, Kerri L. Cavanaugh, Patti L. Ephraim, Jessica M. Ameling, Courtney Cook, Raquel C. Greer and L. Ebony Boulware

    Citation: BMC Nephrology 2021 22:60

    Content type: Research article

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  34. Living-donor transplantation is the best treatment option in patients with chronic kidney failure. Global data show that women are less likely to be kidney recipients than men but are more likely to become liv...

    Authors: Laura Rota-Musoll, Serena Brigidi, Esmeralda Molina-Robles, Ester Oriol-Vila, Laureano Perez-Oller and Mireia Subirana-Casacuberta

    Citation: BMC Nephrology 2021 22:59

    Content type: Research article

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  35. For individuals in need of dialysis, patient participation is important when determining care goals and in decision making regarding dialysis modality. Nephrologists hold a key role in delivering evidence-base...

    Authors: Tone Andersen-Hollekim, Bodil J. Landstad, Marit Solbjør, Marit Kvangarsnes and Torstein Hole

    Citation: BMC Nephrology 2021 22:58

    Content type: Research article

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  36. There is emerging evidence that the 4-variable Kidney Failure Risk Equation (KFRE) can be used for risk prediction of graft failure in transplant recipients. However, geographical validation of the 4-variable ...

    Authors: Ibrahim Ali and Philip A. Kalra

    Citation: BMC Nephrology 2021 22:57

    Content type: Research article

    Published on:

  37. Chronic kidney disease is a systemic disease affecting not only renal function, but also endocrine, cardiovascular, and skeletal muscle systems, with broad impact on functionality. Therefore, the assessment of...

    Authors: Camila Porto Brito, Igor Gutierrez Moraes, Cláudio Luders, Christina May Moran de Brito and Wellington Pereira Yamaguti

    Citation: BMC Nephrology 2021 22:56

    Content type: Research article

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  38. The association of hypertension with congenital renal hypoplasia has been established. We report a case of an infant who underwent nephrectomy for hypertension.

    Authors: Keisuke Sugimoto, Takuji Enya, Kensuke Joh, Kohei Miyazaki, Tomoki Miyazawa, Rina Ohshima, Satoshi Marutani, Takemura Tsukasa and Mitsuru Okada

    Citation: BMC Nephrology 2021 22:55

    Content type: Case report

    Published on:

  39. Recent trials have suggested use of balanced crystalloids may decrease the incidence of major adverse kidney events compared to saline in critically ill adults. The effect of crystalloid composition on biomark...

    Authors: Blake E. Funke, Karen E. Jackson, Wesley H. Self, Sean P. Collins, Christina T. Saunders, Li Wang, Jeffrey D. Blume, Nancy Wickersham, Ryan M. Brown, Jonathan D. Casey, Gordon R. Bernard, Todd W. Rice, Edward D. Siew and Matthew W. Semler

    Citation: BMC Nephrology 2021 22:54

    Content type: Research article

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  40. Anti-glomerular basement membrane (anti-GBM) disease is an organ-specific autoimmune disease that involves the lung and kidneys and leads to rapid glomerulonephritis progression, with or without diffuse alveol...

    Authors: Na Guo, Qinghua Yin, Song Lei, Yanjun He and Ping Fu

    Citation: BMC Nephrology 2021 22:53

    Content type: Case report

    Published on:

  41. Acute kidney injury (AKI) occurs among patients with coronavirus disease-19 (COVID-19) and has also been indicated to be associated with in-hospital mortality. Remdesivir has been authorized for the treatment ...

    Authors: Zhenjian Xu, Ying Tang, Qiuyan Huang, Sha Fu, Xiaomei Li, Baojuan Lin, Anping Xu and Junzhe Chen

    Citation: BMC Nephrology 2021 22:52

    Content type: Research article

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  42. Heterozygous mutations in the inverted formin 2 (INF2) gene are related to secondary focal segmental glomerulosclerosis (FSGS), a rare secondary disease associated with rapidly progressive renal failure.

