Figure 1

(A) Mean hemoglobin (g/dL) and calculated geometric mean weekly erythropoiesis-stimulating agent dose (μg/wk; ± 95% CI) by month in the FAS; (B) Weekly dose day prior to conversion and first dose of darbepoetin alfa. The mean hemoglobin concentration 6 months prior to conversion to darbepoetin Q2W was 11.69 (95% CI, 11.53-11.86) g/dL, trending upwards to 12.25 (95% CI, 12.13-12.38) g/dL at conversion. At month 12 after conversion, the mean hemoglobin concentration was 11.88 (95% CI, 11.74-12.02) g/dL. The calculated weekly dose of ESA decreased from a geometric mean of 25.24 (95% CI, 23.46-27.15) μg/wk 6 months prior to conversion to 20.90 (95% CI, 19.13-22.83) μg/wk the day before conversion (Figure 1B). At conversion, the calculated first dose of darbepoetin alfa was a geometric mean of 18.89 (95% CI, 18.13-19.68) μg/wk (Figure 1B), and 19.04 [95% CI, 17.69-20.49] μg/wk at month 12. ^aHemoglobin each month was defined as the single closest value in a ± 2 week analysis window; at conversion, it was the single closest value in a -8 week analysis window; ^bWeekly dose was the total dose received each month (30 days) converted to a weekly equivalent; ^cNo imputation for missing values; Day -1 was the dose of the regimen the day before conversion (converted to a weekly equivalent); Day +1 (conversion) was the first dose of darbepoetin alfa Q2W (converted to a weekly equivalent) Abbreviations: wk, week; CI, confidence interval; C, at conversion to darbepoetin alfa every 2 weeks; Hb, hemoglobin FAS, full analysis set; Q2W, every 2 weeks;. darbepoetin alfa every 2 weeks; ESA, erythropoietin stimulating agent; FAS, full analysis set; Hb, hemoglobin.