    Authors: Wenbo Zhao, Xinxin Ma, Xiaohao Zhang, Dan Luo, Jun Zhang, Ming Li, Zengchun Ye and Hui Peng

    Citation: BMC Nephrology 2021 22:51

    Content type: Case report

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  43. Cardiac biomarkers Troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (proBNP) and abdominal aortic calcification score (AAC) are associated with cardiovascular events and mortality in patients wit...

    Authors: Roosa Lankinen, Markus Hakamäki, Kaj Metsärinne, Niina Koivuviita, Jussi P. Pärkkä, Maria Saarenhovi, Tapio Hellman and Mikko J. Järvisalo

    Citation: BMC Nephrology 2021 22:50

    Content type: Research article

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  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Anja Gäckler, Ulf Schönermarck, Vladimir Dobronravov, Gaetano La Manna, Andrew Denker, Peng Liu, Maria Vinogradova, Sung-Soo Yoon and Manuel Praga

    Citation: BMC Nephrology 2021 22:49

    Content type: Correction

    Published on:

    The original article was published in BMC Nephrology 2021 22:5

  45. The festival of Ramadan is a month of spiritual reflection for Muslims worldwide. During Ramadan, Muslims are required to refrain from eating and drinking during daylight hours. Although exempted from fasting,...

    Authors: Nurul Iman Hafizah Adanan, Wan Ahmad Hafiz Wan Md Adnan, Pramod Khosla, Tilakavati Karupaiah and Zulfitri Azuan Mat Daud

    Citation: BMC Nephrology 2021 22:48

    Content type: Research article

    Published on:

  46. Tuberous Sclerosis Complex (TSC) is a genetic disorder, with renal manifestations like angiomyolipoma (AML) occurring in 70–80% of patients. AML usually cause more complications in TCS patients than in non-TSC...

    Authors: Kathrin Bausch, Christian Wetterauer, Julian Diethelm, Jan Ebbing, Daniel T. Boll, Patricia Dill, Cyrill A. Rentsch and Hans-H. Seifert

    Citation: BMC Nephrology 2021 22:47

    Content type: Research article

    Published on:

  47. Ankylosing spondylitis (AS) is an insidiously progressive and debilitating form of arthritis involving the axial skeleton, characterized by chronic back pain and progressive spinal stiffness, and lessening of ...

    Authors: Anna Zawiasa-Bryszewska, Olga Brzezińska, Ilona Kurnatowska and Joanna Makowska

    Citation: BMC Nephrology 2021 22:46

    Content type: Case report

    Published on:

    The Correction to this article has been published in BMC Nephrology 2021 22:78

  48. To evaluate the transmembrane clearance (CLTM) of apixaban during modeled in vitro continuous renal replacement therapy (CRRT), assess protein binding and circuit adsorption, and provide initial dosing recommenda...

    Authors: Lauren Andrews, Scott Benken, Xing Tan and Eric Wenzler

    Citation: BMC Nephrology 2021 22:45

    Content type: Research article

    Published on:

  49. Serum parathyroid hormone (PTH) levels have been reported to be associated with infectious mortality in peritoneal dialysis (PD) patients. Peritonitis is the most common and fatal infectious complication, resu...

    Authors: Yuqi Yang, Jingjing Da, Yi Jiang, Jing Yuan and Yan Zha

    Citation: BMC Nephrology 2021 22:44

    Content type: Research article

    Published on:

  50. Immunoglobulin A nephropathy (IgAN) is identified as mesangial IgA deposition and is usually accompanied by other immunofluorescence deposits. The impact of immunofluorescent features in IgAN patients, however...

    Authors: Lingzhi Wu, Di Liu, Ming Xia, Guochun Chen, Yu Liu, Xuejing Zhu and Hong Liu

    Citation: BMC Nephrology 2021 22:43

    Content type: Research article

    Published on:

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